O02720 (LEP_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leptin

Alternative name(s):
Obesity factor

Gene names

Name:	LEP
Synonyms:	OB

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass By similarity.
Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the leptin family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Obesity
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult feeding behavior Inferred from sequence or structural similarity. Source: HGNC negative regulation of appetite Inferred from sequence or structural similarity. Source: HGNC signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 167	146	Leptin		PRO_0000017681
Amino acid modifications
	Disulfide bond	117 ↔ 167		By similarity
Experimental info
	Sequence conflict	148	1	N → S in AAB53654. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O02720 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 9703CFBED2286A55	FASTA	167	18,655
	10 20 30 40 50 60 MRCGPLCRFL WLWPYLSCVE AVPIRKVQDD TKTLIKTIVA RINDISHTQS VSSKQRVAGL 70 80 90 100 110 120 DFIPGLQPVL SLSRMDQTLA IYQQILNSLH SRNVVQISND LENLRDLLHL LASSKSCPLP 130 140 150 160 RARGLETFES LGGVLEASLY STEVVALNRL QAALQDMLRR LDLSPGC

References

[1]	"Molecular cloning of canine leptin cDNA." Iwase M., Sasaki N., Komagome R., Kimura K., Saito M. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: White adipose tissue.
[2]	Smith D.P., Zhang X., Hsiung H.M. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-167. Tissue: Adipose tissue.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB020986 mRNA. Translation: BAA35129.1. U95642 mRNA. Translation: AAB53654.1.
RefSeq	NP_001003070.1. NM_001003070.1.
UniGene	Cfa.3476.
3D structure databases
ProteinModelPortal	O02720.
SMR	O02720. Positions 24-167.
ModBase	Search...
Protein-protein interaction databases
STRING	9615.ENSCAFP00000002433.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	403616.
KEGG	cfa:403616.
Organism-specific databases
CTD	3952.
Phylogenomic databases
eggNOG	NOG45133.
HOGENOM	HOG000252923.
HOVERGEN	HBG007860.
InParanoid	O02720.
KO	K05424.
OrthoDB	EOG4QNMXC.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR000065. Leptin. [Graphical view]
PANTHER	PTHR11724. PTHR11724. 1 hit.
Pfam	PF02024. Leptin. 1 hit. [Graphical view]
PIRSF	PIRSF001837. Leptin. 1 hit.
PRINTS	PR00495. LEPTIN.
ProDom	PD005698. Leptin. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
ProtoNet	Search...
Other
NextBio	20817121.

Entry information

Entry name

LEP_CANFA

Accession

Primary (citable) accession number: O02720
Secondary accession number(s): Q9TSG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	April 27, 2001
Last modified:	April 3, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program