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O02811 (PI4KA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 4-kinase alpha
Short name=PI4-kinase alpha
Short name=PI4K-alpha
Short name=PtdIns-4-kinase alpha
EC=2.7.1.67
Gene names
Name:PI4KA
Synonyms:PIK4CA
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length2043 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.

Enzyme regulation

Inhibited by wortmannin. Ref.1

Sequence similarities

Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

Contains 1 PI3K/PI4K domain.

Contains 1 PIK helical domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20432043Phosphatidylinositol 4-kinase alpha
PRO_0000226047

Regions

Domain1471 – 1659189PIK helical
Domain1787 – 2020234PI3K/PI4K
Region1660 – 1792133Pleckstrin homology (PH) domain conferring phosphoinositide binding specificity By similarity

Amino acid modifications

Modified residue1721Phosphoserine By similarity
Modified residue1981Phosphoserine By similarity
Modified residue1991Phosphoserine By similarity
Modified residue2021Phosphoserine By similarity
Modified residue2071Phosphoserine By similarity
Modified residue10951Phosphotyrosine By similarity
Modified residue13771Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O02811 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 51E20B92183C318D

FASTA2,043229,392
        10         20         30         40         50         60 
MCPVDFHGIF QLDERRRDAV IALGIFLIES DLQHKDSVVP YLLRLLKGLP KVYWVEESTA 

        70         80         90        100        110        120 
RKGRGTLPVA ESLSFCLVTL LSDVAYRDPS LRGEILEALL QVLHVLLGMC QALEIQEKEY 

       130        140        150        160        170        180 
LCKHAVPCLL GIVRAFGRHS SSEDSLLSRL FPRAPAHSPR VPEELEGVRR RSFNDFRSIL 

       190        200        210        220        230        240 
PSSLLTVCQE GSLKRKASSA SSVAQVSPER GAPPPSPPGG SAFHCLEASY SPNGSTSESD 

       250        260        270        280        290        300 
YYFSAVSSSL SVSPLFNGVT YKEFSIPLEM LRELLNLVKK IVEEPVLKSL DAVVTGVIEA 

       310        320        330        340        350        360 
SPSADLCHGA FSDPLYVAVL RMLRDTLYYM RDLPTSFVKE VHDFVLEQFN SSQGELQKIL 

       370        380        390        400        410        420 
HDADRAHSEL SPLKLRCQAS AACVDLMVWA VKDEQGAENL CVKLSEKLQS KTSSKVIIAQ 

       430        440        450        460        470        480 
VPLLICCLQG LGRLCERFPV VVHSVTPSLR DFLVVPSPVL VKLYKCHSQY HTVAGNDIKI 

       490        500        510        520        530        540 
SVTNEHAEST LNVASGKKSQ PSMYEQLRDI AIDNVCRCLK AGLTEDPVIV EAFLASLSNR 

       550        560        570        580        590        600 
LYISQESDKD AHLIPDHTIR ALGHIAVALR DTPKVMEPIL QILQQKFCQP PSPLDVLIID 

       610        620        630        640        650        660 
QLGCLVITGN QYIYQEVWNL FQQISVKASS VVYSATKDYK DHGYRHCSLA VINALANIAA 

       670        680        690        700        710        720 
NIQDEHLVDE LLMNLLELFV QLGLEGKRAS ERASEKGPAL KASSSAGNLG VLIPVIAVLT 

       730        740        750        760        770        780 
RRLPPIEEPK PRLQKLFRDF WLYSVLMGFA VEGSGLWPEE WYEGVCEIAT KSPLLTFPSK 

       790        800        810        820        830        840 
EPLRSVLQYN SAMKNDTVTP AELSELRSTI VNLLDPAPEV SALIGKLDFA MSTYLLSVYR 

       850        860        870        880        890        900 
LEYMRVLRSS DPARFQVMLC YFEDKAIQKD KSGMMQCVIA VADKVFDAFL NMMAEKAKTK 

       910        920        930        940        950        960 
ENEEELERTQ FLLVSFNHVH KRIRRVADKY LSGLVDKFPH LLWSGTVLKT MLDILQTLSL 

       970        980        990       1000       1010       1020 
SLSADIHKDQ PYYDIPDVPY RITVPDTYEA RESIVKDFAA RCGMILQEAM KWAPTVTKSH 

      1030       1040       1050       1060       1070       1080 
LQEYLSKHQN WVSGLSQHTG LAMATESVLH YSGYNKQSTS LGATQLTERP ACVKKDYSNF 

