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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

CYPA

Organism
Leishmania major
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
PPIaseUniRule annotation
Gene namesi
Name:CYPAImported
ORF Names:LMJF_25_0910Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 25

Organism-specific databases

EuPathDBiTriTrypDB:LmjF.25.0910

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.25.0910

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 176PPIase cyclophilin-typeInterPro annotationAdd BLAST160

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
HOGENOMiHOG000065981
KOiK01802
OMAiFFINFKD

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O02614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYTPHYPVV ESNPKVWMDI DIGGKPAGRV TMELFKDAVP QTAENFRALC
60 70 80 90 100
TGEKGFGYAN SPFHRVIPDF MCQGGDFTNG NGTGGKSIYG SKFADESFLG
110 120 130 140 150
KAGKHFGPGT LSMANAGPNT NGSQFFLCTA PTSWLDGKHV VFGQVLEGYE
160 170
VVKAMEAVGS RSGTTSKPVR VSACGQL
Length:177
Mass (Da):18,823
Last modified:June 1, 1998 - v2
Checksum:i451C65B8F4414CD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13576 mRNA Translation: CAA73904.1
FR796421 Genomic DNA Translation: CAJ05016.1
RefSeqiXP_001683845.1, XM_001683793.1

Genome annotation databases

EnsemblProtistsiLmjF.25.0910:mRNA; LmjF.25.0910:pep; LmjF.25.0910
GeneDBiLmjF.25.0910:pep
GeneIDi5652501
KEGGilma:LMJF_25_0910

Similar proteinsi

Entry informationi

Entry nameiO02614_LEIMA
AccessioniPrimary (citable) accession number: O02614
Secondary accession number(s): Q4QA03
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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