Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O02663 (UD2B9_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B9

Short name=UDPGT 2B9
EC=2.4.1.17
Gene names
Name:UGT2B9
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on C18, C19, and C21 steroids, bile acids, and several xenobiotics including eugenol, 1-naphthol, and p-nitrophenol.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 529508UDP-glucuronosyltransferase 2B9
PRO_0000036033

Regions

Transmembrane494 – 51421Helical; Potential

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation881N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O02663 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: F110F85FE3A9DB8D

FASTA52960,970
        10         20         30         40         50         60 
MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG HEVTVLASSA 

        70         80         90        100        110        120 
SILFDPNNSS ALKIEVFPTS LTKTEFENIS MQEVKRWIEL PKDTFWLYFS QMQEIMWRFG 

       130        140        150        160        170        180 
DIIRNFCKDV VSNKKLMKKL QESRFDVVFA DPIFPCSELL AELFNIPLVY SLRFTPGYIF 

       190        200        210        220        230        240 
EKHCGGFLFP PSYVPVVMSE LSDQMTFMER VKNMIYMLSF DFYFQMYDMK KWDQFYSEVL 

       250        260        270        280        290        300 
GRPTTLSETM GKADIWLIRN SWNFQFPHPL LPNVDFVGGL HCKPAKPLPK EMEEFVQSSG 

       310        320        330        340        350        360 
ENGVVVFSLG SMVTNMEEER ANVIASALAQ IPQKVLWRFD GKKPDTLGLN TRLYKWIPQN 

       370        380        390        400        410        420 
DLLGHPKTRA FITHGGANGI YEAIYHGVPM VGIPLFADQP DNIAHMKTKG AAVRLDFDTM 

       430        440        450        460        470        480 
SSTDLANRLK TVINDPLYKE NVMKLSRIQH DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA 

       490        500        510        520 
HDLTWFQYHS LDVIGFLLAC VATVIFVIMK CCLFCFWKFA RKGKKGKSD 

« Hide

References

[1]"Expression and characterization of a novel UDP-glucuronosyltransferase, UGT2B9, from cynomolgus monkey."
Belanger G., Beaulieu M., Levesque E., Hum D.W., Belanger A.
DNA Cell Biol. 16:1195-1205(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Prostate.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U91582 mRNA. Translation: AAB50249.1.
RefSeqNP_001270204.1. NM_001283275.1.
UniGeneMfa.14543.

3D structure databases

ProteinModelPortalO02663.
SMRO02663. Positions 285-451.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102127901.
KEGGmcf:102127901.

Organism-specific databases

CTD102127901.

Phylogenomic databases

HOVERGENHBG004033.
KOK00699.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUD2B9_MACFA
AccessionPrimary (citable) accession number: O02663
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families