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Protein

Acyl-CoA-binding protein homolog 1

Gene

acbp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131Acyl-CoABy similarity
Binding sitei50 – 501Acyl-CoABy similarity
Binding sitei54 – 541Acyl-CoABy similarity
Binding sitei73 – 731Acyl-CoABy similarity

GO - Molecular functioni

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • lipid storage Source: WormBase
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein homolog 1
Short name:
ACBP-1
Alternative name(s):
Diazepam-binding inhibitor homolog
Short name:
DBI
Gene namesi
Name:acbp-1
ORF Names:C44E4.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC44E4.6; CE08720; WBGene00016655; acbp-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8686Acyl-CoA-binding protein homolog 1PRO_0000214012Add
BLAST

Proteomic databases

EPDiO01805.
PaxDbiO01805.

PTM databases

iPTMnetiO01805.

Interactioni

Protein-protein interaction databases

STRINGi6239.C44E4.6.1.

Structurei

3D structure databases

ProteinModelPortaliO01805.
SMRiO01805. Positions 5-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8686ACBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 325Acyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the ACBP family.Curated
Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00840000129776.
HOGENOMiHOG000261845.
InParanoidiO01805.
OMAiDTAKPGL.
OrthoDBiEOG7SN8G8.
PhylomeDBiO01805.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O01805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSFDDAAA TVKTLKTSPS NDELLKLYAL FKQGTVGDNT TDKPGMFDLK
60 70 80
GKAKWSAWDE KKGLAKDDAQ KAYVALVEEL IAKYGA
Length:86
Mass (Da):9,374
Last modified:July 1, 1997 - v1
Checksum:i27A9B4FB1B492CAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080862 Genomic DNA. Translation: CCD67306.1.
PIRiT30954.
RefSeqiNP_491412.1. NM_059011.5.
UniGeneiCel.7084.

Genome annotation databases

EnsemblMetazoaiC44E4.6.1; C44E4.6.1; WBGene00016655.
C44E4.6.2; C44E4.6.2; WBGene00016655.
GeneIDi172071.
KEGGicel:CELE_C44E4.6.
UCSCiC44E4.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080862 Genomic DNA. Translation: CCD67306.1.
PIRiT30954.
RefSeqiNP_491412.1. NM_059011.5.
UniGeneiCel.7084.

3D structure databases

ProteinModelPortaliO01805.
SMRiO01805. Positions 5-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C44E4.6.1.

PTM databases

iPTMnetiO01805.

Proteomic databases

EPDiO01805.
PaxDbiO01805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC44E4.6.1; C44E4.6.1; WBGene00016655.
C44E4.6.2; C44E4.6.2; WBGene00016655.
GeneIDi172071.
KEGGicel:CELE_C44E4.6.
UCSCiC44E4.6.1. c. elegans.

Organism-specific databases

CTDi172071.
WormBaseiC44E4.6; CE08720; WBGene00016655; acbp-1.

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00840000129776.
HOGENOMiHOG000261845.
InParanoidiO01805.
OMAiDTAKPGL.
OrthoDBiEOG7SN8G8.
PhylomeDBiO01805.

Miscellaneous databases

NextBioi873895.
PROiO01805.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiACBP1_CAEEL
AccessioniPrimary (citable) accession number: O01805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.