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O02840

- CADH5_PIG

UniProt

O02840 - CADH5_PIG

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Protein

Cadherin-5

Gene

CDH5

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551Calcium 1By similarity
Metal bindingi55 – 551Calcium 2By similarity
Metal bindingi56 – 561Calcium 1By similarity
Metal bindingi106 – 1061Calcium 1By similarity
Metal bindingi108 – 1081Calcium 1By similarity
Metal bindingi108 – 1081Calcium 2By similarity
Metal bindingi140 – 1401Calcium 2By similarity
Metal bindingi141 – 1411Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi142 – 1421Calcium 3By similarity
Metal bindingi143 – 1431Calcium 1By similarity
Metal bindingi143 – 1431Calcium 2By similarity
Metal bindingi144 – 1441Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi174 – 1741Calcium 3By similarity
Metal bindingi176 – 1761Calcium 2By similarity
Metal bindingi176 – 1761Calcium 3By similarity
Metal bindingi183 – 1831Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi228 – 2281Calcium 3By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  2. regulation of establishment of cell polarity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-5
Alternative name(s):
Vascular endothelial cadherin
Short name:
VE-cadherin
CD_antigen: CD144
Gene namesi
Name:CDH5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Cell junction By similarity. Cell membrane; Single-pass type I membrane protein
Note: Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini45 – 598554ExtracellularSequence AnalysisAdd
BLAST
Transmembranei599 – 61921HelicalSequence AnalysisAdd
BLAST
Topological domaini620 – 782163CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: UniProtKB
  2. cell junction Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 4422Sequence AnalysisPRO_0000003759Add
BLAST
Chaini45 – 782738Cadherin-5PRO_0000003760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi522 – 5221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).By similarity
O-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Interacts (via cadherin 5 domain) with PTPRB. Interacts with TRPC4. Interacts with KRIT1. Interacts with PARD3.By similarity

Structurei

3D structure databases

ProteinModelPortaliO02840.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 148104Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 255107Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini256 – 370115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini371 – 475105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini476 – 592117Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi736 – 75116Ser-richAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005217.
InParanoidiO02840.
KOiK06533.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02840-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVLVMLLAA AGTYLGLLTA PTAASNPGRQ DTPSTLPLHR RQKRDWIWNQ
60 70 80 90 100
MHIDEEKNGS LPHYVGKIKS SVNHKNTKYQ LKGESAGKVF RVDENTGDVY
110 120 130 140 150
AFERLDREKI PEYQLVALVV DKNTEKNLES PSSFTIKVHD INDNWPVFTQ
160 170 180 190 200
LVFNASVPEM SVIGTSVIQL TAVDADDPTV ADHASVIYRL KEGEEHFRIR
210 220 230 240 250
GPGLIETASK NLDRETVPMY KIVVETQDAQ GLRGDSGTAT VFITLQDVND
260 270 280 290 300
NFPVFTQTRY TFSVPEDIRV GSPLGSLFVK DPDEPQNRKT KYSIVQGEYR
310 320 330 340 350
DTFTIEPDPT RNEGIIKPMK PLDYERIQQY SFTIEATDPT IDLRYLSGTS
360 370 380 390 400
TKNIARVIIN VTDVDEPPNF KQPFYHFQLR ENEKKPWIGS VLAVDPDAAQ
410 420 430 440 450
RSIGYSIRRT SDKGQFFGIN KHGNIYNVKE LDREVYPWYN LTVEAKELDS
460 470 480 490 500
RGTPTGKESI VQVHIEVLDE NDNAPEFAKP YEAKVCEDAP QGKLVVQISA
510 520 530 540 550
IDKDVTPRDV KFKFSLSTED SNFTLTDNHD NTANITVKHG YFDRERAKVH
560 570 580 590 600
HLPILISDNG RPSLTGTSTL HVTVCKCNER GEFTLCEEMG AQVGVSIQAL
610 620 630 640 650
VAIFLCILTI AVISLLVYLR RRLRKQARAH GKSVPEIHEQ LVTYDEEGGG
660 670 680 690 700
EMDTTSYDVS VLNSVRHGGA KPPRPALDAR PSLYAQVQKP PRHAPGAHAP
710 720 730 740 750
GEMAAMIEVK KDEADHDGGG PPYDTLHIFG YEGAESIAES LSSLGTDSSD
760 770 780
SDIDYDFLND WGPRFKMLAE LYGSDPREEL LY
Length:782
Mass (Da):87,546
Last modified:July 1, 1997 - v1
Checksum:i7403F974E2DF782F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13919 mRNA. Translation: CAA74225.1.
RefSeqiNP_001001649.2. NM_001001649.2.
UniGeneiSsc.75.

Genome annotation databases

GeneIDi414737.
KEGGissc:414737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13919 mRNA. Translation: CAA74225.1 .
RefSeqi NP_001001649.2. NM_001001649.2.
UniGenei Ssc.75.

3D structure databases

ProteinModelPortali O02840.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414737.
KEGGi ssc:414737.

Organism-specific databases

CTDi 1003.

Phylogenomic databases

HOVERGENi HBG005217.
InParanoidi O02840.
KOi K06533.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Kilshaw P.J.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCADH5_PIG
AccessioniPrimary (citable) accession number: O02840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3