SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O02663

- UD2B9_MACFA

UniProt

O02663 - UD2B9_MACFA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
UDP-glucuronosyltransferase 2B9
Gene
UGT2B9
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on C18, C19, and C21 steroids, bile acids, and several xenobiotics including eugenol, 1-naphthol, and p-nitrophenol.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. bile acid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Bile acid catabolism, Lipid degradation, Lipid metabolism, Steroid metabolism

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B9 (EC:2.4.1.17)
Short name:
UDPGT 2B9
Gene namesi
Name:UGT2B9
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei494 – 51421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 529508UDP-glucuronosyltransferase 2B9
PRO_0000036033Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi88 – 881N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO02663.
SMRiO02663. Positions 285-451.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02663-1 [UniParc]FASTAAdd to Basket

« Hide

MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG    50
HEVTVLASSA SILFDPNNSS ALKIEVFPTS LTKTEFENIS MQEVKRWIEL 100
PKDTFWLYFS QMQEIMWRFG DIIRNFCKDV VSNKKLMKKL QESRFDVVFA 150
DPIFPCSELL AELFNIPLVY SLRFTPGYIF EKHCGGFLFP PSYVPVVMSE 200
LSDQMTFMER VKNMIYMLSF DFYFQMYDMK KWDQFYSEVL GRPTTLSETM 250
GKADIWLIRN SWNFQFPHPL LPNVDFVGGL HCKPAKPLPK EMEEFVQSSG 300
ENGVVVFSLG SMVTNMEEER ANVIASALAQ IPQKVLWRFD GKKPDTLGLN 350
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGVPM VGIPLFADQP 400
DNIAHMKTKG AAVRLDFDTM SSTDLANRLK TVINDPLYKE NVMKLSRIQH 450
DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA HDLTWFQYHS LDVIGFLLAC 500
VATVIFVIMK CCLFCFWKFA RKGKKGKSD 529
Length:529
Mass (Da):60,970
Last modified:July 1, 1997 - v1
Checksum:iF110F85FE3A9DB8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U91582 mRNA. Translation: AAB50249.1.
RefSeqiNP_001270204.1. NM_001283275.1.
UniGeneiMfa.14543.

Genome annotation databases

GeneIDi102127901.
KEGGimcf:102127901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U91582 mRNA. Translation: AAB50249.1 .
RefSeqi NP_001270204.1. NM_001283275.1.
UniGenei Mfa.14543.

3D structure databases

ProteinModelPortali O02663.
SMRi O02663. Positions 285-451.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 102127901.
KEGGi mcf:102127901.

Organism-specific databases

CTDi 102127901.

Phylogenomic databases

HOVERGENi HBG004033.
KOi K00699.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression and characterization of a novel UDP-glucuronosyltransferase, UGT2B9, from cynomolgus monkey."
    Belanger G., Beaulieu M., Levesque E., Hum D.W., Belanger A.
    DNA Cell Biol. 16:1195-1205(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiUD2B9_MACFA
AccessioniPrimary (citable) accession number: O02663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi