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Protein

Synaptobrevin-1

Gene

snb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function.1 Publication

GO - Molecular functioni

GO - Biological processi

  • defecation Source: WormBase
  • nematode larval development Source: WormBase
  • regulation of hindgut contraction Source: WormBase
  • regulation of pharyngeal pumping Source: WormBase
  • synaptic transmission, cholinergic Source: WormBase
  • synaptic vesicle exocytosis Source: WormBase
  • vesicle fusion Source: GO_Central

Enzyme and pathway databases

ReactomeiR-CEL-210500 Glutamate Neurotransmitter Release Cycle
R-CEL-264642 Acetylcholine Neurotransmitter Release Cycle
R-CEL-432720 Lysosome Vesicle Biogenesis
R-CEL-432722 Golgi Associated Vesicle Biogenesis
R-CEL-449836 Other interleukin signaling
R-CEL-6811440 Retrograde transport at the Trans-Golgi-Network
R-CEL-8856825 Cargo recognition for clathrin-mediated endocytosis
R-CEL-8856828 Clathrin-mediated endocytosis

Protein family/group databases

TCDBi1.F.1.1.3 the synaptosomal vesicle fusion pore (svf-pore) family

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptobrevin-1
Alternative name(s):
Synaptobrevin-related protein 1
Gene namesi
Name:snb-1Imported
ORF Names:T10H9.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT10H9.4 ; CE18252 ; WBGene00004897 ; snb-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicSequence analysisAdd BLAST86
Transmembranei87 – 107Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini108 – 109ExtracellularSequence analysis2

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Disruption phenotypei

Worms exhibit arrested development after embryogenesis. Viable mutants appear lethargic with sporadic jerky movements and absent M3 pharynx motorneuron activity. All mutants are resistant to the acetylcholinesterase inhibitor aldicarb indicating impaired cholinergic transmission.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi62L → F in js17; resist to aldicarb. 1 Publication1
Mutagenesisi66A → G in js44; resist to aldicarb. 1 Publication1
Mutagenesisi97I → D in e1563; viable showing only slightly increased rate of thrashing behavior. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073541 – 109Synaptobrevin-1Add BLAST109

Proteomic databases

EPDiO02495
PaxDbiO02495
PeptideAtlasiO02495
PRIDEiO02495

Expressioni

Tissue specificityi

Expressed in the nervous system notably the nerve ring, ventral cord and dorsal cord.1 Publication

Gene expression databases

BgeeiWBGene00004897

Interactioni

Subunit structurei

Part of the SNARE core complex containing ric-4/SNAP25, snb-1/VAMP2 and unc-64/STX1A. This complex binds to cpx-1/CPLX1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-27164N
IntActiO02495, 1 interactor
STRINGi6239.T10H9.4

Structurei

3D structure databases

ProteinModelPortaliO02495
SMRiO02495
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 83v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Sequence analysis

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00550000074449
HOGENOMiHOG000042711
InParanoidiO02495
KOiK13504
OMAiVPYDPYI
OrthoDBiEOG091G0MPE
PhylomeDBiO02495

Family and domain databases

InterProiView protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
PfamiView protein in Pfam
PF00957 Synaptobrevin, 1 hit
PIRSFiPIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

O02495-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAQGDAGAQ GGSQGGPRPS NKRLQQTQAQ VDEVVGIMKV NVEKVLERDQ
60 70 80 90 100
KLSQLDDRAD ALQEGASQFE KSAATLKRKY WWKNIKMMII MCAIVVILII

IIVLWAGGK
Length:109
Mass (Da):12,025
Last modified:July 1, 1997 - v1
Checksum:i3BBC0F085CE070EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003281 mRNA Translation: AAB61234.1
AF003282 Genomic DNA Translation: AAB61235.1
FO081382 Genomic DNA Translation: CCD71211.1
PIRiT33239
RefSeqiNP_504688.1, NM_072287.4
UniGeneiCel.5604

Genome annotation databases

EnsemblMetazoaiT10H9.4; T10H9.4; WBGene00004897
GeneIDi266648
KEGGicel:CELE_T10H9.4
UCSCiT10H9.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiSYB1_CAEEL
AccessioniPrimary (citable) accession number: O02495
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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