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O02608

- PGK_EUPCR

UniProt

O02608 - PGK_EUPCR

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Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Euplotes crassus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401SubstrateBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei170 – 1701SubstrateBy similarity
Binding sitei219 – 2191ATPBy similarity
Binding sitei312 – 3121ATP; via carbonyl oxygenBy similarity
Binding sitei343 – 3431ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi372 – 3754ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK
OrganismiEuplotes crassus
Taxonomic identifieri5936 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataSpirotricheaHypotrichiaEuplotidaEuplotidaeMoneuplotes

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Phosphoglycerate kinasePRO_0000145851Add
BLAST

Proteomic databases

PRIDEiO02608.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO02608.
SMRiO02608. Positions 2-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 273Substrate bindingBy similarity
Regioni64 – 674Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02608-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSKKLTVDK IPHMIKNKRV LVRVDFNVPI KDGKVADPTR IVSTLDTINF
60 70 80 90 100
LKENGAKSIV LMSHLGRPKG VRQEQFSLAP VVPALEDIIG QKVNFLNDCI
110 120 130 140 150
GTEVEGEVAN TKDGNILLLE NLRFYLEEEG KGVINGEKVK ADPTKVESFR
160 170 180 190 200
SQLTRLGDLY VNDAFGTCHR AHSSMVGVNV DTRAAGFLLK KELDYFSKVL
210 220 230 240 250
EDPKRPLTVI LGGAKVADKI QLINNLLDLA DEMIIGGGMA FTFNKVLNNT
260 270 280 290 300
PIGASLYDEE GAKTVHGIME KAKEKGVKIH IPSDFVCAES FAEDAKFAYK
310 320 330 340 350
LKMKESQDGW LGLDIGDKTI RSFDEVIRRS NTLFWNGPSG VFEWKNFAKG
360 370 380 390 400
SHAMLQAVTE STKNGTVSVC GGGDTLNLLK QVDGAKENIS HVSTGGGASL
410
ELVEGKELPG IKALSDIN
Length:418
Mass (Da):45,601
Last modified:July 1, 1997 - v1
Checksum:iD1FEC7D9F850F29D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U97355 Genomic DNA. Translation: AAB58162.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U97355 Genomic DNA. Translation: AAB58162.1 .

3D structure databases

ProteinModelPortali O02608.
SMRi O02608. Positions 2-416.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O02608.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Pearlman R.E.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPGK_EUPCR
AccessioniPrimary (citable) accession number: O02608
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3