Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Presenilin hop-1

Gene

hop-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei182By similarity1
Active sitei278By similarity1

GO - Molecular functioni

GO - Biological processi

  • amyloid precursor protein catabolic process Source: GO_Central
  • beta-amyloid metabolic process Source: GO_Central
  • calcium ion transport Source: GO_Central
  • embryo development ending in birth or egg hatching Source: WormBase
  • gonad development Source: WormBase
  • membrane protein ectodomain proteolysis Source: GO_Central
  • negative regulation of apoptotic process Source: GO_Central
  • nematode larval development Source: WormBase
  • Notch receptor processing Source: GO_Central
  • Notch signaling pathway Source: UniProtKB-KW
  • oviposition Source: WormBase
  • positive regulation of cell proliferation Source: WormBase
  • positive regulation of Notch signaling pathway Source: WormBase
  • protein processing Source: InterPro
  • regulation of cell fate specification Source: WormBase
  • regulation of vulval development Source: WormBase
  • reproduction Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Notch signaling pathway

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.
SignaLinkiO02100.

Protein family/group databases

MEROPSiA22.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Presenilin hop-1
Gene namesi
Name:hop-1
ORF Names:C18E3.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC18E3.8; CE08317; WBGene00001985; hop-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 57LumenalSequence analysisAdd BLAST24
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 86CytoplasmicSequence analysis8
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 115LumenalSequence analysis8
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 148CytoplasmicSequence analysisAdd BLAST12
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170LumenalSequence analysis1
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 273CytoplasmicSequence analysisAdd BLAST82
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 297LumenalSequence analysis3
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 321CytoplasmicSequence analysis3
Intramembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 358CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000739021 – 358Presenilin hop-1Add BLAST358

Proteomic databases

PaxDbiO02100.

Expressioni

Tissue specificityi

Weakly expressed.

Developmental stagei

Expressed both maternally and zygotically. Predominantly expressed in the adult. Weakly expressed in the embryo, L2 and L3 stages, and almost absent in L1 stage larvae.1 Publication

Inductioni

Down-regulated by spr-1, spr-3, spr-4 and spr-5.

Gene expression databases

BgeeiWBGene00001985.

Interactioni

Subunit structurei

Homodimer. Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2 (Probable).Curated

Protein-protein interaction databases

STRINGi6239.C18E3.8.

Structurei

3D structure databases

ProteinModelPortaliO02100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi324 – 326PAL3

Domaini

The PAL motif is required for normal active site conformation.By similarity

Sequence similaritiesi

Belongs to the peptidase A22A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2736. Eukaryota.
ENOG410XPZD. LUCA.
GeneTreeiENSGT00390000016593.
InParanoidiO02100.
KOiK06060.
OMAiVALCMIF.
OrthoDBiEOG091G0HUX.
PhylomeDBiO02100.

Family and domain databases

InterProiIPR033152. Hop-1.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF14. PTHR10202:SF14. 1 hit.
PfamiPF01080. Presenilin. 2 hits.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRTKRVYSG KTITGVLYPV AICMLFVAIN VKLSQPEQQE QSKVVYGLFH
60 70 80 90 100
SYDTADSGTI TLYLIGFLIL TTSLGVFCYQ MKFYKAIKVY VLANSIGILL
110 120 130 140 150
VYSVFHFQRI AEAQSIPVSV PTFFFLILQF GGLGITCLHW KSHRRLHQFY
160 170 180 190 200
LIMLAGLTAI FILNILPDWT VWMALTAISF WDIVAVLTPC GPLKMLVETA
210 220 230 240 250
NRRGDDKFPA ILYNSSSYVN EVDSPDTTRS NSTPLTEFNN SSSSRLLESD
260 270 280 290 300
SLLRPPVIPR QIREVREVEG TIRLGMGDFV FYSLMLGNTV QTCPLPTVVA
310 320 330 340 350
CFVSNLVGLT ITLPIVTLSQ TALPALPFPL AIAAIFYFSS HIALTPFTDL

CTSQLILI
Length:358
Mass (Da):39,865
Last modified:July 1, 1997 - v1
Checksum:iE811624695DB8E1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021905 Genomic DNA. Translation: AAB84394.1.
FO080611 Genomic DNA. Translation: CCD65145.1.
PIRiT15184.
RefSeqiNP_491328.1. NM_058927.1.
UniGeneiCel.18540.

Genome annotation databases

EnsemblMetazoaiC18E3.8; C18E3.8; WBGene00001985.
GeneIDi172017.
KEGGicel:CELE_C18E3.8.
UCSCiC18E3.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021905 Genomic DNA. Translation: AAB84394.1.
FO080611 Genomic DNA. Translation: CCD65145.1.
PIRiT15184.
RefSeqiNP_491328.1. NM_058927.1.
UniGeneiCel.18540.

3D structure databases

ProteinModelPortaliO02100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C18E3.8.

Protein family/group databases

MEROPSiA22.010.

Proteomic databases

PaxDbiO02100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC18E3.8; C18E3.8; WBGene00001985.
GeneIDi172017.
KEGGicel:CELE_C18E3.8.
UCSCiC18E3.8. c. elegans.

Organism-specific databases

CTDi172017.
WormBaseiC18E3.8; CE08317; WBGene00001985; hop-1.

Phylogenomic databases

eggNOGiKOG2736. Eukaryota.
ENOG410XPZD. LUCA.
GeneTreeiENSGT00390000016593.
InParanoidiO02100.
KOiK06060.
OMAiVALCMIF.
OrthoDBiEOG091G0HUX.
PhylomeDBiO02100.

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.
SignaLinkiO02100.

Miscellaneous databases

PROiO02100.

Gene expression databases

BgeeiWBGene00001985.

Family and domain databases

InterProiIPR033152. Hop-1.
IPR001108. Peptidase_A22A.
IPR006639. Preselin/SPP.
[Graphical view]
PANTHERiPTHR10202. PTHR10202. 1 hit.
PTHR10202:SF14. PTHR10202:SF14. 1 hit.
PfamiPF01080. Presenilin. 2 hits.
[Graphical view]
PRINTSiPR01072. PRESENILIN.
SMARTiSM00730. PSN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHOP1_CAEEL
AccessioniPrimary (citable) accession number: O02100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.