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Protein
Submitted name:

DUal OXidase

Gene

duox-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-CEL-209968. Thyroxine biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
DUal OXidaseImported
Gene namesi
Name:duox-2Imported
ORF Names:CELE_F53G12.3Imported, F53G12.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF53G12.3; CE24999; WBGene00018771; duox-2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei600 – 622HelicalSequence analysisAdd BLAST23
Transmembranei994 – 1015HelicalSequence analysisAdd BLAST22
Transmembranei1027 – 1054HelicalSequence analysisAdd BLAST28
Transmembranei1066 – 1089HelicalSequence analysisAdd BLAST24
Transmembranei1131 – 1155HelicalSequence analysisAdd BLAST25
Transmembranei1167 – 1184HelicalSequence analysisAdd BLAST18
Transmembranei1196 – 1213HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO01795.
PeptideAtlasiO01795.

Expressioni

Gene expression databases

BgeeiWBGene00018771.

Interactioni

Protein-protein interaction databases

STRINGi6239.F53G12.3.

Structurei

3D structure databases

ProteinModelPortaliO01795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini825 – 860EF-handInterPro annotationAdd BLAST36
Domaini861 – 896EF-handInterPro annotationAdd BLAST36
Domaini1217 – 1324FAD-binding FR-typeInterPro annotationAdd BLAST108

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0039. Eukaryota.
ENOG410XNZY. LUCA.
GeneTreeiENSGT00550000074350.
HOGENOMiHOG000231774.
InParanoidiO01795.
KOiK13411.
OMAiNENSISW.
OrthoDBiEOG091G00PO.
PhylomeDBiO01795.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.640.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR013112. FAD-bd_8.
IPR017927. Fd_Rdtase_FAD-bd.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF03098. An_peroxidase. 1 hit.
PF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF48113. SSF48113. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
PS51384. FAD_FR. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O01795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAENFYNVN NFQSLPLEIK VQFSKETLFS ALQQEAETQR YDGWYNNLAN
60 70 80 90 100
SEWGSAGSRL HRDARSYYSD GVYSVNNSLP SARELSDILF KGESGIPNTR
110 120 130 140 150
GCTTLLAFFS QVVAYEIMQS NGVSCPLETL KIQVPLCDNV FDNECEGKTT
160 170 180 190 200
IPFYRAKYDK ATGNGLNSPR EQINERTSWI DGSFIYGTTQ PWVSALRSFK
210 220 230 240 250
QGRLAEGVPG YPPLNNPHIP LNNPAPPQVH RLMSPDRLFM LGDSRVNENP
260 270 280 290 300
GLLSFGLILF RWHNYNANQI YREHPDWTDE QIFQAARRLV IASMQKIIAY
310 320 330 340 350
DFVPGLLGED VRLSNYTKYM PHVPPGISHA FGAAAFRFPH SIVPPAMLLR
360 370 380 390 400
KRGNKCEFRT EVGGYPALRL CQNWWNAQDI VKEYSVDEII LGMASQIAER
410 420 430 440 450
DDNIVVEDLR DYIFGPMHFS RLDVVASSIM RGRDNGVPPY NELRRTFGLA
460 470 480 490 500
PKTWETMNED FYKKHTAKVE KLKELYGGNI LYLDAYVGGM LEGGENGPGE
510 520 530 540 550
MFKEIIKDQF TRIRDGDRFW FENKLNRLFT DEEVQMIHSI TLRDIIKATT
560 570 580 590 600
DIDETMLQKD VFFFKEGDPC PQPFQVNTIG LEPCAPLIQS TYWDDNDTTY
610 620 630 640 650
IYTLIGLACI PLICYSIGHY MVERRIRIGH NSACDSLTTD FSTESPKVNV
660 670 680 690 700
YKVNALEWLQ EEYIRQVRIE IENTTLTVKK PRGGILRKIR FETGQKIEVF
710 720 730 740 750
HSIPNPSAMH GPFVLLSQKN NHHLVIRLSS DRDLSKFLDQ IRQAASGINA
760 770 780 790 800
EVIIKDEENS ILLSQAITKE RRQDRLDLFF REAYAKAFND SELQDSETSF
810 820 830 840 850
DSSNDDILNE TISREELASA MGMKANNEFV KRMFAMTAKH NEDSLSFNEF
860 870 880 890 900
LTVLREFVNA PQKQKLQTLF KMCDLEGKNK VLRKDLAELV KSLNQTAGVH
910 920 930 940 950
ITESVQLRLF NDVLHKSGVS DDAEYLTCNN FDALFSEISD VQPIGLPFNR
960 970 980 990 1000
KNYNSHIKEP SCHTSFPIVD HSTPAPLSLI QRICAFLETY RQHVFIIFCF
1010 1020 1030 1040 1050
VAINIVLFFE LFWHSRYLNE DRDLRRVMGA GIAITLSSAG ALSFCMALIL
1060 1070 1080 1090 1100
LTVCRNIITL LRETVIAQYI PFDSAIAFHK IVALFTLFWS TLHTIGHCVN
1110 1120 1130 1140 1150
FYHVGTQSDR GLACLFQETF FGSDVVPTLS YWFYGTITGL TGIGLVIVMS
1160 1170 1180 1190 1200
IIYVFALPKF TRRAYHAFRL THLLNIGFYA LTILHGLPSL FGSPKFGYYV
1210 1220 1230 1240 1250
VGPIVLFVID RIIGLMQYYK SLDIAHAEIL PSDIIYIEYR RPREFEYKSG
1260 1270 1280 1290 1300
QWITVSSPSI SCTFNESHAF SIASSPQDEN MKLYIKAVGP WTWKLRSELI
1310 1320 1330 1340 1350
RSLNTGSPFP LIHMKGPYGD GNQEWMNYEV AIMVGAGIGV TPYASTLVDL
1360 1370 1380 1390 1400
VQKTSSDSFH RVRCRKVYFL WVCSSHKNFE WFVDMLKNVE NQAKPGILET
1410 1420 1430 1440 1450
HIFVTQMFHK FDLRTTMLYI CEKHFRATNS GISMFTGLHA KNHFGRPNFK
1460 1470 1480 1490 1500
AFFQFIQSEH KEQSEIGVFS CGPVNLNESI AEGCADANRQ RDAPSFAHRF

