O02836 (NPY2R_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuropeptide Y receptor type 2
Short name=NPY2-R

Alternative name(s):
NPY-Y2 receptor
Short name=Y2 receptor

Gene names

Name:

NPY2R

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for neuropeptide Y and peptide YY.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence AAD13777.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	neuropeptide Y receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Neuropeptide Y receptor type 2		PRO_0000069932
Regions
	Topological domain	1 – 46	46	Extracellular Potential
	Transmembrane	47 – 67	21	Helical; Name=1; Potential
	Topological domain	68 – 87	20	Cytoplasmic Potential
	Transmembrane	88 – 108	21	Helical; Name=2; Potential
	Topological domain	109 – 125	17	Extracellular Potential
	Transmembrane	126 – 146	21	Helical; Name=3; Potential
	Topological domain	147 – 166	20	Cytoplasmic Potential
	Transmembrane	167 – 187	21	Helical; Name=4; Potential
	Topological domain	188 – 217	30	Extracellular Potential
	Transmembrane	218 – 238	21	Helical; Name=5; Potential
	Topological domain	239 – 269	31	Cytoplasmic Potential
	Transmembrane	270 – 290	21	Helical; Name=6; Potential
	Topological domain	291 – 305	15	Extracellular Potential
	Transmembrane	306 – 326	21	Helical; Name=7; Potential
	Topological domain	327 – 382	56	Cytoplasmic Potential
Amino acid modifications
	Lipidation	343	1	S-palmitoyl cysteine Potential
	Glycosylation	11	1	N-linked (GlcNAc...) Potential
	Disulfide bond	124 ↔ 204		By similarity
Experimental info
	Sequence conflict	4	1	I → L in AAD13777. Ref.3
	Sequence conflict	179	1	L → V in AAD13777. Ref.3
	Sequence conflict	215	1	I → N in AAD13777. Ref.3
	Sequence conflict	366	1	A → V in AAD13777. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O02836 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 5C01FAF3A0423858	FASTA	382	42,557
	10 20 30 40 50 60 MGPIGAEADE NQTVEEMKME PSGPGHTTPR GELAPDSEPE LKDSTKLIEV QIILILAYCS 70 80 90 100 110 120 IILLGVVGNS LVIHVVIKFK SMRTVTNFFI ANLAVADLLV NTLCLPFTLT YTLMGEWKMG 130 140 150 160 170 180 PVLCHLVPYA QGLAVQVSTI TLTVIALDRH RCIVYHLESK ISKRISFLII GLAWGISALL 190 200 210 220 230 240 ASPLAIFREY SLIEIIPDFE IVACTEKWPG EEKSIYGTVY SLSSLLILYV LPLGIISFSY 250 260 270 280 290 300 ARIWSKLKNH VSPGGVNDHY HQRRQKTTKM LVCVVVVFAV SWLPLHAFQL AVDIDSQVLD 310 320 330 340 350 360 LKEYKLIFTV FHIIAMCSTF ANPLLYGWMN SNYRKAFLSA FRCEQRLDAI HSEVSMTSKA 370 380 KKNLEATKNG GPDDSFTEAT NV

References

[1]	"Characterization and molecular cloning of vascular neuropeptide Y receptor subtypes in pig and dog." Malmstroem R.E., Hoekfelt T., Bjoerkman J.-A., Nihlen C., Bystroem M., Ekstrand A.J., Lundberg J.M. Regul. Pept. 75:55-70(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Spleen.
[2]	Ekstrand A.J. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 207.
[3]	"Origins of the many NPY-family receptors in mammals." Larhammar D., Wraith A., Berglund M.M., Holmberg S.K., Lundell I. Peptides 22:295-307(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF005780 mRNA. Translation: AAC26670.2. AF106082 Genomic DNA. Translation: AAD13777.1. Different initiation.
RefSeq	NP_999315.1. NM_214150.1.
UniGene	Ssc.15963.
3D structure databases
ProteinModelPortal	O02836.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000009597.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397291.
KEGG	ssc:397291.
Organism-specific databases
CTD	4887.
Phylogenomic databases
eggNOG	NOG267229.
HOGENOM	HOG000050229.
HOVERGEN	HBG105675.
KO	K04205.
OrthoDB	EOG4JT05M.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001358. NPY2_rcpt. IPR000611. NPY_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01014. NRPEPTIDEY2R. PR01012. NRPEPTIDEYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NPY2R_PIG

Accession

Primary (citable) accession number: O02836
Secondary accession number(s): Q9TSI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	April 27, 2001
Last modified:	April 3, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program