Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O02466 (ILPR_BRALA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like peptide receptor

Short name=ILP receptor
EC=2.7.10.1
OrganismBranchiostoma lanceolatum (Common lancelet) (Amphioxus)
Taxonomic identifier7740 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

Protein attributes

Sequence length1363 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This receptor binds to the insulin related peptide and has a tyrosine-protein kinase activity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Cofactor

Manganese By similarity.

Subunit structure

Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Contains 4 fibronectin type-III domains.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 716687Insulin-like peptide receptor alpha chain Potential
PRO_0000016711
Chain721 – 1363643Insulin-like peptide receptor beta chain Potential
PRO_0000016713

Regions

Topological domain721 – 928208Extracellular Potential
Transmembrane929 – 94921Helical; Potential
Topological domain950 – 1363414Cytoplasmic Potential
Domain473 – 586114Fibronectin type-III 1
Domain590 – 68091Fibronectin type-III 2
Domain712 – 80493Fibronectin type-III 3
Domain813 – 912100Fibronectin type-III 4
Domain994 – 1283290Protein kinase
Nucleotide binding1000 – 10089ATP By similarity

Sites

Active site11481Proton acceptor By similarity
Binding site10281ATP By similarity

Amino acid modifications

Modified residue11741Phosphotyrosine; by autocatalysis By similarity
Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1371N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation4831N-linked (GlcNAc...) Potential
Glycosylation5991N-linked (GlcNAc...) Potential
Glycosylation6171N-linked (GlcNAc...) Potential
Glycosylation6651N-linked (GlcNAc...) Potential
Glycosylation6661N-linked (GlcNAc...) Potential
Glycosylation7111N-linked (GlcNAc...) Potential
Glycosylation7321N-linked (GlcNAc...) Potential
Glycosylation7361N-linked (GlcNAc...) Potential
Glycosylation7431N-linked (GlcNAc...) Potential
Glycosylation8161N-linked (GlcNAc...) Potential
Glycosylation8851N-linked (GlcNAc...) Potential
Glycosylation8981N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O02466 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 238120B4EAB1ED65

FASTA1,363154,105
        10         20         30         40         50         60 
MRVVDKMAGL MWAALTLVIG LGLLVPSNGE EYICDSMDIR NRVSNLRQLE NCTVIEGYLQ 

        70         80         90        100        110        120 
ILLIDFAEEQ DYSGLAFPNL VEITDYFLLY RVRGLTNLSE LFPNLAVIRG TNLFFNYALV 

       130        140        150        160        170        180 
VFEMLDMQKI GLYSLQNITR GSVRIEKNPN LCYLDTIDWS FIAESGYSNN FIVDNREEEE 

       190        200        210        220        230        240 
CVNFCPGRCR IKHPVLQDLC WAEEHCQKVC PESCLGNCRD GISGCCHENC IGGCDGPTER 

       250        260        270        280        290        300 
DCVACKYFVH NGECLIQCPP DTYQYKDRRC ITEEECPNTT NSVWKLHHRK CIPECPSGYT 

       310        320        330        340        350        360 
TDINNPRLCT ECEGQCPKSC KGGLVDSLAA AQRFRGCTII EGELKISIRG GDNIIDELEE 

       370        380        390        400        410        420 
NLGLIEEVGH YVAIVRSYAL VTLDFLRSLK RIRGIQKENG YAFYVLDNRN LEKLFDWDRT 

       430        440        450        460        470        480 
DITIDEGKLF FHFNPKLCRH VILTMVDKVG LPEHAITDTD ISTLTNGDQA QCSFSRLEIE 

       490        500        510        520        530        540 
EINTSKDMII LRWSEFRPPD PRDLLSYTVS YRETEDQGID EYDGQDACGN TEWKEFDVSP 

       550        560        570        580        590        600 
TQTAHIITGL KPWTQYALLV KTYTKAGARE GSGAKSDIVY ARTDADKPTH PQDVVVYSNS 

       610        620        630        640        650        660 
SNTLIITWKP PNRPNGNVTH YIVKYKRQQE DVAEMEQREY CKGGLKPHRP TQGLEDIVNN 

       670        680        690        700        710        720 
EEEPNNSTIG DGTCCECPKS EDEIRIEEEE AAFQQEFENF LHNNVYHKRE NETRAGRRRR 

       730        740        750        760        770        780 
ELPVTARPFY SNQTVNVTLP STNRTVPPTP TPNPNPQLET TVWNEHMVVL TGLRHFSEYI 

       790        800        810        820        830        840 
IEVIACNADA AVGCSGSAVE LARTQADDSA DNIPGNITVV EIKEDMAKLY WPKPDSPNSM 

       850        860        870        880        890        900 
VVHYNIEYKK LGSDFNYEQQ EPKCVENFKF LQSQGYTISN LVAGNYSVRF RATSFAGNGS 

       910        920        930        940        950        960 
WSNYVTFYVE EEDTSPDPQD PQQQVPVSLM IGMGVGFSLL LILAVIFGIW YCTKKRFGDK 

       970        980        990       1000       1010       1020 
QMPNGVLYAS VNPEYMSSDD VYVPDEWEVP REKITLIREL GQGSFGMVYE GEAKDVVKDE 

      1030       1040       1050       1060       1070       1080 
PMVSVAVKTV NESASIRERI EFLNEASVMK TFNCHHVVKL MGVVSKGQPT LVVMELMALG 

      1090       1100       1110       1120       1130       1140 
DLKNYLRRHR PEEDVGLSDS PASNEAKNSP FAENDNDLPP TFKDIIQMAG VIADGMSYLA 

      1150       1160       1170       1180       1190       1200 
AKKFVHRDLA CRNCMVAQDR TVKIGDFGMT RDIYETDYYR KGGKGLLPVR WMSPESLKVG 

      1210       1220       1230       1240       1250       1260 
VFTSQSDVWS YGVVLWEMAT LASQPYQGKS NEEVLKFVID GGMLEKPEGC PNKLYDLMKL 

      1270       1280       1290       1300       1310       1320 
CWQYRQSMRP TFLEIVEILS PELQAHFNEV SFYHSLDNHG REPLEMDDVA LDSGADTETE 

      1330       1340       1350       1360 
MYPSGSEFSS TPSPPSETPY SHMNGSHPQN GSMNLRIPKS TLC 

« Hide

References

[1]"Structure and expression of the insulin-like peptide receptor from amphioxus."
Pashmforoush M., Chan S.J., Steiner D.F.
Mol. Endocrinol. 10:857-866(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S83394 mRNA. Translation: AAB50848.1.
PIRT43220.

3D structure databases

ProteinModelPortalO02466.
SMRO02466. Positions 972-1303.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006134.

Enzyme and pathway databases

BRENDA2.7.10.1. 932.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
3.80.20.20. 2 hits.
InterProIPR000494. EGF_rcpt_L.
IPR003961. Fibronectin_type3.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016246. Tyr_kinase_insulin-like_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamPF00041. fn3. 3 hits.
PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFPIRSF000620. Insulin_receptor. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00060. FN3. 3 hits.
SM00261. FU. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEPS50853. FN3. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILPR_BRALA
AccessionPrimary (citable) accession number: O02466
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families