O02621 (GPX1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glutathione peroxidase F26E4.12
EC=1.11.1.9

Gene names

ORF Names:

F26E4.12

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May constitute a glutathione peroxidase-like protective system against oxidative stresses By similarity.
Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase gamete generation Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase regulation of peptide transport Inferred from mutant phenotype. Source: WormBase response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC phospholipid-hydroperoxide glutathione peroxidase activity Inferred from mutant phenotype. Source: WormBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 163	163	Probable glutathione peroxidase F26E4.12		PRO_0000066646
Sites
	Active site	36	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O02621 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 441535A92DC4330F	FASTA	163	18,424
	10 20 30 40 50 60 MSSVYDFNVK NANGDDVSLS DYKGKVLIIV NVASQCGLTN KNYTQLKELL DVYKKDGLEV 70 80 90 100 110 120 LAFPCNQFAG QEPSCEIDIQ AFVADKFKFE PTLFQKIDVN GDKQSPLFKF LKNEKGGFMF 130 140 150 160 DAIKWNFTKF LVGRDGKIIK RFGPTTDPKD MEKDIKEALG EKL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z81070 Genomic DNA. Translation: CAB03004.1.
PIR	T21418.
RefSeq	NP_492598.1. NM_060197.1.
UniGene	Cel.18867.
3D structure databases
ProteinModelPortal	O02621.
SMR	O02621. Positions 2-160.
ModBase	Search...
Protein-protein interaction databases
STRING	O02621.
Protein family/group databases
PeroxiBase	3746. CelGPx01.
Proteomic databases
PRIDE	O02621.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F26E4.12; F26E4.12; F26E4.12.
GeneID	184981.
KEGG	cel:F26E4.12.
NMPDR	fig|6239.3.peg.2617.
UCSC	F26E4.12. c. elegans.
Organism-specific databases
CTD	184981.
WormBase	F26E4.12; CE09696; WBGene00009165.
Phylogenomic databases
eggNOG	meNOG14651.
GeneTree	EMGT00050000001082.
HOGENOM	HBG648990.
InParanoid	O02621.
OMA	AGTMCAS.
PhylomeDB	O02621.
Gene expression databases
ArrayExpress	O02621.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00432.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	926638.

Entry information

Entry name

GPX1_CAEEL

Accession

Primary (citable) accession number: O02621

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 1, 1997
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project