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O02799

- STAT2_PIG

UniProt

O02799 - STAT2_PIG

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Protein
Signal transducer and activator of transcription 2
Gene
STAT2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. signal transducer activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 2
Gene namesi
Name:STAT2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Translocated into the nucleus upon activation by IFN-alpha/beta By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Signal transducer and activator of transcription 2
PRO_0000182415Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei283 – 2831Phosphoserine By similarity
Modified residuei690 – 6901Phosphotyrosine; by JAK By similarity

Post-translational modificationi

Tyrosine phosphorylated in response to IFN-alpha By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO02799.

Interactioni

Subunit structurei

Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9; interacts with IRF9 in the cytoplasm. Interacts with CRSP2 and CRSP6. Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-467'. Interacts with IFNAR2. Interacts with ARL2BP By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000422.

Structurei

3D structure databases

ProteinModelPortaliO02799.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini572 – 66796SH2
Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG303257.
HOGENOMiHOG000220792.
HOVERGENiHBG055669.
KOiK11221.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02799-1 [UniParc]FASTAAdd to Basket

« Hide

MAQWEMLQNL DSPFQDQLHQ LYSESLLPVD VRQYLAVWIE DQNWQEAALG    50
NDDSKANMLF FHFLDQLNYD CGRCGQDPEC LLLQHNLRKF YRDIQAIPQG 100
PTRLAEMIFN LLLEEKRILI QAQRAQLEQQ EPALEAPGEN QQHEIESRIL 150
ELRAMMEKLV KSISQLKDQQ DIFCFRYKIK ASAKTHSLDP HRTRQEQVLQ 200
ETLNELDKRR KEVLDASKAL LGRLTTLIEL LLPKLEEWKV QQQKACIGAP 250
MDGELEQLEK WFTAEAKLLF HLRQLLKELK GLSSVVKYDE DLLFKGVDLL 300
KAQVTELLQR LLHRAFIVET QPCMPQTPHR PLILKTGSKF TVRTRLLVRL 350
QEGNESLTAE VSIDRNPPKS QGFRKFNILT SNRKTLTPEK GQSQGLIWDF 400
GYLTLMEQRS GGAGKGNNKG PLGVTEELHI ISFTVKYTYQ GLKQELTTDT 450
LPVVIISNMN QLSIAWASIL WFNLLSSDPQ NQQFFSSPPK APWNLLGPAL 500
SWQFSSHVGQ GLNSDQLGML RDKLFGQNSS TEGLSLSWVD FIKRESPPGK 550
LPFWTWLDKI LDLVHDHLKD LWKDGHIMGF VSRSEERRLL KKTISGTFLL 600
RFSETLEGGI TCSWVEHQDD DKVLIYSLQP FTKEVLQSLP LTKIISQYQL 650
LTEENIPENP LRFLYPRIPR DEAFGCYNQE KANLQERKKY LKHKLIVVSN 700
RQVDELQQPP ELKLEPDLES LELDLGLAPG PEPGVGLDLE PLLEAGLDLG 750
PELEPMLQST LEPVLEPILD EVLQGVPEPN LGPELKLEPI LEPVSQPVPE 800
PDLPHDLRHL NTDEMQIFRN SMRIEEIMPN GDPLLASQNT NVDEACVFHR 850
SHFYTDGPLI PSDY 864
Length:864
Mass (Da):99,061
Last modified:July 1, 1997 - v1
Checksum:i2F8CC95569FB5B20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004061 mRNA. Translation: BAA20332.1.
RefSeqiNP_999054.1. NM_213889.1.
UniGeneiSsc.14520.

Genome annotation databases

GeneIDi396923.
KEGGissc:396923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004061 mRNA. Translation: BAA20332.1 .
RefSeqi NP_999054.1. NM_213889.1.
UniGenei Ssc.14520.

3D structure databases

ProteinModelPortali O02799.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000000422.

Proteomic databases

PaxDbi O02799.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396923.
KEGGi ssc:396923.

Organism-specific databases

CTDi 6773.

Phylogenomic databases

eggNOGi NOG303257.
HOGENOMi HOG000220792.
HOVERGENi HBG055669.
KOi K11221.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Ito Y., Mikawa S., Kobayashi E., Wada Y., Minezawa M.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiSTAT2_PIG
AccessioniPrimary (citable) accession number: O02799
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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