SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O01761

- UNC89_CAEEL

UniProt

O01761 - UNC89_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Muscle M-line assembly protein unc-89
Gene
unc-89, C09D1.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Structural component of the muscle M-line. Myofilament lattice assembly begins with positional cues laid down in the basement membrane and muscle cell membrane. UNC-89 responds to these signals, localizes, and then participates in assembling an M-line.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei6749 – 67491Proton acceptor By similarity
Active sitei7901 – 79011Proton acceptor By similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. Rho GTPase binding Source: WormBase
  3. Rho guanyl-nucleotide exchange factor activity Source: WormBase
  4. phosphatase binding Source: WormBase
  5. protein kinase activity Source: InterPro

GO - Biological processi

  1. myosin filament assembly Source: WormBase
  2. regulation of Rho GTPase activity Source: GOC
  3. skeletal muscle myosin thick filament assembly Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Muscle protein, Transferase

Enzyme and pathway databases

SignaLinkiO01761.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Muscle M-line assembly protein unc-89
Alternative name(s):
Uncoordinated protein 89
Gene namesi
Name:unc-89
ORF Names:C09D1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiC09D1.1a; CE30426; WBGene00006820; unc-89.
C09D1.1b; CE34251; WBGene00006820; unc-89.
C09D1.1c; CE34252; WBGene00006820; unc-89.
C09D1.1d; CE37701; WBGene00006820; unc-89.
C09D1.1e; CE37702; WBGene00006820; unc-89.
C09D1.1f; CE37703; WBGene00006820; unc-89.
C09D1.1g; CE37704; WBGene00006820; unc-89.

Subcellular locationi

GO - Cellular componenti

  1. A band Source: WormBase
  2. M band Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 80818081Muscle M-line assembly protein unc-89
PRO_0000072704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi568 ↔ 621 Reviewed prediction
Disulfide bondi2582 ↔ 2635 Reviewed prediction
Disulfide bondi2908 ↔ 2964 Reviewed prediction
Disulfide bondi3015 ↔ 3065 Reviewed prediction
Disulfide bondi3707 ↔ 3759 Reviewed prediction
Disulfide bondi3838 ↔ 3890 Reviewed prediction
Disulfide bondi5298 ↔ 5350 Reviewed prediction
Disulfide bondi5404 ↔ 5456 Reviewed prediction
Disulfide bondi5508 ↔ 5560 Reviewed prediction
Disulfide bondi5616 ↔ 5669 Reviewed prediction
Disulfide bondi5836 ↔ 5888 Reviewed prediction
Disulfide bondi5946 ↔ 5998 Reviewed prediction
Disulfide bondi7549 ↔ 7600 Reviewed prediction

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO01761.
PRIDEiO01761.

Expressioni

Tissue specificityi

Localizes to the middle of A-bands. Expression is seen in body-wall, pharyngeal muscle and few muscle cells of the tail.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi37462. 2 interactions.
IntActiO01761. 11 interactions.
MINTiMINT-1090274.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi349 – 3579
Beta strandi365 – 3728
Beta strandi375 – 3817
Beta strandi384 – 3874
Beta strandi395 – 4006
Beta strandi402 – 4065
Beta strandi412 – 4165
Beta strandi431 – 4344
Helixi437 – 44711
Helixi451 – 4544

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FHONMR-A341-458[»]
ProteinModelPortaliO01761.
SMRiO01761. Positions 341-458.

Miscellaneous databases

EvolutionaryTraceiO01761.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 12765SH3
Add
BLAST
Domaini152 – 330179DH
Add
BLAST
Domaini342 – 498157PH
Add
BLAST
Domaini547 – 63387Ig-like C2-type 1
Add
BLAST
Domaini648 – 73689Ig-like C2-type 2
Add
BLAST
Domaini748 – 83891Ig-like C2-type 3
Add
BLAST
Domaini946 – 103388Ig-like C2-type 4
Add
BLAST
Domaini1044 – 113289Ig-like C2-type 5
Add
BLAST
Domaini1140 – 122788Ig-like C2-type 6
Add
BLAST
Domaini1375 – 1475101RCSD 1
Add
BLAST
Domaini1479 – 1585107RCSD 2
Add
BLAST
Domaini1597 – 169599RCSD 3
Add
BLAST
Domaini1700 – 1799100RCSD 4
Add
BLAST
Domaini1982 – 206786Ig-like C2-type 7
Add
BLAST
Domaini2071 – 216393Ig-like C2-type 8
Add
BLAST
Domaini2171 – 226191Ig-like C2-type 9
Add
BLAST
Domaini2269 – 235991Ig-like C2-type 10
Add
BLAST
Domaini2367 – 245589Ig-like C2-type 11
Add
BLAST
Domaini2463 – 2564102Ig-like C2-type 12
Add
BLAST
Domaini2563 – 265189Ig-like C2-type 13
Add
BLAST
Domaini2657 – 274690Ig-like C2-type 14
Add
BLAST
Domaini2754 – 2858105Ig-like C2-type 15
Add
BLAST
Domaini2887 – 298094Ig-like C2-type 16
Add
BLAST
Domaini2994 – 308188Ig-like C2-type 17
Add
BLAST
Domaini3087 – 318397Ig-like C2-type 18
Add
BLAST
Domaini3189 – 328092Ig-like C2-type 19
Add
BLAST
Domaini3286 – 337691Ig-like C2-type 20
Add
BLAST
Domaini3384 – 346986Ig-like C2-type 21
Add
BLAST
Domaini3482 – 357291Ig-like C2-type 22
Add
BLAST
Domaini3580 – 366788Ig-like C2-type 23
Add
BLAST
Domaini3686 – 377792Ig-like C2-type 24
Add
BLAST
Domaini3817 – 390892Ig-like C2-type 25
Add
BLAST
Domaini3920 – 400990Ig-like C2-type 26
Add
BLAST
Domaini4018 – 410689Ig-like C2-type 27
Add
BLAST
Domaini4109 – 420193Ig-like C2-type 28
Add
BLAST
Domaini4212 – 429786Ig-like C2-type 29
Add
BLAST
Domaini4302 – 438786Ig-like C2-type 30
Add
BLAST
Domaini4400 – 448586Ig-like C2-type 31
Add
BLAST
Domaini4489 – 458092Ig-like C2-type 32
Add
BLAST
Domaini4588 – 467891Ig-like C2-type 33
Add
BLAST
Domaini4681 – 477191Ig-like C2-type 34
Add
BLAST
Domaini4873 – 496189Ig-like C2-type 35
Add
BLAST
Domaini4965 – 505793Ig-like C2-type 36
Add
BLAST
Domaini5067 – 516094Ig-like C2-type 37
Add
BLAST
Domaini5171 – 526090Ig-like C2-type 38
Add
BLAST
Domaini5277 – 536690Ig-like C2-type 39
Add
BLAST
Domaini5383 – 547290Ig-like C2-type 40
Add
BLAST
Domaini5487 – 557892Ig-like C2-type 41
Add
BLAST
Domaini5595 – 568591Ig-like C2-type 42
Add
BLAST
Domaini5701 – 579090Ig-like C2-type 43
Add
BLAST
Domaini5815 – 590490Ig-like C2-type 44
Add
BLAST
Domaini5925 – 601490Ig-like C2-type 45
Add
BLAST
Domaini6038 – 613093Ig-like C2-type 46
Add
BLAST
Domaini6150 – 623990Ig-like C2-type 47
Add
BLAST
Domaini6278 – 637497Fibronectin type-III 1
Add
BLAST
Domaini6413 – 650290Ig-like C2-type 48
Add
BLAST
Domaini6507 – 659690Ig-like C2-type 49
Add
BLAST
Domaini6592 – 6878287Protein kinase 1
Add
BLAST
Domaini7528 – 761790Ig-like C2-type 50
Add
BLAST
Domaini7623 – 772199Fibronectin type-III 2
Add
BLAST
Domaini7785 – 8035251Protein kinase 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi936 – 9416Poly-Glu
Compositional biasi1272 – 131544Thr-rich
Add
BLAST
Compositional biasi1372 – 1886515Lys-rich
Add
BLAST
Compositional biasi7125 – 71284Poly-Gln

Sequence similaritiesi

Contains 1 PH domain.
Contains 4 RCSD domains.
Contains 1 SH3 domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00750000118717.
InParanoidiO01761.
OMAiDQAEYKC.
OrthoDBiEOG74BJR3.
PhylomeDBiO01761.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.10. 55 hits.
InterProiIPR000219. DH-domain.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR007850. RCSD.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 51 hits.
PF00069. Pkinase. 2 hits.
PF05177. RCSD. 6 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 25 hits.
SM00408. IGc2. 24 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 50 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform b (identifier: O01761-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASRRQKQFD RKYSSYRKFT ATEDVNYSTH SSRSSYRSES LTSRTDGRGR     50
STSSEIIAGS ESRSYPVYIA IQDYTPDKED VEAIPLEQGQ IVEVLDKKNS 100
VRWLVRTKAR PPRSGWVPGS YFETPTEFYK QRRRTREIEN VSLSDEQAAL 150
VKRDQVYHEL LRSEEEFVSS LRTCVDDYIK VLDDPEVPEA VKKNREELTL 200
NIPELYNFHA NVMLKGLNYY SDDPGKVGQT FVRLEKDFES HVEFYKQYAD 250
TLKLLEEPEI KRFFEGLSAK NDAGASSFVD HVKEIADRMV QYQNYFKEFV 300
KYSARAHGSS KSIQKALELV TTIPQRVHDL EFTNNLKQHP GDTGKLGRII 350
RHDAFQVWEG DEPPKLRYVF LFRNKIMFTE QDASTSPPSY THYSSIRLDK 400
YNIRQHTTDE DTIVLQPQEP GLPSFRIKPK DFETSEYVRK AWLRDIAEEQ 450
EKYAAERDAI SMTATSEMTA SSVDFDMNAS DQQSEFSEWS GSRKSSLFPG 500
PEEGGPPRKK VKSPPVISPT GSSTSIYSGG SSSIDWTTTG TTLEMQGTRV 550
TRTQYGFRTL QESSAKMCLK VTGYPLPDIT WYKDDVQLHE DERHTFYSDE 600
DGFFAMTIDP VQVTDTGRYT CMATNEYGQA STSAFFRVLK VEKEAAPPAF 650
VTKLRDKECK EGDVIDFECE VEGWPEPELV WLVDDQPLRP SHDFRLQYDG 700
QTAKLEIRDA QPDDTGVYTV KIQNEFGSIE SKAELFVQAD PDKNHVAPEF 750
QATIEYVECD EGEEVRFKSV ITGDPNPEII WFINGKPLSE SEKVKFISED 800
GICILTIKDV TRHFDGMVTC QGSNRLGSAS CDGRLKVRVP PAPPTFNKPL 850
EDKTVQEKST VVFEVDVSGW PEPTLTFTLC GKELKNGEEG VEIVGHDGFY 900
RISIPNTSMD KHDGEIVAKA QNEHGTAESR ARLTVEQEEE ESRSAPTFLK 950
DIEDQTVKTG EFAVFETTVR GNPNPEVTWF INGHKMDQGS PGVKIEAHNH 1000
DHKLTIDSAQ YAGTVLCRAE NAVGRFETKA RLVVLAPEKQ KKPPKFVEIL 1050
VDKTETVDNT VVFEVRVEGE PKPTVTWYLK GEELKQSDRV EIREFDGSIK 1100
ISIKNIKIED AGEIRAVATN SEGSDETKAK LTVQKKPFAP EFDLRPVSLT 1150
VEKGSEAVFS AHAFGIPLPT YEWSVNGRKV RDGQEGARVT RDESTVDGAS 1200
ILTIDTATYY SEVNHLTISV VAENTLGAEE TGAQLTIEPK KESVVVEKQD 1250
LSSSEVQKEI AQQVKEASPE ATTTITMETS LTSTKTTTMS TTEVTSTVGG 1300
VTVETKESES ESATTVIGGG SGGVTEGSIS VSKIEVVSKT DSQTDVREGT 1350
PKRRVSFAEE ELPKEVIDSD RKKKKSPSPD KKEKSPEKTE EKPASPTKKT 1400
GEEVKSPKEK SPASPTKKEK SPAAEEVKSP TKKEKSPSSP TKKEKSPSSP 1450
TKKTGDEVKE KSPPKSPTKK EKSPEKPEDV KSPVKKEKSP DATNIVEVSS 1500
ETTIEKTETT MTTEMTHESE ESRTSVKKEK TPEKVDEKPK SPTKKDKSPE 1550
KSITEEIKSP VKKEKSPEKV EEKPASPTKK EKSPEKPASP TKKSENEVKS 1600
PTKKEKSPEK SVVEELKSPK EKSPEKADDK PKSPTKKEKS PEKSATEDVK 1650
SPTKKEKSPE KVEEKPTSPT KKESSPTKKT DDEVKSPTKK EKSPQTVEEK 1700
PASPTKKEKS PEKSVVEEVK SPKEKSPEKA EEKPKSPTKK EKSPEKSAAE 1750
EVKSPTKKEK SPEKSAEEKP KSPTKKESSP VKMADDEVKS PTKKEKSPEK 1800
VEEKPASPTK KEKTPEKSAA EELKSPTKKE KSPSSPTKKT GDESKEKSPE 1850
KPEEKPKSPT PKKSPPGSPK KKKSKSPEAE KPPAPKLTRD LKLQTVNKTD 1900
LAHFEVVVEH ATECKWFLDG KEITTAQGVT VSKDDQFEFR CSIDTTMFGS 1950
GTVSVVASNA AGSVETKTEL KVLETPKETK KPEFTDKLRD MEVTKGDTVQ 2000
MDVIALHSPL YKWYQNGNLL EDGKNGVTIK NEENKSSLII PNAQDSGKIT 2050
VEASNEVGSS ESSAQLTVNP PSTTPIVVDG PKSVTIKETE TAEFKATISG 2100
FPAPTVKWTI NEKIVEESRT ITTIKTEDVY TLKISNAKIE QTGTVKVTAQ 2150
NSAGQDSKQA DLKVEPNVKA PKFKSQLTDK VADEGEPLRW NLELDGPSPG 2200
TEVSWLLNGQ PLTKSDTVQV VDHGDGTYHV TIAEAKPEMS GTLTAKAKNA 2250
AGECETSAKV TVNGGNKKPE FVQAPQNHET TLEESVKFSA IVTGKPMPNV 2300
TWYLNNKKLI QSEEVKVKYV HETGKTSIRI QKPLMEHNGT IRVEAENVSG 2350
KVQATAQLKV DKKTEVPKFT TNMDDRQVKE GEDVKFTANV EGYPEPSVAW 2400
TLNGEPVSKH PNITVTDKDG EHTIEISAVT PEQAGELSCE ATNPVGSKKR 2450
DVQLAVKKVG DAPTFAKNLE DRLITEGELT LMDAKLNIVK PKPKITWLKD 2500
GVEITSDGHY KIVEEEDGSL KLSILQTKLE DKGRITIKAE SEFGVAECSA 2550
SLGVVKGRPM AKPAFQSDIA PINLTEGDTL ECKLLITGDP TPFVKWYIGT 2600
QLVCATEDTE ISNANGVYTM KIHGVTADMT GKIKCVAYNK AGEVSTEGPL 2650
KVVAPIPVEF ETSLCDATCR EGDTLKLRAV LLGEPEPVVS WYVNGKKLEE 2700
SQNIKIHSEK GTYTVTIKDI TCDYSGQVVC EAINEYGKAT SEATLLVLPR 2750
GEPPDFLEWL SNVRARTGTK VVHKVVFTGD PKPSLTWYIN NKEILNSDLY 2800
TIVTDDKTST LTINSFNPDV HVGEIICKAE NDAGEVSCTA NMITYTSDMF 2850
SESESEAQAE EFVGDDLTED ESLREEMHRT PTPVMAPKFI TKIKDTKAKK 2900
GHSAVFECVV PDTKGVCCKW LKDGKEIELI ARIRVQTRTG PEGHITQELV 2950
LDNVTPEDAG KYTCIVENTA GKDTCEATLT VIESLEKKSE KKAPEFIVAL 3000
QDKTTKTSEK VVLECKVIGE PKPKVSWLHD NKTITQESIT VESVEGVERV 3050
TITSSELSHQ GKYTCIAENT EGTSKTEAFL TVQGEAPVFT KELQNKELSI 3100
GEKLVLSCSV KGSPQPHVDF YSFSETTKVE TKITSSSRIA IEHDQTNTHW 3150
RMVISQITKE DIVSYKAIAT NSIGTATSTS KITTKVEAPV FEQGLKKTSV 3200
KEKEEIKMEV KVGGSAPDVE WFKDDKPVSE DGNHEMKKNP ETGVFTLVVK 3250
QAATTDAGKY TAKASNPAGT AESSAEAEVT QSLEKPTFVR ELVTTEVKIN 3300
ETATLSVTVK GVPDPSVEWL KDGQPVQTDS SHVIAKVEGS GSYSITIKDA 3350
RLEDSGKYAC RATNPAGEAK TEANFAVVKN LVPPEFVEKL SPLEVKEKES 3400
TTLSVKVVGT PEPSVEWFKD DTPISIDNVH VIQKQTAVGS FSLTINDARQ 3450
GDVGIYSCRA RNEAGEALTT ANFGIIRDSI PPEFTQKLRP LEVREQETLD 3500
LKVTVIGTPV PNVEWFKDDK PINIDNSHIF AKDEGSGHHT LTIKQARGED 3550
VGVYTCKATN EAGEAKTTAN MAVQEEIEAP LFVQGLKPYE VEQGKPAELV 3600
VRVEGKPEPE VKWFKDGVPI AIDNQHVIEK KGENGSHTLV IKDTNNADFG 3650
KYTCQATNKA GKDETVGELK IPKYSFEKQT AEEVKPLFIE PLKETFAVEG 3700
DTVVLECKVN KESHPQIKFF KNDQPVEIGQ HMQLEVLEDG NIKLTIQNAK 3750
KEDVGAYRCE AVNVAGKANT NADLKIQFAA KVEEHVTDES GQLEEIGQFE 3800
TVGDTASSKT DTGRGAPEFV ELLRSCTVTE KQQAILKCKV KGEPRPKIKW 3850
TKEGKEVEMS ARVRAEHKDD GTLTLTFDNV TQADAGEYRC EAENEYGSAW 3900
TEGPIIVTLE GAPKIDGEAP DFLQPVKPAV VTVGETAVLE GKISGKPKPS 3950
VKWYKNGEEL KPSDRVKIEN LDDGTQRLTV TNAKLDDMDE YRCEASNEFG 4000
DVWSDVTLTV KEPAQVAPGF FKELSAIQVK ETETAKFECK VSGTKPDVKW 4050
FKDGTPLKED KRVHFESTDD GTQRLVIEDS KTDDQGNYRI EVSNDAGVAN 4100
SKVPLTVVPS ETLKIKKGLT DVNVTQGTKI LLSVEVEGKP KTVKWYKGTE 4150
TVTSSQTTKI VQVTESEYKL EIESAEMSDT GAYRVVLSTD SFSVESSATV 4200
TVTKAAEKIS LPSFKKGLAD QSVPKGTPLV LEVEIEGKPK DVKWYKNGDE 4250
IKDGKVEDLG NGKYRLTIPD FQEKDVGEYS VTAANEAGEI ESKAKVNVSA 4300
KPEIVSGLVP TTVKQGETAT FNVKVKGPVK GVKWYKNGKE IPDAKTKDNG 4350
DGSYSLEIPN AQVEDAADYK VVVSNDAGDA DSSAALTVKL ADDGKDKVKP 4400
EIVSGLIPTT VKQGETATFN VKVKGPVKQV KWYKNGKEIP NAKAKDNGDG 4450
SYSLEIPNAQ LDDTADYKVV VSNDAGDADS SAALTVKLPG IAIVKGLEDA 4500
EVPKGKKAVL QVETNKKPKE IKWYKNGKEI TPSDKAQPGS DGDNKPQLVI 4550
PDAGDDDAAE YKVVLTDEDG NTADSSCALT VKLPAKEPKI IKGLEDQVVS 4600
IGSPIKLEIE TSGSPKTVKW YKNGKELPGA AAKTIKIQKI DDNKYVLEIP 4650
SSVVEDTGDY KVEVANEAGS ANSSGKITVE PKITFLKPLK DQSITEGENA 4700
EFSVETNTKP RIVKWYKNGQ EIKPNSRFII EQKTDTKYQL VIKNAVRDDA 4750
DTYKIVLENT AGEAESSAQL TVKKAKAGLC KIVKGLEDQV VAKGAKMVFE 4800
VKIQGEPEDV RWLRDANVIS AGANAIIEKI DDTTYRLIIP SADLKDAGEY 4850
TVEVINESGK AKSDAKGEVD EKPEIVRGLE NIEIPEGDDD VFKVEVSAPV 4900
RQVKWYKNDQ EIKPNSHLEA KKIGPKKYEL AINRAQLDDG ADYKVVLSNA 4950
AGDCDSSAAL TVVKPNVLKI VDGLKDVDVE EPQPVELKVK VEGIPKVIKW 5000
YKNGQELKPD ADGFKFEEKP ESGEFSLTIP SSKKSDGGAY RVVLGNDKGE 5050
VYSGSVVHVK SAKSSEPTSG ANFLSPLKDT EVEEGDMLTL QCTIAGEPFP 5100
EVIWEKDGVV LQKDDRITMR VALDGTATLR IRSAKKSDIG QYRVTAKNEA 5150
GSATSDCKVT VTEQGEQPSK PKFVIPLKTG AALPGDKKEF NVKVRGLPKP 5200
TLQWFLNGIP IKFDDRITLD DMADGNYCLT IRDVREEDFG TLKCIAKNEN 5250
GTDETVCEFQ QGAGHDDGSR DDLRYPPRFN VPLWDRRIPV GDPMFIECHV 5300
DANPTAEVEW FKDGKKIEHT AHTEIRNTVD GACRIKIIPF EESDIGVYMC 5350
VAVNELGQAE TQATYQVEIL EHVEEEKRRE YAPKINPPLE DKTVNGGQPI 5400
RLSCKVDAIP RASVVWYKDG LPLRADSRTS IQYEEDGTAT LAINDSTEED 5450
IGAYRCVATN AHGTINTSCS VNVKVPKQEV KKEGEEPFFT KGLVDLWADR 5500
GDSFTLKCAV TGDPFPEIKW YRNGQLLRNG PRTVIETSPD GSCSLTVNES 5550
TMSDEGIYRC EAENAHGKAK TQATAHVQMA LGKTEKPKMD EGKPPKFILE 5600
LSDMSVSLGN VIDLECKVTG LPNPSVKWSK DGGPLIEDSR FEWSNEASKG 5650
VYQLRIKNAT VHDEGTYRCV ATNENGSATT KSFVRMDDGL GSGVVTASQP 5700
PRFTLKMGDV RTTEGQPLKL ECKVDASPLP EMVWYKDGAI VTPSDRIQIS 5750
LSPDGVATLL IPSCVYDDDG IYRVIATNPS GTAQDKGTAT VKKLPRDSGA 5800
RRSADRDVFD ANKAPKLMEP LENIRIPEKQ SFRLRCKFSG DPKPTIKWFK 5850
DGERVFPYGR LQLIESPDGV CELVVDSATR QDAGGYRCVA ENTYGSARTS 5900
CDVNVIRGDR KPRDIDSSIR EGKAPGFTTP LTIRRAKPGD SVTFECLPFG 5950
NPFPSIKWLK DGLELFSDEK IKMEAAADGT QRLILSDVTF LSEGYFRCVA 6000
TNEHGTASTK AELVIEGDRT IGSRPLPEVN GEPEECKPRI RRGLYNMSIH 6050
EGNVVEMIVC ATGIPTPTVK WYKDGQEIVG DGPDGKRVIF TDERGIHHLV 6100
IVNASPDDEG EYSLEATNKL GSAKTEGSLN IIRPRHIADA DERGGMPFPP 6150
GFVRQLKNKH VFNHMPTIFD CLVVGHPAPE VEWFHNGKKI VPGGRIKIQS 6200
CGGGSHALII LDTTLEDAGE YVATAKNSHG SASSSAVLDV TVPFLDSIKF 6250
NGEIDVTPYL TEEYGFKKLN TASLPTPPDR GPFIKEVTGH YLTLSWIPTK 6300
RAPPRYPQVT YVIEIRELPE KQWSLLEYNI PEPVCKVRNL ELGKSYQFRV 6350
RAENIYGISD PSPASPPSRL MAPPQPVFDR RTNKVIPLLD PYAEKALDMR 6400
YSEQYACAPW FSPGVVEKRY CAENDTLTIV LNVSGFPDPD IKWKFRGWDI 6450
DTSSPTSKCK VYTYGGSETT LAITGFSKEN VGQYQCFAKN DYGDAQQNIM 6500
VDLATRPNFI QPLVNKTFSS AQPMRMDVRV DGEPFPELKW MKEWRPIVES 6550
SRIKFVQDGP YLCSLIINDP MWRDSGIYSC VAVNDAGQAT TSCTVTVEAE 6600
GDYNDVELPR RRVTIESRRV RELYEISEKD EKLAAEGAPF RVKEKATGRE 6650
FLAQLRPIDD ALMRHVDIHN SLDHPGIVQM HRVLRDEKLA LVVFDNANST 6700
IDGLSSLAHP GVEIAEPKGV NRETCVRVFV RQLLLALKHM HDLRIAHLDL 6750
RPETILLQDD KLKLADFGQA RRLLRGLITG EIKGSPEFVS PEIVRSYPLT 6800
LATDMWSTGV LTYVLLTGLS PFHGDNDNET LANVDSCQFD SSPLGNFSYD 6850
AGDFVKKLLT EIPVSRLTVD EALDHPWIND EKLKTEPLSA DTLREFKYQH 6900
KWLERRVFVQ QTPSEQILEA ILGPATAQAQ QNAPVAPEGR RPAEIYDYLR 6950
IQPKKPPPTV EYVPQPRKEH PPFIDEFGQL IDGDAFDRPE GTGFEGPHRQ 7000
PPQIPPQPQR PNQAAHDSRR HEQQPQHQGQ PQRIPVDQYG RPLVDPRYLN 7050
DPSHRPSSLD DAPFYVDKYG NPVHFDKYGR PMAPQNLEKR KLIPQDKGET 7100
PSHSKKEKTQ HPVATPILAS PGGDQQQQKI PMRMIRGERR EIEEEIANRI 7150
LSDISEEGSI AGSLASLEDF EIPKDFQVEA SEPSTPTLTP EVTIRETIPK 7200
PTPSPTSPQK SPVPQPQGLL IPAKVTYSDS ILAGLPAADK KVLEDAENDP 7250
SIPVGAPLFL EGLHGSDLTI DTTSASGLIK VTSPAINLSP NPKSPRRSTP 7300
GTKSPVVLSP RQEHSMEVLI ATKRGKPGFL PPGELAEDID DEDAFMDDRK 7350
KQVKPKDHDG ENDFKDEKER LEKDKNRRTV NLDDLDKYRP SAFYKDDSDF 7400
GHPGYDIDAT PWDSHYQIGP DTYLMAARGA AFNSRVRNYR EELFGMGAPT 7450
VKQGFLGVRN RDITVRERRR YTDILRETTQ GLEPKSHEQS TALLQKAPSA 7500
TAIERIKADI EKVTPCATKK NDDGTFAPIF TARLRDVYLR KNQPAIFECA 7550
VSASPAPKVT WDFQGKILES NDRVTIEQDN NVARLILNHA APYDLGEYVC 7600
TAINEYGTDK SSCRLISGET PSRPGRPEAE LSSDTEIFIQ WEAPEGPTYL 7650
EGITYRLEYR VAGPNDHGDP WITVSEKIDD ESVIVKHLSP LGIYQFRVTA 7700
QNGFGLGLPS LSSRIVQTHG KGAPKLQIDV LKSEIRLNVV SMPQKSTNQL 7750
GGISEESEED SEARTANEDM KSNLQLQTDD PTGRFQIGGL KFKGRFSVIR 7800
DAVDSTTEGH AHCAVKIRHP SSEAISEYES LRDGQHENVQ RLIAAFNNSN 7850
FLYLLSERLY EDVFSRFVFN DYYTEEQVAL TMRQVTSALH FLHFKGIAHL 7900
DVNPHNIMFQ SKRSWVVKLV DFGRAQKVSG AVKPVDFDTK WASPEFHIPE 7950
TPVTVQSDMW GMGVVTFCLL AGFHPFTSEY DREEEIKENV INVKCDPNLI 8000
PVNASQECLS FATWALKKSP VRRMRTDEAL SHKFLSSDPS MVRRRESIKY 8050
SASRLRKLAA MIRQPTFSQP ISEELESKYG K 8081
Length:8,081
Mass (Da):894,252
Last modified:September 13, 2005 - v3
Checksum:i67C804953CF62228
GO
Isoform a (identifier: O01761-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     6633-8081: Missing.

