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Protein

Alpha-1A adrenergic receptor

Gene

ADRA1A

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1A adrenergic receptor
Alternative name(s):
Alpha-1A adrenoreceptor
Short name:
Alpha-1A adrenoceptor
Alpha-1C adrenergic receptor
Gene namesi
Name:ADRA1A
Synonyms:ADRA1C
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Nucleus membrane; Multi-pass membrane protein
  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cytoplasm By similarity
  • Membranecaveola By similarity

  • Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularBy similarityAdd BLAST25
Transmembranei26 – 51Helical; Name=1By similarityAdd BLAST26
Topological domaini52 – 63CytoplasmicBy similarityAdd BLAST12
Transmembranei64 – 89Helical; Name=2By similarityAdd BLAST26
Topological domaini90 – 99ExtracellularBy similarity10
Transmembranei100 – 122Helical; Name=3By similarityAdd BLAST23
Topological domaini123 – 143CytoplasmicBy similarityAdd BLAST21
Transmembranei144 – 168Helical; Name=4By similarityAdd BLAST25
Topological domaini169 – 181ExtracellularBy similarityAdd BLAST13
Transmembranei182 – 205Helical; Name=5By similarityAdd BLAST24
Topological domaini206 – 272CytoplasmicBy similarityAdd BLAST67
Transmembranei273 – 297Helical; Name=6By similarityAdd BLAST25
Topological domaini298 – 304ExtracellularBy similarity7
Transmembranei305 – 329Helical; Name=7By similarityAdd BLAST25
Topological domaini330 – 466CytoplasmicBy similarityAdd BLAST137

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3637.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690651 – 466Alpha-1A adrenergic receptorAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi345S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Expressioni

Tissue specificityi

Abundant in liver, vas deferens, brain, and aorta, but not in heart.

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000018013.

Chemistry databases

BindingDBiO02824.

Structurei

3D structure databases

ProteinModelPortaliO02824.
SMRiO02824.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi334 – 349Nuclear localization signalBy similarityAdd BLAST16

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiO02824.
KOiK04135.

Family and domain databases

InterProiView protein in InterPro
IPR002233. ADR_fam.
IPR001004. ADRA1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR01103. ADRENERGICR.
PR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O02824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFLSGNASD SSNCTHPPAP VNISKAILLG VILGGLILFG VLGNILVILS
60 70 80 90 100
VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN
110 120 130 140 150
IWAAVDVLCC TASIISLCVI SIDRYIGVSY PLRYPTIVTQ RRGLRALLCV
160 170 180 190 200
WAFSLVISVG PLFGWRQPAP DDETICQINE EPGYVLFSAL GSFYVPLTII
210 220 230 240 250
LAMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN APAGGSGVAS
260 270 280 290 300
AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD
310 320 330 340 350
FKPPETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LKIQCLRRKQ
360 370 380 390 400
SSKHALGYTL HAPSQALEGQ HKDMVRIPVG SGETFYKISK TDGVCEWKFF
410 420 430 440 450
SSMPRGSARI TVPKDQSACT TARVRSKSFL QVCCCVGPST PNPGENHQVP
460
TIKIHTISLS ENGEEV
Length:466
Mass (Da):51,365
Last modified:July 1, 1997 - v1
Checksum:i9446D356B50FCDE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81982 mRNA. Translation: AAB61334.1.
RefSeqiNP_001075849.1. NM_001082380.1.
UniGeneiOcu.2154.

Genome annotation databases

GeneIDi100009237.
KEGGiocu:100009237.

Similar proteinsi

Entry informationi

Entry nameiADA1A_RABIT
AccessioniPrimary (citable) accession number: O02824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: August 30, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families