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Protein

60 kDa heat shock protein, mitochondrial

Gene

Hsp60

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.By similarity

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: FlyBase
  • apoptotic mitochondrial changes Source: GO_Central
  • cellular response to heat Source: FlyBase
  • chaperone-mediated protein folding Source: GO_Central
  • mitochondrion organization Source: FlyBase
  • protein import into mitochondrial intermembrane space Source: GO_Central
  • protein refolding Source: InterPro
  • protein targeting to mitochondrion Source: FlyBase
  • sleep Source: FlyBase

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa heat shock protein, mitochondrial
Alternative name(s):
60 kDa chaperonin
CPN60
Heat shock protein 60
Short name:
HSP-60
Hsp60
Mitochondrial matrix protein P1
Gene namesi
Name:Hsp60
Synonyms:Mmp-P1
ORF Names:CG12101
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0015245. Hsp60.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • mitochondrial inner membrane Source: FlyBase
  • mitochondrial matrix Source: FlyBase
  • mitochondrion Source: FlyBase

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 57Mitochondrion1 PublicationAdd BLAST57
ChainiPRO_000000503158 – 57360 kDa heat shock protein, mitochondrialAdd BLAST516

Proteomic databases

PaxDbiO02649.
PRIDEiO02649.

Expressioni

Gene expression databases

BgeeiFBgn0015245.
ExpressionAtlasiO02649. differential.
GenevisibleiO02649. DM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi58460. 49 interactors.
DIPiDIP-20404N.
MINTiMINT-1555277.
STRINGi7227.FBpp0073290.

Structurei

3D structure databases

ProteinModelPortaliO02649.
SMRiO02649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.
InParanoidiO02649.
KOiK04077.
OMAiTDTDKME.
OrthoDBiEOG091G04JM.
PhylomeDBiO02649.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRLPVSLAR SSISRQLAMR GYAKDVRFGP EVRAMMLQGV DVLADAVAVT
60 70 80 90 100
MGPKGRNVII EQSWGSPKIT KDGVTVAKSI ELKDKFQNIG AKLVQDVANN
110 120 130 140 150
TNEEAGDGTT TATVLARAIA KEGFEKISKG ANPVEIRRGV MLAVETVKDN
160 170 180 190 200
LKTMSRPVST PEEIAQVATI SANGDQAIGN LISEAMKKVG RDGVITVKDG
210 220 230 240 250
KTLTDELEVI EGMKFDRGYI SPYFINSSKG AKVEFQDALL LLSEKKISSV
260 270 280 290 300
QSIIPALELA NAQRKPLVII AEDIDGEALS TLVVNRLKIG LQVAAVKAPG
310 320 330 340 350
FGDNRKSTLT DMAIASGGIV FGDDADLVKL EDVKVSDLGQ VGEVVITKDD
360 370 380 390 400
TLLLKGKGKK DDVLRRANQI KDQIEDTTSE YEKEKLQERL ARLASGVALL
410 420 430 440 450
RVGGSSEVEV NEKKDRVHDA LNATRAAVEE GIVPGGGTAL LRCIEKLEGV
460 470 480 490 500
ETTNEDQKLG VEIVRRALRM PCMTIAKNAG VDGAMVVAKV ENQAGDYGYD
510 520 530 540 550
ALKGEYGNLI EKGIIDPTKV VRTAITDASG VASLLTTAEA VVTEIPKEDG
560 570
APAMPGMGGM GGMGGMGGMG GMM
Length:573
Mass (Da):60,809
Last modified:December 1, 2000 - v3
Checksum:i7A3792C1D2F3BE4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261 – 262NA → KS in CAA67720 (Ref. 1) Curated2
Sequence conflicti318 – 321GIVF → ARVG in CAA70287 (PubMed:10071211).Curated4
Sequence conflicti371 – 373KDQ → RTK in CAA67720 (Ref. 1) Curated3
Sequence conflicti414K → E in CAA67720 (Ref. 1) Curated1
Sequence conflicti439 – 443ALLRC → RLVRL in CAA67720 (Ref. 1) Curated5
Sequence conflicti468L → S in CAA67720 (Ref. 1) Curated1
Sequence conflicti492N → T in AAQ23524 (Ref. 4) Curated1
Sequence conflicti492N → T in CAA70287 (PubMed:10071211).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99341 mRNA. Translation: CAA67720.1.
AE014298 Genomic DNA. Translation: AAF47998.1.
AE014298 Genomic DNA. Translation: AAF47999.1.
BT010206 mRNA. Translation: AAQ23524.1.
Y09066 mRNA. Translation: CAA70287.1.
RefSeqiNP_511115.2. NM_078560.3.
NP_727489.1. NM_167266.1.
UniGeneiDm.313.

Genome annotation databases

EnsemblMetazoaiFBtr0073434; FBpp0073290; FBgn0015245.
FBtr0073435; FBpp0073291; FBgn0015245.
GeneIDi32045.
KEGGidme:Dmel_CG12101.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCH60_DROME
AccessioniPrimary (citable) accession number: O02649
Secondary accession number(s): A4V4A0
, P35380, Q6NR71, Q95026, Q9VZ31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: July 5, 2017
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families