Show »
Length:6,632
Mass (Da):731,685
Checksum:i262D3EDD62960E89
GO
Isoform c (identifier: O01761-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6688: Missing.
     6689-6696: LALVVFDN → MVRFTINC

Note: No experimental confirmation available.

Show »
Length:1,393
Mass (Da):156,297
Checksum:iF947C1BCE4EB9CE9
GO
Isoform d (identifier: O01761-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6685: Missing.
     6686-6696: DEKLALVVFDN → MFRLVEDCELC

Note: No experimental confirmation available.

Show »
Length:1,396
Mass (Da):156,671
Checksum:iF42D06301E7185C2
GO
Isoform e (identifier: O01761-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1880: Missing.
     6633-8081: Missing.

Note: No experimental confirmation available.

Show »
Length:5,992
Mass (Da):661,677
Checksum:i7E5F00BF18A251D4
GO
Isoform f (identifier: O01761-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1880: Missing.

Show »
Length:7,441
Mass (Da):824,244
Checksum:i4B102760FC1131D7
GO
Isoform g (identifier: O01761-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     6632-6695: Missing.
     7175-7186: DFQVEASEPSTP → VTEGDGCNMCGE
     7187-8081: Missing.

Note: No experimental confirmation available.

Show »
Length:7,122
Mass (Da):786,772
Checksum:iE0AADE021082BD5B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66886688Missing in isoform c.
VSP_015541Add
BLAST
Alternative sequencei1 – 66856685Missing in isoform d.
VSP_015542Add
BLAST
Alternative sequencei1241 – 1880640Missing in isoform e and isoform f.
VSP_015543Add
BLAST
Alternative sequencei6632 – 669564Missing in isoform g.
VSP_015544Add
BLAST
Alternative sequencei6633 – 80811449Missing in isoform a and isoform e.
VSP_015545Add
BLAST
Alternative sequencei6686 – 669611DEKLALVVFDN → MFRLVEDCELC in isoform d.
VSP_015546Add
BLAST
Alternative sequencei6689 – 66968LALVVFDN → MVRFTINC in isoform c.
VSP_015547
Alternative sequencei7175 – 718612DFQVE…EPSTP → VTEGDGCNMCGE in isoform g.
VSP_015548Add
BLAST
Alternative sequencei7187 – 8081895Missing in isoform g.
VSP_015549Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2137 – 21371A → P in AAB00542. 1 Publication
Sequence conflicti2245 – 22473AKA → PKP in AAB00542. 1 Publication
Sequence conflicti2258 – 22581A → P in AAB00542. 1 Publication
Sequence conflicti2284 – 22841E → G in AAB00542. 1 Publication
Sequence conflicti2297 – 22971M → I in AAB00542. 1 Publication
Sequence conflicti3531 – 35311A → G in AAB00542. 1 Publication
Sequence conflicti3884 – 38885DAGEY → RRRRI in AAB00542. 1 Publication
Sequence conflicti3929 – 39291A → V in AAB00542. 1 Publication
Sequence conflicti5134 – 51341A → P in AAB00542. 1 Publication
Sequence conflicti5145 – 51451T → S in AAB00542. 1 Publication
Sequence conflicti5185 – 51851G → A in AAB00542. 1 Publication
Sequence conflicti5199 – 51991K → N in AAB00542. 1 Publication
Sequence conflicti5202 – 52021L → F in AAB00542. 1 Publication
Sequence conflicti5213 – 52131F → L in AAB00542. 1 Publication
Sequence conflicti6178 – 61781A → G in AAB00542. 1 Publication
Sequence conflicti6268 – 62681K → E in AAB00542. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33058 Genomic DNA. Translation: AAB00542.1.
FO080458 Genomic DNA. Translation: CCD63864.1.
FO080458 Genomic DNA. Translation: CCD63865.1.
FO080458 Genomic DNA. Translation: CCD63866.1.
FO080458 Genomic DNA. Translation: CCD63867.1.
FO080458 Genomic DNA. Translation: CCD63868.1.
FO080458 Genomic DNA. Translation: CCD63869.1.
FO080458 Genomic DNA. Translation: CCD63870.1.
AY724774 mRNA. Translation: AAU21474.1.
AY714779 mRNA. Translation: AAU14146.1.
PIRiT29757.
RefSeqiNP_001020984.1. NM_001025813.1. [O01761-2]
NP_001020985.1. NM_001025814.2. [O01761-1]
NP_001020988.1. NM_001025817.2. [O01761-5]
NP_001020989.1. NM_001025818.1. [O01761-6]
NP_001020990.1. NM_001025819.1. [O01761-7]
UniGeneiCel.7125.

