Reviewed,
UniProtKB/Swiss-Prot O02373 (UGDH_DROME)
Last modified
June 16, 2009.
Version 80.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: UDP-glucose 6-dehydrogenase Short name=UDP-Glc dehydrogenase Short name=UDP-GlcDH Short name=UDPGDH EC=1.1.1.22 Alternative name(s): Protein sugarless | ||||||
| Gene names |
| ||||||
| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||||
| Taxonomic identifier | 7227 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 476 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. |
| Catalytic activity | UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH. |
| Pathway | |
| Sequence similarities | Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 476 | 476 | UDP-glucose 6-dehydrogenase | PRO_0000074064 | |||||
Regions | |||||||||
| Nucleotide binding | 2 – 19 | 18 | NAD By similarity | ||||||
| Region | 158 – 161 | 4 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 272 | 1 | Nucleophile By similarity | ||||||
| Binding site | 32 | 1 | NAD By similarity | ||||||
| Binding site | 37 | 1 | NAD By similarity | ||||||
| Binding site | 89 | 1 | NAD By similarity | ||||||
| Binding site | 127 | 1 | NAD; via amide nitrogen By similarity | ||||||
| Binding site | 161 | 1 | NAD By similarity | ||||||
| Binding site | 216 | 1 | Substrate By similarity | ||||||
| Binding site | 269 | 1 | Substrate; via amide nitrogen By similarity | ||||||
| Binding site | 275 | 1 | NAD By similarity | ||||||
| Binding site | 335 | 1 | Substrate By similarity | ||||||
| Binding site | 342 | 1 | NAD By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 59 | 1 | K → R in AAC97125. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling." Binari R.C., Staveley B.E., Johnson W.A., Godavarti R., Sasisekharan R., Manoukian A.S. Development 124:2623-2632(1997) [PubMed: 9217004] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis." Haecker U., Lin X., Perrimon N. Development 124:3565-3573(1997) [PubMed: 9342049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila." Haerry T.E., Heslip T.R., Marsh J.L., O'Connor M.B. Development 124:3055-3064(1997) [PubMed: 9272947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Mutation in the Drosophila gene encoding UDP-glucose dehydrogenase affects expression of unlinked genes." Benevolenskaya E.V., Frolov M.V., Birchler J.A. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Canton-S. |
| [5] | "The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. Venter J.C.Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley. |
| [6] | "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. Lewis S.E.Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. |
| [7] | "A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo. |
Cross-references
Sequence databases | |
|---|---|
| AF007870 mRNA. Translation: AAB63208.1. AF000570 mRNA. Translation: AAB58714.1. AF009013 mRNA. Translation: AAB63462.1. AF001310 mRNA. Translation: AAC97125.1. AF001312, AF001311 Genomic DNA. Translation: AAC97126.1. AE014296 Genomic DNA. Translation: AAF50631.1. AY052137 mRNA. Translation: AAK93561.1. | |
| RefSeq | NP_476980.1. |
| UniGene | Dm.4371 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O02373. 1 interaction. |
Proteomic databases | |
| PRIDE | O02373. |
Genome annotation databases | |
| Ensembl | FBgn0010851. Drosophila melanogaster. [Contig view] |
| GeneID | 38760. |
| KEGG | dme:Dmel_CG10072. |
| NMPDR | fig|7227.3.peg.8592. |
Organism-specific databases | |
| FlyBase | FBgn0010851. sgl. |
Phylogenomic databases | |
| HOGENOM | O02373. |
| OMA | O02373. YEHWIPK. |
Enzyme and pathway databases | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-015497-MON. |
| BRENDA | 1.1.1.22. 48. |
Gene expression databases | |
| ArrayExpress | O02373. |
| GermOnline | CG10072. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DH_C. IPR014026. UDP-Glc/GDP-Man_DH_dimer. IPR014028. UDP-Glc/GDP-Man_DH_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DH_N. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit. |
| PANTHER | PTHR11374. UDPG_MGDP_DH_Creg. 1 hit. |
| Pfam | PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03026. NDP-sugDHase. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 810251. |
Entry information
| Entry name | UGDH_DROME | ||||||||
| Accession | Primary (citable) accession number: O02373 Secondary accession number(s): O02647, Q9VRZ9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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