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O03167

- COX1_LATCH

UniProt

O03167 - COX1_LATCH

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Protein

Cytochrome c oxidase subunit 1

Gene

MT-CO1

Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand)Curated
Metal bindingi240 – 2401Copper BCurated
Metal bindingi244 – 2441Copper BCurated
Metal bindingi290 – 2901Copper BCurated
Metal bindingi291 – 2911Copper BCurated
Metal bindingi376 – 3761Iron (heme A3 axial ligand)Curated
Metal bindingi378 – 3781Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
  3. response to cadmium ion Source: Ensembl
  4. response to methylmercury Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiLatimeria chalumnae (West Indian ocean coelacanth)
Taxonomic identifieri7897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
ProteomesiUP000008672: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence AnalysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence AnalysisAdd
BLAST
Transmembranei338 – 35821HelicalSequence AnalysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence AnalysisAdd
BLAST
Transmembranei414 – 43421HelicalSequence AnalysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Cytochrome c oxidase subunit 1PRO_0000183349Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliO03167.
SMRiO03167. Positions 3-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000001518.
HOVERGENiHBG003841.
InParanoidiO03167.
KOiK02256.
OMAiHFGVMFT.
OrthoDBiEOG7Q8CMW.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O03167-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMITRWLFST NHKDIGTLYM IFGAWAGMVG TALSLLIRAE LSQPGALLGD
60 70 80 90 100
DQIYNVVVTA HAFVMIFFMV MPIMIGGFGN WLIPLMIGAP DMAFPRMNNM
110 120 130 140 150
SFWLLPPSLL LLLASSGVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL
160 170 180 190 200
HLAGVSSILG AINFITTVIN MKPPTMTQYQ TPLFIWSVLV TAVLLLLSLP
210 220 230 240 250
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG
260 270 280 290 300
FGMISHIVAY YSGKKEPFGY MGMVWAMMAI GLLGFIVWAH HMFTVGMDVD
310 320 330 340 350
TRAYFTSATM IIAIPTGVKV FSWLATLHGG VTKWDTPLLW ALGFIFLFTV
360 370 380 390 400
GGLTGIVLAN SSLDIILHDT YYVVAHFHYV LSMGAVFAIM GGLVHWFPLM
410 420 430 440 450
TGYTLHNTWT KIHFGVMFTG VNLTFFPQHF LGLAGMPRRY SDYPDAYTLW
460 470 480 490 500
NTVSSIGSLI SLIAVIMFMF ILWEAFSAKR EVLIVEMTTT NVEWLHGCPP
510
PHHTYEEPAF VQAPR
Length:515
Mass (Da):56,894
Last modified:July 1, 1997 - v1
Checksum:i5B83B66071771D07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82228 Genomic DNA. Translation: AAC60320.1.
PIRiC58892.
RefSeqiNP_008331.1. NC_001804.1.

Genome annotation databases

EnsembliENSLACT00000024855; ENSLACP00000021807; ENSLACG00000022071.
GeneIDi808085.
KEGGilcm:808085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82228 Genomic DNA. Translation: AAC60320.1 .
PIRi C58892.
RefSeqi NP_008331.1. NC_001804.1.

3D structure databases

ProteinModelPortali O03167.
SMRi O03167. Positions 3-511.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSLACT00000024855 ; ENSLACP00000021807 ; ENSLACG00000022071 .
GeneIDi 808085.
KEGGi lcm:808085.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

GeneTreei ENSGT00390000001518.
HOVERGENi HBG003841.
InParanoidi O03167.
KOi K02256.
OMAi HFGVMFT.
OrthoDBi EOG7Q8CMW.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the mitochondrial genome of a 'living fossil,' the coelacanth (Latimeria chalumnae)."
    Zardoya R., Meyer A.
    Genetics 146:995-1010(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCOX1_LATCH
AccessioniPrimary (citable) accession number: O03167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3