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Protein

Aryl hydrocarbon receptor

Gene

AHR

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor
Short name:
Ah receptor
Short name:
AhR
Gene namesi
Name:AHR
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: First cytoplasmic, upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 847847Aryl hydrocarbon receptorPRO_0000127116Add
BLAST

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with MYBBP1A, NEDD8 and IVNS1ABP. Interacts with ARNTL/BMAL1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003361.

Chemistry

BindingDBiO02747.

Structurei

3D structure databases

ProteinModelPortaliO02747.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 8054bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini120 – 17354PAS 1PROSITE-ProRule annotationAdd
BLAST
Domaini281 – 33656PAS 2PROSITE-ProRule annotationAdd
BLAST
Domaini346 – 38439PACAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi596 – 63843Gln-richAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3560. Eukaryota.
ENOG410XRZH. LUCA.
HOGENOMiHOG000252935.
HOVERGENiHBG007313.
InParanoidiO02747.
KOiK09093.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR033348. AHR.
IPR011598. bHLH_dom.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PANTHERiPTHR10649:SF9. PTHR10649:SF9. 1 hit.
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGGGANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL
60 70 80 90 100
ASLLPFPQDV INKLDKLSVL RLSVSYLRAK SFFDVALKSS SADRNGGQDP
110 120 130 140 150
CRAKFGEGLN LQEGEFLLQA LNGFVLVVTV DALVFYASST IQDYLGFQQS
160 170 180 190 200
DVIHQSVYEL IHTEDRAEFQ RQLHWALNPS QCTDPGQGAD ETHGLPQPVY
210 220 230 240 250
YNPDQLPPEN SSFMERCFIC RLRCLLDNSS GFLAMNFQGR LKFLHGQNKK
260 270 280 290 300
GKDGSLLPPQ LALFAIATPL QPPSILEIRT KNFIFRTKHK LDFTPTGCDA
310 320 330 340 350
KGQIVLGYTE AELCMRGSGY QFIHAADMLY CAESHIRMIK TGESGLAVFR
360 370 380 390 400
LLTKDNRWAW VQSNARFIYK NGRPDFIIAT QRPLTDEEGR EHLLKRNTKL
410 420 430 440 450
PFMFTTGEAV LYEMTSPFPP IMDPLPIRPK SGTCGKDSAT KPTPSKDSVH
460 470 480 490 500
PSSLLSALMQ QDESIYLYPP SSNAPFERNF FTESLNECSN WPENVASVAG
510 520 530 540 550
GSVLKHEQIG QSQEVSPAFS GDQTVLFPDN KNCDLYNIMK NLGVDFEDIK
560 570 580 590 600
NMQNEEFFGA DFSGEVDFRD IDITDEILTY VQDSLNKSPF GSPGYQPQPA
610 620 630 640 650
TALNSSCMVQ ERLQLGPPQQ PPCRSEQATV EPQQQLCQKM EHMQVNSMFA
660 670 680 690 700
NWSANQPVPF SEPQQDLQPY SVFTDFHTAD QAFPYTAAMN TMPYTQNFTP
710 720 730 740 750
CNQTVAPQHS RCTQLDFAMG NFDSSPYPST SNLEDFVTCL QVPDRQTHGG
760 770 780 790 800
NPQSAMVAPQ TCYAGAVSMY QCQPGPAHTL MGQMQCEPPV PGPEAFLNKF
810 820 830 840
PNGGMLNETY PADLHDINNT VASTHLPPLH HPSEARPFPD LASGRLL
Length:847
Mass (Da):94,437
Last modified:July 1, 1997 - v1
Checksum:i097DEBA6BF467F6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38226 mRNA. Translation: BAA19930.1.
RefSeqiNP_001075674.1. NM_001082205.1.
UniGeneiOcu.2134.

Genome annotation databases

GeneIDi100008995.
KEGGiocu:100008995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38226 mRNA. Translation: BAA19930.1.
RefSeqiNP_001075674.1. NM_001082205.1.
UniGeneiOcu.2134.

3D structure databases

ProteinModelPortaliO02747.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000003361.

Chemistry

BindingDBiO02747.
ChEMBLiCHEMBL4725.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008995.
KEGGiocu:100008995.

Organism-specific databases

CTDi196.

Phylogenomic databases

eggNOGiKOG3560. Eukaryota.
ENOG410XRZH. LUCA.
HOGENOMiHOG000252935.
HOVERGENiHBG007313.
InParanoidiO02747.
KOiK09093.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR033348. AHR.
IPR011598. bHLH_dom.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PANTHERiPTHR10649:SF9. PTHR10649:SF9. 1 hit.
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAHR_RABIT
AccessioniPrimary (citable) accession number: O02747
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.