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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene
N/A
Organism
Cyanea capillata (Lion's mane jellyfish) (Cyanea arctica)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Protein family/group databases

TCDBi1.A.1.11.14. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
OrganismiCyanea capillata (Lion's mane jellyfish) (Cyanea arctica)Imported
Taxonomic identifieri27804 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaScyphozoaSemaeostomeaeCyaneidaeCyanea

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei153 – 17220HelicalSequence analysisAdd
BLAST
Transmembranei184 – 20118HelicalSequence analysisAdd
BLAST
Transmembranei246 – 26318HelicalSequence analysisAdd
BLAST
Transmembranei358 – 38023HelicalSequence analysisAdd
BLAST
Transmembranei498 – 51619HelicalSequence analysisAdd
BLAST
Transmembranei536 – 55722HelicalSequence analysisAdd
BLAST
Transmembranei627 – 64620HelicalSequence analysisAdd
BLAST
Transmembranei701 – 72727HelicalSequence analysisAdd
BLAST
Transmembranei870 – 88920HelicalSequence analysisAdd
BLAST
Transmembranei901 – 92323HelicalSequence analysisAdd
BLAST
Transmembranei943 – 96725HelicalSequence analysisAdd
BLAST
Transmembranei988 – 102134HelicalSequence analysisAdd
BLAST
Transmembranei1113 – 113725HelicalSequence analysisAdd
BLAST
Transmembranei1190 – 121122HelicalSequence analysisAdd
BLAST
Transmembranei1223 – 124321HelicalSequence analysisAdd
BLAST
Transmembranei1255 – 127420HelicalSequence analysisAdd
BLAST
Transmembranei1315 – 133319HelicalSequence analysisAdd
BLAST
Transmembranei1403 – 142624HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliO02038.
SMRiO02038. Positions 1567-1593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1564 – 159835Ca_chan_IQInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili733 – 76028Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O02038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDVQVKQSD GETERQGKWE SRPSEDDDDS IPFENSSPQY DWDDNDLTSG
60 70 80 90 100
KDQDDEKNLA LLATQKMATS TYPTKKTKKQ PGAGQNLRPK RALFCLTLDN
110 120 130 140 150
PVRSAAITIV DWKPFDFFIL ASIFANCAAL AAYEPLPAGD MTSTNQDLEV
160 170 180 190 200
AEYFFLAVFA IEGLLKIIAY GFILHPGAYL RNGWNILDFS IVVIGFASMI
210 220 230 240 250
FEEYLKSGFD VKALRAFRVL RPLRLVSGVP SLQVVMNSIV KAMLPLFHIA
260 270 280 290 300
LLVVFVIIIY AIIGVELFTG KLHQTCYDNI TNLPASSEPK PCSTTTSYGR
310 320 330 340 350
QCPSGSICKN NWEGPNYGIT NFDNVALAAL TVFQCTTLEG WTDVLYDINN
360 370 380 390 400
VSGGGWPWIY FVTLITFGSF FVLNLILGVL SGEFAKEKAR QTKSGEFHKI
410 420 430 440 450
REKHMLDDAV KGYLDWINQA SDIENVTVTQ EGAVEPGDST SERKLSSRRA
460 470 480 490 500
SGISHASSGI YNIAAPNPLT TKERIEKNLT KFHHRLRRQC RGIVKSQTFY
510 520 530 540 550
WMVIIAVFLN SLVLAVEHYD QPDYITMFLD RANYFFLGLF TFEMLLKIYC
