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Protein

Caspase-1

Gene

Dcp-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541By similarity
Active sitei196 – 1961By similarity

GO - Molecular functioni

  • BIR domain binding Source: FlyBase
  • cysteine-type endopeptidase activity Source: FlyBase
  • cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: FlyBase

GO - Biological processi

  • actin filament organization Source: FlyBase
  • apoptotic process Source: FlyBase
  • autophagic cell death Source: FlyBase
  • cellular response to starvation Source: FlyBase
  • cytoplasmic transport, nurse cell to oocyte Source: FlyBase
  • execution phase of apoptosis Source: FlyBase
  • multicellular organism development Source: FlyBase
  • negative regulation of neuromuscular synaptic transmission Source: FlyBase
  • neuron remodeling Source: FlyBase
  • nurse cell apoptotic process Source: FlyBase
  • oogenesis Source: FlyBase
  • ovarian nurse cell to oocyte transport Source: FlyBase
  • positive regulation of autophagy Source: FlyBase
  • positive regulation of macroautophagy Source: FlyBase
  • programmed cell death Source: FlyBase
  • programmed cell death involved in cell development Source: FlyBase
  • salivary gland cell autophagic cell death Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BRENDAi3.4.22.36. 1994.
ReactomeiR-DME-111459. Activation of caspases through apoptosome-mediated cleavage.
R-DME-111465. Apoptotic cleavage of cellular proteins.
R-DME-2028269. Signaling by Hippo.
R-DME-211227. Activation of DNA fragmentation factor.
R-DME-264870. Caspase-mediated cleavage of cytoskeletal proteins.
R-DME-351906. Apoptotic cleavage of cell adhesion proteins.
R-DME-418889. Ligand-independent caspase activation via DCC.

Protein family/group databases

MEROPSiC14.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-1 (EC:3.4.22.-)
Cleaved into the following 2 chains:
Gene namesi
Name:Dcp-1
ORF Names:CG5370
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010501. Dcp-1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: FlyBase
  • mitochondrion Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 3333CuratedPRO_0000004662Add
BLAST
Chaini34 – 202169Caspase-1 subunit p22PRO_0000004663Add
BLAST
Propeptidei203 – 215131 PublicationPRO_0000004664Add
BLAST
Chaini216 – 323108Caspase-1 subunit p13PRO_0000004665Add
BLAST

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiO02002.
PRIDEiO02002.

Expressioni

Developmental stagei

Present uniformly throughout embryos of stages 4 and 10. In stage 16 embryos, the expression becomes restricted to the central nervous system, the developing gonads, and a portion of the gut. In stage 17 embryos, expression is mainly localized in cells along the midline of the central nervous system.

Gene expression databases

BgeeiFBgn0010501.
GenevisibleiO02002. DM.

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 22 kDa (p22) and a 13 kDa (p13) subunit.

GO - Molecular functioni

  • BIR domain binding Source: FlyBase

Protein-protein interaction databases

BioGridi63329. 5 interactions.
IntActiO02002. 1 interaction.
STRINGi7227.FBpp0071971.

Structurei

3D structure databases

ProteinModelPortaliO02002.
SMRiO02002. Positions 59-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
InParanoidiO02002.
KOiK20008.
OMAiNHKHRGL.
OrthoDBiEOG091G05YD.
PhylomeDBiO02002.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
[Graphical view]
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDECVTRNY GVGIRSPNGS ENRGSFIMAD NTDAKGCTPE SLVVGGATAA
60 70 80 90 100
SPLPANKFVA RMPVERYASE YNMSHKHRGV ALIFNHEFFD IPSLKSRTGT
110 120 130 140 150
NVDAQELKKA FENLGFAVSV HKDCKLRDIL KHVGKAAELD HTDNDCLAVA
160 170 180 190 200
ILSHGEHGYL YAKDTQYKLD NIWHYFTATF CPSLAGKPKL FFIQACQGDR
210 220 230 240 250
LDGGITLEKG VTETDGESST SYKIPIHADF LFSYSTIPGY FSWRNINNGS
260 270 280 290 300
WYMQSLIREL NANGKKYDLL TLLTFVNQRV ALDFESNVPA TPMMDRQKQI
310 320
PCLTSMLTRI LRFGDKPNGN KAG
Length:323
Mass (Da):35,927
Last modified:July 1, 1997 - v1
Checksum:iB5FF0FF75EB8E2BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001464 mRNA. Translation: AAB58237.1.
AE013599 Genomic DNA. Translation: AAF47027.1.
BT010065 mRNA. Translation: AAQ22534.1.
RefSeqiNP_476974.1. NM_057626.4.
UniGeneiDm.4849.

Genome annotation databases

EnsemblMetazoaiFBtr0072062; FBpp0071971; FBgn0010501.
GeneIDi37729.
KEGGidme:Dmel_CG5370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001464 mRNA. Translation: AAB58237.1.
AE013599 Genomic DNA. Translation: AAF47027.1.
BT010065 mRNA. Translation: AAQ22534.1.
RefSeqiNP_476974.1. NM_057626.4.
UniGeneiDm.4849.

3D structure databases

ProteinModelPortaliO02002.
SMRiO02002. Positions 59-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63329. 5 interactions.
IntActiO02002. 1 interaction.
STRINGi7227.FBpp0071971.

Protein family/group databases

MEROPSiC14.016.

Proteomic databases

PaxDbiO02002.
PRIDEiO02002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072062; FBpp0071971; FBgn0010501.
GeneIDi37729.
KEGGidme:Dmel_CG5370.

Organism-specific databases

CTDi37729.
FlyBaseiFBgn0010501. Dcp-1.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
InParanoidiO02002.
KOiK20008.
OMAiNHKHRGL.
OrthoDBiEOG091G05YD.
PhylomeDBiO02002.

Enzyme and pathway databases

BRENDAi3.4.22.36. 1994.
ReactomeiR-DME-111459. Activation of caspases through apoptosome-mediated cleavage.
R-DME-111465. Apoptotic cleavage of cellular proteins.
R-DME-2028269. Signaling by Hippo.
R-DME-211227. Activation of DNA fragmentation factor.
R-DME-264870. Caspase-mediated cleavage of cytoskeletal proteins.
R-DME-351906. Apoptotic cleavage of cell adhesion proteins.
R-DME-418889. Ligand-independent caspase activation via DCC.

Miscellaneous databases

GenomeRNAii37729.
PROiO02002.

Gene expression databases

BgeeiFBgn0010501.
GenevisibleiO02002. DM.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
[Graphical view]
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASP1_DROME
AccessioniPrimary (citable) accession number: O02002
Secondary accession number(s): Q9W1N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.