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Protein

Abhydrolase domain-containing protein lid-1

Gene

lid-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts coordinately with atgl-1 within the lipolytic cascade to distribute stored energy to tissues during nutritional deprivation.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-CEL-1482839. Acyl chain remodelling of PE.

Protein family/group databases

ESTHERicaeel-C25A1.12. CGI-58_ABHD5_ABHD4.
MEROPSiS33.975.

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein lid-1Curated
Alternative name(s):
Lipid droplet protein 1Imported
Gene namesi
Name:lid-1Imported
ORF Names:C25A1.12Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC25A1.12; CE41871; WBGene00007711; lid-1.

Subcellular locationi

GO - Cellular componenti

  • lipid particle Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown suppresses fasting-induced oxygen consumption.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004354261 – 360Abhydrolase domain-containing protein lid-1Add BLAST360

Proteomic databases

EPDiO02218.
PaxDbiO02218.
PeptideAtlasiO02218.

Expressioni

Gene expression databases

BgeeiWBGene00007711.

Interactioni

Subunit structurei

Interacts with atgl-1.1 Publication

Protein-protein interaction databases

STRINGi6239.C25A1.12.

Structurei

3D structure databases

ProteinModelPortaliO02218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 203AB hydrolase-1Sequence analysisAdd BLAST131

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410ITZ1. Eukaryota.
ENOG4111Y24. LUCA.
GeneTreeiENSGT00390000016277.
HOGENOMiHOG000007445.
InParanoidiO02218.
OMAiAYVDIKI.
OrthoDBiEOG091G0AEW.
PhylomeDBiO02218.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

O02218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIATTKTAL TTIMNWMTFT DDSKEQLKIV EGRLFQSCEV SYEAKYVPVR
60 70 80 90 100
FKRGEVYTVT VRPREAENLN GEAIVFIPGL GAGVAMFTAN FNSCAKNHAV
110 120 130 140 150
HSFDPLGFGR SSRSRFSDDN AIAELEMVEV MEDWRKAMGI EKMYIIGHAF
160 170 180 190 200
GGYLASAYAL ENPSRVAHLI LVDPWGFAEK VETTEKLIKP YAWMSFLGGV
210 220 230 240 250
AGYFNPFSPM RWMGPYAPAI VKKLRPDLLL RFPGLHDYDI YKYVYYLNLP
260 270 280 290 300
NPTGETAFMN MTLPVGWAKR PMIKRFNGID KNVGVSFIYG SKSWIDPGPA
310 320 330 340 350
IDIQSTRENA YVDIKIVRGA GTHVYADDPA AFNEIVSDVV EGRLSNPSND
360
FEIEECCHSD
Length:360
Mass (Da):40,389
Last modified:February 5, 2008 - v2
Checksum:i43268DA2F7591516
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB02763.2.
RefSeqiNP_492685.2. NM_060284.3.
UniGeneiCel.19198.

Genome annotation databases

EnsemblMetazoaiC25A1.12; C25A1.12; WBGene00007711.
GeneIDi172888.
KEGGicel:CELE_C25A1.12.
UCSCiC25A1.12. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB02763.2.
RefSeqiNP_492685.2. NM_060284.3.
UniGeneiCel.19198.

3D structure databases

ProteinModelPortaliO02218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C25A1.12.

Protein family/group databases

ESTHERicaeel-C25A1.12. CGI-58_ABHD5_ABHD4.
MEROPSiS33.975.

Proteomic databases

EPDiO02218.
PaxDbiO02218.
PeptideAtlasiO02218.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC25A1.12; C25A1.12; WBGene00007711.
GeneIDi172888.
KEGGicel:CELE_C25A1.12.
UCSCiC25A1.12. c. elegans.

Organism-specific databases

CTDi172888.
WormBaseiC25A1.12; CE41871; WBGene00007711; lid-1.

Phylogenomic databases

eggNOGiENOG410ITZ1. Eukaryota.
ENOG4111Y24. LUCA.
GeneTreeiENSGT00390000016277.
HOGENOMiHOG000007445.
InParanoidiO02218.
OMAiAYVDIKI.
OrthoDBiEOG091G0AEW.
PhylomeDBiO02218.

Enzyme and pathway databases

ReactomeiR-CEL-1482839. Acyl chain remodelling of PE.

Miscellaneous databases

PROiO02218.

Gene expression databases

BgeeiWBGene00007711.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLID1_CAEEL
AccessioniPrimary (citable) accession number: O02218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 17, 2016
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.