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Protein

UDP-glucose 6-dehydrogenase

Gene

sgl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues.3 Publications

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.1 Publication

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.1 Publication
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase (sgl)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32NADBy similarity1
Binding sitei37NADBy similarity1
Binding sitei161NADBy similarity1
Binding sitei256SubstrateBy similarity1
Active sitei272NucleophileBy similarity1
Binding sitei342NADBy similarity1
Binding sitei439SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 12NADBy similarity6
Nucleotide bindingi85 – 89NADBy similarity5
Nucleotide bindingi126 – 127NADBy similarity2
Nucleotide bindingi272 – 275NADBy similarity4

GO - Molecular functioni

  • NAD binding Source: InterPro
  • UDP-glucose 6-dehydrogenase activity Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: FlyBase
  • chondroitin sulfate biosynthetic process Source: UniProtKB
  • epithelial cell migration, open tracheal system Source: UniProtKB
  • fibroblast growth factor receptor signaling pathway Source: UniProtKB
  • glycosaminoglycan biosynthetic process Source: UniProtKB
  • heparan sulfate proteoglycan biosynthetic process Source: FlyBase
  • heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process Source: UniProtKB
  • mesoderm migration involved in gastrulation Source: UniProtKB
  • primary branching, open tracheal system Source: FlyBase
  • segment polarity determination Source: FlyBase
  • UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase
Biological processWnt signaling pathway
LigandNAD

Enzyme and pathway databases

ReactomeiR-DME-173599 Formation of the active cofactor, UDP-glucuronate
UniPathwayiUPA00038; UER00491

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Alternative name(s):
Protein sugarless
Protein suppenkasper
Gene namesi
Name:sgl
Synonyms:kiwi, ska
ORF Names:CG10072
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0261445 sgl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

'Wingless-like' cuticular phenotype; reduced growth of imaginal disks and pattern defects.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740641 – 476UDP-glucose 6-dehydrogenaseAdd BLAST476

Proteomic databases

PaxDbiO02373
PRIDEiO02373

Expressioni

Gene expression databases

BgeeiFBgn0261445
ExpressionAtlasiO02373 baseline and differential
GenevisibleiO02373 DM

Interactioni

Protein-protein interaction databases

BioGridi64209, 9 interactors
IntActiO02373, 1 interactor
STRINGi7227.FBpp0076647

Structurei

3D structure databases

ProteinModelPortaliO02373
SMRiO02373
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 161Substrate bindingBy similarity5
Regioni216 – 220Substrate bindingBy similarity5
Regioni263 – 269Substrate bindingBy similarity7
Regioni334 – 335Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
InParanoidiO02373
KOiK00012
OMAiLCTEWDE
OrthoDBiEOG091G05RK
PhylomeDBiO02373

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

O02373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVCCIGAGY VGGPTCAVMA LKCPDIVITL VDKSSERIAQ WNSDKLPIYE
60 70 80 90 100
PGLDEVVKKC RNVNLFFSTD IETAIKEADL IFISVNTPTK TCGNGKGRAA
110 120 130 140 150
DLKYVESAAR MIAEIAQSNK IVVEKSTVPV RAAESIMHIL RANQKPGIHY
160 170 180 190 200
DILSNPEFLA EGTAINDLLN ADRVLIGGEE TPEGHQAVEK LSWIYEHWIP
210 220 230 240 250
KQNILTTNTW SSELSKLAAN AFLAQRISSI NSLSAVCEAT GADVSEVARA
260 270 280 290 300
VGLDSRIGSK FLQASVGFGG SCFQKDILNL IYICENLNLP EVAAYWQQVI
310 320 330 340 350
DMNEYQKRRF SQKIIESLFN TVSDKRIAIL GFAFKKNTGD TRETAAITVC
360 370 380 390 400
QTLLEEGAAL DIYDPKVEPE QIIDDLTHPS VTESPEKVKK AVQIHSDPYS
410 420 430 440 450
AVRATHALVI CTEWDEFVDL DFKRIYQSMM KPAYIFDGRK ILDHERLQQI
460 470
GFHVQTIGKK YQRTGLLRSW GIVPQL
Length:476
Mass (Da):52,875
Last modified:July 1, 1997 - v1
Checksum:i1450B9A0C802BBE7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59K → R in AAC97125 (PubMed:9272947).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007870 mRNA Translation: AAB63208.1
AF000570 mRNA Translation: AAB58714.1
AF009013 mRNA Translation: AAB63462.1
AF001310 mRNA Translation: AAC97125.1
AH007072 Genomic DNA Translation: AAC97126.1
AE014296 Genomic DNA Translation: AAF50631.1
AY052137 mRNA Translation: AAK93561.1
RefSeqiNP_476980.1, NM_057632.4
UniGeneiDm.4371

Genome annotation databases

EnsemblMetazoaiFBtr0076938; FBpp0076647; FBgn0261445
GeneIDi38760
KEGGidme:Dmel_CG10072

Similar proteinsi

Entry informationi

Entry nameiUGDH_DROME
AccessioniPrimary (citable) accession number: O02373
Secondary accession number(s): O02647, Q9VRZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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