      1090       1100       1110       1120       1130       1140 
MASLNLRNRY AAEVYGMIRF SDATGHTSDL NKMMVQELKA ALGAGDAQQY TQAMFKLTAM 

      1150       1160       1170       1180       1190       1200 
LISSRDCDPQ LLHHLCWGPL QMFNEHGMET ALACWEWLLA GKNGVEVPFM REMAGAWQMT 

      1210       1220       1230       1240       1250       1260 
VEQKFGLFSA EMKEADPLAA SEASQPKPCA PEVTPHYIWI DFLVQRFEIA KYCSSDQVEI 

      1270       1280       1290       1300       1310       1320 
FCSLLQRSLS LSIGGTAGSM NRHVAAIGPR FKLLTLGLSL LHADVLPNAT IRNVLREKIY 

      1330       1340       1350       1360       1370       1380 
STAFDYFSCP PRFPTQGEKR LREDISVMIK FWTAMFSDKK YLTASQLVPP DNQDTRSNLD 

      1390       1400       1410       1420       1430       1440 
IAVGSRQQAT QGWINTYPLS SGMSTISKKS GMSKKTNRGS QLHKYYMKRR TLLLSLLATE 

      1450       1460       1470       1480       1490       1500 
IERLITWYNP LSAPELELDQ AGESSVANWR SKYISLSEKQ WKDNVNLAWS ISPHLAVQLP 

      1510       1520       1530       1540       1550       1560 
ARFKNTEAIG NEVTRLVRLD PGAVSDVPEA IKFLVTWHTI DADAPELSHV LCWAPADPPT 

      1570       1580       1590       1600       1610       1620 
GLSYFSSMSP PHPLTAQYGV KVLRSFPPDA ILFYIPQIVQ ALRYDKMGYV REYILWAASQ 

      1630       1640       1650       1660       1670       1680 
SQLLAHQFIW NMKTNIYVDE EGHQKDPDIG DLLEQLVEEI TGSLSGPAKD FYQREFDFFN 

      1690       1700       1710       1720       1730       1740 
KITNVSAIIK PYPKGDERKK ACLSALSEVK VQPGCYLPSN PEAIVLDIDY KSGTPMQSAA 

      1750       1760       1770       1780       1790       1800 
KAPYLAKFKV KRCGVSELEK EGLRCRSDPE EEGSMQEADG QKISWQAAIF KVGDDCRQDM 

      1810       1820       1830       1840       1850       1860 
LALQIIDLFK NIFQLVGLDL FVFPYRVVAT APGCGVIECI PDCTSRDQLG RQTDFGMYDY 

      1870       1880       1890       1900       1910       1920 
FTRQYGDEST LAFQQARYNF IRSMAAYSLL LFLLQIKDRH NGNIMLDKKG HLIHIDFGFM 

      1930       1940       1950       1960       1970       1980 
FESSPGGNLG WEPDIKLTDE MVMIMGGKME ATPFKWFMEM CVRGYLAVRP YMDAVVSLVT 

      1990       2000       2010       2020       2030       2040 
LMLDTGLPCF RGQTIKLLKH RFSPNMTERE AANFILKVIQ NCFLSNRSRT YDMIQYYQND 


IPY

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References

[1]"Isolation and molecular cloning of wortmannin-sensitive bovine type III phosphatidylinositol 4-kinases."
Balla T., Downing G.J., Jaffe H., Kim S., Zolyomi A., Catt K.J.
J. Biol. Chem. 272:18358-18366(1997) [PubMed: 9218477] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ENZYME REGULATION.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U88532 mRNA. Translation: AAC48730.1.
IPIIPI00701244.
RefSeqNP_777002.1. NM_174577.2.
UniGeneBt.14142.

3D structure databases

ProteinModelPortalO02811.
ModBaseSearch...

Protein-protein interaction databases

STRINGO02811.

Proteomic databases

PRIDEO02811.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID282309.
KEGGbta:282309.

Organism-specific databases

CTD5297.

Phylogenomic databases

eggNOGmaNOG05377.
HOVERGENHBG052742.
InParanoidO02811.
OrthoDBEOG4FJ87V.
PhylomeDBO02811.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
Gene3DG3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit.
G3DSA:1.25.40.70. PI3Ka. 1 hit.
KOK00888.
PANTHERPTHR10048. PI_Kinase. 1 hit.
PfamPF00454. PI3_PI4_kinase. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTSM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF48371. ARM-type_fold. 1 hit.
SSF56112. Kinase_like. 1 hit.
PROSITEPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePI4KA_BOVIN
AccessionPrimary (citable) accession number: O02811
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 1, 1997
Last modified: November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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