O02750 (LEP_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leptin

Alternative name(s):
Obesity factor

Gene names

Name:	LEP
Synonyms:	OB

Organism

Pan troglodytes (Chimpanzee) [Reference proteome]

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass By similarity.
Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the leptin family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Obesity
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adipose tissue development Inferred from electronic annotation. Source: Compara adult feeding behavior Inferred from sequence or structural similarity. Source: HGNC bile acid metabolic process Inferred from electronic annotation. Source: Compara central nervous system neuron development Inferred from electronic annotation. Source: Compara cholesterol metabolic process Inferred from electronic annotation. Source: Compara eating behavior Inferred from electronic annotation. Source: Compara glucose metabolic process Inferred from electronic annotation. Source: Compara hormone metabolic process Inferred from electronic annotation. Source: Compara insulin secretion Inferred from electronic annotation. Source: Compara negative regulation of appetite Inferred from sequence or structural similarity. Source: HGNC negative regulation of glucagon secretion Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara placenta development Inferred from electronic annotation. Source: Compara positive regulation of STAT protein import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of developmental growth Inferred from electronic annotation. Source: Compara positive regulation of myeloid cell differentiation Inferred from electronic annotation. Source: Compara regulation of gluconeogenesis Inferred from electronic annotation. Source: Compara regulation of insulin secretion Inferred from electronic annotation. Source: Compara regulation of intestinal cholesterol absorption Inferred from electronic annotation. Source: Compara regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara regulation of steroid biosynthetic process Inferred from electronic annotation. Source: Compara response to dietary excess Inferred from electronic annotation. Source: Compara response to insulin stimulus Inferred from electronic annotation. Source: Compara tyrosine phosphorylation of STAT protein Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 146	146	Leptin		PRO_0000160606
Amino acid modifications
	Disulfide bond	96 ↔ 146		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O02750 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 02C42A06B554D55C	FASTA	146	16,059
	10 20 30 40 50 60 VPIQKVQDDT KTLIKTIVTR INDISHTQSV SSKQKVTGLD FIPGLHPILT LSKMDQTLAV 70 80 90 100 110 120 YQQILTSMPS RNMIQISNDL ENLRDLLHVL AFSKSCHLPW ASGLETLDSL GGVLEASGYS 130 140 TEVVALSRLQ GSLQDMLWQL DLSPGC

References

[1]

"Cloning of obese genes from different species: a comparison of the gene structures and the sequences of the obese gene products, leptin." Schoner B., Basinski M.B., Smith D.P., Hsiung H.M., Zhang X., Rockey P.K., Rosteck P.R. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U96450 mRNA. Translation: AAB54023.1.
RefSeq	NP_001180601.1. NM_001193672.1.
UniGene	Ptr.6237.
3D structure databases
ProteinModelPortal	O02750.
ModBase	Search...
Protein-protein interaction databases
STRING	9598.ENSPTRP00000033657.
Proteomic databases
PRIDE	O02750.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	449638.
KEGG	ptr:449638.
Organism-specific databases
CTD	3952.
Phylogenomic databases
eggNOG	NOG45133.
HOGENOM	HOG000252923.
HOVERGEN	HBG007860.
InParanoid	O02750.
KO	K05424.
OrthoDB	EOG4QNMXC.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR000065. Leptin. [Graphical view]
PANTHER	PTHR11724. PTHR11724. 1 hit.
Pfam	PF02024. Leptin. 1 hit. [Graphical view]
PIRSF	PIRSF001837. Leptin. 1 hit.
PRINTS	PR00495. LEPTIN.
ProDom	PD005698. Leptin. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
ProtoNet	Search...
Other
NextBio	20832743.

Entry information

Entry name

LEP_PANTR

Accession

Primary (citable) accession number: O02750

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program