560 570 580 590 600
LGIYGYLNSL FNRFDCLVVL SSLLEVAITV PTGWPPIGIS VLRCVRLLRI
610 620 630 640 650
FKVTRYWESL SNLVQSLVNS IKSIGSLLLL LSLFILIFSL LGMQIFGGRF
660 670 680 690 700
NLDEQAPPRT NFDSFWRSLI TVFQILTGED WNAVMYVGIQ SWGGIKNPSS
710 720 730 740 750
IIAIIYFVAL VIVGNYILLN VFLAIAVDNL ADAENMTKVN EEEKRKKKDA
760 770 780 790 800
KLMKKLARKK MDSLDSAEGK KETTESITDG SKDPLSGSEG PEDVELGNPK
810 820 830 840 850
SKNGTLRHMG ETTSTEMSEG KEARIRPLRL SELNLLKDIP DPMPPESSFF
860 870 880 890 900
IFSANNKLRY LCYRLAVNKI FINSILVLII MSSVALAAED PIGRDVLRNK
910 920 930 940 950
ILGYFDIFFT AMFTFEVTVK MIAFGVILHK RSFCRSFFNQ LDLVIVAVSW
960 970 980 990 1000
AAIMLSRGSA TSVVRILRVL RVLRPLRAIN RAKGLKHVVQ CVFLAIKSIG
1010 1020 1030 1040 1050
NIMIVTLLFQ FLFAVIGIQL FKGTFFYCTD RSKMTAEECK GTFNSYPEVN
1060 1070 1080 1090 1100
LANPVVAART WEKHTFRFDN VFQAYLSLFV VMTFEGWPSI LEHSIDSTTV
1110 1120 1130 1140 1150
NQGPKFNNRP FVAIYYVIYI IIIAFFMINI FVGFVIVTFQ NEGEEEFADC
1160 1170 1180 1190 1200
ELDKNQRKCV EYVLTVKPTY RFVPRKRFQY HIWRVVTSRL FEYMIFGFIL
1210 1220 1230 1240 1250
GNTIVLAAQY HNASKLYERV LDGFNIGFTA VFLLECVLKL MAFNAKNYFR
1260 1270 1280 1290 1300
DPWNIFDFVI VVGSIADIII GEISKDGGIK VNFFRLFRAL RLVKLLSQGD
1310 1320 1330 1340 1350
GIRTLLWTFM KSFQALPFVG LLILLLFFIY AVIGMQVFGT IRLDSGTVIN
1360 1370 1380 1390 1400
SNNNFQTFPQ ALIVLFRSAT GENWQQIMMA CVNSESVKCE VDPSKTCGTD
1410 1420 1430 1440 1450
FAYLYFMSFY MICSFLIINL FVAVIMDNFD YLTRDWSILG AHHLEEYVRI
1460 1470 1480 1490 1500
WAEYDPEASG RMKHVDIVSM LKRIEPPLGF GKCCPHREAC KRLVSMNMMM
1510 1520 1530 1540 1550
NNDGTVDFHA TLFALVRTSL NIKKPDATET ILHANNELRG ILKHLWPRTN
1560 1570 1580 1590 1600
ENLFDKLIPP PDYAEGITVG KFYATFLIQE YFRKFKKKRQ EERKKKNADS
1610 1620 1630 1640 1650
TVALKAGLRT LQELGPKIKR AISGDLMEEG TKEEEEKEKE PNKRHSFMAG
1660 1670 1680 1690 1700
LRKGIISSFA GDKKRNSYYN ALQDTPKQTP KQTPTSSVSH LAAPNTQGKR
1710 1720 1730 1740 1750
ISLPSLQTKT NSSQDNIPRG ALHEGPSIMQ RLSPRLKRKG QRPKSTPFEI
1760 1770 1780 1790 1800
IHHDSDDLAL PQIVLSSQSD VSNPSSKDRD NSRSSTPQHA SSIPGADLNS
1810 1820 1830 1840 1850
NLLDSNLGPR RSRSSSTSSL VGQALAHEGV PQDEAILRTV QKELSDSLNI
1860 1870 1880 1890 1900
SESQLEGAAR NIIYDFEKES GTSIPPPEAA PPQEQPNAEQ LSPYNDNNDN
1910
RSSRPDRTSY L
Length:1,911
Mass (Da):215,698
Last modified:July 1, 1997 - v1
Checksum:i43D29A672436A8C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93075 mRNA. Translation: AAC63050.1.
PIRiT43048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93075 mRNA. Translation: AAC63050.1.
PIRiT43048.

3D structure databases

ProteinModelPortaliO02038.
SMRiO02038. Positions 1567-1593.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.A.1.11.14. the voltage-gated ion channel (vic) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO02038_CYACP
AccessioniPrimary (citable) accession number: O02038
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.