Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-dependent RNA helicase glh-3

Gene

glh-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable ATP-binding RNA helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri202 – 219CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri222 – 239CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Nucleotide bindingi342 – 349ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • DEAD/H-box RNA helicase binding Source: WormBase
  • JUN kinase binding Source: WormBase
  • protein self-association Source: WormBase
  • RNA binding Source: UniProtKB-KW
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase glh-3 (EC:3.6.4.13)
Alternative name(s):
Germline helicase 3
Gene namesi
Name:glh-3
ORF Names:B0414.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiB0414.6; CE07736; WBGene00001600; glh-3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550911 – 720ATP-dependent RNA helicase glh-3Add BLAST720

Proteomic databases

EPDiO01836.
PaxDbiO01836.
PeptideAtlasiO01836.
PRIDEiO01836.

PTM databases

iPTMnetiO01836.

Expressioni

Developmental stagei

During germline proliferation.

Gene expression databases

BgeeiWBGene00001600.

Interactioni

Subunit structurei

Interacts with csn-5. Interacts (via C-terminus) with kgb-1. Interacts with zyx-1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • DEAD/H-box RNA helicase binding Source: WormBase
  • JUN kinase binding Source: WormBase
  • protein self-association Source: WormBase

Protein-protein interaction databases

IntActiO01836. 4 interactors.
STRINGi6239.B0414.6.2.

Structurei

3D structure databases

ProteinModelPortaliO01836.
SMRiO01836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini329 – 513Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST185
Domaini549 – 698Helicase C-terminalPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi298 – 326Q motifAdd BLAST29
Motifi456 – 459DEAD box4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri202 – 219CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri222 – 239CCHC-type 2PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0335. Eukaryota.
ENOG410XNTI. LUCA.
GeneTreeiENSGT00890000139383.
InParanoidiO01836.
KOiK13982.
OrthoDBiEOG091G04U3.
PhylomeDBiO01836.

Family and domain databases

Gene3Di4.10.60.10. 3 hits.
InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
IPR001878. Znf_CCHC.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00098. zf-CCHC. 2 hits.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF57756. SSF57756. 1 hit.
PROSITEiView protein in PROSITE
PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
PS50158. ZF_CCHC. 2 hits.

Sequencei

Sequence statusi: Complete.

O01836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSPTKTSI RTKFARHQPI SDVDTTEQSS SCIKKDDRGL SSFGVQSSVF
60 70 80 90 100
SRRSCRMSEL EAKPTIISED QRIAVRSEIG GSFSGFDDKV DNVFHSNNNL
110 120 130 140 150
HGSPSTTELE CPGIMNPRFL VGRSLNSRSR AVTRGSKRTS NVKENEGSIH
160 170 180 190 200
RSDDQVSTEN CSAKDEERDR DSGGVSSYGN KRSDEFCGTS PILEAKGFGI
210 220 230 240 250
SNTCFNCKKY GHRATECSAP QRECANCGDP NHRANECASW SKNGVQEPTK
260 270 280 290 300
VTYVPVVDKM EEVFSMLKIN AGDFFDKFFD ASVQLVSRGQ PVTIQPCKSF
310 320 330 340 350
SDSDIPQSMR RNVERAGYTR TTPIQQYTLP LVADGKDILA CAQTGSGKTA
360 370 380 390 400
AFLLPIMSRL ILEKDLNYGA EGGCYPRCII LTPTRELADQ IYNEGRKFSY
410 420 430 440 450
QSVMEIKPVY GGINVGYNKS QIMKGCTIIV GTIGRVKHFC EDGAIKLDKC
460 470 480 490 500
RYLVLDEADR MIDSMGFGPE IEQIINYKNM PKNDKRQTMM FSATFPSSVQ
510 520 530 540 550
EAARKLLRED YTMITIDKIG AANKCVIQEF ELCDRTSKVD KLLKLLGIDI
560 570 580 590 600
DTYTTEKNSD VFVKKTIVFV AQQKMADTLA SIMSAAQVPA ITIHGAREQK
610 620 630 640 650
ERSAALKLFR SGAKPVLIAT AVVERGLDIK GVDHVINYDM PNNIDDYIHR
660 670 680 690 700
IGRTGRVGNS GRATSFISLA DDVQILPQLV RTLADAEQVV PSWMKEAAGG
710 720
TSNPNKFEKS IDTEEPEEAW
Length:720
Mass (Da):79,728
Last modified:July 1, 1997 - v1
Checksum:iA91F49FE2B79DEAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079509 mRNA. Translation: AAC28388.1.
FO080197 Genomic DNA. Translation: CCD61900.1.
PIRiT15231.
RefSeqiNP_491681.1. NM_059280.4.
UniGeneiCel.19392.

Genome annotation databases

EnsemblMetazoaiB0414.6; B0414.6; WBGene00001600.
GeneIDi172245.
KEGGicel:CELE_B0414.6.
UCSCiB0414.6. c. elegans.

Entry informationi

Entry nameiGLH3_CAEEL
AccessioniPrimary (citable) accession number: O01836
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: August 30, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families