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O02799

- STAT2_PIG

UniProt

O02799 - STAT2_PIG

Protein

Signal transducer and activator of transcription 2

Gene

STAT2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. signal transducer activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and activator of transcription 2
    Gene namesi
    Name:STAT2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Translocated into the nucleus upon activation by IFN-alpha/beta.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 864864Signal transducer and activator of transcription 2PRO_0000182415Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei283 – 2831PhosphoserineBy similarity
    Modified residuei690 – 6901Phosphotyrosine; by JAKBy similarity

    Post-translational modificationi

    Tyrosine phosphorylated in response to IFN-alpha.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO02799.

    Interactioni

    Subunit structurei

    Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9; interacts with IRF9 in the cytoplasm. Interacts with CRSP2 and CRSP6. Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-467'. Interacts with IFNAR2. Interacts with ARL2BP By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000000422.

    Structurei

    3D structure databases

    ProteinModelPortaliO02799.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini572 – 66796SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG303257.
    HOGENOMiHOG000220792.
    HOVERGENiHBG055669.
    KOiK11221.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR022756. STAT2_C.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF12188. STAT2_C. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O02799-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQWEMLQNL DSPFQDQLHQ LYSESLLPVD VRQYLAVWIE DQNWQEAALG    50
    NDDSKANMLF FHFLDQLNYD CGRCGQDPEC LLLQHNLRKF YRDIQAIPQG 100
    PTRLAEMIFN LLLEEKRILI QAQRAQLEQQ EPALEAPGEN QQHEIESRIL 150
    ELRAMMEKLV KSISQLKDQQ DIFCFRYKIK ASAKTHSLDP HRTRQEQVLQ 200
    ETLNELDKRR KEVLDASKAL LGRLTTLIEL LLPKLEEWKV QQQKACIGAP 250
    MDGELEQLEK WFTAEAKLLF HLRQLLKELK GLSSVVKYDE DLLFKGVDLL 300
    KAQVTELLQR LLHRAFIVET QPCMPQTPHR PLILKTGSKF TVRTRLLVRL 350
    QEGNESLTAE VSIDRNPPKS QGFRKFNILT SNRKTLTPEK GQSQGLIWDF 400
    GYLTLMEQRS GGAGKGNNKG PLGVTEELHI ISFTVKYTYQ GLKQELTTDT 450
    LPVVIISNMN QLSIAWASIL WFNLLSSDPQ NQQFFSSPPK APWNLLGPAL 500
    SWQFSSHVGQ GLNSDQLGML RDKLFGQNSS TEGLSLSWVD FIKRESPPGK 550
    LPFWTWLDKI LDLVHDHLKD LWKDGHIMGF VSRSEERRLL KKTISGTFLL 600
    RFSETLEGGI TCSWVEHQDD DKVLIYSLQP FTKEVLQSLP LTKIISQYQL 650
    LTEENIPENP LRFLYPRIPR DEAFGCYNQE KANLQERKKY LKHKLIVVSN 700
    RQVDELQQPP ELKLEPDLES LELDLGLAPG PEPGVGLDLE PLLEAGLDLG 750
    PELEPMLQST LEPVLEPILD EVLQGVPEPN LGPELKLEPI LEPVSQPVPE 800
    PDLPHDLRHL NTDEMQIFRN SMRIEEIMPN GDPLLASQNT NVDEACVFHR 850
    SHFYTDGPLI PSDY 864
    Length:864
    Mass (Da):99,061
    Last modified:July 1, 1997 - v1
    Checksum:i2F8CC95569FB5B20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004061 mRNA. Translation: BAA20332.1.
    RefSeqiNP_999054.1. NM_213889.1.
    UniGeneiSsc.14520.

    Genome annotation databases

    GeneIDi396923.
    KEGGissc:396923.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004061 mRNA. Translation: BAA20332.1 .
    RefSeqi NP_999054.1. NM_213889.1.
    UniGenei Ssc.14520.

    3D structure databases

    ProteinModelPortali O02799.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000000422.

    Proteomic databases

    PaxDbi O02799.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396923.
    KEGGi ssc:396923.

    Organism-specific databases

    CTDi 6773.

    Phylogenomic databases

    eggNOGi NOG303257.
    HOGENOMi HOG000220792.
    HOVERGENi HBG055669.
    KOi K11221.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR022756. STAT2_C.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF12188. STAT2_C. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ito Y., Mikawa S., Kobayashi E., Wada Y., Minezawa M.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Muscle.

    Entry informationi

    Entry nameiSTAT2_PIG
    AccessioniPrimary (citable) accession number: O02799
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3