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Protein

Nuclear hormone receptor family member nhr-14

Gene

nhr-14

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 9276Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri20 – 4021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri56 – 8025NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiO02151.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-14
Gene namesi
Name:nhr-14
ORF Names:T01B10.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT01B10.4a; CE33818; WBGene00003613; nhr-14.
T01B10.4b; CE33819; WBGene00003613; nhr-14.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Nuclear hormone receptor family member nhr-14PRO_0000053767Add
BLAST

Proteomic databases

EPDiO02151.
PaxDbiO02151.
PRIDEiO02151.

Interactioni

Protein-protein interaction databases

BioGridi46023. 1 interaction.
MINTiMINT-1085288.
STRINGi6239.T01B10.4a.2.

Structurei

3D structure databases

ProteinModelPortaliO02151.
SMRiO02151. Positions 19-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated
Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri20 – 4021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri56 – 8025NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4215. Eukaryota.
ENOG410XQT8. LUCA.
GeneTreeiENSGT00840000130053.
HOGENOMiHOG000022323.
InParanoidiO02151.
OMAiLMIGWAN.
PhylomeDBiO02151.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: O02151-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFLISTSLS ESTSTSADFC VVCGDKAIGK HYGAVACNGC KGFFRRSVWQ
60 70 80 90 100
NLQYTCRFNK QCNIDKDHRN ACRYCRFQKC LADGMKPEAI QNERDRIGST
110 120 130 140 150
KRRKRSGANS ENNSDSEGTP SPKIEVMGNS VSRKLIEMLL DIEHRLASNQ
160 170 180 190 200
SMNALLRDES EMKNSRQRAV NYLIGWTNML HPLPEVPLAD KVLLLKKFSS
210 220 230 240 250
AFTLLGTLQR SMALPHFVLP NDQVLSISAS HPPELFEALT RIIDELLTPL
260 270 280 290 300
RRLRTDHAEF SCLKALLLLN PDVVGISNNT RERIREARDA LLKTLFAYMS
310 320 330 340 350
NTQNSIDASL RVSSLLMIIP SLISVSSSIM EFPALSDLFG LGDVIKRDTI
360 370 380 390 400
SPKIETPPLE MKPMMPKIAQ PPVTSAPTVP TNIMMNKDLI SQIMNNPQLF
410 420 430
PLLPMPQTAS PPMSFMGQSE FGCHLQSMPV KVILS
Length:435
Mass (Da):48,560
Last modified:March 1, 2004 - v3
Checksum:iF0F6E770ED804536
GO
Isoform b (identifier: O02151-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-435: EFGCHLQSMPVKVILS → YNRNSDVIFSQCPSK

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):48,530
Checksum:iD633A0F96D5CDACC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei420 – 43516EFGCH…KVILS → YNRNSDVIFSQCPSK in isoform b. CuratedVSP_007344Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081164 Genomic DNA. Translation: CCD69597.1.
FO081164 Genomic DNA. Translation: CCD69598.1.
AF083229 mRNA. Translation: AAD03687.1.
PIRiT43353.
RefSeqiNP_741860.2. NM_171742.3. [O02151-1]
NP_741861.2. NM_171743.3. [O02151-2]
UniGeneiCel.630.

Genome annotation databases

EnsemblMetazoaiT01B10.4a.1; T01B10.4a.1; WBGene00003613. [O02151-1]
T01B10.4a.2; T01B10.4a.2; WBGene00003613. [O02151-1]
GeneIDi181102.
KEGGicel:CELE_T01B10.4.
UCSCiT01B10.4b. c. elegans. [O02151-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081164 Genomic DNA. Translation: CCD69597.1.
FO081164 Genomic DNA. Translation: CCD69598.1.
AF083229 mRNA. Translation: AAD03687.1.
PIRiT43353.
RefSeqiNP_741860.2. NM_171742.3. [O02151-1]
NP_741861.2. NM_171743.3. [O02151-2]
UniGeneiCel.630.

3D structure databases

ProteinModelPortaliO02151.
SMRiO02151. Positions 19-344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46023. 1 interaction.
MINTiMINT-1085288.
STRINGi6239.T01B10.4a.2.

Proteomic databases

EPDiO02151.
PaxDbiO02151.
PRIDEiO02151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT01B10.4a.1; T01B10.4a.1; WBGene00003613. [O02151-1]
T01B10.4a.2; T01B10.4a.2; WBGene00003613. [O02151-1]
GeneIDi181102.
KEGGicel:CELE_T01B10.4.
UCSCiT01B10.4b. c. elegans. [O02151-1]

Organism-specific databases

CTDi181102.
WormBaseiT01B10.4a; CE33818; WBGene00003613; nhr-14.
T01B10.4b; CE33819; WBGene00003613; nhr-14.

Phylogenomic databases

eggNOGiKOG4215. Eukaryota.
ENOG410XQT8. LUCA.
GeneTreeiENSGT00840000130053.
HOGENOMiHOG000022323.
InParanoidiO02151.
OMAiLMIGWAN.
PhylomeDBiO02151.

Enzyme and pathway databases

SignaLinkiO02151.

Miscellaneous databases

PROiO02151.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes."
    Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V.
    Genome Res. 9:103-120(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 148-435 (ISOFORM A).
    Strain: Bristol N2.

Entry informationi

Entry nameiNHR14_CAEEL
AccessioniPrimary (citable) accession number: O02151
Secondary accession number(s): Q8MPT6, Q9UAN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 1, 2004
Last modified: June 8, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.