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O01761

- UNC89_CAEEL

UniProt

O01761 - UNC89_CAEEL

Protein

Muscle M-line assembly protein unc-89

Gene

unc-89

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 3 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Structural component of the muscle M-line. Myofilament lattice assembly begins with positional cues laid down in the basement membrane and muscle cell membrane. UNC-89 responds to these signals, localizes, and then participates in assembling an M-line.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei6749 – 67491Proton acceptorPROSITE-ProRule annotation
    Active sitei7901 – 79011Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. phosphatase binding Source: WormBase
    3. protein kinase activity Source: InterPro
    4. Rho GTPase binding Source: WormBase
    5. Rho guanyl-nucleotide exchange factor activity Source: WormBase

    GO - Biological processi

    1. myosin filament assembly Source: WormBase
    2. positive regulation of Rho GTPase activity Source: GOC
    3. skeletal muscle myosin thick filament assembly Source: WormBase

    Keywords - Molecular functioni

    Kinase, Muscle protein, Transferase

    Enzyme and pathway databases

    SignaLinkiO01761.

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Muscle M-line assembly protein unc-89
    Alternative name(s):
    Uncoordinated protein 89
    Gene namesi
    Name:unc-89
    ORF Names:C09D1.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiC09D1.1a; CE30426; WBGene00006820; unc-89.
    C09D1.1b; CE34251; WBGene00006820; unc-89.
    C09D1.1c; CE34252; WBGene00006820; unc-89.
    C09D1.1d; CE37701; WBGene00006820; unc-89.
    C09D1.1e; CE37702; WBGene00006820; unc-89.
    C09D1.1f; CE37703; WBGene00006820; unc-89.
    C09D1.1g; CE37704; WBGene00006820; unc-89.

    Subcellular locationi

    GO - Cellular componenti

    1. A band Source: WormBase
    2. M band Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 80818081Muscle M-line assembly protein unc-89PRO_0000072704Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi568 ↔ 621CuratedPROSITE-ProRule annotation
    Disulfide bondi2582 ↔ 2635PROSITE-ProRule annotation
    Disulfide bondi2908 ↔ 2964PROSITE-ProRule annotation
    Disulfide bondi3015 ↔ 3065CuratedPROSITE-ProRule annotation
    Disulfide bondi3707 ↔ 3759CuratedPROSITE-ProRule annotation
    Disulfide bondi3838 ↔ 3890PROSITE-ProRule annotation
    Disulfide bondi5298 ↔ 5350CuratedPROSITE-ProRule annotation
    Disulfide bondi5404 ↔ 5456PROSITE-ProRule annotation
    Disulfide bondi5508 ↔ 5560CuratedPROSITE-ProRule annotation
    Disulfide bondi5616 ↔ 5669CuratedPROSITE-ProRule annotation
    Disulfide bondi5836 ↔ 5888PROSITE-ProRule annotation
    Disulfide bondi5946 ↔ 5998CuratedPROSITE-ProRule annotation
    Disulfide bondi7549 ↔ 7600PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiO01761.
    PRIDEiO01761.

    Expressioni

    Tissue specificityi

    Localizes to the middle of A-bands. Expression is seen in body-wall, pharyngeal muscle and few muscle cells of the tail.2 Publications

    Interactioni

    Protein-protein interaction databases

    BioGridi37462. 2 interactions.
    IntActiO01761. 11 interactions.
    MINTiMINT-1090274.

