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Protein

Alpha-1D adrenergic receptor

Gene

ADRA1D

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1D adrenoreceptor
Short name:
Alpha-1D adrenoceptor
Gene namesi
Name:ADRA1D
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 101ExtracellularBy similarityAdd BLAST101
Transmembranei102 – 126Helical; Name=1By similarityAdd BLAST25
Topological domaini127 – 138CytoplasmicBy similarityAdd BLAST12
Transmembranei139 – 164Helical; Name=2By similarityAdd BLAST26
Topological domaini165 – 174ExtracellularBy similarity10
Transmembranei175 – 197Helical; Name=3By similarityAdd BLAST23
Topological domaini198 – 218CytoplasmicBy similarityAdd BLAST21
Transmembranei219 – 243Helical; Name=4By similarityAdd BLAST25
Topological domaini244 – 256ExtracellularBy similarityAdd BLAST13
Transmembranei257 – 280Helical; Name=5By similarityAdd BLAST24
Topological domaini281 – 353CytoplasmicBy similarityAdd BLAST73
Transmembranei354 – 378Helical; Name=6By similarityAdd BLAST25
Topological domaini379 – 385ExtracellularBy similarity7
Transmembranei386 – 410Helical; Name=7By similarityAdd BLAST25
Topological domaini411 – 576CytoplasmicBy similarityAdd BLAST166

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690761 – 576Alpha-1D adrenergic receptorAdd BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi424S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiO02666

Interactioni

Subunit structurei

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.By similarity

Structurei

3D structure databases

ProteinModelPortaliO02666
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 59Poly-Gly6
Compositional biasi78 – 84Poly-Gly7
Compositional biasi427 – 433Poly-Arg7

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962
InParanoidiO02666
KOiK04137

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000363 ADRA1D_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF14 PTHR24248:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00240 ADRENRGCA1DR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O02666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFRDLLSVT FEGPRPDISA GGSGAGGGAG AGAGAGDTAS SESPAVGGVP
60 70 80 90 100
GAAGGGGGGS VVGAGSGEDN RSSAGEPGGA GGGGEVNGTA AVGGLVVSAQ
110 120 130 140 150
SVGVGVFLAA FILTAVAGNL LVILSVACNR HLQTVTNYFI VNLAVADLLL
160 170 180 190 200
SATVLPFSAT MEVLGFWAFG RAFCDVWAAV DVLCCTASIL SLCTISVDRY
210 220 230 240 250
VGVRHSLKYP AIMTERKAAA ILALLWAVAL VVSMGPLLGW KEPVPPDERF
260 270 280 290 300
CGITEEVGYA VFSSLCSFYL PMAVIVVMYC RVYVVARSTT RSLEAGVKRE
310 320 330 340 350
RGKASEVVLR IHCRGAASGA DGAPGTRGAK GHTFRSSLSV RLLKFSREKK
360 370 380 390 400
AAKTLAIVVG VFVLCWFPFF FVLPLGSLFP QLKPSEGVFK VIFWLGYFNS
410 420 430 440 450
CVNPLIYPCS SREFKRAFLR LLRCQCRRRR RRRPLWRVYG HHWRASAGGG
460 470 480 490 500
PHPDCALSAG AALPGAALAL TAAPAPSSAA APEGQAAGAG RRKPPCAFRE
510 520 530 540 550
WRLLGPLRRP TTQLRAKVSS LSHKIRAGGA QRAEAACALR SEVEAVALSV
560 570
ARDVAEDNTC QAYELADYRN LRETDI
Length:576
Mass (Da):60,267
Last modified:July 1, 1997 - v1
Checksum:i21EDF1025D0144CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64032 mRNA Translation: AAB53098.1
RefSeqiNP_001076147.1, NM_001082678.1
UniGeneiOcu.2132

Genome annotation databases

GeneIDi100009398
KEGGiocu:100009398

Similar proteinsi

Entry informationi

Entry nameiADA1D_RABIT
AccessioniPrimary (citable) accession number: O02666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health