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Protein

Proliferating cell nuclear antigen

Gene

pcn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi61 – 8020Sequence analysisAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA polymerase binding Source: WormBase
  • DNA polymerase processivity factor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-110312. Translesion synthesis by REV1.
R-CEL-110320. Translesion Synthesis by POLH.
R-CEL-113510. E2F mediated regulation of DNA replication.
R-CEL-1538133. G0 and Early G1.
R-CEL-174411. Polymerase switching on the C-strand of the telomere.
R-CEL-4615885. SUMOylation of DNA replication proteins.
R-CEL-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
R-CEL-5655862. Translesion synthesis by POLK.
R-CEL-5696400. Dual Incision in GG-NER.
R-CEL-6782135. Dual incision in TC-NER.
R-CEL-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-CEL-69091. Polymerase switching.
R-CEL-69166. Removal of the Flap Intermediate.
R-CEL-69183. Processive synthesis on the lagging strand.
R-CEL-69205. G1/S-Specific Transcription.

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigen
Short name:
PCNA
Gene namesi
Name:pcn-1
ORF Names:W03D2.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiW03D2.4; CE14512; WBGene00003955; pcn-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Proliferating cell nuclear antigenPRO_0000149168Add
BLAST

Proteomic databases

EPDiO02115.
PaxDbiO02115.

Expressioni

Gene expression databases

BgeeiWBGene00003955.

Interactioni

Subunit structurei

Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
mrt-2G5EC443EBI-318162,EBI-323732

GO - Molecular functioni

  • DNA polymerase binding Source: WormBase

Protein-protein interaction databases

BioGridi42297. 9 interactions.
DIPiDIP-25347N.
IntActiO02115. 10 interactions.
MINTiMINT-226524.
STRINGi6239.W03D2.4.1.

Structurei

3D structure databases

ProteinModelPortaliO02115.
SMRiO02115. Positions 1-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Phylogenomic databases

eggNOGiKOG1636. Eukaryota.
COG0592. LUCA.
GeneTreeiENSGT00390000004965.
HOGENOMiHOG000211098.
InParanoidiO02115.
OMAiSDGFDKY.
OrthoDBiEOG091G0GQ7.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
TIGRFAMsiTIGR00590. pcna. 1 hit.
PROSITEiPS01251. PCNA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEAKLANAG LLKKIVESIK DLVTDAPFDC SETAMSLQAM DSSHVALVSL
60 70 80 90 100
KLEVGLFDTY RCDRTINLGL SLANMSKALK CANNDDTCML KYEENEGDSI
110 120 130 140 150
IFTFADPKRD KTQDVTVKMM DIDSEHLGIP DQDYAVVCEM PAGEFQKTCK
160 170 180 190 200
DLSTFSDSLN ITATKAGIVF TGKGDIGSSV VTYSPSSNTD DETEAVTLEV
210 220 230 240 250
KDPVNVNFSI KYMNQFTKAT ALSDRVRLSL CNDVPVVVEY PIEENGYLRF
260
YLAPKIDDDE NMD
Length:263
Mass (Da):29,036
Last modified:October 19, 2011 - v3
Checksum:iED56F971AC68471C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080786 Genomic DNA. Translation: CCD66765.1.
PIRiT28761.
RefSeqiNP_500466.3. NM_068065.6.
UniGeneiCel.6560.

Genome annotation databases

EnsemblMetazoaiW03D2.4; W03D2.4; WBGene00003955.
GeneIDi177161.
KEGGicel:CELE_W03D2.4.
UCSCiW03D2.4.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080786 Genomic DNA. Translation: CCD66765.1.
PIRiT28761.
RefSeqiNP_500466.3. NM_068065.6.
UniGeneiCel.6560.

3D structure databases

ProteinModelPortaliO02115.
SMRiO02115. Positions 1-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42297. 9 interactions.
DIPiDIP-25347N.
IntActiO02115. 10 interactions.
MINTiMINT-226524.
STRINGi6239.W03D2.4.1.

Proteomic databases

EPDiO02115.
PaxDbiO02115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW03D2.4; W03D2.4; WBGene00003955.
GeneIDi177161.
KEGGicel:CELE_W03D2.4.
UCSCiW03D2.4.1. c. elegans.

Organism-specific databases

CTDi177161.
WormBaseiW03D2.4; CE14512; WBGene00003955; pcn-1.

Phylogenomic databases

eggNOGiKOG1636. Eukaryota.
COG0592. LUCA.
GeneTreeiENSGT00390000004965.
HOGENOMiHOG000211098.
InParanoidiO02115.
OMAiSDGFDKY.
OrthoDBiEOG091G0GQ7.

Enzyme and pathway databases

ReactomeiR-CEL-110312. Translesion synthesis by REV1.
R-CEL-110320. Translesion Synthesis by POLH.
R-CEL-113510. E2F mediated regulation of DNA replication.
R-CEL-1538133. G0 and Early G1.
R-CEL-174411. Polymerase switching on the C-strand of the telomere.
R-CEL-4615885. SUMOylation of DNA replication proteins.
R-CEL-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
R-CEL-5655862. Translesion synthesis by POLK.
R-CEL-5696400. Dual Incision in GG-NER.
R-CEL-6782135. Dual incision in TC-NER.
R-CEL-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-CEL-69091. Polymerase switching.
R-CEL-69166. Removal of the Flap Intermediate.
R-CEL-69183. Processive synthesis on the lagging strand.
R-CEL-69205. G1/S-Specific Transcription.

Miscellaneous databases

PROiO02115.

Gene expression databases

BgeeiWBGene00003955.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
TIGRFAMsiTIGR00590. pcna. 1 hit.
PROSITEiPS01251. PCNA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCNA_CAEEL
AccessioniPrimary (citable) accession number: O02115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 19, 2011
Last modified: September 7, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.