Reviewed, UniProtKB/Swiss-Prot O02606 (PGM2_PARTE)

Names and origin

Protein names

Recommended name:
    Phosphoglucomutase-2
      Short name=PGM 2
    EC=5.4.2.2
Alternative name(s):
    Glucose phosphomutase 2
    Parafusin-2
      Short name=Pf-2

Gene names

Name:	pp63-2
ORF Names:	GSPATT00000627001

Organism

Paramecium tetraurelia

Taxonomic identifier

5888 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Peniculida › Parameciidae › Paramecium

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in membrane fusion in exocytosis By similarity.
Catalytic activity	Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Post-translational modification	Phosphorylated via a calcium-dependent protein kinase By similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglucomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 572	572	Phosphoglucomutase-2		PRO_0000307834
Sites
	Active site	126	1	Phosphoserine intermediate By similarity
	Metal binding	126	1	Magnesium; via phosphate group By similarity
	Metal binding	308	1	Magnesium By similarity
	Metal binding	310	1	Magnesium By similarity
	Metal binding	312	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	O02606-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: A2489D239595D5B8	FASTA	572	63,718
	10 20 30 40 50 60 MQQVIPAPRV QVTQPYAGQK PGTSGLRKKV TEATQPHYLE NFVQSIFNTL RKDELKPKNV 70 80 90 100 110 120 LFVGGDGRYF NRQAIFSIIR LAYANDISEV HVGQAGLMST PASSHYIRKV NEEVGNCIGG 130 140 150 160 170 180 IILTASHNPG GKEHGDFGIK FNVRTGAPAP EDFTDQIYTH TTKIKEYLTV DYEFEKHINL 190 200 210 220 230 240 DQIGVYKFEG TRLEKSHFEV KVVDTVQDYT SLMQKLFDFD LLKGLFSNKD FTFSFDGMHG 250 260 270 280 290 300 VAGPYAKHIF GTLLGCSKES LLNCDPSEDF GGGHPDPNLT YAHDLVELLD IHKKKDVGAV 310 320 330 340 350 360 PQFGAACDGD ADRNMILGRQ FFVTPSDSLA VIAANANLIF KNGLLGAARS MPTSGALDKV 370 380 390 400 410 420 AAKNGIKLFE TPTGWKFFGN LMDAGLINLC GEESFGTGSN HIREKDGIWA VLAWLTILAH 430 440 450 460 470 480 KNKNTDHFVT VEEIVTQYWQ QFGRNYYSRY DYEQVDSAGA NKMMEHLKTK FQYFEQLKQG 490 500 510 520 530 540 NKADIYDYVD PVDQSVSKNQ GVRFVFGDGS RIIFRLSGTG SVGATIRIYF EQFEQQEIQH 550 560 570 ETATALANII KLGLEISDIA QFTGRNEPTV IT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of isoforms of the exocytosis-sensitive phosphoprotein PP63/parafusin in Paramecium tetraurelia and demonstration of phosphoglucomutase activity." Hauser K., Kissmehl R., Linder J., Schultz J.E., Lottspeich F., Plattner H. Biochem. J. 323:289-296(1997) [PubMed: 9173895] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Stock 51.
[2]	"Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia." Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M., Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A., Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R. , Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F., Le Mouel A., Lepere G., Malinsky S., Nowacki M., Nowak J.K., Plattner H., Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M., Weissenbach J., Scarpelli C., Schaechter V., Sperling L., Meyer E., Cohen J., Wincker P. Nature 444:171-178(2006) [PubMed: 17086204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Stock d4-2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y09970 mRNA. Translation: CAA71089.1. CT868096 Genomic DNA. Translation: CAK70916.1.
RefSeq	XP_001438313.1.
UniGene	Pte.8242
3D structure databases
HSSP	HSSP built from PDB template 1KFQ based on UniProtKB P47244.
SMR	O02606. Positions 3-572.
ModBase	Search...
Genome annotation databases
GeneID	5024098.
KEGG	ptm:GSPATT00000627001.
Enzyme and pathway databases
BRENDA	5.4.2.2. 21526.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 2 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGM2_PARTE

Accession

Primary (citable) accession number: O02606

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	July 1, 1997
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)