    Structurei

    Secondary structure

    1
    8081
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi349 – 3579
    Beta strandi365 – 3728
    Beta strandi375 – 3817
    Beta strandi384 – 3874
    Beta strandi395 – 4006
    Beta strandi402 – 4065
    Beta strandi412 – 4165
    Beta strandi431 – 4344
    Helixi437 – 44711
    Helixi451 – 4544

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FHONMR-A341-458[»]
    ProteinModelPortaliO01761.
    SMRiO01761. Positions 341-458.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO01761.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 12765SH3CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini152 – 330179DHCuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini342 – 498157PHCuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini547 – 63387Ig-like C2-type 1Add
    BLAST
    Domaini648 – 73689Ig-like C2-type 2Add
    BLAST
    Domaini748 – 83891Ig-like C2-type 3Add
    BLAST
    Domaini946 – 103388Ig-like C2-type 4Add
    BLAST
    Domaini1044 – 113289Ig-like C2-type 5Add
    BLAST
    Domaini1140 – 122788Ig-like C2-type 6Add
    BLAST
    Domaini1375 – 1475101RCSD 1CuratedAdd
    BLAST
    Domaini1479 – 1585107RCSD 2CuratedAdd
    BLAST
    Domaini1597 – 169599RCSD 3CuratedAdd
    BLAST
    Domaini1700 – 1799100RCSD 4CuratedAdd
    BLAST
    Domaini1982 – 206786Ig-like C2-type 7Add
    BLAST
    Domaini2071 – 216393Ig-like C2-type 8Add
    BLAST
    Domaini2171 – 226191Ig-like C2-type 9Add
    BLAST
    Domaini2269 – 235991Ig-like C2-type 10Add
    BLAST
    Domaini2367 – 245589Ig-like C2-type 11Add
    BLAST
    Domaini2463 – 2564102Ig-like C2-type 12Add
    BLAST
    Domaini2563 – 265189Ig-like C2-type 13Add
    BLAST
    Domaini2657 – 274690Ig-like C2-type 14Add
    BLAST
    Domaini2754 – 2858105Ig-like C2-type 15Add
    BLAST
    Domaini2887 – 298094Ig-like C2-type 16Add
    BLAST
    Domaini2994 – 308188Ig-like C2-type 17Add
    BLAST
    Domaini3087 – 318397Ig-like C2-type 18Add
    BLAST
    Domaini3189 – 328092Ig-like C2-type 19Add
    BLAST
    Domaini3286 – 337691Ig-like C2-type 20Add
    BLAST
    Domaini3384 – 346986Ig-like C2-type 21Add
    BLAST
    Domaini3482 – 357291Ig-like C2-type 22Add
    BLAST
    Domaini3580 – 366788Ig-like C2-type 23Add
    BLAST
    Domaini3686 – 377792Ig-like C2-type 24Add
    BLAST
    Domaini3817 – 390892Ig-like C2-type 25Add
    BLAST
    Domaini3920 – 400990Ig-like C2-type 26Add
    BLAST
    Domaini4018 – 410689Ig-like C2-type 27Add
    BLAST
    Domaini4109 – 420193Ig-like C2-type 28Add
    BLAST
    Domaini4212 – 429786Ig-like C2-type 29Add
    BLAST
    Domaini4302 – 438786Ig-like C2-type 30Add
    BLAST
    Domaini4400 – 448586Ig-like C2-type 31Add
    BLAST
    Domaini4489 – 458092Ig-like C2-type 32Add
    BLAST
    Domaini4588 – 467891Ig-like C2-type 33Add
    BLAST
    Domaini4681 – 477191Ig-like C2-type 34Add
    BLAST
    Domaini4873 – 496189Ig-like C2-type 35Add
    BLAST
    Domaini4965 – 505793Ig-like C2-type 36Add
    BLAST
    Domaini5067 – 516094Ig-like C2-type 37Add
    BLAST
    Domaini5171 – 526090Ig-like C2-type 38Add
    BLAST
    Domaini5277 – 536690Ig-like C2-type 39Add
    BLAST
    Domaini5383 – 547290Ig-like C2-type 40Add
    BLAST
    Domaini5487 – 557892Ig-like C2-type 41Add
    BLAST
    Domaini5595 – 568591Ig-like C2-type 42Add
    BLAST
    Domaini5701 – 579090Ig-like C2-type 43Add
    BLAST
    Domaini5815 – 590490Ig-like C2-type 44Add
    BLAST
    Domaini5925 – 601490Ig-like C2-type 45Add
    BLAST
    Domaini6038 – 613093Ig-like C2-type 46Add
    BLAST
    Domaini6150 – 623990Ig-like C2-type 47Add
    BLAST
    Domaini6278 – 637497Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini6413 – 650290Ig-like C2-type 48Add
    BLAST
    Domaini6507 – 659690Ig-like C2-type 49Add
    BLAST
    Domaini6592 – 6878287Protein kinase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini7528 – 761790Ig-like C2-type 50Add
    BLAST
    Domaini7623 – 772199Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini7785 – 8035251Protein kinase 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi936 – 9416Poly-Glu
    Compositional biasi1272 – 131544Thr-richAdd
    BLAST
    Compositional biasi1372 – 1886515Lys-richAdd
    BLAST
    Compositional biasi7125 – 71284Poly-Gln

