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Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-35a2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • response to xenobiotic stimulus Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-35a2Imported
Synonyms:cyp-35A2Imported
ORF Names:C03G6.15Imported, CELE_C03G6.15Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC03G6.15; CE35217; WBGene00015400; cyp-35A2.

PTM / Processingi

Proteomic databases

PaxDbiO02628.
PRIDEiO02628.

Expressioni

Gene expression databases

BgeeiWBGene00015400.

Interactioni

Protein-protein interaction databases

STRINGi6239.C03G6.15.

Structurei

3D structure databases

ProteinModelPortaliO02628.
SMRiO02628. Positions 24-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129897.
HOGENOMiHOG000036993.
InParanoidiO02628.
KOiK17957.
OrthoDBiEOG091G0BT8.
PhylomeDBiO02628.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFVLFFSVL LGYLIVRQYQ KVSRLPPGPI SLPLIGNLPQ IIYYLWSTGG
60 70 80 90 100
IVSTLDLFRK RYGNIFTLWV GPIPHVSIAD YETSHEVFVK NAGKYADKFH
110 120 130 140 150
APVMRDVRND IGVLITNGDH WQEMRRFSLQ AFRNMGVGKD IMETRIMEEL
160 170 180 190 200
DARCSDIDKL ATNGVTITHA SEFFDLTVGS IINSILVGKR FEEDTKHEFL
210 220 230 240 250
KIKETMDASF ETFSPFDMTA PVWFLKTFFK HRYDKIWSAQ ETAKNFAAAE
260 270 280 290 300
AIKRVESIKS GKYVIDENNL QDYTDAFLLK IQKEGESKDF NIETLKTMII
310 320 330 340 350
DLWMTGQETT TTTLISGFNQ LLLHPEVMIK AREEILKITE NGSRHLSLTD
360 370 380 390 400
RTSTPYVNAV IGEIQRHASI LNVSFWKINK EFTYMGGHPV DAGALVTSQL
410 420 430 440 450
SALHVNETVF KNPQEFNPER FIRDGKLLQK VIPFGVGKRN CLGESLAKAE
460 470 480 490
LYLIFGNLLL RYKFEQHGKL STTELMPYSA GKRPFKLEMK FVKI
Length:494
Mass (Da):56,549
Last modified:October 1, 2003 - v2
Checksum:i077BEDC78C2ADE06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD62699.1.
PIRiT25495.
RefSeqiNP_504880.2. NM_072479.5.
UniGeneiCel.9345.

Genome annotation databases

EnsemblMetazoaiC03G6.15; C03G6.15; WBGene00015400.
GeneIDi182177.
KEGGicel:CELE_C03G6.15.
UCSCiC03G6.15. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD62699.1.
PIRiT25495.
RefSeqiNP_504880.2. NM_072479.5.
UniGeneiCel.9345.

3D structure databases

ProteinModelPortaliO02628.
SMRiO02628. Positions 24-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C03G6.15.

Proteomic databases

PaxDbiO02628.
PRIDEiO02628.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC03G6.15; C03G6.15; WBGene00015400.
GeneIDi182177.
KEGGicel:CELE_C03G6.15.
UCSCiC03G6.15. c. elegans.

Organism-specific databases

CTDi182177.
WormBaseiC03G6.15; CE35217; WBGene00015400; cyp-35A2.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129897.
HOGENOMiHOG000036993.
InParanoidiO02628.
KOiK17957.
OrthoDBiEOG091G0BT8.
PhylomeDBiO02628.

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Gene expression databases

BgeeiWBGene00015400.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO02628_CAEEL
AccessioniPrimary (citable) accession number: O02628
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.