Receptor-type tyrosine-protein phosphatase N2 precursor - Macaca nemestrina (Pig-tailed macaque)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase N2
Short name=R-PTP-N2
EC=3.1.3.48

Alternative name(s):
M1851

Gene names

Name:

PTPRN2

Organism

Macaca nemestrina (Pig-tailed macaque)

Taxonomic identifier

9545 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	1013 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Implicated in development of nervous system and pancreatic endocrine cells.
Catalytic activity	Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.
Subcellular location	Cytoplasmic vesicle › secretory vesicle membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Brain, prostate, pancreatic islets. Lower expression in spinal cord, thyroid, adrenal medulla and gastrointestinal tract.
Post-translational modification	Appears to undergo multiple proteolytic cleavage at consecutive basic residues By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase Receptor
PTM	Acetylation Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW transport vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Potential

Chain

20 – 1013

994

Receptor-type tyrosine-protein phosphatase N2

PRO_0000025455

Regions

Topological domain

20 – 613

594

Extracellular Potential

Transmembrane

614 – 634

21

Helical; Potential

Topological domain

635 – 1013

379

Cytoplasmic Potential

Domain

743 – 1003

261

Tyrosine-protein phosphatase

Region

943 – 949

7

Substrate binding By similarity

Sites

Active site

943

1

Phosphocysteine intermediate Potential

Binding site

911

1

Substrate By similarity

Binding site

988

1

Substrate By similarity

Site

425 – 426

2

Cleavage By similarity

Amino acid modifications

Modified residue

690

1

Phosphoserine By similarity

Modified residue

968

1

N6-acetyllysine By similarity

Glycosylation

562

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O02695 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 4808D43937A2EF59
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FASTA

1,013

111,191

        10         20         30         40         50         60 
MALPLLLLLL LLLPPRVLPA APSSVPHGRQ LPGRLGCLLE EGLCGASEAC VNDGVFGRCQ 

        70         80         90        100        110        120 
KVPAMDFYRY EVSPVALQRL RVALQKLSGT GFTWQDDYTQ YVMDQELADL PKTYLRHPEA 

       130        140        150        160        170        180 
SGPARPSKHS IGSERRYSQE GGAALAKAFR RHLPFLEALS QAPASDALAR TRMAQDRPRA 

       190        200        210        220        230        240 
EGDDRFSKSI LTYVAHTSVL TYPPGPQAQL PEDLLPRTLS QLQPDELSPK VDSSVERHHL 

       250        260        270        280        290        300 
MAALSAYAAQ RPPAPPGKGS LEPQYLLRAP SRMPRPLLSP AVPQKWPSPL GDPEDPPSTG 

       310        320        330        340        350        360 
EGARIHTLLK DLQRQPAEAR GLSDLELDSM AELMAGLMQG MDHRGALGGP GKAALGESGE 

       370        380        390        400        410        420 
QADGPKAALR GESFPDDGVQ DDDDRLYQEV HRLSATLGGL LQDHGSRLSP GALPFAKPLK 

       430        440        450        460        470        480 
MERKKSERPE ASLSSEEETA GVENVKSQTY SKDLLGQQPH SEPGAGAFGE LQNQMPGPSE 

       490        500        510        520        530        540 
EEQSLPAGAQ EALGDGLQLE VKPSEEEARG YIVTDRDPLR PEEGRQLVED VARLLQMPSS 

       550        560        570        580        590        600 
TFADVEVLGP AVTFKVGANV QNVTTADVEK ATVDNKDKLE ETSGLKILQT GVGSKSKLKF 

       610        620        630        640        650        660 
LPPQAEQEDS TKFIALTLVS LACILGVLLA SGLIYCLRHS SQHRLKEKLS GLGRDPGADA 

       670        680        690        700        710        720 
TAAYQELCRQ RMATRPPDRP EGPHTSRISS VSSQFSDGPM PSPSARSSAS SWSEEPVQSN 

       730        740        750        760        770        780 
MDISTGHMIL SYMEDHLKNK NRLEKEWEAL CAYQAEPNSS LVAQKEENVP KNRSLAVLTY 

       790        800        810        820        830        840 
DHSRVLLKAE NSHSHSDYIN ASPIMDHDPR NPAYIATQGP LPATVADFWQ MVWESGCVVI 

       850        860        870        880        890        900 
VMLTPLTENG VRQCYHYWPD EGSNLYHIYE VNLVSEHIWC EDFLVRSFYL KNLQTNETRT 

       910        920        930        940        950        960 
VTQFHFLSWY DRGVPSSSRS LLDFRRKVNK CYRGRSCPII VHCSDGAGRS GTYVLIDMVL 

       970        980        990       1000       1010 
NKMAKGAKEI DIAATLEHLR DQRPGMVQTK EQFEFALTAV AEEVNAILKA LPQ

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References

[1]

"An islet-cell protein tyrosine phosphatase is a likely precursor to the 37-kDa autoantigen in type 1 diabetes: human and macaque sequences, tissue distribution, unique and shared epitopes, and predictive autoantibodies."
Lagasse J., Jelinek L., Sexson S., Lofton-Day C.E., Breininger J., Sheppard P., Kindsvogel W., Hagopian W.A.
Mol. Med. 3:163-173(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreatic islet.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U91574 mRNA. Translation: AAC51186.1.
3D structure databases
ProteinModelPortal	O02695.
SMR	O02695. Positions 722-1008.
ModBase	Search...
Proteomic databases
PRIDE	O02695.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG105788.
Family and domain databases
InterPro	IPR021613. Receptor_IA-2. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF11548. Receptor_IA-2. 1 hit. PF00102. Y_phosphatase. 1 hit. [Graphical view]
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00194. PTPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTPR2_MACNE

Accession

Primary (citable) accession number: O02695

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families