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 PH domain.CuratedPROSITE-ProRule annotation
    Contains 2 protein kinase domains.PROSITE-ProRule annotation
    Contains 4 RCSD domains.Curated
    Contains 1 SH3 domain.CuratedPROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000118717.
    InParanoidiO01761.
    OMAiDQAEYKC.
    OrthoDBiEOG74BJR3.
    PhylomeDBiO01761.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.10. 55 hits.
    InterProiIPR000219. DH-domain.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR007850. RCSD.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF07679. I-set. 51 hits.
    PF00069. Pkinase. 2 hits.
    PF05177. RCSD. 6 hits.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 2 hits.
    SM00409. IG. 25 hits.
    SM00408. IGc2. 24 hits.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF49265. SSF49265. 2 hits.
    SSF50044. SSF50044. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS50010. DH_2. 1 hit.
    PS50853. FN3. 2 hits.
    PS50835. IG_LIKE. 50 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform b (identifier: O01761-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MASRRQKQFD RKYSSYRKFT ATEDVNYSTH SSRSSYRSES LTSRTDGRGR     50
    STSSEIIAGS ESRSYPVYIA IQDYTPDKED VEAIPLEQGQ IVEVLDKKNS 100
    VRWLVRTKAR PPRSGWVPGS YFETPTEFYK QRRRTREIEN VSLSDEQAAL 150
    VKRDQVYHEL LRSEEEFVSS LRTCVDDYIK VLDDPEVPEA VKKNREELTL 200
    NIPELYNFHA NVMLKGLNYY SDDPGKVGQT FVRLEKDFES HVEFYKQYAD 250
    TLKLLEEPEI KRFFEGLSAK NDAGASSFVD HVKEIADRMV QYQNYFKEFV 300
    KYSARAHGSS KSIQKALELV TTIPQRVHDL EFTNNLKQHP GDTGKLGRII 350
    RHDAFQVWEG DEPPKLRYVF LFRNKIMFTE QDASTSPPSY THYSSIRLDK 400
    YNIRQHTTDE DTIVLQPQEP GLPSFRIKPK DFETSEYVRK AWLRDIAEEQ 450
    EKYAAERDAI SMTATSEMTA SSVDFDMNAS DQQSEFSEWS GSRKSSLFPG 500
    PEEGGPPRKK VKSPPVISPT GSSTSIYSGG SSSIDWTTTG TTLEMQGTRV 550
    TRTQYGFRTL QESSAKMCLK VTGYPLPDIT WYKDDVQLHE DERHTFYSDE 600
    DGFFAMTIDP VQVTDTGRYT CMATNEYGQA STSAFFRVLK VEKEAAPPAF 650
