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Reviewed, UniProtKB/Swiss-Prot O02621 (GPX1_CAEEL)

Last modified January 19, 2010. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable glutathione peroxidase F26E4.12
    EC=1.11.1.9
Gene names
ORF Names: F26E4.12
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May constitute a glutathione peroxidase-like protective system against oxidative stresses By similarity.

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the glutathione peroxidase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

response to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglutathione peroxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 163163Probable glutathione peroxidase F26E4.12
PRO_0000066646

Sites

Active site361 By similarity

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Sequences

Sequence LengthMass (Da)Tools
O02621-1 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 441535A92DC4330F

FASTA16318,424
        10         20         30         40         50         60 
MSSVYDFNVK NANGDDVSLS DYKGKVLIIV NVASQCGLTN KNYTQLKELL DVYKKDGLEV 

        70         80         90        100        110        120 
LAFPCNQFAG QEPSCEIDIQ AFVADKFKFE PTLFQKIDVN GDKQSPLFKF LKNEKGGFMF 

       130        140        150        160 
DAIKWNFTKF LVGRDGKIIK RFGPTTDPKD MEKDIKEALG EKL

« Hide

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z81070 Genomic DNA. Translation: CAB03004.1.
PIRT21418.
RefSeqNP_492598.1.
UniGeneCel.18867

3D structure databases

SMRO02621. Positions 2-162.
ModBaseSearch...

Protein-protein interaction databases

STRINGO02621.

Protein family/group databases

PeroxiBase3746. CelGPx01.

Genome annotation databases

EnsemblF26E4.12; F26E4.12; F26E4.12; Caenorhabditis elegans. [Genome view]
GeneID184981.
KEGGcel:F26E4.12.
NMPDRfig|6239.3.peg.2617.
UCSCF26E4.12. c. elegans.

Organism-specific databases

CTD184981.
WormBaseWBGene00009165. F26E4.12.
WormPepF26E4.12. CE09696. [WorfDB]

Phylogenomic databases

eggNOGmeNOG14651.
HOGENOMHBG648990.
InParanoidO02621.
OMAGDKASPL.
PhylomeDBO02621.

Enzyme and pathway databases

BRENDA1.11.1.9. 672.

Gene expression databases

ArrayExpressO02621.

Family and domain databases

InterProIPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR11592. Glut_peroxidase. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio926638.

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Entry information

Entry nameGPX1_CAEEL
AccessionPrimary (citable) accession number: O02621
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: January 19, 2010
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents