Reviewed, UniProtKB/Swiss-Prot O02858 (ACOD_PIG)

Names and origin

Protein names

Recommended name:
    Acyl-CoA desaturase
    EC=1.14.19.1
Alternative name(s):
    Stearoyl-CoA desaturase
    Fatty acid desaturase
    Delta(9)-desaturase

Gene names

Name:

SCD

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	334 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA By similarity.
Catalytic activity	Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.
Cofactor	Iron.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Probable.
Domain	The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence similarities	Belongs to the fatty acid desaturase family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Ligand	Iron
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW stearoyl-CoA 9-desaturase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›334	›334	Acyl-CoA desaturase		PRO_0000185399
Regions
	Transmembrane	65 – 85	21	Potential
	Transmembrane	87 – 107	21	Potential
	Transmembrane	212 – 232	21	Potential
	Transmembrane	304 – 324	21	Potential
	Motif	109 – 114	6	Histidine box-1
	Motif	146 – 150	5	Histidine box-2
	Motif	287 – 291	5	Histidine box-3
Amino acid modifications
	Modified residue	192	1	Phosphoserine By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	334	1

Sequences

	Sequence		Length	Mass (Da)
	O02858-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 79183E3918469977	FASTA	334	38,482
	10 20 30 40 50 60 SSYTTTTTIT APSSRVLQNG GGKSEKTPQY VEEDIRPEMK DDIYDPTYQD KEGPQGKLEY 70 80 90 100 110 120 VWRNIILMSL LHLGALYGII LIPTCKIYTL LWAFAYYLLS AVGVTAGAHR LWSHRTYKAR 130 140 150 160 170 180 LPLRVFLIIA NTMAFQNDVY EWARDHRAHH KFSETDADPH NSRRGFFFSH VGWLLVRKHP 190 200 210 220 230 240 AVKEKGGLLN MSDLKAEKLV MFQRRYYKPG ILLMCFILPT IVPWYCWGEA FPQSLFVATF 250 260 270 280 290 300 LRYAIVLNAT WLVNSAAHLY GYRPYDKTIS PRENILVSLG AVGEGFHNYH HTFPYDYSAS 310 320 330 EYRWHINLTT FFIDCMAALG LAYDRKKVSK AAIL

References

[1]	Fumiere O. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z97186 mRNA. Translation: CAB10004.1.
UniGene	Ssc.16159
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	O02858.
Enzyme and pathway databases
BRENDA	1.14.19.1. 249.
Family and domain databases
InterPro	IPR005804. Fatty_acid_desaturase-1. IPR001522. Fatty_acid_desaturase-1_C. IPR015876. Fatty_acid_desaturase-1_core. [Graphical view]
Pfam	PF00487. FA_desaturase. 1 hit. [Graphical view]
PRINTS	PR00075. FACDDSATRASE.
ProDom	PD002221. Desaturase. 1 hit. PD001081. FA_desat_sub. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00476. FATTY_ACID_DESATUR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACOD_PIG

Accession

Primary (citable) accession number: O02858

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)