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Protein

Mannose-binding protein C

Gene

MBL

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processComplement activation lectin pathway, Complement pathway, Immunity, Innate immunity
LigandCalcium, Lectin, Mannose-binding

Enzyme and pathway databases

ReactomeiR-BTA-166662 Lectin pathway of complement activation
R-BTA-166663 Initial triggering of complement

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-binding protein C
Short name:
MBP-C
Alternative name(s):
Mannan-binding protein
Gene namesi
Name:MBL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 26

Organism-specific databases

VGNCiVGNC:31280 MBL2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001739721 – 249Mannose-binding protein CAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34InterchainPROSITE-ProRule annotation
Disulfide bondi39InterchainPROSITE-ProRule annotation
Modified residuei484-hydroxyprolineSequence analysis1
Modified residuei634-hydroxyprolineSequence analysis1
Modified residuei744-hydroxyprolineSequence analysis1
Modified residuei834-hydroxyprolineSequence analysis1
Modified residuei864-hydroxyprolineSequence analysis1
Disulfide bondi156 ↔ 245PROSITE-ProRule annotation
Disulfide bondi223 ↔ 237PROSITE-ProRule annotation

Post-translational modificationi

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity

Keywords - PTMi

Disulfide bond, Hydroxylation

Proteomic databases

PaxDbiO02659
PeptideAtlasiO02659
PRIDEiO02659

Expressioni

Gene expression databases

BgeeiENSBTAG00000007049

Interactioni

Subunit structurei

Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009270

Structurei

3D structure databases

ProteinModelPortaliO02659
SMRiO02659
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 101Collagen-likeAdd BLAST59
Domaini135 – 246C-type lectinPROSITE-ProRule annotationAdd BLAST112

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili113 – 131By similarityAdd BLAST19

Domaini

The coiled-coil domain mediates trimerization.By similarity

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IS48 Eukaryota
ENOG4110NRD LUCA
GeneTreeiENSGT00700000104102
HOGENOMiHOG000085660
HOVERGENiHBG108270
InParanoidiO02659
KOiK03991
OMAiYSETVTC
OrthoDBiEOG091G0R93
TreeFamiTF330481

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR008160 Collagen
IPR016187 CTDL_fold
IPR037570 Mannose-binding_protein
PANTHERiPTHR24020:SF0 PTHR24020:SF0, 1 hit
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFTSLPFL LLTAVTASCA DTETENCENI RKTCPVIACG PPGINGIPGK
60 70 80 90 100
DGRDGAKGEK GEPGQGLRGS QGPPGKMGPQ GTPGIPGIPG PIGQKGDPGE
110 120 130 140 150
NMGDYIRLAT SERATLQSEL NQIKNWLIFS LGKRVGKKAF FTNGKKMPFN
160 170 180 190 200
EVKTLCAQFQ GRVATPMNAE ENRALKDLVT EEAFLGITDQ ETEGKFVDLT
210 220 230 240
GKGVTYQNWN DGEPNNASPG EHCVTLLSDG TWNDIACSAS FLTVCEFSL
Length:249
Mass (Da):26,471
Last modified:July 1, 1997 - v1
Checksum:i29FC9F5927A66DD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D73408 mRNA Translation: BAA18935.1
BC134704 mRNA Translation: AAI34705.1
RefSeqiNP_776532.1, NM_174107.2
XP_005225409.1, XM_005225352.3
UniGeneiBt.360

Genome annotation databases

EnsembliENSBTAT00000009270; ENSBTAP00000009270; ENSBTAG00000007049
GeneIDi281297
KEGGibta:281297

Similar proteinsi

Entry informationi

Entry nameiMBL2_BOVIN
AccessioniPrimary (citable) accession number: O02659
Secondary accession number(s): A4IFQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health