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Protein

G protein-activated inward rectifier potassium channel 4

Gene

KCNJ5

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei179Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-SSC-1296041 Activation of G protein gated Potassium channels
R-SSC-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-activated inward rectifier potassium channel 4
Short name:
GIRK-4
Alternative name(s):
Cardiac inward rectifier
Short name:
CIR
Heart KATP channel
Inward rectifier K(+) channel Kir3.4
KATP-1
Potassium channel, inwardly rectifying subfamily J member 5
Gene namesi
Name:KCNJ5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicBy similarityAdd BLAST86
Transmembranei87 – 111Helical; Name=M1By similarityAdd BLAST25
Topological domaini112 – 135ExtracellularBy similarityAdd BLAST24
Intramembranei136 – 147Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei148 – 154Pore-formingBy similarity7
Topological domaini155 – 163ExtracellularBy similarity9
Transmembranei164 – 185Helical; Name=M2By similarityAdd BLAST22
Topological domaini186 – 419CytoplasmicBy similarityAdd BLAST234

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549361 – 419G protein-activated inward rectifier potassium channel 4Add BLAST419

Proteomic databases

PaxDbiO02670
PRIDEiO02670

Expressioni

Gene expression databases

BgeeiENSSSCG00000021573
GenevisibleiO02670 SS

Interactioni

Subunit structurei

May associate with GIRK1 and GIRK2 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000020421

Structurei

3D structure databases

ProteinModelPortaliO02670
SMRiO02670
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi149 – 154Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
HOVERGENiHBG006178
InParanoidiO02670
KOiK04999
OMAiQARSSYM
OrthoDBiEOG091G08HC
TreeFamiTF313676

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003277 K_chnl_inward-rec_Kir3.4
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01330 KIR34CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

O02670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGDSRNAMN QDMEIGVTPR DPKKIPKQAR DYIPIATDRT RLLAEGKKPR
60 70 80 90 100
QRYMEKSGKC NVHHGNVQET YRYLSDLFTT LVDLKWRFNL LVFTMVYTVT
110 120 130 140 150
WLFFGFIWWL IAYIRGDLDH VGDQEWIPCV ENLSGFVSAF LFSIETETTI
160 170 180 190 200
GYGFRVITEK CPEGIVLLLV QAILGSIVNA FMVGCMFVKI SQPKKRAETL
210 220 230 240 250
MFSNHAVISL RDEKLCLMFR VGDLRNSHIV EASIRAKLIK SRQTKEGEFI
260 270 280 290 300
PLNQTDINVG FDTGDDRLFL VSPLIISHEI NEKSPFWEMS RAQLNQEEFE
310 320 330 340 350
VVVILEGMVE ATGMTCQARS SYMDTEVLWG HRFTPVLTLE KGFYEVDYNT
360 370 380 390 400
FHDTYETNTP SCCAKELAEM KREGRLLQYL PSPPLPGGCA GAELEAEAEQ
410
EGEDEPEGLR GSRETRDSV
Length:419
Mass (Da):47,778
Last modified:July 1, 1997 - v1
Checksum:i8FCB123056EB10AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50133 mRNA Translation: BAA08813.1
RefSeqiNP_999390.1, NM_214225.1
UniGeneiSsc.16170

Genome annotation databases

EnsembliENSSSCT00000027719; ENSSSCP00000020421; ENSSSCG00000021573
GeneIDi397448
KEGGissc:397448

Similar proteinsi

Entry informationi

Entry nameiKCNJ5_PIG
AccessioniPrimary (citable) accession number: O02670
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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