Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable malate dehydrogenase, mitochondrial

Gene

mdh-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61NADBy similarity1
Binding sitei108SubstratePROSITE-ProRule annotation1
Binding sitei114SubstratePROSITE-ProRule annotation1
Binding sitei121NADBy similarity1
Binding sitei146SubstratePROSITE-ProRule annotation1
Binding sitei180SubstratePROSITE-ProRule annotation1
Active sitei204Proton acceptorBy similarity1
Binding sitei255NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 41NADBy similarity7
Nucleotide bindingi144 – 146NADBy similarity3

GO - Molecular functioni

  • L-malate dehydrogenase activity Source: WormBase

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • malate metabolic process Source: WormBase
  • tricarboxylic acid cycle Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

ReactomeiR-CEL-70263 Gluconeogenesis
R-CEL-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate dehydrogenase, mitochondrial (EC:1.1.1.37)
Gene namesi
Name:mdh-2
ORF Names:F20H11.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF20H11.3 ; CE09512 ; WBGene00003162 ; mdh-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000018632? – 341Probable malate dehydrogenase, mitochondrial
Transit peptidei1 – ?Mitochondrion

Proteomic databases

EPDiO02640
PaxDbiO02640
PeptideAtlasiO02640
PRIDEiO02640

Expressioni

Gene expression databases

BgeeiWBGene00003162

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.F20H11.3.1

Structurei

3D structure databases

ProteinModelPortaliO02640
SMRiO02640
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1494 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00390000016686
HOGENOMiHOG000213792
InParanoidiO02640
KOiK00026
OMAiQCTPKVE
OrthoDBiEOG091G0AVO
PhylomeDBiO02640

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPAKTLVQ AAANSGLRAV SVRHSSQAPK VALLGAAGGI GQPLGLLLKQ
60 70 80 90 100
DPLVAHLALY DVVNTPGVAA DLSHIDSNAK VTAHTGPKEL YAAVENADVI
110 120 130 140 150
VIPAGVPRKP GMTRDDLFNT NAGIVRDLAA VIAKASPKAL IAIITNPVNS
160 170 180 190 200
TVPIASEVLK KAGVYDPKRV FGVTTLDVVR SQAFVSELKG HDASKTVVPV
210 220 230 240 250
VGGHAGITII PLLSQVKPST KFSEEEISKL TPRIQDAGTE VVNAKAGAGS
260 270 280 290 300
ATLSMALAGA RFANALVRGI KGEKNVQCAY VASDAVKGVE YFSTPVELGP
310 320 330 340
NGVEKILGVG KVSAYEQKLI DASVPELNKN IAKGVAFVKG N
Length:341
Mass (Da):35,120
Last modified:July 1, 1997 - v1
Checksum:i7515F9C1727AEFB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081189 Genomic DNA Translation: CCD69776.1
PIRiC88486
RefSeqiNP_498457.1, NM_066056.5
UniGeneiCel.5076

Genome annotation databases

EnsemblMetazoaiF20H11.3; F20H11.3; WBGene00003162
GeneIDi175936
KEGGicel:CELE_F20H11.3
UCSCiF20H11.3.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiMDHM_CAEEL
AccessioniPrimary (citable) accession number: O02640
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health