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Protein

Cadherin-5

Gene

CDH5

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi55Calcium 1By similarity1
Metal bindingi55Calcium 2By similarity1
Metal bindingi56Calcium 1By similarity1
Metal bindingi106Calcium 1By similarity1
Metal bindingi108Calcium 1By similarity1
Metal bindingi108Calcium 2By similarity1
Metal bindingi140Calcium 2By similarity1
Metal bindingi141Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi142Calcium 3By similarity1
Metal bindingi143Calcium 1By similarity1
Metal bindingi143Calcium 2By similarity1
Metal bindingi144Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi174Calcium 3By similarity1
Metal bindingi176Calcium 2By similarity1
Metal bindingi176Calcium 3By similarity1
Metal bindingi183Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi228Calcium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-5
Alternative name(s):
Vascular endothelial cadherin
Short name:
VE-cadherin
CD_antigen: CD144
Gene namesi
Name:CDH5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 598ExtracellularSequence analysisAdd BLAST554
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Topological domaini620 – 782CytoplasmicSequence analysisAdd BLAST163

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000000375923 – 44Sequence analysisAdd BLAST22
ChainiPRO_000000376045 – 782Cadherin-5Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi154N-linked (GlcNAc...)Sequence analysis1
Glycosylationi360N-linked (GlcNAc...)Sequence analysis1
Glycosylationi440N-linked (GlcNAc...)Sequence analysis1
Glycosylationi522N-linked (GlcNAc...)Sequence analysis1
Glycosylationi534N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).By similarity
O-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PeptideAtlasiO02840.
PRIDEiO02840.

Interactioni

Subunit structurei

Interacts (via cadherin 5 domain) with PTPRB. Interacts with TRPC4. Interacts with KRIT1. Interacts with PARD3.By similarity

Structurei

3D structure databases

ProteinModelPortaliO02840.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 148Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini149 – 255Cadherin 2PROSITE-ProRule annotationAdd BLAST107
Domaini256 – 370Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini371 – 475Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini476 – 592Cadherin 5PROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi736 – 751Ser-richAdd BLAST16

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005217.
InParanoidiO02840.
KOiK06533.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR030052. CDH5.
[Graphical view]
PANTHERiPTHR24027:SF89. PTHR24027:SF89. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVLVMLLAA AGTYLGLLTA PTAASNPGRQ DTPSTLPLHR RQKRDWIWNQ
60 70 80 90 100
MHIDEEKNGS LPHYVGKIKS SVNHKNTKYQ LKGESAGKVF RVDENTGDVY
110 120 130 140 150
AFERLDREKI PEYQLVALVV DKNTEKNLES PSSFTIKVHD INDNWPVFTQ
160 170 180 190 200
LVFNASVPEM SVIGTSVIQL TAVDADDPTV ADHASVIYRL KEGEEHFRIR
210 220 230 240 250
GPGLIETASK NLDRETVPMY KIVVETQDAQ GLRGDSGTAT VFITLQDVND
260 270 280 290 300
NFPVFTQTRY TFSVPEDIRV GSPLGSLFVK DPDEPQNRKT KYSIVQGEYR
310 320 330 340 350
DTFTIEPDPT RNEGIIKPMK PLDYERIQQY SFTIEATDPT IDLRYLSGTS
360 370 380 390 400
TKNIARVIIN VTDVDEPPNF KQPFYHFQLR ENEKKPWIGS VLAVDPDAAQ
410 420 430 440 450
RSIGYSIRRT SDKGQFFGIN KHGNIYNVKE LDREVYPWYN LTVEAKELDS
460 470 480 490 500
RGTPTGKESI VQVHIEVLDE NDNAPEFAKP YEAKVCEDAP QGKLVVQISA
510 520 530 540 550
IDKDVTPRDV KFKFSLSTED SNFTLTDNHD NTANITVKHG YFDRERAKVH
560 570 580 590 600
HLPILISDNG RPSLTGTSTL HVTVCKCNER GEFTLCEEMG AQVGVSIQAL
610 620 630 640 650
VAIFLCILTI AVISLLVYLR RRLRKQARAH GKSVPEIHEQ LVTYDEEGGG
660 670 680 690 700
EMDTTSYDVS VLNSVRHGGA KPPRPALDAR PSLYAQVQKP PRHAPGAHAP
710 720 730 740 750
GEMAAMIEVK KDEADHDGGG PPYDTLHIFG YEGAESIAES LSSLGTDSSD
760 770 780
SDIDYDFLND WGPRFKMLAE LYGSDPREEL LY
Length:782
Mass (Da):87,546
Last modified:July 1, 1997 - v1
Checksum:i7403F974E2DF782F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13919 mRNA. Translation: CAA74225.1.
RefSeqiNP_001001649.2. NM_001001649.2.
UniGeneiSsc.75.

Genome annotation databases

GeneIDi414737.
KEGGissc:414737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13919 mRNA. Translation: CAA74225.1.
RefSeqiNP_001001649.2. NM_001001649.2.
UniGeneiSsc.75.

3D structure databases

ProteinModelPortaliO02840.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiO02840.
PRIDEiO02840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414737.
KEGGissc:414737.

Organism-specific databases

CTDi1003.

Phylogenomic databases

HOVERGENiHBG005217.
InParanoidiO02840.
KOiK06533.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR030052. CDH5.
[Graphical view]
PANTHERiPTHR24027:SF89. PTHR24027:SF89. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADH5_PIG
AccessioniPrimary (citable) accession number: O02840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: October 5, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.