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O02840

- CADH5_PIG

UniProt

O02840 - CADH5_PIG

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Protein
Cadherin-5
Gene
CDH5
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551Calcium 1 By similarity
Metal bindingi55 – 551Calcium 2 By similarity
Metal bindingi56 – 561Calcium 1 By similarity
Metal bindingi106 – 1061Calcium 1 By similarity
Metal bindingi108 – 1081Calcium 1 By similarity
Metal bindingi108 – 1081Calcium 2 By similarity
Metal bindingi140 – 1401Calcium 2 By similarity
Metal bindingi141 – 1411Calcium 2; via carbonyl oxygen By similarity
Metal bindingi142 – 1421Calcium 3 By similarity
Metal bindingi143 – 1431Calcium 1 By similarity
Metal bindingi143 – 1431Calcium 2 By similarity
Metal bindingi144 – 1441Calcium 3; via carbonyl oxygen By similarity
Metal bindingi174 – 1741Calcium 3 By similarity
Metal bindingi176 – 1761Calcium 2 By similarity
Metal bindingi176 – 1761Calcium 3 By similarity
Metal bindingi183 – 1831Calcium 3; via carbonyl oxygen By similarity
Metal bindingi228 – 2281Calcium 3 By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
  2. regulation of establishment of cell polarity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-5
Alternative name(s):
Vascular endothelial cadherin
Short name:
VE-cadherin
CD_antigen: CD144
Gene namesi
Name:CDH5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Cell junction By similarity. Cell membrane; Single-pass type I membrane protein
Note: Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini45 – 598554Extracellular Reviewed prediction
Add
BLAST
Transmembranei599 – 61921Helical; Reviewed prediction
Add
BLAST
Topological domaini620 – 782163Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB
  2. cell-cell junction Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Propeptidei23 – 4422 Reviewed prediction
PRO_0000003759Add
BLAST
Chaini45 – 782738Cadherin-5
PRO_0000003760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi154 – 1541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi360 – 3601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi440 – 4401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi522 – 5221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi534 – 5341N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB By similarity.
O-glycosylated By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Interacts (via cadherin 5 domain) with PTPRB By similarity. Interacts with TRPC4 By similarity. Interacts with KRIT1 By similarity. Interacts with PARD3 By similarity.

Structurei

3D structure databases

ProteinModelPortaliO02840.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 148104Cadherin 1
Add
BLAST
Domaini149 – 255107Cadherin 2
Add
BLAST
Domaini256 – 370115Cadherin 3
Add
BLAST
Domaini371 – 475105Cadherin 4
Add
BLAST
Domaini476 – 592117Cadherin 5
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi736 – 75116Ser-rich
Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 5 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005217.
KOiK06533.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02840-1 [UniParc]FASTAAdd to Basket

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MQVLVMLLAA AGTYLGLLTA PTAASNPGRQ DTPSTLPLHR RQKRDWIWNQ    50
MHIDEEKNGS LPHYVGKIKS SVNHKNTKYQ LKGESAGKVF RVDENTGDVY 100
AFERLDREKI PEYQLVALVV DKNTEKNLES PSSFTIKVHD INDNWPVFTQ 150
LVFNASVPEM SVIGTSVIQL TAVDADDPTV ADHASVIYRL KEGEEHFRIR 200
GPGLIETASK NLDRETVPMY KIVVETQDAQ GLRGDSGTAT VFITLQDVND 250
NFPVFTQTRY TFSVPEDIRV GSPLGSLFVK DPDEPQNRKT KYSIVQGEYR 300
DTFTIEPDPT RNEGIIKPMK PLDYERIQQY SFTIEATDPT IDLRYLSGTS 350
TKNIARVIIN VTDVDEPPNF KQPFYHFQLR ENEKKPWIGS VLAVDPDAAQ 400
RSIGYSIRRT SDKGQFFGIN KHGNIYNVKE LDREVYPWYN LTVEAKELDS 450
RGTPTGKESI VQVHIEVLDE NDNAPEFAKP YEAKVCEDAP QGKLVVQISA 500
IDKDVTPRDV KFKFSLSTED SNFTLTDNHD NTANITVKHG YFDRERAKVH 550
HLPILISDNG RPSLTGTSTL HVTVCKCNER GEFTLCEEMG AQVGVSIQAL 600
VAIFLCILTI AVISLLVYLR RRLRKQARAH GKSVPEIHEQ LVTYDEEGGG 650
EMDTTSYDVS VLNSVRHGGA KPPRPALDAR PSLYAQVQKP PRHAPGAHAP 700
GEMAAMIEVK KDEADHDGGG PPYDTLHIFG YEGAESIAES LSSLGTDSSD 750
SDIDYDFLND WGPRFKMLAE LYGSDPREEL LY 782
Length:782
Mass (Da):87,546
Last modified:July 1, 1997 - v1
Checksum:i7403F974E2DF782F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13919 mRNA. Translation: CAA74225.1.
RefSeqiNP_001001649.2. NM_001001649.2.
UniGeneiSsc.75.

Genome annotation databases

GeneIDi414737.
KEGGissc:414737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13919 mRNA. Translation: CAA74225.1 .
RefSeqi NP_001001649.2. NM_001001649.2.
UniGenei Ssc.75.

3D structure databases

ProteinModelPortali O02840.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414737.
KEGGi ssc:414737.

Organism-specific databases

CTDi 1003.

Phylogenomic databases

HOVERGENi HBG005217.
KOi K06533.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Kilshaw P.J.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCADH5_PIG
AccessioniPrimary (citable) accession number: O02840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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