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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

CYPA

Organism
Leishmania major
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RotamaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
PPIaseUniRule annotation
Gene namesi
Name:CYPAImported
ORF Names:LMJF_25_0910Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 25

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.25.0910.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 176PPIase cyclophilin-typeInterPro annotationAdd BLAST160

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065981.
KOiK01802.
OMAiCTAKTER.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiView protein in InterPro
IPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiView protein in Pfam
PF00160. Pro_isomerase. 1 hit.
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiView protein in PROSITE
PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O02614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYTPHYPVV ESNPKVWMDI DIGGKPAGRV TMELFKDAVP QTAENFRALC
60 70 80 90 100
TGEKGFGYAN SPFHRVIPDF MCQGGDFTNG NGTGGKSIYG SKFADESFLG
110 120 130 140 150
KAGKHFGPGT LSMANAGPNT NGSQFFLCTA PTSWLDGKHV VFGQVLEGYE
160 170
VVKAMEAVGS RSGTTSKPVR VSACGQL
Length:177
Mass (Da):18,823
Last modified:June 1, 1998 - v2
Checksum:i451C65B8F4414CD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13576 mRNA. Translation: CAA73904.1.
FR796421 Genomic DNA. Translation: CAJ05016.1.
RefSeqiXP_001683845.1. XM_001683793.1.

Genome annotation databases

EnsemblProtistsiLmjF.25.0910:mRNA; LmjF.25.0910:pep; LmjF.25.0910.
GeneDBiLmjF.25.0910:pep.
GeneIDi5652501.
KEGGilma:LMJF_25_0910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13576 mRNA. Translation: CAA73904.1.
FR796421 Genomic DNA. Translation: CAJ05016.1.
RefSeqiXP_001683845.1. XM_001683793.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.25.0910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiLmjF.25.0910:mRNA; LmjF.25.0910:pep; LmjF.25.0910.
GeneDBiLmjF.25.0910:pep.
GeneIDi5652501.
KEGGilma:LMJF_25_0910.

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065981.
KOiK01802.
OMAiCTAKTER.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiView protein in InterPro
IPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiView protein in Pfam
PF00160. Pro_isomerase. 1 hit.
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiView protein in PROSITE
PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO02614_LEIMA
AccessioniPrimary (citable) accession number: O02614
Secondary accession number(s): Q4QA03
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: June 1, 1998
Last modified: May 10, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.