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Protein

Neuropeptide Y receptor type 1

Gene

NPY1R

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 1
Short name:
NPY1-R
Gene namesi
Name:NPY1R
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence analysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini66 – 7611CytoplasmicSequence analysisAdd
BLAST
Transmembranei77 – 9721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini98 – 11619ExtracellularSequence analysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 15417CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini176 – 21136ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini233 – 26028CytoplasmicSequence analysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini282 – 29918ExtracellularSequence analysisAdd
BLAST
Transmembranei300 – 32021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini321 – 38363CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Neuropeptide Y receptor type 1PRO_0000069922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi113 ↔ 198PROSITE-ProRule annotation
Lipidationi338 – 3381S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO02835.

Expressioni

Gene expression databases

GenevisibleiO02835. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009480.

Structurei

3D structure databases

ProteinModelPortaliO02835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiO02835.
KOiK04204.
OrthoDBiEOG7C2R16.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTLSSQVE NHSIYYNFSE KNSQFLAFEN DDCHLPLAMI FTLALAYGAV
60 70 80 90 100
IILGVSGNLA LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY
110 120 130 140 150
TLMDHWVFGE VMCKLNPFVQ CVSITVSIFS LVLIAVERHQ LIINPRGWRP
160 170 180 190 200
SNRHAYVGIA VIWVLAVASS LPFLIYQVLT DEPFQNVTLD AFKDKYVCFD
210 220 230 240 250
KFLSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR RNNMMDKMRD
260 270 280 290 300
NKYRSSETKR INVMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL
310 320 330 340 350
LFLLCHLTAM ISTCINPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYEVI
360 370 380
AMSTMHTDVS KTSLKQASPV ALKKIHSDDN EKI
Length:383
Mass (Da):44,327
Last modified:July 15, 1999 - v2
Checksum:i0D58CBCA549B62CF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031L → P in AAD13776 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005779 mRNA. Translation: AAC26836.1.
AF106081 Genomic DNA. Translation: AAD13776.2.
RefSeqiNP_999453.1. NM_214288.1.
XP_005666733.1. XM_005666676.2.
XP_005666734.1. XM_005666677.2.
UniGeneiSsc.80403.

Genome annotation databases

GeneIDi397547.
KEGGissc:397547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005779 mRNA. Translation: AAC26836.1.
AF106081 Genomic DNA. Translation: AAD13776.2.
RefSeqiNP_999453.1. NM_214288.1.
XP_005666733.1. XM_005666676.2.
XP_005666734.1. XM_005666677.2.
UniGeneiSsc.80403.

3D structure databases

ProteinModelPortaliO02835.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009480.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO02835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397547.
KEGGissc:397547.

Organism-specific databases

CTDi4886.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiO02835.
KOiK04204.
OrthoDBiEOG7C2R16.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Gene expression databases

GenevisibleiO02835. SS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization and molecular cloning of vascular neuropeptide Y receptor subtypes in pig and dog."
    Malmstroem R.E., Hoekfelt T., Bjoerkman J.-A., Nihlen C., Bystroem M., Ekstrand A.J., Lundberg J.M.
    Regul. Pept. 75:55-70(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Hypothalamus.
  2. "Porcine NPY receptors NPY1R, NPY2R and NPY5R: cloning, mapping and comparative analysis."
    Wraith A., Tornsten A., Chardon P., Harbitz I., Chowdhary B.P., Andersson L., Larhammar D.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNPY1R_PIG
AccessioniPrimary (citable) accession number: O02835
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1999
Last modified: February 17, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.