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O02765

- TNFL4_RABIT

UniProt

O02765 - TNFL4_RABIT

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Protein

Tumor necrosis factor ligand superfamily member 4

Gene

TNFSF4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

GO - Biological processi

  1. acute inflammatory response Source: Ensembl
  2. CD4-positive, alpha-beta T cell costimulation Source: Ensembl
  3. cellular response to lipopolysaccharide Source: Ensembl
  4. cellular response to nitrogen dioxide Source: Ensembl
  5. cellular response to prostaglandin E stimulus Source: Ensembl
  6. chemokine (C-C motif) ligand 11 production Source: Ensembl
  7. cholesterol metabolic process Source: Ensembl
  8. defense response to nematode Source: Ensembl
  9. immune response Source: InterPro
  10. memory T cell activation Source: Ensembl
  11. negative regulation of cytokine secretion Source: Ensembl
  12. negative regulation of interferon-gamma production Source: Ensembl
  13. negative regulation of interleukin-17 production Source: Ensembl
  14. negative regulation of regulatory T cell differentiation Source: Ensembl
  15. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  16. negative regulation of T-helper 1 cell differentiation Source: Ensembl
  17. negative regulation of transcription, DNA-templated Source: Ensembl
  18. positive regulation of alpha-beta T cell proliferation Source: Ensembl
  19. positive regulation of CD4-positive, alpha-beta T cell costimulation Source: Ensembl
  20. positive regulation of immunoglobulin mediated immune response Source: Ensembl
  21. positive regulation of immunoglobulin secretion Source: Ensembl
  22. positive regulation of inflammatory response Source: Ensembl
  23. positive regulation of interferon-gamma production Source: Ensembl
  24. positive regulation of interleukin-10 production Source: Ensembl
  25. positive regulation of interleukin-12 production Source: Ensembl
  26. positive regulation of interleukin-13 production Source: Ensembl
  27. positive regulation of interleukin-4-dependent isotype switching to IgE isotypes Source: Ensembl
  28. positive regulation of interleukin-4 production Source: Ensembl
  29. positive regulation of interleukin-6 production Source: Ensembl
  30. positive regulation of memory T cell activation Source: Ensembl
  31. positive regulation of memory T cell differentiation Source: Ensembl
  32. positive regulation of T cell cytokine production Source: Ensembl
  33. positive regulation of T-helper 2 cell activation Source: Ensembl
  34. positive regulation of T-helper 2 cell differentiation Source: Ensembl
  35. positive regulation of type 2 immune response Source: Ensembl
  36. response to virus Source: Ensembl
  37. T-helper 2 cell activation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 4
Alternative name(s):
OX40 ligand
Short name:
OX40L
CD_antigen: CD252
Gene namesi
Name:TNFSF4
Synonyms:TXGP1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187Tumor necrosis factor ligand superfamily member 4PRO_0000185495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi74 ↔ 164By similarity
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 185By similarity
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotrimer.Curated

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007420.

Structurei

3D structure databases

ProteinModelPortaliO02765.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini45 – 187143ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47572.
HOGENOMiHOG000076309.
HOVERGENiHBG056457.
InParanoidiO02765.
OMAiMEGVQPL.
OrthoDBiEOG74BJVD.
TreeFamiTF336384.

Family and domain databases

InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02765-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGVRPLEEN VGNAPRPRFE RNKLLLVASV VQALGLLLCL TYVCQHSHAP
60 70 80 90 100
EVSLQYPPIE NIMTQLQILT SHECEEDSFI LPLQKRDGTM EVQNNSVVIQ
110 120 130 140 150
CDGFYLLSLK GYFSQEVSIS LHYRKGEEPF PILKKTKFAN SNVVLKLGYK
160 170 180
DKVYLNVTTD SASCKQLSVN AGELIVILQN PGGYCAP
Length:187
Mass (Da):20,886
Last modified:July 1, 1997 - v1
Checksum:iF19B1370E723D608
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB003912 mRNA. Translation: BAA20060.1.
RefSeqiNP_001075454.1. NM_001081985.1.
UniGeneiOcu.2137.

Genome annotation databases

GeneIDi100008595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB003912 mRNA. Translation: BAA20060.1 .
RefSeqi NP_001075454.1. NM_001081985.1.
UniGenei Ocu.2137.

3D structure databases

ProteinModelPortali O02765.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000007420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100008595.

Organism-specific databases

CTDi 7292.

Phylogenomic databases

eggNOGi NOG47572.
HOGENOMi HOG000076309.
HOVERGENi HBG056457.
InParanoidi O02765.
OMAi MEGVQPL.
OrthoDBi EOG74BJVD.
TreeFami TF336384.

Family and domain databases

InterProi IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of OX40 and OX40 ligand genes in rabbit HTLV-I-transformed T cell lines."
    Isono T., Seto A.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CHBB:HM.

Entry informationi

Entry nameiTNFL4_RABIT
AccessioniPrimary (citable) accession number: O02765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3