ID   TNFL4_RABIT             Reviewed;         187 AA.
AC   O02765;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   08-NOV-2023, entry version 94.
DE   RecName: Full=Tumor necrosis factor ligand superfamily member 4;
DE   AltName: Full=OX40 ligand;
DE            Short=OX40L;
DE   AltName: CD_antigen=CD252;
GN   Name=TNFSF4; Synonyms=TXGP1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=CHBB:HM;
RA   Isono T., Seto A.;
RT   "Expression of OX40 and OX40 ligand genes in rabbit HTLV-I-transformed T
RT   cell lines.";
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytokine that binds to TNFRSF4. Co-stimulates T-cell
CC       proliferation and cytokine production.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
CC   -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR   EMBL; AB003912; BAA20060.1; -; mRNA.
DR   RefSeq; NP_001075454.1; NM_001081985.1.
DR   AlphaFoldDB; O02765; -.
DR   SMR; O02765; -.
DR   STRING; 9986.ENSOCUP00000007420; -.
DR   GlyCosmos; O02765; 2 sites, No reported glycans.
DR   PaxDb; 9986-ENSOCUP00000007420; -.
DR   GeneID; 100008595; -.
DR   KEGG; ocu:100008595; -.
DR   CTD; 7292; -.
DR   eggNOG; ENOG502ST4X; Eukaryota.
DR   InParanoid; O02765; -.
DR   OrthoDB; 4334524at2759; -.
DR   TreeFam; TF336384; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd00184; TNF; 1.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR021184; TNF_CS.
DR   InterPro; IPR006052; TNF_dom.
DR   InterPro; IPR042338; TNFSF4.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR17534; OX40 LIGAND; 1.
DR   PANTHER; PTHR17534:SF4; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 4; 1.
DR   SMART; SM00207; TNF; 1.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS00251; TNF_1; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..187
FT                   /note="Tumor necrosis factor ligand superfamily member 4"
FT                   /id="PRO_0000185495"
FT   TOPO_DOM        1..23
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..187
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        74..164
FT                   /evidence="ECO:0000250"
FT   DISULFID        101..185
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   187 AA;  20886 MW;  F19B1370E723D608 CRC64;
     MEGVRPLEEN VGNAPRPRFE RNKLLLVASV VQALGLLLCL TYVCQHSHAP EVSLQYPPIE
     NIMTQLQILT SHECEEDSFI LPLQKRDGTM EVQNNSVVIQ CDGFYLLSLK GYFSQEVSIS
     LHYRKGEEPF PILKKTKFAN SNVVLKLGYK DKVYLNVTTD SASCKQLSVN AGELIVILQN
     PGGYCAP
//