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O02695 (PTPR2_MACNE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase N2

Short name=R-PTP-N2
EC=3.1.3.48
Alternative name(s):
M1851
Gene names
Name:PTPRN2
OrganismMacaca nemestrina (Pig-tailed macaque)
Taxonomic identifier9545 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length1013 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Implicated in development of nervous system and pancreatic endocrine cells.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasmic vesiclesecretory vesicle membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Brain, prostate, pancreatic islets. Lower expression in spinal cord, thyroid, adrenal medulla and gastrointestinal tract.

Post-translational modification

Appears to undergo multiple proteolytic cleavage at consecutive basic residues By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 1013994Receptor-type tyrosine-protein phosphatase N2
PRO_0000025455

Regions

Topological domain20 – 613594Extracellular Potential
Transmembrane614 – 63421Helical; Potential
Topological domain635 – 1013379Cytoplasmic Potential
Domain743 – 1003261Tyrosine-protein phosphatase
Region943 – 9497Substrate binding By similarity

Sites

Active site9431Phosphocysteine intermediate Potential
Binding site9111Substrate By similarity
Binding site9881Substrate By similarity
Site425 – 4262Cleavage By similarity

Amino acid modifications

Modified residue9681N6-acetyllysine By similarity
Glycosylation5621N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O02695 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 4808D43937A2EF59

FASTA1,013111,191
        10         20         30         40         50         60 
MALPLLLLLL LLLPPRVLPA APSSVPHGRQ LPGRLGCLLE EGLCGASEAC VNDGVFGRCQ 

        70         80         90        100        110        120 
KVPAMDFYRY EVSPVALQRL RVALQKLSGT GFTWQDDYTQ YVMDQELADL PKTYLRHPEA 

       130        140        150        160        170        180 
SGPARPSKHS IGSERRYSQE GGAALAKAFR RHLPFLEALS QAPASDALAR TRMAQDRPRA 

       190        200        210        220        230        240 
EGDDRFSKSI LTYVAHTSVL TYPPGPQAQL PEDLLPRTLS QLQPDELSPK VDSSVERHHL 

       250        260        270        280        290        300 
MAALSAYAAQ RPPAPPGKGS LEPQYLLRAP SRMPRPLLSP AVPQKWPSPL GDPEDPPSTG 

       310        320        330        340        350        360 
EGARIHTLLK DLQRQPAEAR GLSDLELDSM AELMAGLMQG MDHRGALGGP GKAALGESGE 

       370        380        390        400        410        420 
QADGPKAALR GESFPDDGVQ DDDDRLYQEV HRLSATLGGL LQDHGSRLSP GALPFAKPLK 

       430        440        450        460        470        480 
MERKKSERPE ASLSSEEETA GVENVKSQTY SKDLLGQQPH SEPGAGAFGE LQNQMPGPSE 

       490        500        510        520        530        540 
EEQSLPAGAQ EALGDGLQLE VKPSEEEARG YIVTDRDPLR PEEGRQLVED VARLLQMPSS 

       550        560        570        580        590        600 
TFADVEVLGP AVTFKVGANV QNVTTADVEK ATVDNKDKLE ETSGLKILQT GVGSKSKLKF 

       610        620        630        640        650        660 
LPPQAEQEDS TKFIALTLVS LACILGVLLA SGLIYCLRHS SQHRLKEKLS GLGRDPGADA 

       670        680        690        700        710        720 
TAAYQELCRQ RMATRPPDRP EGPHTSRISS VSSQFSDGPM PSPSARSSAS SWSEEPVQSN 

       730        740        750        760        770        780 
MDISTGHMIL SYMEDHLKNK NRLEKEWEAL CAYQAEPNSS LVAQKEENVP KNRSLAVLTY 

       790        800        810        820        830        840 
DHSRVLLKAE NSHSHSDYIN ASPIMDHDPR NPAYIATQGP LPATVADFWQ MVWESGCVVI 

       850        860        870        880        890        900 
VMLTPLTENG VRQCYHYWPD EGSNLYHIYE VNLVSEHIWC EDFLVRSFYL KNLQTNETRT 

       910        920        930        940        950        960 
VTQFHFLSWY DRGVPSSSRS LLDFRRKVNK CYRGRSCPII VHCSDGAGRS GTYVLIDMVL 

       970        980        990       1000       1010 
NKMAKGAKEI DIAATLEHLR DQRPGMVQTK EQFEFALTAV AEEVNAILKA LPQ 

« Hide

References

[1]"An islet-cell protein tyrosine phosphatase is a likely precursor to the 37-kDa autoantigen in type 1 diabetes: human and macaque sequences, tissue distribution, unique and shared epitopes, and predictive autoantibodies."
Lagasse J., Jelinek L., Sexson S., Lofton-Day C.E., Breininger J., Sheppard P., Kindsvogel W., Hagopian W.A.
Mol. Med. 3:163-173(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreatic islet.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U91574 mRNA. Translation: AAC51186.1.

3D structure databases

ProteinModelPortalO02695.
SMRO02695. Positions 722-1008.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO02695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG105788.

Family and domain databases

InterProIPR021613. Receptor_IA-2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF11548. Receptor_IA-2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTPR2_MACNE
AccessionPrimary (citable) accession number: O02695
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families