ID   MTR1A_PIG               Reviewed;         154 AA.
AC   O02781;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   24-JAN-2024, entry version 97.
DE   RecName: Full=Melatonin receptor type 1A;
DE            Short=Mel-1A-R;
DE            Short=Mel1a receptor;
DE   Flags: Fragment;
GN   Name=MTNR1A;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Hypothalamus, and Pituitary;
RX   PubMed=9107687; DOI=10.1007/s003359900444;
RA   Messer L.A., Wang L., Tuggle C.K., Yerle M., Chardon P., Pomp D.,
RA   Womack J.E., Barendse W., Crawford A.M., Notter D.R., Rothschild M.F.;
RT   "Mapping of the melatonin receptor 1a (MTNR1A) gene in pigs, sheep, and
RT   cattle.";
RL   Mamm. Genome 8:368-370(1997).
CC   -!- FUNCTION: High affinity receptor for melatonin. Likely to mediate the
CC       reproductive and circadian actions of melatonin. The activity of this
CC       receptor is mediated by pertussis toxin sensitive G proteins that
CC       inhibit adenylate cyclase activity.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U73326; AAC48726.1; -; Genomic_DNA.
DR   AlphaFoldDB; O02781; -.
DR   SMR; O02781; -.
DR   STRING; 9823.ENSSSCP00000053039; -.
DR   BindingDB; O02781; -.
DR   InParanoid; O02781; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Proteomes; UP000694570; Unplaced.
DR   Proteomes; UP000694571; Unplaced.
DR   Proteomes; UP000694720; Unplaced.
DR   Proteomes; UP000694722; Unplaced.
DR   Proteomes; UP000694723; Unplaced.
DR   Proteomes; UP000694724; Unplaced.
DR   Proteomes; UP000694725; Unplaced.
DR   Proteomes; UP000694726; Unplaced.
DR   Proteomes; UP000694727; Unplaced.
DR   Proteomes; UP000694728; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002278; Mel_1A/1B_rcpt.
DR   InterPro; IPR000025; Melatonin_rcpt.
DR   PANTHER; PTHR24228; B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR; 1.
DR   PANTHER; PTHR24228:SF53; MELATONIN RECEPTOR TYPE 1A; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01149; MELATONIN1AR.
DR   PRINTS; PR00857; MELATONINR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>154
FT                   /note="Melatonin receptor type 1A"
FT                   /id="PRO_0000069865"
FT   TOPO_DOM        <1..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        20..40
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..62
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        84..115
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..149
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         154
SQ   SEQUENCE   154 AA;  17900 MW;  DFE85FB2C5B55C93 CRC64;
     YCYICHSLKY DRWYSNRNSL CCVFLICVLT LVAIVPNLCM GTLQYDPRIY SCTFAQSVSS
     AYTIAVVVFH FLVPMVIVIF RYLRIWVLVL QIRWRAKPEN NPRLKPQDFR NFVTMFVVFV
     LFAICWAPLN FIGLAVASDP ASMAPRIPEW LFVA
//