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O02663

- UD2B9_MACFA

UniProt

O02663 - UD2B9_MACFA

Protein

UDP-glucuronosyltransferase 2B9

Gene

UGT2B9

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on C18, C19, and C21 steroids, bile acids, and several xenobiotics including eugenol, 1-naphthol, and p-nitrophenol.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. bile acid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Bile acid catabolism, Lipid degradation, Lipid metabolism, Steroid metabolism

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B9 (EC:2.4.1.17)
    Short name:
    UDPGT 2B9
    Gene namesi
    Name:UGT2B9
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 529508UDP-glucuronosyltransferase 2B9PRO_0000036033Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliO02663.
    SMRiO02663. Positions 285-451.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004033.
    KOiK00699.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O02663-1 [UniParc]FASTAAdd to Basket

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    MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG    50
    HEVTVLASSA SILFDPNNSS ALKIEVFPTS LTKTEFENIS MQEVKRWIEL 100
    PKDTFWLYFS QMQEIMWRFG DIIRNFCKDV VSNKKLMKKL QESRFDVVFA 150
    DPIFPCSELL AELFNIPLVY SLRFTPGYIF EKHCGGFLFP PSYVPVVMSE 200
    LSDQMTFMER VKNMIYMLSF DFYFQMYDMK KWDQFYSEVL GRPTTLSETM 250
    GKADIWLIRN SWNFQFPHPL LPNVDFVGGL HCKPAKPLPK EMEEFVQSSG 300
    ENGVVVFSLG SMVTNMEEER ANVIASALAQ IPQKVLWRFD GKKPDTLGLN 350
    TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGVPM VGIPLFADQP 400
    DNIAHMKTKG AAVRLDFDTM SSTDLANRLK TVINDPLYKE NVMKLSRIQH 450
    DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA HDLTWFQYHS LDVIGFLLAC 500
    VATVIFVIMK CCLFCFWKFA RKGKKGKSD 529
    Length:529
    Mass (Da):60,970
    Last modified:July 1, 1997 - v1
    Checksum:iF110F85FE3A9DB8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91582 mRNA. Translation: AAB50249.1.
    RefSeqiNP_001270204.1. NM_001283275.1.
    UniGeneiMfa.14543.

    Genome annotation databases

    GeneIDi102127901.
    KEGGimcf:102127901.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91582 mRNA. Translation: AAB50249.1 .
    RefSeqi NP_001270204.1. NM_001283275.1.
    UniGenei Mfa.14543.

    3D structure databases

    ProteinModelPortali O02663.
    SMRi O02663. Positions 285-451.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102127901.
    KEGGi mcf:102127901.

    Organism-specific databases

    CTDi 102127901.

    Phylogenomic databases

    HOVERGENi HBG004033.
    KOi K00699.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and characterization of a novel UDP-glucuronosyltransferase, UGT2B9, from cynomolgus monkey."
      Belanger G., Beaulieu M., Levesque E., Hum D.W., Belanger A.
      DNA Cell Biol. 16:1195-1205(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiUD2B9_MACFA
    AccessioniPrimary (citable) accession number: O02663
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3