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Protein

Aryl hydrocarbon receptor nuclear translocator homolog

Gene

aha-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in cellular differentiation. Required for pharyngeal development. In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration. Acts in the cellular response to hypoxia. Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons.5 Publications

GO - Molecular functioni

  • DNA binding Source: WormBase
  • RNA polymerase II transcription factor binding Source: WormBase
  • signal transducer activity Source: WormBase
  • transcription factor activity, sequence-specific DNA binding Source: WormBase

GO - Biological processi

  • cell fate specification Source: UniProtKB
  • intracellular receptor signaling pathway Source: WormBase
  • neurogenesis Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • response to xenobiotic stimulus Source: WormBase
  • social behavior Source: UniProtKB
  • transcription from RNA polymerase II promoter Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-1234158. Regulation of gene expression by Hypoxia-inducible Factor.

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor nuclear translocator homolog2 PublicationsBy similarity
Short name:
ARNT2 Publications
Alternative name(s):
AHR-associated protein1 Publication
Gene namesi
Name:aha-1Imported
ORF Names:C25A1.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC25A1.11a; CE08377; WBGene00000095; aha-1.
C25A1.11b; CE44231; WBGene00000095; aha-1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

  • Note: Nuclear location dependent on hif-1 expression in intestinal tissue but not in neuronal cells.1 Publication

GO - Cellular componenti

  • cytoplasm Source: InterPro
  • intracellular Source: WormBase
  • nucleus Source: WormBase
  • RNA polymerase II transcription factor complex Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Abnormal cell morphology of developing RMEL/R neurons. Arrested development at larvae life stage due to its requirement in the pharynx. Defects in SDQR neuron cell dorsal-ventral migration. Aggregation behavior is diminished. Abolishes guanylate cyclase gene expression in the URX neurons.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004160491 – 453Aryl hydrocarbon receptor nuclear translocator homologAdd BLAST453

Proteomic databases

PaxDbiO02219.
PeptideAtlasiO02219.

Expressioni

Tissue specificityi

Expressed in many cell types throughout development, including hypodermal cells, intestinal cells, pharyngeal cells, and neurons. Expressed in every cell during embryo.1 Publication

Gene expression databases

BgeeiWBGene00000095.

Interactioni

Subunit structurei

Interacts with hif-1. Forms a heterodimer with ahr-1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ahr-1O447123EBI-2408984,EBI-2409183
cky-1G5EFA53EBI-2408984,EBI-313013
hif-1G5EGD23EBI-2408984,EBI-319821

GO - Molecular functioni

  • RNA polymerase II transcription factor binding Source: WormBase

Protein-protein interaction databases

IntActiO02219. 11 interactors.
STRINGi6239.C25A1.11a.

Structurei

3D structure databases

ProteinModelPortaliO02219.
SMRiO02219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 97bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini115 – 193PAS 1PROSITE-ProRule annotationAdd BLAST79
Domaini277 – 347PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini348 – 392PACSequence analysisAdd BLAST45

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 1 PAC (PAS-associated C-terminal) domain.Sequence analysis
Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQ5T. Eukaryota.
ENOG410XVHF. LUCA.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000234379.
InParanoidiO02219.
KOiK09097.
OMAiEYVVATH.
OrthoDBiEOG091G03AI.
PhylomeDBiO02219.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00785. NCTRNSLOCATR.
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a2 Publications (identifier: O02219-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQDIFMDPW QSATSFAMED EDMGMPSGKY ARMEDEMGEN KERFARENHS
60 70 80 90 100
EIERRRRNKM THYINELAEM VPQCASLGRK PDKLTILRMA VSHMKGIRGH
110 120 130 140 150
TAQDETSYKP SFLTDQELKH LILEAANGFL FVVCCQTGKV LYVADSITPV
160 170 180 190 200
LNLKQEDWLQ RNLNELIHPD DQDKIRDQLC GSEVSVNKVL DLKSGSVKRE
210 220 230 240 250
GASTRVHMSC RRGFICRMRV GALEPLHRLR NRRPLFQHAG QNYVVMHCTG
260 270 280 290 300
YIKNAPPQGI NAPASSCLVA IARLQVASMP VCADPTSTNQ FSVRVSEDGK
310 320 330 340 350
MTFIDARVSD LIGLSSDQLI GRYWWNLAHP ADEKTLQDSF VALLSDQPMR
360 370 380 390 400
INIRVRTSTD YIPCTVSAYK FMNPYSEQFE YVVATHQIAP QEDINNWVTA
410 420 430 440 450
PTVPQPQASE FGELGGAPSA VDYGQSSSGG WRPEAQGAPQ AQWQWDPMNG

YNQ
Length:453
Mass (Da):51,037
Last modified:July 1, 1997 - v1
Checksum:iB00FFE005C9B0BCB
GO
Isoform b1 Publication (identifier: O02219-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-275: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:451
Mass (Da):50,795
Checksum:iED2ABE0A9D321AD0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042476274 – 275Missing in isoform b. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039569 mRNA. Translation: AAB99999.1.
Z81038 Genomic DNA. Translation: CAB02764.1.
Z81038 Genomic DNA. Translation: CBH29653.1.
PIRiT19440.
T42397.
RefSeqiNP_001251326.1. NM_001264397.1. [O02219-2]
NP_001251327.1. NM_001264398.1. [O02219-1]
UniGeneiCel.38989.

Genome annotation databases

EnsemblMetazoaiC25A1.11a; C25A1.11a; WBGene00000095. [O02219-1]
GeneIDi172889.
KEGGicel:CELE_C25A1.11.
UCSCiC25A1.11. c. elegans. [O02219-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039569 mRNA. Translation: AAB99999.1.
Z81038 Genomic DNA. Translation: CAB02764.1.
Z81038 Genomic DNA. Translation: CBH29653.1.
PIRiT19440.
T42397.
RefSeqiNP_001251326.1. NM_001264397.1. [O02219-2]
NP_001251327.1. NM_001264398.1. [O02219-1]
UniGeneiCel.38989.

3D structure databases

ProteinModelPortaliO02219.
SMRiO02219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO02219. 11 interactors.
STRINGi6239.C25A1.11a.

Proteomic databases

PaxDbiO02219.
PeptideAtlasiO02219.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC25A1.11a; C25A1.11a; WBGene00000095. [O02219-1]
GeneIDi172889.
KEGGicel:CELE_C25A1.11.
UCSCiC25A1.11. c. elegans. [O02219-1]

Organism-specific databases

CTDi172889.
WormBaseiC25A1.11a; CE08377; WBGene00000095; aha-1.
C25A1.11b; CE44231; WBGene00000095; aha-1.

Phylogenomic databases

eggNOGiENOG410IQ5T. Eukaryota.
ENOG410XVHF. LUCA.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000234379.
InParanoidiO02219.
KOiK09097.
OMAiEYVVATH.
OrthoDBiEOG091G03AI.
PhylomeDBiO02219.

Enzyme and pathway databases

ReactomeiR-CEL-1234158. Regulation of gene expression by Hypoxia-inducible Factor.

Miscellaneous databases

PROiO02219.

Gene expression databases

BgeeiWBGene00000095.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00785. NCTRNSLOCATR.
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAHA1_CAEEL
AccessioniPrimary (citable) accession number: O02219
Secondary accession number(s): G5EGG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.