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Protein

Neuropeptide Y receptor type 1

Gene

NPY1R

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 1
Short name:
NPY1-R
Gene namesi
Name:NPY1R
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 75CytoplasmicSequence analysisAdd BLAST21
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 115ExtracellularSequence analysisAdd BLAST19
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 153CytoplasmicSequence analysisAdd BLAST17
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 210ExtracellularSequence analysisAdd BLAST36
Transmembranei211 – 231Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini232 – 259CytoplasmicSequence analysisAdd BLAST28
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini281 – 298ExtracellularSequence analysisAdd BLAST18
Transmembranei299 – 319Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini320 – 382CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699181 – 382Neuropeptide Y receptor type 1Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 197PROSITE-ProRule annotation
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi337S-palmitoyl cysteineSequence analysis1
Modified residuei367PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiO02813.

Expressioni

Gene expression databases

BgeeiENSCAFG00000008791.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012917.

Structurei

3D structure databases

ProteinModelPortaliO02813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00900000140797.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiO02813.
KOiK04204.
OMAiQVENHSI.
OrthoDBiEOG091G0A5E.
TreeFamiTF315303.

Family and domain databases

CDDicd15395. 7tmA_NPY1R. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
PANTHERiPTHR43916:SF5. PTHR43916:SF5. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O02813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTSFSQVE NHSIFCNFSE NSQFLAFESD DCHLPLAMIF TLALAYGAVI
60 70 80 90 100
ILGVTGNLAL IMIILKQKEM RNVTNILIVN LSFSDLLVAI MCLPFTFVYT
110 120 130 140 150
LMDHWVFGEA MCKLNPFVQC VSITVSIFSL VLIAVERHQL IINPRGWRPN
160 170 180 190 200
NRHAYVGIAV IWVLAVVSSL PFLIYQVLTD EPFQNVTLDA FKDKYVCFDK
210 220 230 240 250
FPSDSHRLSY TTLLLMLQYF GPLCFIFICY FKIYIRLKRR NNMMDKMRDN
260 270 280 290 300
KYRSSETKRI NIMLLSIVVA FAVCWLPLTI FNTVFDWNHQ IIATCNHNLL
310 320 330 340 350
FLLCHLTAMI STCVNPIFYG FLNKNFQRDL QFFFNFCDFR SRDDDYETIA
360 370 380
MSTMHTDVSK TSLKQASPVA FKKINNDDNE KI
Length:382
Mass (Da):44,245
Last modified:December 15, 1998 - v2
Checksum:i95B57D20D6299803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005778 mRNA. Translation: AAC08046.1.
RefSeqiNP_001002930.1. NM_001002930.1.
XP_005628870.1. XM_005628813.1.
XP_005628871.1. XM_005628814.1.
XP_005628872.1. XM_005628815.2.
XP_005628874.1. XM_005628817.1.
XP_005628877.1. XM_005628820.2.
UniGeneiCfa.3576.

Genome annotation databases

EnsembliENSCAFT00000013961; ENSCAFP00000012917; ENSCAFG00000008791.
GeneIDi399518.
KEGGicfa:399518.

Similar proteinsi

Entry informationi

Entry nameiNPY1R_CANLF
AccessioniPrimary (citable) accession number: O02813
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 15, 1998
Last modified: November 22, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families