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Protein

T-box transcription factor 18

Gene

sea-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Probable transcriptional regulator involved in developmental processes. Activates xol-1 transcription, either directly or indirectly, establishing that xol-1 acts as the master regulator to integrate both X chromosome and autosomal signals to determine sexual fate.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi171 – 364T-boxPROSITE-ProRule annotationAdd BLAST194

GO - Molecular functioni

GO - Biological processi

  • dosage compensation by hypoactivation of X chromosome Source: WormBase
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • sex determination Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor 18
Alternative name(s):
Signal element on autosome protein 1
Gene namesi
Name:sea-1
Synonyms:tbx-18
ORF Names:F19B10.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF19B10.9; CE09476; WBGene00004750; sea-1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • nucleus Source: WormBase

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844751 – 376T-box transcription factor 18Add BLAST376

Proteomic databases

PaxDbiO02073.

Expressioni

Gene expression databases

BgeeiWBGene00004750.

Interactioni

Protein-protein interaction databases

STRINGi6239.F19B10.9.

Structurei

3D structure databases

ProteinModelPortaliO02073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 71Ser-richAdd BLAST38

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
GeneTreeiENSGT00730000114153.
InParanoidiO02073.
OMAiSEFHENA.
OrthoDBiEOG091G1PF4.
PhylomeDBiO02073.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiView protein in Pfam
PF00907. T-box. 1 hit.
PRINTSiPR00937. TBOX.
SMARTiView protein in SMART
SM00425. TBOX. 1 hit.
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiView protein in PROSITE
PS01283. TBOX_1. 1 hit.
PS50252. TBOX_3. 1 hit.

Sequencei

Sequence statusi: Complete.

O02073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTIININNN NQKYPQSAEE YHKVLCNYFI TLQSAMQSTS RPSSSSPPSL
60 70 80 90 100
PAVSSELLSS SFPTNAPESS SRDLAPKQNQ FTINVVLFDE KKKKNPEENL
110 120 130 140 150
PANGDQLATL RSLMMQINPS SPPSIPATSP QLPLAESENV PESSSTLKDH
160 170 180 190 200
KFSLNTMLFN VKKNDAVKIS LANQEQWAKF HEIGTEMMVF NSGRRLFPLL
210 220 230 240 250
AYKVSGLDPH KLYCAGVHMI PDSAYKQEYD HDLQQWVNCL NQKKTIFKPT
260 270 280 290 300
SEILGRIENG FKLMSLGIDM SDVKIFNIAI RKKTPLQIEK SRKPNLDKTI
310 320 330 340 350
EVLIQYKYLP VIKIYELSNS GMEKKEIAQA TFPETSFVTV SIYRNQKIKE
360 370
MKTLGNKYCR TDRKQIVMEQ RGELEQ
Length:376
Mass (Da):42,705
Last modified:July 1, 1997 - v1
Checksum:i627864FA475D8D07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081177 Genomic DNA. Translation: CCD69699.1.
PIRiT15166.
RefSeqiNP_494611.1. NM_062210.5.
UniGeneiCel.15351.

Genome annotation databases

EnsemblMetazoaiF19B10.9; F19B10.9; WBGene00004750.
GeneIDi173710.
KEGGicel:CELE_F19B10.9.
UCSCiF19B10.9. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTBX18_CAEEL
AccessioniPrimary (citable) accession number: O02073
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: July 1, 1997
Last modified: March 15, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase