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O02691

- HCD2_BOVIN

UniProt

O02691 - HCD2_BOVIN

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Protein

3-hydroxyacyl-CoA dehydrogenase type-2

Gene
HSD17B10, HADH2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids By similarity.

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ = 2-methylacetoacetyl-CoA + NADH.
Testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei155 – 1551Substrate By similarity
Active sitei168 – 1681Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 3726NAD By similarityAdd
BLAST

GO - Molecular functioni

  1. 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity Source: UniProtKB-EC
  2. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
  3. testosterone dehydrogenase [NAD(P)] activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6663-MONOMER.
BRENDAi1.1.1.135. 908.
ReactomeiREACT_216656. Branched-chain amino acid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-CoA dehydrogenase type-2 (EC:1.1.1.35)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase 10 (EC:1.1.1.51)
Short name:
17-beta-HSD 10
3-hydroxy-2-methylbutyryl-CoA dehydrogenase (EC:1.1.1.178)
3-hydroxyacyl-CoA dehydrogenase type II
Mitochondrial ribonuclease P protein 2
Short name:
Mitochondrial RNase P protein 2
Type II HADH
Gene namesi
Name:HSD17B10
Synonyms:HADH2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome X

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. mitochondrial inner membrane Source: Ensembl
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 2612603-hydroxyacyl-CoA dehydrogenase type-2PRO_0000054809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei53 – 531N6-acetyllysine; alternate By similarity
Modified residuei53 – 531N6-succinyllysine; alternate By similarity
Modified residuei69 – 691N6-acetyllysine By similarity
Modified residuei99 – 991N6-acetyllysine By similarity
Modified residuei105 – 1051N6-acetyllysine By similarity
Modified residuei212 – 2121N6-acetyllysine; alternate By similarity
Modified residuei212 – 2121N6-succinyllysine; alternate By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO02691.
PRIDEiO02691.

Interactioni

Subunit structurei

Homotetramer. Interacts with MRPP1/TRMT10C and MRPP3/KIAA0391 By similarity.

Protein-protein interaction databases

IntActiO02691. 1 interaction.
STRINGi9913.ENSBTAP00000023642.

Structurei

3D structure databases

ProteinModelPortaliO02691.
SMRiO02691. Positions 7-261.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00710000106273.
HOVERGENiHBG002145.
InParanoidiO02691.
KOiK08683.
OMAiLMGANEP.
OrthoDBiEOG7JT6X7.
TreeFamiTF354307.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02691-1 [UniParc]FASTAAdd to Basket

« Hide

MAAACRSVKG LVALITGGAS GLGLATAERL VGQGATAVLL DLPNSDGETQ    50
AKKLGKSCAF APADVTSEKD VQAALTLARE KFGRVDVAVN CAGIAVASKT 100
YNLKKSQAHT LEDFQRVINV NLIGTFNVIR LVAGEMGQNE PDQGGQRGVI 150
INTASVAAFE GQVGQAAYSA SKGGIVGMTL PIARDLAPMG IRVMTIAPGL 200
FGTPLLTTLP DKVRNFLASQ VPFPSRLGDP AEYAHLVQAI IENSFLNGEV 250
IRLDGAIRMQ P 261
Length:261
Mass (Da):27,140
Last modified:January 23, 2007 - v3
Checksum:i8C7572B6A9A49780
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002156 mRNA. Translation: BAA19510.1.
BC110264 mRNA. Translation: AAI10265.1.
RefSeqiNP_776759.1. NM_174334.3.
UniGeneiBt.5231.

Genome annotation databases

EnsembliENSBTAT00000023642; ENSBTAP00000023642; ENSBTAG00000017779.
GeneIDi281809.
KEGGibta:281809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002156 mRNA. Translation: BAA19510.1 .
BC110264 mRNA. Translation: AAI10265.1 .
RefSeqi NP_776759.1. NM_174334.3.
UniGenei Bt.5231.

3D structure databases

ProteinModelPortali O02691.
SMRi O02691. Positions 7-261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O02691. 1 interaction.
STRINGi 9913.ENSBTAP00000023642.

Proteomic databases

PaxDbi O02691.
PRIDEi O02691.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000023642 ; ENSBTAP00000023642 ; ENSBTAG00000017779 .
GeneIDi 281809.
KEGGi bta:281809.

Organism-specific databases

CTDi 3028.

Phylogenomic databases

eggNOGi COG1028.
GeneTreei ENSGT00710000106273.
HOVERGENi HBG002145.
InParanoidi O02691.
KOi K08683.
OMAi LMGANEP.
OrthoDBi EOG7JT6X7.
TreeFami TF354307.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-6663-MONOMER.
BRENDAi 1.1.1.135. 908.
Reactomei REACT_216656. Branched-chain amino acid catabolism.

Miscellaneous databases

NextBioi 20805721.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of cDNA for a newly identified isozyme of bovine liver 3-hydroxyacyl-CoA dehydrogenase and its import into mitochondria."
    Furuta S., Kobayashi A., Miyazawa S., Hashimoto T.
    Biochim. Biophys. Acta 1350:317-324(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Liver.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiHCD2_BOVIN
AccessioniPrimary (citable) accession number: O02691
Secondary accession number(s): Q2TBG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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