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Protein

Adenosine receptor A3

Gene

ADORA3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A3
Gene namesi
Name:ADORA3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15ExtracellularBy similarityAdd BLAST15
Transmembranei16 – 38Helical; Name=1By similarityAdd BLAST23
Topological domaini39 – 49CytoplasmicBy similarityAdd BLAST11
Transmembranei50 – 73Helical; Name=2By similarityAdd BLAST24
Topological domaini74 – 85ExtracellularBy similarityAdd BLAST12
Transmembranei86 – 107Helical; Name=3By similarityAdd BLAST22
Topological domaini108 – 127CytoplasmicBy similarityAdd BLAST20
Transmembranei128 – 149Helical; Name=4By similarityAdd BLAST22
Topological domaini150 – 178ExtracellularBy similarityAdd BLAST29
Transmembranei179 – 199Helical; Name=5By similarityAdd BLAST21
Topological domaini200 – 232CytoplasmicBy similarityAdd BLAST33
Transmembranei233 – 256Helical; Name=6By similarityAdd BLAST24
Topological domaini257 – 262ExtracellularBy similarity6
Transmembranei263 – 285Helical; Name=7By similarityAdd BLAST23
Topological domaini286 – 319CytoplasmicBy similarityAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2603.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690121 – 319Adenosine receptor A3Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi84 ↔ 167PROSITE-ProRule annotation
Lipidationi304S-palmitoyl cysteineSequence analysis1
Modified residuei318PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation on Ser-318 may be crucial for rapid desensitization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000017694.

Chemistry databases

BindingDBiO02667.

Structurei

3D structure databases

ProteinModelPortaliO02667.
SMRiO02667.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiO02667.

Family and domain databases

InterProiView protein in InterPro
IPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O02667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDNSTTLFL AIRASYIVFE IVIGVCAVVG NVLVIWVIKL NPSLKTTTFY
60 70 80 90 100
FIFSLALADI AVGFLVMPLA IVISLGITIG FYSCLVMSCL LLVFTHASIM
110 120 130 140 150
SLLAIAVDRY LRVKLTVRYR RVTTQRRIWL ALGLCWVVSL LVGFTPMFGW
160 170 180 190 200
NMKPTLESAR NYSDFQCKFD SVIPMEYMVF FSFFTWILIP LLLMCALYVY
210 220 230 240 250
IFYIIRNKLV QSFSSFKETG AFYRREFKTA KSLFLVLALF AGCWLPLSII
260 270 280 290 300
NCVTYFKCKV PDVVLLVGIL LSHANSMMNP IVYACKIQKF KETYLLIFKA
310
RVTCQPSDSL DPSSEQNSE
Length:319
Mass (Da):36,307
Last modified:July 1, 1997 - v1
Checksum:iBB82C34B1AF96500
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90718 mRNA. Translation: AAB50560.1.
UniGeneiOcu.2128.

Similar proteinsi

Entry informationi

Entry nameiAA3R_RABIT
AccessioniPrimary (citable) accession number: O02667
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: October 25, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families