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Protein

Alpha-1D adrenergic receptor

Gene

ADRA1D

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1D adrenoreceptor
Short name:
Alpha-1D adrenoceptor
Gene namesi
Name:ADRA1D
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 101ExtracellularBy similarityAdd BLAST101
Transmembranei102 – 126Helical; Name=1By similarityAdd BLAST25
Topological domaini127 – 138CytoplasmicBy similarityAdd BLAST12
Transmembranei139 – 164Helical; Name=2By similarityAdd BLAST26
Topological domaini165 – 174ExtracellularBy similarity10
Transmembranei175 – 197Helical; Name=3By similarityAdd BLAST23
Topological domaini198 – 218CytoplasmicBy similarityAdd BLAST21
Transmembranei219 – 243Helical; Name=4By similarityAdd BLAST25
Topological domaini244 – 256ExtracellularBy similarityAdd BLAST13
Transmembranei257 – 280Helical; Name=5By similarityAdd BLAST24
Topological domaini281 – 353CytoplasmicBy similarityAdd BLAST73
Transmembranei354 – 378Helical; Name=6By similarityAdd BLAST25
Topological domaini379 – 385ExtracellularBy similarity7
Transmembranei386 – 410Helical; Name=7By similarityAdd BLAST25
Topological domaini411 – 576CytoplasmicBy similarityAdd BLAST166

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690761 – 576Alpha-1D adrenergic receptorAdd BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Lipidationi424S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.By similarity

Structurei

3D structure databases

ProteinModelPortaliO02666.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 59Poly-Gly6
Compositional biasi78 – 84Poly-Gly7
Compositional biasi427 – 433Poly-Arg7

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962.
InParanoidiO02666.
KOiK04137.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000363. ADRA1D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF14. PTHR24248:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFRDLLSVT FEGPRPDISA GGSGAGGGAG AGAGAGDTAS SESPAVGGVP
60 70 80 90 100
GAAGGGGGGS VVGAGSGEDN RSSAGEPGGA GGGGEVNGTA AVGGLVVSAQ
110 120 130 140 150
SVGVGVFLAA FILTAVAGNL LVILSVACNR HLQTVTNYFI VNLAVADLLL
160 170 180 190 200
SATVLPFSAT MEVLGFWAFG RAFCDVWAAV DVLCCTASIL SLCTISVDRY
210 220 230 240 250
VGVRHSLKYP AIMTERKAAA ILALLWAVAL VVSMGPLLGW KEPVPPDERF
260 270 280 290 300
CGITEEVGYA VFSSLCSFYL PMAVIVVMYC RVYVVARSTT RSLEAGVKRE
310 320 330 340 350
RGKASEVVLR IHCRGAASGA DGAPGTRGAK GHTFRSSLSV RLLKFSREKK
360 370 380 390 400
AAKTLAIVVG VFVLCWFPFF FVLPLGSLFP QLKPSEGVFK VIFWLGYFNS
410 420 430 440 450
CVNPLIYPCS SREFKRAFLR LLRCQCRRRR RRRPLWRVYG HHWRASAGGG
460 470 480 490 500
PHPDCALSAG AALPGAALAL TAAPAPSSAA APEGQAAGAG RRKPPCAFRE
510 520 530 540 550
WRLLGPLRRP TTQLRAKVSS LSHKIRAGGA QRAEAACALR SEVEAVALSV
560 570
ARDVAEDNTC QAYELADYRN LRETDI
Length:576
Mass (Da):60,267
Last modified:July 1, 1997 - v1
Checksum:i21EDF1025D0144CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64032 mRNA. Translation: AAB53098.1.
RefSeqiNP_001076147.1. NM_001082678.1.
UniGeneiOcu.2132.

Genome annotation databases

GeneIDi100009398.
KEGGiocu:100009398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64032 mRNA. Translation: AAB53098.1.
RefSeqiNP_001076147.1. NM_001082678.1.
UniGeneiOcu.2132.

3D structure databases

ProteinModelPortaliO02666.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009398.
KEGGiocu:100009398.

Organism-specific databases

CTDi146.

Phylogenomic databases

HOVERGENiHBG106962.
InParanoidiO02666.
KOiK04137.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000363. ADRA1D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF14. PTHR24248:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA1D_RABIT
AccessioniPrimary (citable) accession number: O02666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.