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O02640 (MDHM_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable malate dehydrogenase, mitochondrial

EC=1.1.1.37
Gene names
Name:mdh-2
ORF Names:F20H11.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix Potential.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion
Chain? – 341Probable malate dehydrogenase, mitochondrialPRO_0000018632

Regions

Nucleotide binding35 – 417NAD By similarity
Nucleotide binding144 – 1463NAD By similarity

Sites

Active site2041Proton acceptor By similarity
Binding site611NAD By similarity
Binding site1081Substrate By similarity
Binding site1141Substrate By similarity
Binding site1211NAD By similarity
Binding site1461Substrate By similarity
Binding site1801Substrate By similarity
Binding site2551NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
O02640 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 7515F9C1727AEFB5

FASTA34135,120
        10         20         30         40         50         60 
MSLPAKTLVQ AAANSGLRAV SVRHSSQAPK VALLGAAGGI GQPLGLLLKQ DPLVAHLALY 

        70         80         90        100        110        120 
DVVNTPGVAA DLSHIDSNAK VTAHTGPKEL YAAVENADVI VIPAGVPRKP GMTRDDLFNT 

       130        140        150        160        170        180 
NAGIVRDLAA VIAKASPKAL IAIITNPVNS TVPIASEVLK KAGVYDPKRV FGVTTLDVVR 

       190        200        210        220        230        240 
SQAFVSELKG HDASKTVVPV VGGHAGITII PLLSQVKPST KFSEEEISKL TPRIQDAGTE 

       250        260        270        280        290        300 
VVNAKAGAGS ATLSMALAGA RFANALVRGI KGEKNVQCAY VASDAVKGVE YFSTPVELGP 

       310        320        330        340 
NGVEKILGVG KVSAYEQKLI DASVPELNKN IAKGVAFVKG N 

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081189 Genomic DNA. Translation: CCD69776.1.
PIRC88486.
RefSeqNP_498457.1. NM_066056.5.
UniGeneCel.5076.

3D structure databases

ProteinModelPortalO02640.
SMRO02640. Positions 30-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F20H11.3.2.

Proteomic databases

PaxDbO02640.
PRIDEO02640.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF20H11.3.1; F20H11.3.1; F20H11.3.
F20H11.3.2; F20H11.3.2; F20H11.3.
GeneID175936.
KEGGcel:CELE_F20H11.3.
UCSCF20H11.3.1. c. elegans.

Organism-specific databases

CTD175936.
WormBaseF20H11.3; CE09512; WBGene00003162; mdh-2.

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213792.
InParanoidO02640.
KOK00026.
OMAVEVKGFA.
OrthoDBEOG74R1R7.
PhylomeDBO02640.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PTHR11540:SF1. PTHR11540:SF1. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio890380.
PROO02640.

Entry information

Entry nameMDHM_CAEEL
AccessionPrimary (citable) accession number: O02640
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase