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O02666 (ADA1D_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1D adrenoreceptor
Short name=Alpha-1D adrenoceptor
Gene names
Name:ADRA1D
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Alpha-1D adrenergic receptor
PRO_0000069076

Regions

Topological domain1 – 101101Extracellular By similarity
Transmembrane102 – 12625Helical; Name=1; By similarity
Topological domain127 – 13812Cytoplasmic By similarity
Transmembrane139 – 16426Helical; Name=2; By similarity
Topological domain165 – 17410Extracellular By similarity
Transmembrane175 – 19723Helical; Name=3; By similarity
Topological domain198 – 21821Cytoplasmic By similarity
Transmembrane219 – 24325Helical; Name=4; By similarity
Topological domain244 – 25613Extracellular By similarity
Transmembrane257 – 28024Helical; Name=5; By similarity
Topological domain281 – 35373Cytoplasmic By similarity
Transmembrane354 – 37825Helical; Name=6; By similarity
Topological domain379 – 3857Extracellular By similarity
Transmembrane386 – 41025Helical; Name=7; By similarity
Topological domain411 – 576166Cytoplasmic By similarity
Compositional bias54 – 596Poly-Gly
Compositional bias78 – 847Poly-Gly
Compositional bias427 – 4337Poly-Arg

Amino acid modifications

Lipidation4241S-palmitoyl cysteine Potential
Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O02666 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 21EDF1025D0144CE

FASTA57660,267
        10         20         30         40         50         60 
MTFRDLLSVT FEGPRPDISA GGSGAGGGAG AGAGAGDTAS SESPAVGGVP GAAGGGGGGS 

        70         80         90        100        110        120 
VVGAGSGEDN RSSAGEPGGA GGGGEVNGTA AVGGLVVSAQ SVGVGVFLAA FILTAVAGNL 

       130        140        150        160        170        180 
LVILSVACNR HLQTVTNYFI VNLAVADLLL SATVLPFSAT MEVLGFWAFG RAFCDVWAAV 

       190        200        210        220        230        240 
DVLCCTASIL SLCTISVDRY VGVRHSLKYP AIMTERKAAA ILALLWAVAL VVSMGPLLGW 

       250        260        270        280        290        300 
KEPVPPDERF CGITEEVGYA VFSSLCSFYL PMAVIVVMYC RVYVVARSTT RSLEAGVKRE 

       310        320        330        340        350        360 
RGKASEVVLR IHCRGAASGA DGAPGTRGAK GHTFRSSLSV RLLKFSREKK AAKTLAIVVG 

       370        380        390        400        410        420 
VFVLCWFPFF FVLPLGSLFP QLKPSEGVFK VIFWLGYFNS CVNPLIYPCS SREFKRAFLR 

       430        440        450        460        470        480 
LLRCQCRRRR RRRPLWRVYG HHWRASAGGG PHPDCALSAG AALPGAALAL TAAPAPSSAA 

       490        500        510        520        530        540 
APEGQAAGAG RRKPPCAFRE WRLLGPLRRP TTQLRAKVSS LSHKIRAGGA QRAEAACALR 

       550        560        570 
SEVEAVALSV ARDVAEDNTC QAYELADYRN LRETDI

« Hide

References

[1]"Cloning, functional expression and tissue distribution of rabbit alpha 1d-adrenoceptor."
Suzuki F., Miyamoto S., Takita M., Oshita M., Watanabe Y., Kakizuka A., Narumiya S., Taniguchi T., Muramatsu I.
Biochim. Biophys. Acta 1323:6-11(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U64032 mRNA. Translation: AAB53098.1.
RefSeqNP_001076147.1. NM_001082678.1.
UniGeneOcu.2132.

3D structure databases

ProteinModelPortalO02666.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009398.

Organism-specific databases

CTD146.

Phylogenomic databases

HOVERGENHBG106962.

Family and domain databases

InterProIPR000363. Adren_rcpt_A1A.
IPR002233. Adrnrgc_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBO02666.
ChEMBLCHEMBL4407.

Entry information

Entry nameADA1D_RABIT
AccessionPrimary (citable) accession number: O02666
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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