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O02373

- UGDH_DROME

UniProt

O02373 - UGDH_DROME

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Protein

UDP-glucose 6-dehydrogenase

Gene
sgl, kiwi, ska, CG10072
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues.3 Publications

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321NAD By similarity
Binding sitei37 – 371NAD By similarity
Binding sitei161 – 1611NAD By similarity
Active sitei272 – 2721Nucleophile By similarity
Binding sitei342 – 3421NAD By similarity
Binding sitei439 – 4391Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NAD By similarity
Nucleotide bindingi85 – 895NAD By similarity
Nucleotide bindingi126 – 1272NAD By similarity
Nucleotide bindingi272 – 2754NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB

GO - Biological processi

  1. cell surface receptor signaling pathway Source: FlyBase
  2. chondroitin sulfate biosynthetic process Source: UniProtKB
  3. epithelial cell migration, open tracheal system Source: UniProtKB
  4. fibroblast growth factor receptor signaling pathway Source: UniProtKB
  5. glycosaminoglycan biosynthetic process Source: UniProtKB
  6. heart development Source: FlyBase
  7. heparan sulfate proteoglycan biosynthetic process Source: FlyBase
  8. heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process Source: UniProtKB
  9. imaginal disc-derived wing morphogenesis Source: FlyBase
  10. inter-male aggressive behavior Source: FlyBase
  11. mesoderm migration involved in gastrulation Source: UniProtKB
  12. mushroom body development Source: FlyBase
  13. olfactory behavior Source: FlyBase
  14. primary branching, open tracheal system Source: FlyBase
  15. segment polarity determination Source: FlyBase
  16. smoothened signaling pathway Source: FlyBase
  17. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
  18. Wnt signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_203410. Formation of the active cofactor, UDP-glucuronate.
UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Alternative name(s):
Protein sugarless
Protein suppenkasper
Gene namesi
Name:sgl
Synonyms:kiwi, ska
ORF Names:CG10072
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0261445. sgl.

Pathology & Biotechi

Disruption phenotypei

'Wingless-like' cuticular phenotype; reduced growth of imaginal disks and pattern defects.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476UDP-glucose 6-dehydrogenasePRO_0000074064Add
BLAST

Proteomic databases

PaxDbiO02373.
PRIDEiO02373.

Expressioni

Gene expression databases

BgeeiO02373.

Interactioni

Protein-protein interaction databases

BioGridi64209. 9 interactions.

Structurei

3D structure databases

ProteinModelPortaliO02373.
SMRiO02373. Positions 2-460.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni157 – 1615Substrate binding By similarity
Regioni216 – 2238Substrate binding By similarity
Regioni256 – 26914Substrate binding By similarityAdd
BLAST
Regioni334 – 3352Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1004.
GeneTreeiENSGT00390000015355.
InParanoidiO02373.
KOiK00012.
OMAiVELNTWQ.
OrthoDBiEOG7034GP.
PhylomeDBiO02373.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

O02373-1 [UniParc]FASTAAdd to Basket

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MKVCCIGAGY VGGPTCAVMA LKCPDIVITL VDKSSERIAQ WNSDKLPIYE    50
PGLDEVVKKC RNVNLFFSTD IETAIKEADL IFISVNTPTK TCGNGKGRAA 100
DLKYVESAAR MIAEIAQSNK IVVEKSTVPV RAAESIMHIL RANQKPGIHY 150
DILSNPEFLA EGTAINDLLN ADRVLIGGEE TPEGHQAVEK LSWIYEHWIP 200
KQNILTTNTW SSELSKLAAN AFLAQRISSI NSLSAVCEAT GADVSEVARA 250
VGLDSRIGSK FLQASVGFGG SCFQKDILNL IYICENLNLP EVAAYWQQVI 300
DMNEYQKRRF SQKIIESLFN TVSDKRIAIL GFAFKKNTGD TRETAAITVC 350
QTLLEEGAAL DIYDPKVEPE QIIDDLTHPS VTESPEKVKK AVQIHSDPYS 400
AVRATHALVI CTEWDEFVDL DFKRIYQSMM KPAYIFDGRK ILDHERLQQI 450
GFHVQTIGKK YQRTGLLRSW GIVPQL 476
Length:476
Mass (Da):52,875
Last modified:July 1, 1997 - v1
Checksum:i1450B9A0C802BBE7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591K → R in AAC97125. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007870 mRNA. Translation: AAB63208.1.
AF000570 mRNA. Translation: AAB58714.1.
AF009013 mRNA. Translation: AAB63462.1.
AF001310 mRNA. Translation: AAC97125.1.
AH007072 Genomic DNA. Translation: AAC97126.1.
AE014296 Genomic DNA. Translation: AAF50631.1.
AY052137 mRNA. Translation: AAK93561.1.
RefSeqiNP_476980.1. NM_057632.4.
UniGeneiDm.4371.

Genome annotation databases

EnsemblMetazoaiFBtr0076938; FBpp0076647; FBgn0261445.
GeneIDi38760.
KEGGidme:Dmel_CG10072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007870 mRNA. Translation: AAB63208.1 .
AF000570 mRNA. Translation: AAB58714.1 .
AF009013 mRNA. Translation: AAB63462.1 .
AF001310 mRNA. Translation: AAC97125.1 .
AH007072 Genomic DNA. Translation: AAC97126.1 .
AE014296 Genomic DNA. Translation: AAF50631.1 .
AY052137 mRNA. Translation: AAK93561.1 .
RefSeqi NP_476980.1. NM_057632.4.
UniGenei Dm.4371.

3D structure databases

ProteinModelPortali O02373.
SMRi O02373. Positions 2-460.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 64209. 9 interactions.

Proteomic databases

PaxDbi O02373.
PRIDEi O02373.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0076938 ; FBpp0076647 ; FBgn0261445 .
GeneIDi 38760.
KEGGi dme:Dmel_CG10072.

Organism-specific databases

CTDi 24054.
FlyBasei FBgn0261445. sgl.

Phylogenomic databases

eggNOGi COG1004.
GeneTreei ENSGT00390000015355.
InParanoidi O02373.
KOi K00012.
OMAi VELNTWQ.
OrthoDBi EOG7034GP.
PhylomeDBi O02373.

Enzyme and pathway databases

UniPathwayi UPA00038 ; UER00491 .
Reactomei REACT_203410. Formation of the active cofactor, UDP-glucuronate.

Miscellaneous databases

GenomeRNAii 38760.
NextBioi 810251.
PROi O02373.

Gene expression databases

Bgeei O02373.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view ]
PANTHERi PTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
Pfami PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling."
    Binari R.C., Staveley B.E., Johnson W.A., Godavarti R., Sasisekharan R., Manoukian A.S.
    Development 124:2623-2632(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, PATHWAY, DISRUPTION PHENOTYPE.
  2. "The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis."
    Haecker U., Lin X., Perrimon N.
    Development 124:3565-3573(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  3. "Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila."
    Haerry T.E., Heslip T.R., Marsh J.L., O'Connor M.B.
    Development 124:3055-3064(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE.
  4. "Mutation in the Drosophila gene encoding UDP-glucose dehydrogenase affects expression of unlinked genes."
    Benevolenskaya E.V., Frolov M.V., Birchler J.A.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-76.
    Strain: Canton-S.
  5. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  6. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiUGDH_DROME
AccessioniPrimary (citable) accession number: O02373
Secondary accession number(s): O02647, Q9VRZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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