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Protein

Transcription factor unc-37

Gene

unc-37

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that functions with the neural specificity gene unc-4 to govern motor neuron identity.1 Publication

GO - Molecular functioni

  • transcription corepressor activity Source: WormBase
  • transcription factor binding Source: WormBase

GO - Biological processi

  • chemical synaptic transmission Source: WormBase
  • negative regulation of transcription, DNA-templated Source: WormBase
  • regulation of axonogenesis Source: WormBase
  • regulation of neurotransmitter levels Source: WormBase
  • regulation of synapse structure or activity Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-CEL-3769402. Deactivation of the beta-catenin transactivating complex.
R-CEL-4641265. Repression of WNT target genes.
SignaLinkiO02482.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor unc-37
Alternative name(s):
Uncoordinated protein 37
Gene namesi
Name:unc-37
Synonyms:esg
ORF Names:W02D3.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiW02D3.9; CE14434; WBGene00006773; unc-37.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Transcription factor unc-37PRO_0000051316Add
BLAST

Proteomic databases

EPDiO02482.
PaxDbiO02482.

Expressioni

Gene expression databases

BgeeiWBGene00006773.

Interactioni

Subunit structurei

Interacts with unc-4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_ZK1053.3O625054EBI-314716,EBI-326955
ces-1G5ECN84EBI-314716,EBI-322161
lsy-22Q936167EBI-314716,EBI-2005589
nhr-67Q9XVV33EBI-314716,EBI-314697
pax-3G5ED665EBI-314716,EBI-2416749
pop-1Q106663EBI-314716,EBI-317870
sptf-2Q226785EBI-314716,EBI-2420648
unc-130Q186943EBI-314716,EBI-2414897

GO - Molecular functioni

  • transcription factor binding Source: WormBase

Protein-protein interaction databases

BioGridi37842. 9 interactions.
DIPiDIP-27333N.
IntActiO02482. 48 interactions.
MINTiMINT-1056160.
STRINGi6239.W02D3.9.2.

Structurei

3D structure databases

ProteinModelPortaliO02482.
SMRiO02482. Positions 7-102, 276-612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati308 – 33932WD 1Add
BLAST
Repeati372 – 40231WD 2Add
BLAST
Repeati414 – 44431WD 3Add
BLAST
Repeati456 – 48631WD 4Add
BLAST
Repeati538 – 56831WD 5Add
BLAST
Repeati579 – 60931WD 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni153 – 19644CCN domainAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 102102Gln-richAdd
BLAST
Compositional biasi102 – 15251Gly/Pro-richAdd
BLAST
Compositional biasi196 – 28792Pro/Ser-richAdd
BLAST
Compositional biasi225 – 2284Poly-Gln

Sequence similaritiesi

Belongs to the WD repeat Groucho/TLE family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0639. Eukaryota.
ENOG410XPX3. LUCA.
GeneTreeiENSGT00550000074465.
HOGENOMiHOG000293211.
InParanoidiO02482.
OMAiDGTKLWS.
OrthoDBiEOG091G181Y.
PhylomeDBiO02482.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR005617. Groucho/TLE_N.
IPR009146. Groucho_enhance.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03920. TLE_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR01850. GROUCHOFAMLY.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASYLETLD RIKDEHAEMS KHVNQQRSDI EKVALEKENM NRSYMTYAEV
60 70 80 90 100
SNTLRSDLRK AEEINKRLQE FIMQSLAPQL SQDNQANCLA ALEAFKTASP
110 120 130 140 150
RENGNGAPAL PPGFPPGAAG MLGMMPNMPF GMSPAMSQLF NQFASPHVNG
160 170 180 190 200
GDGAGGSSGG ASEAKKAKLE DPDDGELEID VTNDDHPSTA SNGGAANKNG
210 220 230 240 250
RDSTNSVASS GASTPSIASN SRARQQQQPL AGLQGLEQMN FLAGFNPNLL
260 270 280 290 300
RQASAAGGFN FLNDPHAQAR LAAAIGQIGS RPAYSFKIVD GGVPTPTSFP
310 320 330 340 350
PDAQKGPGIP TGLKKKMELN HGEVVCAATI SRDNSRVYTG GKGCVKIWDV
360 370 380 390 400
KESDISGATV VNRPPIASLD CLKENYIRSC KLFEDGNTLL IGGEASTVAL
410 420 430 440 450
WDLTTETKTL DLETDSQACY ALAMSPDEKL LFACLADGNI LIYDIHNKVK
460 470 480 490 500
VGTLPGHQDG ASCLDLSKDG TKLWSGGLDN SVRCWDLAQR KEVAKHDFAS
510 520 530 540 550
QVFSLGCCPN DEWVAVGMEN NYVEVLSTTG KEKYQLTQHE SCVLSLKFAH
560 570 580 590 600
SGKFFISTGK DNALNAWRTP YGASLFQLKE NSSVLSCDIS FDDSLIVTGS
610
GEKKATLYAV EY
Length:612
Mass (Da):65,617
Last modified:July 1, 1997 - v1
Checksum:iD3AFF39E526F8249
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661K → T in AAB49459 (PubMed:9165118).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89245 mRNA. Translation: AAB49459.1.
AF001271 mRNA. Translation: AAB84234.1.
AF001272 Genomic DNA. Translation: AAB84235.1.
FO081084 Genomic DNA. Translation: CCD68992.1.
PIRiT15211.
RefSeqiNP_491932.1. NM_059531.6.
UniGeneiCel.7359.

Genome annotation databases

EnsemblMetazoaiW02D3.9.1; W02D3.9.1; WBGene00006773.
W02D3.9.2; W02D3.9.2; WBGene00006773.
GeneIDi172394.
KEGGicel:CELE_W02D3.9.
UCSCiW02D3.9.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89245 mRNA. Translation: AAB49459.1.
AF001271 mRNA. Translation: AAB84234.1.
AF001272 Genomic DNA. Translation: AAB84235.1.
FO081084 Genomic DNA. Translation: CCD68992.1.
PIRiT15211.
RefSeqiNP_491932.1. NM_059531.6.
UniGeneiCel.7359.

3D structure databases

ProteinModelPortaliO02482.
SMRiO02482. Positions 7-102, 276-612.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37842. 9 interactions.
DIPiDIP-27333N.
IntActiO02482. 48 interactions.
MINTiMINT-1056160.
STRINGi6239.W02D3.9.2.

Proteomic databases

EPDiO02482.
PaxDbiO02482.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW02D3.9.1; W02D3.9.1; WBGene00006773.
W02D3.9.2; W02D3.9.2; WBGene00006773.
GeneIDi172394.
KEGGicel:CELE_W02D3.9.
UCSCiW02D3.9.2. c. elegans.

Organism-specific databases

CTDi172394.
WormBaseiW02D3.9; CE14434; WBGene00006773; unc-37.

Phylogenomic databases

eggNOGiKOG0639. Eukaryota.
ENOG410XPX3. LUCA.
GeneTreeiENSGT00550000074465.
HOGENOMiHOG000293211.
InParanoidiO02482.
OMAiDGTKLWS.
OrthoDBiEOG091G181Y.
PhylomeDBiO02482.

Enzyme and pathway databases

ReactomeiR-CEL-3769402. Deactivation of the beta-catenin transactivating complex.
R-CEL-4641265. Repression of WNT target genes.
SignaLinkiO02482.

Miscellaneous databases

PROiO02482.

Gene expression databases

BgeeiWBGene00006773.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR005617. Groucho/TLE_N.
IPR009146. Groucho_enhance.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03920. TLE_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR01850. GROUCHOFAMLY.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUNC37_CAEEL
AccessioniPrimary (citable) accession number: O02482
Secondary accession number(s): P91912
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.