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Protein

Tumor necrosis factor ligand superfamily member 4

Gene

TNFSF4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 4
Alternative name(s):
OX40 ligand
Short name:
OX40L
CD_antigen: CD252
Gene namesi
Name:TNFSF4
Synonyms:TXGP1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini45 – 187143ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187Tumor necrosis factor ligand superfamily member 4PRO_0000185495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi74 ↔ 164By similarity
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 185By similarity
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotrimer.Curated

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007420.

Structurei

3D structure databases

ProteinModelPortaliO02765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47572.
HOGENOMiHOG000076309.
HOVERGENiHBG056457.
InParanoidiO02765.
KOiK05469.
OMAiMEGVQPL.
OrthoDBiEOG74BJVD.
TreeFamiTF336384.

Family and domain databases

InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGVRPLEEN VGNAPRPRFE RNKLLLVASV VQALGLLLCL TYVCQHSHAP
60 70 80 90 100
EVSLQYPPIE NIMTQLQILT SHECEEDSFI LPLQKRDGTM EVQNNSVVIQ
110 120 130 140 150
CDGFYLLSLK GYFSQEVSIS LHYRKGEEPF PILKKTKFAN SNVVLKLGYK
160 170 180
DKVYLNVTTD SASCKQLSVN AGELIVILQN PGGYCAP
Length:187
Mass (Da):20,886
Last modified:July 1, 1997 - v1
Checksum:iF19B1370E723D608
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003912 mRNA. Translation: BAA20060.1.
RefSeqiNP_001075454.1. NM_001081985.1.
UniGeneiOcu.2137.

Genome annotation databases

GeneIDi100008595.
KEGGiocu:100008595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003912 mRNA. Translation: BAA20060.1.
RefSeqiNP_001075454.1. NM_001081985.1.
UniGeneiOcu.2137.

3D structure databases

ProteinModelPortaliO02765.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007420.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008595.
KEGGiocu:100008595.

Organism-specific databases

CTDi7292.

Phylogenomic databases

eggNOGiNOG47572.
HOGENOMiHOG000076309.
HOVERGENiHBG056457.
InParanoidiO02765.
KOiK05469.
OMAiMEGVQPL.
OrthoDBiEOG74BJVD.
TreeFamiTF336384.

Family and domain databases

InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of OX40 and OX40 ligand genes in rabbit HTLV-I-transformed T cell lines."
    Isono T., Seto A.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CHBB:HM.

Entry informationi

Entry nameiTNFL4_RABIT
AccessioniPrimary (citable) accession number: O02765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: February 4, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.