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Protein

Aryl hydrocarbon receptor nuclear translocator homolog

Gene

aha-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a role in cellular differentiation. Required for pharyngeal development. In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration. Acts in the cellular response to hypoxia. Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons.5 Publications

GO - Molecular functioni

  • DNA binding Source: WormBase
  • DNA binding transcription factor activity Source: WormBase
  • protein dimerization activity Source: InterPro
  • RNA polymerase II transcription factor binding Source: WormBase
  • signal transducer activity Source: WormBase

GO - Biological processi

  • cell fate specification Source: UniProtKB
  • intracellular receptor signaling pathway Source: WormBase
  • neurogenesis Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: WormBase
  • response to xenobiotic stimulus Source: WormBase
  • social behavior Source: UniProtKB
  • transcription by RNA polymerase II Source: WormBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Receptor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-CEL-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-CEL-211945 Phase I - Functionalization of compounds
R-CEL-8937144 Aryl hydrocarbon receptor signalling

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor nuclear translocator homolog2 PublicationsBy similarity
Short name:
ARNT2 Publications
Alternative name(s):
AHR-associated protein1 Publication
Gene namesi
Name:aha-1Imported
ORF Names:C25A1.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC25A1.11a ; CE08377 ; WBGene00000095 ; aha-1
C25A1.11b ; CE44231 ; WBGene00000095 ; aha-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Abnormal cell morphology of developing RMEL/R neurons. Arrested development at larvae life stage due to its requirement in the pharynx. Defects in SDQR neuron cell dorsal-ventral migration. Aggregation behavior is diminished. Abolishes guanylate cyclase gene expression in the URX neurons.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004160491 – 453Aryl hydrocarbon receptor nuclear translocator homologAdd BLAST453

Proteomic databases

PaxDbiO02219
PeptideAtlasiO02219

Expressioni

Tissue specificityi

Expressed in many cell types throughout development, including hypodermal cells, intestinal cells, pharyngeal cells, and neurons. Expressed in every cell during embryo.1 Publication

Gene expression databases

BgeeiWBGene00000095

Interactioni

Subunit structurei

Interacts with hif-1. Forms a heterodimer with ahr-1.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein dimerization activity Source: InterPro
  • RNA polymerase II transcription factor binding Source: WormBase

Protein-protein interaction databases

IntActiO02219, 11 interactors
STRINGi6239.C25A1.11a

Structurei

3D structure databases

ProteinModelPortaliO02219
SMRiO02219
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 97bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini115 – 193PAS 1PROSITE-ProRule annotationAdd BLAST79
Domaini277 – 347PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini348 – 392PACSequence analysisAdd BLAST45

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQ5T Eukaryota
ENOG410XVHF LUCA
GeneTreeiENSGT00760000118788
HOGENOMiHOG000234379
InParanoidiO02219
KOiK09097
OMAiEYVVATH
OrthoDBiEOG091G03AI
PhylomeDBiO02219

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PRINTSiPR00785 NCTRNSLOCATR
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a2 Publications (identifier: O02219-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQDIFMDPW QSATSFAMED EDMGMPSGKY ARMEDEMGEN KERFARENHS
60 70 80 90 100
EIERRRRNKM THYINELAEM VPQCASLGRK PDKLTILRMA VSHMKGIRGH
110 120 130 140 150
TAQDETSYKP SFLTDQELKH LILEAANGFL FVVCCQTGKV LYVADSITPV
160 170 180 190 200
LNLKQEDWLQ RNLNELIHPD DQDKIRDQLC GSEVSVNKVL DLKSGSVKRE
210 220 230 240 250
GASTRVHMSC RRGFICRMRV GALEPLHRLR NRRPLFQHAG QNYVVMHCTG
260 270 280 290 300
YIKNAPPQGI NAPASSCLVA IARLQVASMP VCADPTSTNQ FSVRVSEDGK
310 320 330 340 350
MTFIDARVSD LIGLSSDQLI GRYWWNLAHP ADEKTLQDSF VALLSDQPMR
360 370 380 390 400
INIRVRTSTD YIPCTVSAYK FMNPYSEQFE YVVATHQIAP QEDINNWVTA
410 420 430 440 450
PTVPQPQASE FGELGGAPSA VDYGQSSSGG WRPEAQGAPQ AQWQWDPMNG

YNQ
Length:453
Mass (Da):51,037
Last modified:July 1, 1997 - v1
Checksum:iB00FFE005C9B0BCB
GO
Isoform b1 Publication (identifier: O02219-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-275: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:451
Mass (Da):50,795
Checksum:iED2ABE0A9D321AD0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042476274 – 275Missing in isoform b. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039569 mRNA Translation: AAB99999.1
Z81038 Genomic DNA Translation: CAB02764.1
Z81038 Genomic DNA Translation: CBH29653.1
PIRiT19440
T42397
RefSeqiNP_001251326.1, NM_001264397.1 [O02219-2]
NP_001251327.1, NM_001264398.1 [O02219-1]
UniGeneiCel.38989

Genome annotation databases

EnsemblMetazoaiC25A1.11a; C25A1.11a; WBGene00000095 [O02219-1]
GeneIDi172889
KEGGicel:CELE_C25A1.11
UCSCiC25A1.11 c. elegans [O02219-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAHA1_CAEEL
AccessioniPrimary (citable) accession number: O02219
Secondary accession number(s): G5EGG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health