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O02663

- UD2B9_MACFA

UniProt

O02663 - UD2B9_MACFA

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Protein

UDP-glucuronosyltransferase 2B9

Gene

UGT2B9

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on C18, C19, and C21 steroids, bile acids, and several xenobiotics including eugenol, 1-naphthol, and p-nitrophenol.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. bile acid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Bile acid catabolism, Lipid degradation, Lipid metabolism, Steroid metabolism

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B9 (EC:2.4.1.17)
Short name:
UDPGT 2B9
Gene namesi
Name:UGT2B9
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei494 – 51421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 529508UDP-glucuronosyltransferase 2B9PRO_0000036033Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO02663.
SMRiO02663. Positions 285-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02663-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG
60 70 80 90 100
HEVTVLASSA SILFDPNNSS ALKIEVFPTS LTKTEFENIS MQEVKRWIEL
110 120 130 140 150
PKDTFWLYFS QMQEIMWRFG DIIRNFCKDV VSNKKLMKKL QESRFDVVFA
160 170 180 190 200
DPIFPCSELL AELFNIPLVY SLRFTPGYIF EKHCGGFLFP PSYVPVVMSE
210 220 230 240 250
LSDQMTFMER VKNMIYMLSF DFYFQMYDMK KWDQFYSEVL GRPTTLSETM
260 270 280 290 300
GKADIWLIRN SWNFQFPHPL LPNVDFVGGL HCKPAKPLPK EMEEFVQSSG
310 320 330 340 350
ENGVVVFSLG SMVTNMEEER ANVIASALAQ IPQKVLWRFD GKKPDTLGLN
360 370 380 390 400
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGVPM VGIPLFADQP
410 420 430 440 450
DNIAHMKTKG AAVRLDFDTM SSTDLANRLK TVINDPLYKE NVMKLSRIQH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA HDLTWFQYHS LDVIGFLLAC
510 520
VATVIFVIMK CCLFCFWKFA RKGKKGKSD
Length:529
Mass (Da):60,970
Last modified:July 1, 1997 - v1
Checksum:iF110F85FE3A9DB8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91582 mRNA. Translation: AAB50249.1.
RefSeqiNP_001270204.1. NM_001283275.1.
UniGeneiMfa.14543.

Genome annotation databases

GeneIDi102127901.
KEGGimcf:102127901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91582 mRNA. Translation: AAB50249.1 .
RefSeqi NP_001270204.1. NM_001283275.1.
UniGenei Mfa.14543.

3D structure databases

ProteinModelPortali O02663.
SMRi O02663. Positions 285-451.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 102127901.
KEGGi mcf:102127901.

Organism-specific databases

CTDi 102127901.

Phylogenomic databases

HOVERGENi HBG004033.
KOi K00699.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression and characterization of a novel UDP-glucuronosyltransferase, UGT2B9, from cynomolgus monkey."
    Belanger G., Beaulieu M., Levesque E., Hum D.W., Belanger A.
    DNA Cell Biol. 16:1195-1205(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiUD2B9_MACFA
AccessioniPrimary (citable) accession number: O02663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3