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O02608 (PGK_EUPCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:PGK
OrganismEuplotes crassus
Taxonomic identifier5936 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataSpirotricheaHypotrichiaEuplotidaEuplotidaeMoneuplotes

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145851

Regions

Nucleotide binding372 – 3754ATP By similarity
Region25 – 273Substrate binding By similarity
Region64 – 674Substrate binding By similarity

Sites

Binding site401Substrate By similarity
Binding site1231Substrate By similarity
Binding site1701Substrate By similarity
Binding site2191ATP By similarity
Binding site3121ATP; via carbonyl oxygen By similarity
Binding site3431ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O02608 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: D1FEC7D9F850F29D

FASTA41845,601
        10         20         30         40         50         60 
MLSKKLTVDK IPHMIKNKRV LVRVDFNVPI KDGKVADPTR IVSTLDTINF LKENGAKSIV 

        70         80         90        100        110        120 
LMSHLGRPKG VRQEQFSLAP VVPALEDIIG QKVNFLNDCI GTEVEGEVAN TKDGNILLLE 

       130        140        150        160        170        180 
NLRFYLEEEG KGVINGEKVK ADPTKVESFR SQLTRLGDLY VNDAFGTCHR AHSSMVGVNV 

       190        200        210        220        230        240 
DTRAAGFLLK KELDYFSKVL EDPKRPLTVI LGGAKVADKI QLINNLLDLA DEMIIGGGMA 

       250        260        270        280        290        300 
FTFNKVLNNT PIGASLYDEE GAKTVHGIME KAKEKGVKIH IPSDFVCAES FAEDAKFAYK 

       310        320        330        340        350        360 
LKMKESQDGW LGLDIGDKTI RSFDEVIRRS NTLFWNGPSG VFEWKNFAKG SHAMLQAVTE 

       370        380        390        400        410 
STKNGTVSVC GGGDTLNLLK QVDGAKENIS HVSTGGGASL ELVEGKELPG IKALSDIN 

« Hide

References

[1]Pearlman R.E.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U97355 Genomic DNA. Translation: AAB58162.1.

3D structure databases

ProteinModelPortalO02608.
SMRO02608. Positions 2-416.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO02608.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_EUPCR
AccessionPrimary (citable) accession number: O02608
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways