Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O02765

- TNFL4_RABIT

UniProt

O02765 - TNFL4_RABIT

Protein

Tumor necrosis factor ligand superfamily member 4

Gene

TNFSF4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

    GO - Biological processi

    1. acute inflammatory response Source: Ensembl
    2. CD4-positive, alpha-beta T cell costimulation Source: Ensembl
    3. cellular response to lipopolysaccharide Source: Ensembl
    4. cellular response to nitrogen dioxide Source: Ensembl
    5. cellular response to prostaglandin E stimulus Source: Ensembl
    6. chemokine (C-C motif) ligand 11 production Source: Ensembl
    7. cholesterol metabolic process Source: Ensembl
    8. defense response to nematode Source: Ensembl
    9. immune response Source: InterPro
    10. memory T cell activation Source: Ensembl
    11. negative regulation of cytokine secretion Source: Ensembl
    12. negative regulation of interferon-gamma production Source: Ensembl
    13. negative regulation of interleukin-17 production Source: Ensembl
    14. negative regulation of regulatory T cell differentiation Source: Ensembl
    15. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    16. negative regulation of T-helper 1 cell differentiation Source: Ensembl
    17. negative regulation of transcription, DNA-templated Source: Ensembl
    18. positive regulation of alpha-beta T cell proliferation Source: Ensembl
    19. positive regulation of CD4-positive, alpha-beta T cell costimulation Source: Ensembl
    20. positive regulation of immunoglobulin mediated immune response Source: Ensembl
    21. positive regulation of immunoglobulin secretion Source: Ensembl
    22. positive regulation of inflammatory response Source: Ensembl
    23. positive regulation of interferon-gamma production Source: Ensembl
    24. positive regulation of interleukin-10 production Source: Ensembl
    25. positive regulation of interleukin-12 production Source: Ensembl
    26. positive regulation of interleukin-13 production Source: Ensembl
    27. positive regulation of interleukin-4-dependent isotype switching to IgE isotypes Source: Ensembl
    28. positive regulation of interleukin-4 production Source: Ensembl
    29. positive regulation of interleukin-6 production Source: Ensembl
    30. positive regulation of memory T cell activation Source: Ensembl
    31. positive regulation of memory T cell differentiation Source: Ensembl
    32. positive regulation of T cell cytokine production Source: Ensembl
    33. positive regulation of T-helper 2 cell activation Source: Ensembl
    34. positive regulation of T-helper 2 cell differentiation Source: Ensembl
    35. positive regulation of type 2 immune response Source: Ensembl
    36. response to virus Source: Ensembl
    37. T-helper 2 cell activation Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 4
    Alternative name(s):
    OX40 ligand
    Short name:
    OX40L
    CD_antigen: CD252
    Gene namesi
    Name:TNFSF4
    Synonyms:TXGP1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular space Source: UniProtKB-KW
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 187187Tumor necrosis factor ligand superfamily member 4PRO_0000185495Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi74 ↔ 164By similarity
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi101 ↔ 185By similarity
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homotrimer.Curated

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000007420.

    Structurei

    3D structure databases

    ProteinModelPortaliO02765.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini45 – 187143ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47572.
    HOGENOMiHOG000076309.
    HOVERGENiHBG056457.
    OMAiMEGVQPL.
    OrthoDBiEOG74BJVD.
    TreeFamiTF336384.

    Family and domain databases

    InterProiIPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O02765-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGVRPLEEN VGNAPRPRFE RNKLLLVASV VQALGLLLCL TYVCQHSHAP    50
    EVSLQYPPIE NIMTQLQILT SHECEEDSFI LPLQKRDGTM EVQNNSVVIQ 100
    CDGFYLLSLK GYFSQEVSIS LHYRKGEEPF PILKKTKFAN SNVVLKLGYK 150
    DKVYLNVTTD SASCKQLSVN AGELIVILQN PGGYCAP 187
    Length:187
    Mass (Da):20,886
    Last modified:July 1, 1997 - v1
    Checksum:iF19B1370E723D608
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003912 mRNA. Translation: BAA20060.1.
    RefSeqiNP_001075454.1. NM_001081985.1.
    UniGeneiOcu.2137.

    Genome annotation databases

    GeneIDi100008595.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003912 mRNA. Translation: BAA20060.1 .
    RefSeqi NP_001075454.1. NM_001081985.1.
    UniGenei Ocu.2137.

    3D structure databases

    ProteinModelPortali O02765.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000007420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100008595.

    Organism-specific databases

    CTDi 7292.

    Phylogenomic databases

    eggNOGi NOG47572.
    HOGENOMi HOG000076309.
    HOVERGENi HBG056457.
    OMAi MEGVQPL.
    OrthoDBi EOG74BJVD.
    TreeFami TF336384.

    Family and domain databases

    InterProi IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of OX40 and OX40 ligand genes in rabbit HTLV-I-transformed T cell lines."
      Isono T., Seto A.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CHBB:HM.

    Entry informationi

    Entry nameiTNFL4_RABIT
    AccessioniPrimary (citable) accession number: O02765
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3