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Protein
Submitted name:

Calnexin

Gene

Cnx99A

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • protein folding Source: InterPro
  • regulation of calcium ion transport into cytosol Source: FlyBase
  • retina homeostasis Source: FlyBase
  • rhodopsin biosynthetic process Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DME-901042. Calnexin/calreticulin cycle.

Names & Taxonomyi

Protein namesi
Submitted name:
CalnexinImported
Gene namesi
Name:Cnx99AImported
ORF Names:CG11958Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0015622. Cnx99A.

Subcellular locationi

  • Endoplasmic reticulum SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei489 – 508HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

  • endomembrane system Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear endoplasmic reticulum Source: FlyBase
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29UniRule annotationAdd BLAST29
ChainiPRO_500415673130 – 605UniRule annotationAdd BLAST576

Proteomic databases

PRIDEiO02393.

Expressioni

Gene expression databases

BgeeiFBgn0015622.

Interactioni

Protein-protein interaction databases

IntActiO02393. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliO02393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calreticulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

OrthoDBiEOG091G04SS.

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWKMGGNRA ATLALLFASS LLLLSSANAA DLDTESDDFE DGYVEDVQEE
60 70 80 90 100
PAVIGGDEKL AYESPVIDAK KFHFADHFDD VEESRKRWVL SQAKKDDIAE
110 120 130 140 150
EISKYDGIWN WESPQRIVWA NDLGLVLKSK AKHAAIAAPL RKPFEFKSDK
160 170 180 190 200
PLVVQYEVTL QEGQECGGSY LKLLSAGKDT EQLKAFNDKT PYTIMFGPDK
210 220 230 240 250
CGNDVKMHFI FRHVNPINGT ITEKHCNKPK NRLEEPFKDK LPHLYQLVVR
260 270 280 290 300
PDNSFEIRVD HKIINEGSLL TDFKPPVNPP AEIDDPNDHK PESWDEREKI
310 320 330 340 350
PDPTAHKPED WDEDAPPQLP DTDAVMPNGW LEDEPDMIFD PTATKPEDWD
360 370 380 390 400
AEIDGEWEAP LVDNPVCEKA PGCGKWKAPL IPNPNYKGKW RAPMIENPNY
410 420 430 440 450
QGKWAPRKIP NPDFFEDLKP FQMTPISAVG LELWSMSSDI LFDNLIITDD
460 470 480 490 500
VEVARDFAAN SFDIKRRYID RESDSFVNKV VELAKANPSI WGIGLVAIVA
510 520 530 540 550
LVALTIYCRF GTAKSQDSAA KKAAAEAKKS DDPQPDDEPE AEEESDERAA
560 570 580 590 600
GDTSKESTPL SASPKKNQKS DLDDNEEESK AAESREPAQT EESNTKTRKR

QARKE
Length:605
Mass (Da):68,035
Last modified:July 1, 1997 - v1
Checksum:i8ED9359840E121FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99488 mRNA. Translation: CAA67846.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99488 mRNA. Translation: CAA67846.1.

3D structure databases

ProteinModelPortaliO02393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO02393. 1 interactor.

Proteomic databases

PRIDEiO02393.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0015622. Cnx99A.

Phylogenomic databases

OrthoDBiEOG091G04SS.

Enzyme and pathway databases

ReactomeiR-DME-901042. Calnexin/calreticulin cycle.

Miscellaneous databases

ChiTaRSiCnx99A. fly.

Gene expression databases

BgeeiFBgn0015622.

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO02393_DROME
AccessioniPrimary (citable) accession number: O02393
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.