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Protein

Eukaryotic translation initiation factor 3 subunit I

Gene

eIF3i

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

  • translation initiation factor activity Source: FlyBase

GO - Biological processi

  • translational initiation Source: FlyBase

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-72649 Translation initiation complex formation
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702 Ribosomal scanning and start codon recognition
SignaLinkiO02195

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit IUniRule annotation
Short name:
eIF3iUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 2UniRule annotation
TRIP-1 homolog
eIF-3-betaUniRule annotation
Gene namesi
Name:eIF3iUniRule annotation
Synonyms:eif3-S2UniRule annotation, Trip1UniRule annotation
ORF Names:CG8882Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0015834 eIF3i

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510381 – 326Eukaryotic translation initiation factor 3 subunit IAdd BLAST326

Proteomic databases

PaxDbiO02195
PRIDEiO02195

Expressioni

Gene expression databases

BgeeiFBgn0015834
GenevisibleiO02195 DM

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi59895, 22 interactors
DIPiDIP-18772N
IntActiO02195, 12 interactors
STRINGi7227.FBpp0078689

Structurei

3D structure databases

ProteinModelPortaliO02195
SMRiO02195
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 47WD 1Add BLAST40
Repeati50 – 89WD 2Add BLAST40
Repeati145 – 184WD 3Add BLAST40
Repeati188 – 227WD 4Add BLAST40
Repeati285 – 326WD 5Add BLAST42

Sequence similaritiesi

Belongs to the eIF-3 subunit I family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0643 Eukaryota
ENOG410XQ3E LUCA
GeneTreeiENSGT00630000089849
InParanoidiO02195
KOiK03246
OMAiFETRFWH
OrthoDBiEOG091G0AIZ
PhylomeDBiO02195

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03008 eIF3i, 1 hit
InterProiView protein in InterPro
IPR027525 eIF3i
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19877 PTHR19877, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 4 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

O02195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLMLQGHE RSITQIKYNR EGDLLFSCSK DQKPNVWYSL NGERLGTYDG
60 70 80 90 100
HQGAVWCLDV DWESRKLITG AGDMTAKIWD VEYGTVIASI PTKSSVRTSN
110 120 130 140 150
FSFSGNQAAY STDKAMGQSC ELFLIDVRNA DSSLSEQEPT LRIPMTESKI
160 170 180 190 200
TSMLWGPLDE TIITGHDNGN IAIWDIRKGQ KVVDSGTDHS AGINDMQLSK
210 220 230 240 250
DGTMFVTASK DTTAKLFDSE SLMCLKTYKT ERPVNSAAIS PIMDHVVLGG
260 270 280 290 300
GQDAMEVTTT STKAGKFDSR FFHLIYEEEF ARLKGHFGPI NSLAFHPDGK
310 320
SYASGGEDGF VRVQTFDSTY FENIFE
Length:326
Mass (Da):36,160
Last modified:July 1, 1997 - v1
Checksum:iB07D35F9E47F3F31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90930 mRNA Translation: AAB53431.1
AE014134 Genomic DNA Translation: AAF52183.1
AY118527 mRNA Translation: AAM49896.1
RefSeqiNP_523478.1, NM_078754.4
UniGeneiDm.2654

Genome annotation databases

EnsemblMetazoaiFBtr0079053; FBpp0078689; FBgn0015834
GeneIDi33710
KEGGidme:Dmel_CG8882
UCSCiCG8882-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiEIF3I_DROME
AccessioniPrimary (citable) accession number: O02195
Secondary accession number(s): Q540Y6, Q9VMX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health