O02663 (UD2B9_MACFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-glucuronosyltransferase 2B9
Short name=UDPGT 2B9
EC=2.4.1.17

Gene names

Name:

UGT2B9

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on C18, C19, and C21 steroids, bile acids, and several xenobiotics including eugenol, 1-naphthol, and p-nitrophenol.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Biological process	Bile acid catabolism Lipid metabolism Steroid metabolism
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	bile acid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 529	508	UDP-glucuronosyltransferase 2B9		PRO_0000036033
Regions
	Transmembrane	494 – 514	21	Helical; Potential
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	68	1	N-linked (GlcNAc...) Potential
	Glycosylation	88	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O02663 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: F110F85FE3A9DB8D	FASTA	529	60,970
	10 20 30 40 50 60 MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG HEVTVLASSA 70 80 90 100 110 120 SILFDPNNSS ALKIEVFPTS LTKTEFENIS MQEVKRWIEL PKDTFWLYFS QMQEIMWRFG 130 140 150 160 170 180 DIIRNFCKDV VSNKKLMKKL QESRFDVVFA DPIFPCSELL AELFNIPLVY SLRFTPGYIF 190 200 210 220 230 240 EKHCGGFLFP PSYVPVVMSE LSDQMTFMER VKNMIYMLSF DFYFQMYDMK KWDQFYSEVL 250 260 270 280 290 300 GRPTTLSETM GKADIWLIRN SWNFQFPHPL LPNVDFVGGL HCKPAKPLPK EMEEFVQSSG 310 320 330 340 350 360 ENGVVVFSLG SMVTNMEEER ANVIASALAQ IPQKVLWRFD GKKPDTLGLN TRLYKWIPQN 370 380 390 400 410 420 DLLGHPKTRA FITHGGANGI YEAIYHGVPM VGIPLFADQP DNIAHMKTKG AAVRLDFDTM 430 440 450 460 470 480 SSTDLANRLK TVINDPLYKE NVMKLSRIQH DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA 490 500 510 520 HDLTWFQYHS LDVIGFLLAC VATVIFVIMK CCLFCFWKFA RKGKKGKSD

References

[1]	"Expression and characterization of a novel UDP-glucuronosyltransferase, UGT2B9, from cynomolgus monkey." Belanger G., Beaulieu M., Levesque E., Hum D.W., Belanger A. DNA Cell Biol. 16:1195-1205(1997) [PubMed: 9364930] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Prostate.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U91582 mRNA. Translation: AAB50249.1.
3D structure databases
ProteinModelPortal	O02663.
SMR	O02663. Positions 285-451.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG004033.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UD2B9_MACFA

Accession

Primary (citable) accession number: O02663

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 1, 1997
Last modified:	May 31, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program