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Protein

Glutathione peroxidase 1

Gene

gpx-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May constitute a glutathione peroxidase-like protective system against oxidative stresses.By similarity

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei36By similarity1

GO - Molecular functioni

  • glutathione peroxidase activity Source: UniProtKB-EC
  • phospholipid-hydroperoxide glutathione peroxidase activity Source: WormBase

GO - Biological processi

  • innate immune response Source: WormBase
  • oxidation-reduction process Source: WormBase
  • regulation of peptide transport Source: WormBase
  • response to oxidative stress Source: InterPro

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei3746. CelGPx01.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 1 (EC:1.11.1.9)
Gene namesi
Name:gpx-1
ORF Names:F26E4.12
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF26E4.12; CE09696; WBGene00009165; gpx-1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666461 – 163Glutathione peroxidase 1Add BLAST163

Proteomic databases

EPDiO02621.
PaxDbiO02621.
PeptideAtlasiO02621.
PRIDEiO02621.

Expressioni

Gene expression databases

BgeeiWBGene00009165.

Interactioni

Protein-protein interaction databases

STRINGi6239.F26E4.12.

Structurei

3D structure databases

ProteinModelPortaliO02621.
SMRiO02621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00840000130500.
HOGENOMiHOG000277054.
InParanoidiO02621.
KOiK00432.
OMAiMFDAIKW.
OrthoDBiEOG091G0OJG.
PhylomeDBiO02621.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
InterProiView protein in InterPro
IPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiView protein in Pfam
PF00255. GSHPx. 1 hit.
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.

Sequencei

Sequence statusi: Complete.

O02621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVYDFNVK NANGDDVSLS DYKGKVLIIV NVASQCGLTN KNYTQLKELL
60 70 80 90 100
DVYKKDGLEV LAFPCNQFAG QEPSCEIDIQ AFVADKFKFE PTLFQKIDVN
110 120 130 140 150
GDKQSPLFKF LKNEKGGFMF DAIKWNFTKF LVGRDGKIIK RFGPTTDPKD
160
MEKDIKEALG EKL
Length:163
Mass (Da):18,424
Last modified:July 1, 1997 - v1
Checksum:i441535A92DC4330F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81070 Genomic DNA. Translation: CAB03004.1.
PIRiT21418.
RefSeqiNP_492598.1. NM_060197.1.
UniGeneiCel.18867.

Genome annotation databases

EnsemblMetazoaiF26E4.12; F26E4.12; WBGene00009165.
GeneIDi184981.
KEGGicel:CELE_F26E4.12.
UCSCiF26E4.12. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGPX1_CAEEL
AccessioniPrimary (citable) accession number: O02621
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: June 7, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families