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Protein

Transcription factor unc-37

Gene

unc-37

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity (PubMed:9165118). May function with transcription factor mls-1 to promote uterine muscle specification and formation (PubMed:21852953).2 Publications

GO - Molecular functioni

  • transcription corepressor activity Source: WormBase
  • transcription factor binding Source: WormBase

GO - Biological processi

  • chemical synaptic transmission Source: WormBase
  • negative regulation of transcription, DNA-templated Source: WormBase
  • regulation of axonogenesis Source: WormBase
  • regulation of neurotransmitter levels Source: WormBase
  • regulation of synapse structure or activity Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-CEL-201722 Formation of the beta-catenin:TCF transactivating complex
R-CEL-3769402 Deactivation of the beta-catenin transactivating complex
R-CEL-4641265 Repression of WNT target genes
SignaLinkiO02482

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor unc-37
Alternative name(s):
Uncoordinated protein 37
Gene namesi
Name:unc-37
Synonyms:esg
ORF Names:W02D3.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiW02D3.9 ; CE14434 ; WBGene00006773 ; unc-37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Maternal effect embryonic lethal. RNAi-mediated knockdown results in reduced uterine cell specification.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513161 – 612Transcription factor unc-37Add BLAST612

Proteomic databases

EPDiO02482
PaxDbiO02482
PeptideAtlasiO02482
PRIDEiO02482

Expressioni

Gene expression databases

BgeeiWBGene00006773

Interactioni

Subunit structurei

Interacts with unc-4 (PubMed:10557206). May interact with mls-1 (PubMed:21852953).2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • transcription factor binding Source: WormBase

Protein-protein interaction databases

BioGridi37842, 9 interactors
DIPiDIP-27333N
IntActiO02482, 48 interactors
STRINGi6239.W02D3.9.2

Structurei

3D structure databases

ProteinModelPortaliO02482
SMRiO02482
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati308 – 339WD 1Add BLAST32
Repeati372 – 402WD 2Add BLAST31
Repeati414 – 444WD 3Add BLAST31
Repeati456 – 486WD 4Add BLAST31
Repeati538 – 568WD 5Add BLAST31
Repeati579 – 609WD 6Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 196CCN domainAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 102Gln-richAdd BLAST102
Compositional biasi102 – 152Gly/Pro-richAdd BLAST51
Compositional biasi196 – 287Pro/Ser-richAdd BLAST92
Compositional biasi225 – 228Poly-Gln4

Sequence similaritiesi

Belongs to the WD repeat Groucho/TLE family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
GeneTreeiENSGT00550000074465
HOGENOMiHOG000293211
InParanoidiO02482
OMAiDGTKLWS
OrthoDBiEOG091G181Y
PhylomeDBiO02482

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF03920 TLE_N, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR01850 GROUCHOFAMLY
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

O02482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASYLETLD RIKDEHAEMS KHVNQQRSDI EKVALEKENM NRSYMTYAEV
60 70 80 90 100
SNTLRSDLRK AEEINKRLQE FIMQSLAPQL SQDNQANCLA ALEAFKTASP
110 120 130 140 150
RENGNGAPAL PPGFPPGAAG MLGMMPNMPF GMSPAMSQLF NQFASPHVNG
160 170 180 190 200
GDGAGGSSGG ASEAKKAKLE DPDDGELEID VTNDDHPSTA SNGGAANKNG
210 220 230 240 250
RDSTNSVASS GASTPSIASN SRARQQQQPL AGLQGLEQMN FLAGFNPNLL
260 270 280 290 300
RQASAAGGFN FLNDPHAQAR LAAAIGQIGS RPAYSFKIVD GGVPTPTSFP
310 320 330 340 350
PDAQKGPGIP TGLKKKMELN HGEVVCAATI SRDNSRVYTG GKGCVKIWDV
360 370 380 390 400
KESDISGATV VNRPPIASLD CLKENYIRSC KLFEDGNTLL IGGEASTVAL
410 420 430 440 450
WDLTTETKTL DLETDSQACY ALAMSPDEKL LFACLADGNI LIYDIHNKVK
460 470 480 490 500
VGTLPGHQDG ASCLDLSKDG TKLWSGGLDN SVRCWDLAQR KEVAKHDFAS
510 520 530 540 550
QVFSLGCCPN DEWVAVGMEN NYVEVLSTTG KEKYQLTQHE SCVLSLKFAH
560 570 580 590 600
SGKFFISTGK DNALNAWRTP YGASLFQLKE NSSVLSCDIS FDDSLIVTGS
610
GEKKATLYAV EY
Length:612
Mass (Da):65,617
Last modified:July 1, 1997 - v1
Checksum:iD3AFF39E526F8249
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66K → T in AAB49459 (PubMed:9165118).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89245 mRNA Translation: AAB49459.1
AF001271 mRNA Translation: AAB84234.1
AF001272 Genomic DNA Translation: AAB84235.1
FO081084 Genomic DNA Translation: CCD68992.1
PIRiT15211
RefSeqiNP_491932.1, NM_059531.6
UniGeneiCel.7359

Genome annotation databases

EnsemblMetazoaiW02D3.9.1; W02D3.9.1; WBGene00006773
W02D3.9.2; W02D3.9.2; WBGene00006773
GeneIDi172394
KEGGicel:CELE_W02D3.9
UCSCiW02D3.9.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiUNC37_CAEEL
AccessioniPrimary (citable) accession number: O02482
Secondary accession number(s): P91912
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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