ETF
Length:1,503
Mass (Da):171,593
Last modified:October 1, 2001 - v2
Checksum:iB429705C221711DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CCD71702.1.
RefSeqiNP_490684.1. NM_058283.1.
UniGeneiCel.32759.

Genome annotation databases

EnsemblMetazoaiF53G12.3; F53G12.3; WBGene00018771.
GeneIDi186188.
KEGGicel:CELE_F53G12.3.
UCSCiF53G12.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CCD71702.1.
RefSeqiNP_490684.1. NM_058283.1.
UniGeneiCel.32759.

3D structure databases

ProteinModelPortaliO01795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F53G12.3.

Proteomic databases

PaxDbiO01795.
PeptideAtlasiO01795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF53G12.3; F53G12.3; WBGene00018771.
GeneIDi186188.
KEGGicel:CELE_F53G12.3.
UCSCiF53G12.3. c. elegans.

Organism-specific databases

CTDi186188.
WormBaseiF53G12.3; CE24999; WBGene00018771; duox-2.

Phylogenomic databases

eggNOGiKOG0039. Eukaryota.
ENOG410XNZY. LUCA.
GeneTreeiENSGT00550000074350.
HOGENOMiHOG000231774.
InParanoidiO01795.
KOiK13411.
OMAiNENSISW.
OrthoDBiEOG091G00PO.
PhylomeDBiO01795.

Enzyme and pathway databases

ReactomeiR-CEL-209968. Thyroxine biosynthesis.

Gene expression databases

BgeeiWBGene00018771.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.640.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR013112. FAD-bd_8.
IPR017927. Fd_Rdtase_FAD-bd.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF03098. An_peroxidase. 1 hit.
PF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF48113. SSF48113. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
PS51384. FAD_FR. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO01795_CAEEL
AccessioniPrimary (citable) accession number: O01795
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.