Reviewed, UniProtKB/Swiss-Prot O02747 (AHR_RABIT)

Names and origin

Protein names

Recommended name:
    Aryl hydrocarbon receptor
      Short name=Ah receptor
      Short name=AhR

Gene names

Name:

AHR

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	847 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Ref.1
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with MYBBP1A and NEDD8 and IVNS1ABP By similarity.
Subcellular location	Cytoplasm. Nucleus. Note: First cytoplasmic, upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Domain	Repeat
Ligand	DNA-binding
Molecular function	Activator
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW transcription regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 847	847	Aryl hydrocarbon receptor		PRO_0000127116
Regions
	Domain	41 – 81	41	Helix-loop-helix motif
	Domain	120 – 173	54	PAS 1
	Domain	281 – 336	56	PAS 2
	Domain	346 – 384	39	PAC
	DNA binding	13 – 40	28	Basic motif
	Compositional bias	596 – 638	43	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	O02747-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 097DEBA6BF467F6C	FASTA	847	94,437
	10 20 30 40 50 60 MNGGGANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL ASLLPFPQDV 70 80 90 100 110 120 INKLDKLSVL RLSVSYLRAK SFFDVALKSS SADRNGGQDP CRAKFGEGLN LQEGEFLLQA 130 140 150 160 170 180 LNGFVLVVTV DALVFYASST IQDYLGFQQS DVIHQSVYEL IHTEDRAEFQ RQLHWALNPS 190 200 210 220 230 240 QCTDPGQGAD ETHGLPQPVY YNPDQLPPEN SSFMERCFIC RLRCLLDNSS GFLAMNFQGR 250 260 270 280 290 300 LKFLHGQNKK GKDGSLLPPQ LALFAIATPL QPPSILEIRT KNFIFRTKHK LDFTPTGCDA 310 320 330 340 350 360 KGQIVLGYTE AELCMRGSGY QFIHAADMLY CAESHIRMIK TGESGLAVFR LLTKDNRWAW 370 380 390 400 410 420 VQSNARFIYK NGRPDFIIAT QRPLTDEEGR EHLLKRNTKL PFMFTTGEAV LYEMTSPFPP 430 440 450 460 470 480 IMDPLPIRPK SGTCGKDSAT KPTPSKDSVH PSSLLSALMQ QDESIYLYPP SSNAPFERNF 490 500 510 520 530 540 FTESLNECSN WPENVASVAG GSVLKHEQIG QSQEVSPAFS GDQTVLFPDN KNCDLYNIMK 550 560 570 580 590 600 NLGVDFEDIK NMQNEEFFGA DFSGEVDFRD IDITDEILTY VQDSLNKSPF GSPGYQPQPA 610 620 630 640 650 660 TALNSSCMVQ ERLQLGPPQQ PPCRSEQATV EPQQQLCQKM EHMQVNSMFA NWSANQPVPF 670 680 690 700 710 720 SEPQQDLQPY SVFTDFHTAD QAFPYTAAMN TMPYTQNFTP CNQTVAPQHS RCTQLDFAMG 730 740 750 760 770 780 NFDSSPYPST SNLEDFVTCL QVPDRQTHGG NPQSAMVAPQ TCYAGAVSMY QCQPGPAHTL 790 800 810 820 830 840 MGQMQCEPPV PGPEAFLNKF PNGGMLNETY PADLHDINNT VASTHLPPLH HPSEARPFPD LASGRLL

References

[1]

"Expression of aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (Arnt) in adult rabbits known to be non-responsive to cytochrome P-450 1A1 (CYP1A1) inducers." Takahashi Y., Nakayama K., Shimojima T., Itoh S., Kamataki T. Eur. J. Biochem. 242:512-518(1996) [PubMed: 9022676] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Strain: New Zealand white. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D38226 mRNA. Translation: BAA19930.1.
RefSeq	NP_001075674.1.
UniGene	Ocu.2134
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSOCUG00000003877. Oryctolagus cuniculus. [Contig view]
GeneID	100008995.
Phylogenomic databases
HOVERGEN	O02747.
Family and domain databases
InterPro	IPR001092. HLH_basic. IPR001610. PAC. IPR000014. PAS. IPR013767. PAS_fold. IPR013655. PAS_fold_3. [Graphical view]
Pfam	PF00010. HLH. 1 hit. PF00989. PAS. 1 hit. PF08447. PAS_3. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. SM00086. PAC. 1 hit. SM00091. PAS. 2 hits. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. PS50113. PAC. False negative. PS50112. PAS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AHR_RABIT

Accession

Primary (citable) accession number: O02747

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	July 1, 1997
Last modified:	June 16, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)