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Protein

Neuropeptide Y receptor type 1

Gene

NPY1R

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 1
Short name:
NPY1-R
Gene namesi
Name:NPY1R
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 15

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 7521CytoplasmicSequence analysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini97 – 11519ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini137 – 15317CytoplasmicSequence analysisAdd
BLAST
Transmembranei154 – 17421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini175 – 21036ExtracellularSequence analysisAdd
BLAST
Transmembranei211 – 23121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini232 – 25928CytoplasmicSequence analysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini281 – 29818ExtracellularSequence analysisAdd
BLAST
Transmembranei299 – 31921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini320 – 38263CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Neuropeptide Y receptor type 1PRO_0000069918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi112 ↔ 197PROSITE-ProRule annotation
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence analysis
Lipidationi337 – 3371S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO02813.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012917.

Structurei

3D structure databases

ProteinModelPortaliO02813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiO02813.
KOiK04204.
OMAiQVENHSI.
OrthoDBiEOG7C2R16.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTSFSQVE NHSIFCNFSE NSQFLAFESD DCHLPLAMIF TLALAYGAVI
60 70 80 90 100
ILGVTGNLAL IMIILKQKEM RNVTNILIVN LSFSDLLVAI MCLPFTFVYT
110 120 130 140 150
LMDHWVFGEA MCKLNPFVQC VSITVSIFSL VLIAVERHQL IINPRGWRPN
160 170 180 190 200
NRHAYVGIAV IWVLAVVSSL PFLIYQVLTD EPFQNVTLDA FKDKYVCFDK
210 220 230 240 250
FPSDSHRLSY TTLLLMLQYF GPLCFIFICY FKIYIRLKRR NNMMDKMRDN
260 270 280 290 300
KYRSSETKRI NIMLLSIVVA FAVCWLPLTI FNTVFDWNHQ IIATCNHNLL
310 320 330 340 350
FLLCHLTAMI STCVNPIFYG FLNKNFQRDL QFFFNFCDFR SRDDDYETIA
360 370 380
MSTMHTDVSK TSLKQASPVA FKKINNDDNE KI
Length:382
Mass (Da):44,245
Last modified:December 15, 1998 - v2
Checksum:i95B57D20D6299803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005778 mRNA. Translation: AAC08046.1.
RefSeqiNP_001002930.1. NM_001002930.1.
XP_005628870.1. XM_005628813.1.
XP_005628871.1. XM_005628814.1.
XP_005628872.1. XM_005628815.2.
XP_005628874.1. XM_005628817.1.
XP_005628877.1. XM_005628820.2.
UniGeneiCfa.3576.

Genome annotation databases

EnsembliENSCAFT00000013961; ENSCAFP00000012917; ENSCAFG00000008791.
GeneIDi399518.
KEGGicfa:399518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005778 mRNA. Translation: AAC08046.1.
RefSeqiNP_001002930.1. NM_001002930.1.
XP_005628870.1. XM_005628813.1.
XP_005628871.1. XM_005628814.1.
XP_005628872.1. XM_005628815.2.
XP_005628874.1. XM_005628817.1.
XP_005628877.1. XM_005628820.2.
UniGeneiCfa.3576.

3D structure databases

ProteinModelPortaliO02813.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012917.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO02813.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000013961; ENSCAFP00000012917; ENSCAFG00000008791.
GeneIDi399518.
KEGGicfa:399518.

Organism-specific databases

CTDi4886.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiO02813.
KOiK04204.
OMAiQVENHSI.
OrthoDBiEOG7C2R16.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-418594. G alpha (i) signalling events.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization and molecular cloning of vascular neuropeptide Y receptor subtypes in pig and dog."
    Malmstroem R.E., Hoekfelt T., Bjoerkman J.-A., Nihlen C., Bystroem M., Ekstrand A.J., Lundberg J.M.
    Regul. Pept. 75:55-70(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNPY1R_CANLF
AccessioniPrimary (citable) accession number: O02813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 15, 1998
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.