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Protein

Glutathione peroxidase 1

Gene

gpx-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May constitute a glutathione peroxidase-like protective system against oxidative stresses.By similarity

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361By similarity

GO - Molecular functioni

  • glutathione peroxidase activity Source: UniProtKB-EC
  • phospholipid-hydroperoxide glutathione peroxidase activity Source: WormBase

GO - Biological processi

  • innate immune response Source: WormBase
  • oxidation-reduction process Source: WormBase
  • regulation of peptide transport Source: WormBase
  • response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

ReactomeiR-CEL-2142712. Synthesis of 12-eicosatetraenoic acid derivatives.
R-CEL-2142770. Synthesis of 15-eicosatetraenoic acid derivatives.

Protein family/group databases

PeroxiBasei3746. CelGPx01.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 1 (EC:1.11.1.9)
Gene namesi
Name:gpx-1
ORF Names:F26E4.12
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF26E4.12; CE09696; WBGene00009165; gpx-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Glutathione peroxidase 1PRO_0000066646Add
BLAST

Proteomic databases

EPDiO02621.
PaxDbiO02621.
PRIDEiO02621.

Interactioni

Protein-protein interaction databases

STRINGi6239.F26E4.12.

Structurei

3D structure databases

ProteinModelPortaliO02621.
SMRiO02621. Positions 3-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00840000130500.
HOGENOMiHOG000277054.
InParanoidiO02621.
KOiK00432.
OMAiEPKCELE.
OrthoDBiEOG7B5WZH.
PhylomeDBiO02621.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVYDFNVK NANGDDVSLS DYKGKVLIIV NVASQCGLTN KNYTQLKELL
60 70 80 90 100
DVYKKDGLEV LAFPCNQFAG QEPSCEIDIQ AFVADKFKFE PTLFQKIDVN
110 120 130 140 150
GDKQSPLFKF LKNEKGGFMF DAIKWNFTKF LVGRDGKIIK RFGPTTDPKD
160
MEKDIKEALG EKL
Length:163
Mass (Da):18,424
Last modified:July 1, 1997 - v1
Checksum:i441535A92DC4330F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81070 Genomic DNA. Translation: CAB03004.1.
PIRiT21418.
RefSeqiNP_492598.1. NM_060197.1.
UniGeneiCel.18867.

Genome annotation databases

EnsemblMetazoaiF26E4.12; F26E4.12; WBGene00009165.
GeneIDi184981.
KEGGicel:CELE_F26E4.12.
UCSCiF26E4.12. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81070 Genomic DNA. Translation: CAB03004.1.
PIRiT21418.
RefSeqiNP_492598.1. NM_060197.1.
UniGeneiCel.18867.

3D structure databases

ProteinModelPortaliO02621.
SMRiO02621. Positions 3-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F26E4.12.

Protein family/group databases

PeroxiBasei3746. CelGPx01.

Proteomic databases

EPDiO02621.
PaxDbiO02621.
PRIDEiO02621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF26E4.12; F26E4.12; WBGene00009165.
GeneIDi184981.
KEGGicel:CELE_F26E4.12.
UCSCiF26E4.12. c. elegans.

Organism-specific databases

CTDi184981.
WormBaseiF26E4.12; CE09696; WBGene00009165; gpx-1.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00840000130500.
HOGENOMiHOG000277054.
InParanoidiO02621.
KOiK00432.
OMAiEPKCELE.
OrthoDBiEOG7B5WZH.
PhylomeDBiO02621.

Enzyme and pathway databases

ReactomeiR-CEL-2142712. Synthesis of 12-eicosatetraenoic acid derivatives.
R-CEL-2142770. Synthesis of 15-eicosatetraenoic acid derivatives.

Miscellaneous databases

NextBioi926638.
PROiO02621.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGPX1_CAEEL
AccessioniPrimary (citable) accession number: O02621
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.