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Protein

Mite group 2 allergen Tyr p 2

Gene
N/A
Organism
Tyrophagus putrescentiae (Mold mite) (Acarus putrescentiae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mite group 2 allergen Tyr p 2
Alternative name(s):
Allergen: Typ p 2
OrganismiTyrophagus putrescentiae (Mold mite) (Acarus putrescentiae)
Taxonomic identifieri59818 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataAcaroideaAcaridaeTyrophaginaeTyrophagus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3511. Tyr p 2.0101.
657. Tyr p 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 15151 PublicationAdd
BLAST
Chaini16 – 141126Mite group 2 allergen Tyr p 2PRO_0000019865Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 132By similarity
Disulfide bondi36 ↔ 41By similarity
Disulfide bondi87 ↔ 92By similarity
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO02380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPC2 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLILFALV AVAAAGQVKF TDCGKKEIAS VAVDGCEGDL CVIHKSKPVH
60 70 80 90 100
VIAEFTANQD TCKIEVKVTG QLNGLEVPIP GIETDGCKVL KCPLKKGTKY
110 120 130 140
TMNYSVNVPS VVPNIKTVVK LLATGEHGVL ACGAVNTDVK P
Length:141
Mass (Da):14,852
Last modified:July 1, 1997 - v1
Checksum:i38EF9520010A04C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12690 mRNA. Translation: CAA73221.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12690 mRNA. Translation: CAA73221.1.

3D structure databases

ProteinModelPortaliO02380.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3511. Tyr p 2.0101.
657. Tyr p 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterisation of a group II allergen from the dust mite Tyrophagus putrescentiae."
    Eriksson T.L.J., Johansson E., Whitley P., Schmidt M., Elsayed S., van Hage-Hamsten M.
    Eur. J. Biochem. 251:443-447(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 16-22.

Entry informationi

Entry nameiALL2_TYRPU
AccessioniPrimary (citable) accession number: O02380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: March 4, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.