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O02777 (CNR1_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cannabinoid receptor 1
Short name=CB-R
Short name=CB1
Gene names
Name:CNR1
OrganismFelis catus (Cat) (Felis silvestris catus) [Complete proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca2+ channel current. Ref.1

Subunit structure

Interacts (via C-terminus) with CNRIP1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in cerebral arterial muscle cells and cerebral cortex (at protein level). Ref.1

Post-translational modification

Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Cannabinoid receptor 1
PRO_0000069313

Regions

Topological domain1 – 116116Extracellular Potential
Transmembrane117 – 14226Helical; Name=1; Potential
Topological domain143 – 15412Cytoplasmic Potential
Transmembrane155 – 17521Helical; Name=2; Potential
Topological domain176 – 18712Extracellular Potential
Transmembrane188 – 21225Helical; Name=3; Potential
Topological domain213 – 23220Cytoplasmic Potential
Transmembrane233 – 25523Helical; Name=4; Potential
Topological domain256 – 27318Extracellular Potential
Transmembrane274 – 29926Helical; Name=5; Potential
Topological domain300 – 34445Cytoplasmic Potential
Transmembrane345 – 36521Helical; Name=6; Potential
Topological domain366 – 37712Extracellular Potential
Transmembrane378 – 39922Helical; Name=7; Potential
Topological domain400 – 47273Cytoplasmic Potential

Amino acid modifications

Lipidation4151S-palmitoyl cysteine By similarity
Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation831N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O02777 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: A2774DBF8F2DAF34

FASTA47252,887
        10         20         30         40         50         60 
MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE 

        70         80         90        100        110        120 
KMTAGDNSQL VPADQVNITE FYNKSLSSYK ENEENIQCGE NFMDMECFMI LNPSQQLAIA 

       130        140        150        160        170        180 
VLSLTLGTFT VLENLLVLCV ILHSRSLRCR PSYHFIGSLA VADLLGSVIF VYSFVDFHVF 

       190        200        210        220        230        240 
HRKDSPNVFL FKLGGVTASF TASVGSLFLT AIDRYISIHR PLAYKKIVTR PKAVVAFCLM 

       250        260        270        280        290        300 
WTIAIVIAVL PLLGWNCKKL QSVCSDIFPL IDETYLMFWI GVTSVLLLFI VYAYMYILWK 

       310        320        330        340        350        360 
AHIHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV VLIICWGPLL 

       370        380        390        400        410        420 
AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR SKDLRHAFRS MFPSCEGTAQ 

       430        440        450        460        470 
PLDNSMGDSD CLHKHANNTA NVHRAAENCI KNTVQIAKVT ISVSTNTSAK AL

« Hide

References

[1]"Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current."
Gebremedhin D., Lange A.R., Campbell W.B., Hillard C.J., Harder D.R.
Am. J. Physiol. 276:H2085-H2093(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Cerebral vascular smooth muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U94342 mRNA. Translation: AAB53440.1.
RefSeqNP_001009331.1. NM_001009331.1.

3D structure databases

ProteinModelPortalO02777.
ModBaseSearch...

Protein-protein interaction databases

STRING9685.ENSFCAP00000011905.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSFCAT00000012841; ENSFCAP00000011905; ENSFCAG00000012837.
GeneID493926.
KEGGfca:493926.

Organism-specific databases

CTD1268.

Phylogenomic databases

eggNOGNOG148018.
GeneTreeENSGT00700000104088.
HOGENOMHOG000049272.
HOVERGENHBG051045.
KOK04277.
OrthoDBEOG41ZF9S.

Family and domain databases

InterProIPR002230. Cnbnoid_rcpt.
IPR000810. Cnoid_rcpt_1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR22750:SF10. PTHR22750:SF10. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PIRSFPIRSF037995. Cnoid_rcpt_1. 1 hit.
PRINTSPR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCNR1_FELCA
AccessionPrimary (citable) accession number: O02777
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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