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O02640

- MDHM_CAEEL

UniProt

O02640 - MDHM_CAEEL

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Protein

Probable malate dehydrogenase, mitochondrial

Gene

mdh-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611NADBy similarity
Binding sitei108 – 1081SubstratePROSITE-ProRule annotation
Binding sitei114 – 1141SubstratePROSITE-ProRule annotation
Binding sitei121 – 1211NADBy similarity
Binding sitei146 – 1461SubstratePROSITE-ProRule annotation
Binding sitei180 – 1801SubstratePROSITE-ProRule annotation
Active sitei204 – 2041Proton acceptorBy similarity
Binding sitei255 – 2551NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 417NADBy similarity
Nucleotide bindingi144 – 1463NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: WormBase

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: WormBase
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_232421. Citric acid cycle (TCA cycle).
REACT_261547. Gluconeogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate dehydrogenase, mitochondrial (EC:1.1.1.37)
Gene namesi
Name:mdh-2
ORF Names:F20H11.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF20H11.3; CE09512; WBGene00003162; mdh-2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 341Probable malate dehydrogenase, mitochondrialPRO_0000018632
Transit peptidei1 – ?Mitochondrion

Proteomic databases

PaxDbiO02640.
PRIDEiO02640.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.F20H11.3.2.

Structurei

3D structure databases

ProteinModelPortaliO02640.
SMRiO02640. Positions 30-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0039.
GeneTreeiENSGT00390000016686.
HOGENOMiHOG000213792.
InParanoidiO02640.
KOiK00026.
OMAiNINASIC.
OrthoDBiEOG74R1R7.
PhylomeDBiO02640.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02640-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLPAKTLVQ AAANSGLRAV SVRHSSQAPK VALLGAAGGI GQPLGLLLKQ
60 70 80 90 100
DPLVAHLALY DVVNTPGVAA DLSHIDSNAK VTAHTGPKEL YAAVENADVI
110 120 130 140 150
VIPAGVPRKP GMTRDDLFNT NAGIVRDLAA VIAKASPKAL IAIITNPVNS
160 170 180 190 200
TVPIASEVLK KAGVYDPKRV FGVTTLDVVR SQAFVSELKG HDASKTVVPV
210 220 230 240 250
VGGHAGITII PLLSQVKPST KFSEEEISKL TPRIQDAGTE VVNAKAGAGS
260 270 280 290 300
ATLSMALAGA RFANALVRGI KGEKNVQCAY VASDAVKGVE YFSTPVELGP
310 320 330 340
NGVEKILGVG KVSAYEQKLI DASVPELNKN IAKGVAFVKG N
Length:341
Mass (Da):35,120
Last modified:July 1, 1997 - v1
Checksum:i7515F9C1727AEFB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081189 Genomic DNA. Translation: CCD69776.1.
PIRiC88486.
RefSeqiNP_498457.1. NM_066056.5.
UniGeneiCel.5076.

Genome annotation databases

EnsemblMetazoaiF20H11.3; F20H11.3; WBGene00003162.
GeneIDi175936.
KEGGicel:CELE_F20H11.3.
UCSCiF20H11.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081189 Genomic DNA. Translation: CCD69776.1 .
PIRi C88486.
RefSeqi NP_498457.1. NM_066056.5.
UniGenei Cel.5076.

3D structure databases

ProteinModelPortali O02640.
SMRi O02640. Positions 30-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F20H11.3.2.

Proteomic databases

PaxDbi O02640.
PRIDEi O02640.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F20H11.3 ; F20H11.3 ; WBGene00003162 .
GeneIDi 175936.
KEGGi cel:CELE_F20H11.3.
UCSCi F20H11.3.1. c. elegans.

Organism-specific databases

CTDi 175936.
WormBasei F20H11.3 ; CE09512 ; WBGene00003162 ; mdh-2.

Phylogenomic databases

eggNOGi COG0039.
GeneTreei ENSGT00390000016686.
HOGENOMi HOG000213792.
InParanoidi O02640.
KOi K00026.
OMAi NINASIC.
OrthoDBi EOG74R1R7.
PhylomeDBi O02640.

Enzyme and pathway databases

Reactomei REACT_232421. Citric acid cycle (TCA cycle).
REACT_261547. Gluconeogenesis.

Miscellaneous databases

NextBioi 890380.
PROi O02640.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMDHM_CAEEL
AccessioniPrimary (citable) accession number: O02640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3