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O02765 (TNFL4_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor ligand superfamily member 4
Alternative name(s):
OX40 ligand
Short name=OX40L
CD_antigen=CD252
Gene names
Name:TNFSF4
Synonyms:TXGP1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

Subunit structure

Homotrimer Probable.

Subcellular location

Membrane; Single-pass type II membrane protein.

Sequence similarities

Belongs to the tumor necrosis factor family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processCD4-positive, alpha-beta T cell costimulation

Inferred from electronic annotation. Source: Ensembl

T-helper 2 cell activation

Inferred from electronic annotation. Source: Ensembl

acute inflammatory response

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

cellular response to nitrogen dioxide

Inferred from electronic annotation. Source: Ensembl

cellular response to prostaglandin E stimulus

Inferred from electronic annotation. Source: Ensembl

chemokine (C-C motif) ligand 11 production

Inferred from electronic annotation. Source: Ensembl

cholesterol metabolic process

Inferred from electronic annotation. Source: Ensembl

defense response to nematode

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

memory T cell activation

Inferred from electronic annotation. Source: Ensembl

negative regulation of T-helper 1 cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of cytokine secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of regulatory T cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

positive regulation of CD4-positive, alpha-beta T cell costimulation

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell cytokine production

Inferred from electronic annotation. Source: Ensembl

positive regulation of T-helper 2 cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of T-helper 2 cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of alpha-beta T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of immunoglobulin mediated immune response

Inferred from electronic annotation. Source: Ensembl

positive regulation of immunoglobulin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-10 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-13 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-4 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-4-dependent isotype switching to IgE isotypes

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of memory T cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of memory T cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of type 2 immune response

Inferred from electronic annotation. Source: Ensembl

response to virus

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 187187Tumor necrosis factor ligand superfamily member 4
PRO_0000185495

Regions

Topological domain1 – 2323Cytoplasmic Potential
Transmembrane24 – 4421Helical; Signal-anchor for type II membrane protein; Potential
Topological domain45 – 187143Extracellular Potential

Amino acid modifications

Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Disulfide bond74 ↔ 164 By similarity
Disulfide bond101 ↔ 185 By similarity

Sequences

Sequence LengthMass (Da)Tools
O02765 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: F19B1370E723D608

FASTA18720,886
        10         20         30         40         50         60 
MEGVRPLEEN VGNAPRPRFE RNKLLLVASV VQALGLLLCL TYVCQHSHAP EVSLQYPPIE 

        70         80         90        100        110        120 
NIMTQLQILT SHECEEDSFI LPLQKRDGTM EVQNNSVVIQ CDGFYLLSLK GYFSQEVSIS 

       130        140        150        160        170        180 
LHYRKGEEPF PILKKTKFAN SNVVLKLGYK DKVYLNVTTD SASCKQLSVN AGELIVILQN 


PGGYCAP 

« Hide

References

[1]"Expression of OX40 and OX40 ligand genes in rabbit HTLV-I-transformed T cell lines."
Isono T., Seto A.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CHBB:HM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB003912 mRNA. Translation: BAA20060.1.
RefSeqNP_001075454.1. NM_001081985.1.
UniGeneOcu.2137.

3D structure databases

ProteinModelPortalO02765.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000007420.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100008595.

Organism-specific databases

CTD7292.

Phylogenomic databases

eggNOGNOG47572.
HOGENOMHOG000076309.
HOVERGENHBG056457.
OMAMEGVQPL.
OrthoDBEOG74BJVD.
TreeFamTF336384.

Family and domain databases

InterProIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00229. TNF. 1 hit.
[Graphical view]
SMARTSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS00251. TNF_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTNFL4_RABIT
AccessionPrimary (citable) accession number: O02765
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families