Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O02640

- MDHM_CAEEL

UniProt

O02640 - MDHM_CAEEL

Protein

Probable malate dehydrogenase, mitochondrial

Gene

mdh-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611NADBy similarity
    Binding sitei108 – 1081SubstratePROSITE-ProRule annotation
    Binding sitei114 – 1141SubstratePROSITE-ProRule annotation
    Binding sitei121 – 1211NADBy similarity
    Binding sitei146 – 1461SubstratePROSITE-ProRule annotation
    Binding sitei180 – 1801SubstratePROSITE-ProRule annotation
    Active sitei204 – 2041Proton acceptorBy similarity
    Binding sitei255 – 2551NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi35 – 417NADBy similarity
    Nucleotide bindingi144 – 1463NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: WormBase

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: WormBase
    3. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable malate dehydrogenase, mitochondrial (EC:1.1.1.37)
    Gene namesi
    Name:mdh-2
    ORF Names:F20H11.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiF20H11.3; CE09512; WBGene00003162; mdh-2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: WormBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 341Probable malate dehydrogenase, mitochondrialPRO_0000018632
    Transit peptidei1 – ?Mitochondrion

    Proteomic databases

    PaxDbiO02640.
    PRIDEiO02640.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi6239.F20H11.3.2.

    Structurei

    3D structure databases

    ProteinModelPortaliO02640.
    SMRiO02640. Positions 30-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0039.
    GeneTreeiENSGT00390000016686.
    HOGENOMiHOG000213792.
    InParanoidiO02640.
    KOiK00026.
    OMAiNINASIC.
    OrthoDBiEOG74R1R7.
    PhylomeDBiO02640.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O02640-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPAKTLVQ AAANSGLRAV SVRHSSQAPK VALLGAAGGI GQPLGLLLKQ    50
    DPLVAHLALY DVVNTPGVAA DLSHIDSNAK VTAHTGPKEL YAAVENADVI 100
    VIPAGVPRKP GMTRDDLFNT NAGIVRDLAA VIAKASPKAL IAIITNPVNS 150
    TVPIASEVLK KAGVYDPKRV FGVTTLDVVR SQAFVSELKG HDASKTVVPV 200
    VGGHAGITII PLLSQVKPST KFSEEEISKL TPRIQDAGTE VVNAKAGAGS 250
    ATLSMALAGA RFANALVRGI KGEKNVQCAY VASDAVKGVE YFSTPVELGP 300
    NGVEKILGVG KVSAYEQKLI DASVPELNKN IAKGVAFVKG N 341
    Length:341
    Mass (Da):35,120
    Last modified:July 1, 1997 - v1
    Checksum:i7515F9C1727AEFB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081189 Genomic DNA. Translation: CCD69776.1.
    PIRiC88486.
    RefSeqiNP_498457.1. NM_066056.5.
    UniGeneiCel.5076.

    Genome annotation databases

    EnsemblMetazoaiF20H11.3; F20H11.3; WBGene00003162.
    GeneIDi175936.
    KEGGicel:CELE_F20H11.3.
    UCSCiF20H11.3.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081189 Genomic DNA. Translation: CCD69776.1 .
    PIRi C88486.
    RefSeqi NP_498457.1. NM_066056.5.
    UniGenei Cel.5076.

    3D structure databases

    ProteinModelPortali O02640.
    SMRi O02640. Positions 30-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F20H11.3.2.

    Proteomic databases

    PaxDbi O02640.
    PRIDEi O02640.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F20H11.3 ; F20H11.3 ; WBGene00003162 .
    GeneIDi 175936.
    KEGGi cel:CELE_F20H11.3.
    UCSCi F20H11.3.1. c. elegans.

    Organism-specific databases

    CTDi 175936.
    WormBasei F20H11.3 ; CE09512 ; WBGene00003162 ; mdh-2.

    Phylogenomic databases

    eggNOGi COG0039.
    GeneTreei ENSGT00390000016686.
    HOGENOMi HOG000213792.
    InParanoidi O02640.
    KOi K00026.
    OMAi NINASIC.
    OrthoDBi EOG74R1R7.
    PhylomeDBi O02640.

    Miscellaneous databases

    NextBioi 890380.
    PROi O02640.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMDHM_CAEEL
    AccessioniPrimary (citable) accession number: O02640
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3