Genome annotation databases

EnsemblMetazoaiC09D1.1b; C09D1.1b; WBGene00006820. [O01761-1]
GeneIDi171990.
KEGGicel:CELE_C09D1.1.
UCSCiC09D1.1g. c. elegans. [O01761-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33058 Genomic DNA. Translation: AAB00542.1 .
FO080458 Genomic DNA. Translation: CCD63864.1 .
FO080458 Genomic DNA. Translation: CCD63865.1 .
FO080458 Genomic DNA. Translation: CCD63866.1 .
FO080458 Genomic DNA. Translation: CCD63867.1 .
FO080458 Genomic DNA. Translation: CCD63868.1 .
FO080458 Genomic DNA. Translation: CCD63869.1 .
FO080458 Genomic DNA. Translation: CCD63870.1 .
AY724774 mRNA. Translation: AAU21474.1 .
AY714779 mRNA. Translation: AAU14146.1 .
PIRi T29757.
RefSeqi NP_001020984.1. NM_001025813.1. [O01761-2 ]
NP_001020985.1. NM_001025814.2. [O01761-1 ]
NP_001020988.1. NM_001025817.2. [O01761-5 ]
NP_001020989.1. NM_001025818.1. [O01761-6 ]
NP_001020990.1. NM_001025819.1. [O01761-7 ]
UniGenei Cel.7125.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FHO NMR - A 341-458 [» ]
ProteinModelPortali O01761.
SMRi O01761. Positions 341-458.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 37462. 2 interactions.
IntActi O01761. 11 interactions.
MINTi MINT-1090274.

Protein family/group databases

MEROPSi I43.001.

Proteomic databases

PaxDbi O01761.
PRIDEi O01761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C09D1.1b ; C09D1.1b ; WBGene00006820 . [O01761-1 ]
GeneIDi 171990.
KEGGi cel:CELE_C09D1.1.
UCSCi C09D1.1g. c. elegans. [O01761-1 ]

Organism-specific databases

CTDi 3346201.
WormBasei C09D1.1a ; CE30426 ; WBGene00006820 ; unc-89.
C09D1.1b ; CE34251 ; WBGene00006820 ; unc-89.
C09D1.1c ; CE34252 ; WBGene00006820 ; unc-89.
C09D1.1d ; CE37701 ; WBGene00006820 ; unc-89.
C09D1.1e ; CE37702 ; WBGene00006820 ; unc-89.
C09D1.1f ; CE37703 ; WBGene00006820 ; unc-89.
C09D1.1g ; CE37704 ; WBGene00006820 ; unc-89.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00750000118717.
InParanoidi O01761.
OMAi DQAEYKC.
OrthoDBi EOG74BJR3.
PhylomeDBi O01761.

Enzyme and pathway databases

SignaLinki O01761.

Miscellaneous databases

EvolutionaryTracei O01761.
NextBioi 873555.
PROi O01761.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.10. 55 hits.
InterProi IPR000219. DH-domain.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR007850. RCSD.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 51 hits.
PF00069. Pkinase. 2 hits.
PF05177. RCSD. 6 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 2 hits.
SM00409. IG. 25 hits.
SM00408. IGc2. 24 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEi PS50010. DH_2. 1 hit.
PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 50 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains."
    Benian G.M., Tinley T.L., Tang X., Borodovsky M.
    J. Cell Biol. 132:835-848(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A), FUNCTION, TISSUE SPECIFICITY.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  3. "Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains."
    Small T.M., Gernert K.M., Flaherty D.B., Mercer K.B., Borodovsky M., Benian G.M.
    J. Mol. Biol. 342:91-108(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5922-7990 (ISOFORMS B/F), ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY.
    Strain: Bristol N2.
  4. "Functional diversity of PH domains: an exhaustive modelling study."
    Blomberg N., Nilges M.
    Fold. Des. 2:343-355(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 341-458.

Entry informationi

Entry nameiUNC89_CAEEL
AccessioniPrimary (citable) accession number: O01761
Secondary accession number(s): Q17362
, Q5W614, Q5W615, Q5W616, Q5W617, Q646H5, Q64EQ8, Q7Z119, Q7Z120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi