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Protein

Signal transducer and activator of transcription 2

Gene

STAT2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-SSC-8854691 Interleukin-20 family signaling
R-SSC-909733 Interferon alpha/beta signaling
R-SSC-912694 Regulation of IFNA signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 2
Gene namesi
Name:STAT2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824151 – 864Signal transducer and activator of transcription 2Add BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei283PhosphoserineBy similarity1
Modified residuei690Phosphotyrosine; by JAKBy similarity1
Modified residuei812PhosphothreonineBy similarity1

Post-translational modificationi

Tyrosine phosphorylated in response to IFN-alpha.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO02799
PeptideAtlasiO02799
PRIDEiO02799

Expressioni

Gene expression databases

ExpressionAtlasiO02799 baseline and differential

Interactioni

Subunit structurei

Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9; interacts with IRF9 in the cytoplasm. Interacts with CRSP2 and CRSP6. Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-467'. Interacts with IFNAR2. Interacts with ARL2BP (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000422

Structurei

3D structure databases

ProteinModelPortaliO02799
SMRiO02799
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini572 – 667SH2PROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOGENOMiHOG000220792
HOVERGENiHBG055669
InParanoidiO02799
KOiK11221

Family and domain databases

CDDicd10373 SH2_STAT2, 1 hit
Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR022756 STAT2_C
IPR035854 STAT2_SH2
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12188 STAT2_C, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

O02799-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQWEMLQNL DSPFQDQLHQ LYSESLLPVD VRQYLAVWIE DQNWQEAALG
60 70 80 90 100
NDDSKANMLF FHFLDQLNYD CGRCGQDPEC LLLQHNLRKF YRDIQAIPQG
110 120 130 140 150
PTRLAEMIFN LLLEEKRILI QAQRAQLEQQ EPALEAPGEN QQHEIESRIL
160 170 180 190 200
ELRAMMEKLV KSISQLKDQQ DIFCFRYKIK ASAKTHSLDP HRTRQEQVLQ
210 220 230 240 250
ETLNELDKRR KEVLDASKAL LGRLTTLIEL LLPKLEEWKV QQQKACIGAP
260 270 280 290 300
MDGELEQLEK WFTAEAKLLF HLRQLLKELK GLSSVVKYDE DLLFKGVDLL
310 320 330 340 350
KAQVTELLQR LLHRAFIVET QPCMPQTPHR PLILKTGSKF TVRTRLLVRL
360 370 380 390 400
QEGNESLTAE VSIDRNPPKS QGFRKFNILT SNRKTLTPEK GQSQGLIWDF
410 420 430 440 450
GYLTLMEQRS GGAGKGNNKG PLGVTEELHI ISFTVKYTYQ GLKQELTTDT
460 470 480 490 500
LPVVIISNMN QLSIAWASIL WFNLLSSDPQ NQQFFSSPPK APWNLLGPAL
510 520 530 540 550
SWQFSSHVGQ GLNSDQLGML RDKLFGQNSS TEGLSLSWVD FIKRESPPGK
560 570 580 590 600
LPFWTWLDKI LDLVHDHLKD LWKDGHIMGF VSRSEERRLL KKTISGTFLL
610 620 630 640 650
RFSETLEGGI TCSWVEHQDD DKVLIYSLQP FTKEVLQSLP LTKIISQYQL
660 670 680 690 700
LTEENIPENP LRFLYPRIPR DEAFGCYNQE KANLQERKKY LKHKLIVVSN
710 720 730 740 750
RQVDELQQPP ELKLEPDLES LELDLGLAPG PEPGVGLDLE PLLEAGLDLG
760 770 780 790 800
PELEPMLQST LEPVLEPILD EVLQGVPEPN LGPELKLEPI LEPVSQPVPE
810 820 830 840 850
PDLPHDLRHL NTDEMQIFRN SMRIEEIMPN GDPLLASQNT NVDEACVFHR
860
SHFYTDGPLI PSDY
Length:864
Mass (Da):99,061
Last modified:July 1, 1997 - v1
Checksum:i2F8CC95569FB5B20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004061 mRNA Translation: BAA20332.1
RefSeqiNP_999054.1, NM_213889.1
UniGeneiSsc.14520

Genome annotation databases

EnsembliENSSSCT00000000428; ENSSSCP00000000422; ENSSSCG00000000396
GeneIDi396923
KEGGissc:396923

Similar proteinsi

Entry informationi

Entry nameiSTAT2_PIG
AccessioniPrimary (citable) accession number: O02799
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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