    VTKLRDKECK EGDVIDFECE VEGWPEPELV WLVDDQPLRP SHDFRLQYDG 700
    QTAKLEIRDA QPDDTGVYTV KIQNEFGSIE SKAELFVQAD PDKNHVAPEF 750
    QATIEYVECD EGEEVRFKSV ITGDPNPEII WFINGKPLSE SEKVKFISED 800
    GICILTIKDV TRHFDGMVTC QGSNRLGSAS CDGRLKVRVP PAPPTFNKPL 850
    EDKTVQEKST VVFEVDVSGW PEPTLTFTLC GKELKNGEEG VEIVGHDGFY 900
    RISIPNTSMD KHDGEIVAKA QNEHGTAESR ARLTVEQEEE ESRSAPTFLK 950
    DIEDQTVKTG EFAVFETTVR GNPNPEVTWF INGHKMDQGS PGVKIEAHNH 1000
    DHKLTIDSAQ YAGTVLCRAE NAVGRFETKA RLVVLAPEKQ KKPPKFVEIL 1050
    VDKTETVDNT VVFEVRVEGE PKPTVTWYLK GEELKQSDRV EIREFDGSIK 1100
    ISIKNIKIED AGEIRAVATN SEGSDETKAK LTVQKKPFAP EFDLRPVSLT 1150
    VEKGSEAVFS AHAFGIPLPT YEWSVNGRKV RDGQEGARVT RDESTVDGAS 1200
    ILTIDTATYY SEVNHLTISV VAENTLGAEE TGAQLTIEPK KESVVVEKQD 1250
    LSSSEVQKEI AQQVKEASPE ATTTITMETS LTSTKTTTMS TTEVTSTVGG 1300
    VTVETKESES ESATTVIGGG SGGVTEGSIS VSKIEVVSKT DSQTDVREGT 1350
    PKRRVSFAEE ELPKEVIDSD RKKKKSPSPD KKEKSPEKTE EKPASPTKKT 1400
    GEEVKSPKEK SPASPTKKEK SPAAEEVKSP TKKEKSPSSP TKKEKSPSSP 1450
    TKKTGDEVKE KSPPKSPTKK EKSPEKPEDV KSPVKKEKSP DATNIVEVSS 1500
    ETTIEKTETT MTTEMTHESE ESRTSVKKEK TPEKVDEKPK SPTKKDKSPE 1550
    KSITEEIKSP VKKEKSPEKV EEKPASPTKK EKSPEKPASP TKKSENEVKS 1600
    PTKKEKSPEK SVVEELKSPK EKSPEKADDK PKSPTKKEKS PEKSATEDVK 1650
    SPTKKEKSPE KVEEKPTSPT KKESSPTKKT DDEVKSPTKK EKSPQTVEEK 1700
    PASPTKKEKS PEKSVVEEVK SPKEKSPEKA EEKPKSPTKK EKSPEKSAAE 1750
    EVKSPTKKEK SPEKSAEEKP KSPTKKESSP VKMADDEVKS PTKKEKSPEK 1800
    VEEKPASPTK KEKTPEKSAA EELKSPTKKE KSPSSPTKKT GDESKEKSPE 1850
    KPEEKPKSPT PKKSPPGSPK KKKSKSPEAE KPPAPKLTRD LKLQTVNKTD 1900
    LAHFEVVVEH ATECKWFLDG KEITTAQGVT VSKDDQFEFR CSIDTTMFGS 1950
    GTVSVVASNA AGSVETKTEL KVLETPKETK KPEFTDKLRD MEVTKGDTVQ 2000
    MDVIALHSPL YKWYQNGNLL EDGKNGVTIK NEENKSSLII PNAQDSGKIT 2050
    VEASNEVGSS ESSAQLTVNP PSTTPIVVDG PKSVTIKETE TAEFKATISG 2100
    FPAPTVKWTI NEKIVEESRT ITTIKTEDVY TLKISNAKIE QTGTVKVTAQ 2150
    NSAGQDSKQA DLKVEPNVKA PKFKSQLTDK VADEGEPLRW NLELDGPSPG 2200
    TEVSWLLNGQ PLTKSDTVQV VDHGDGTYHV TIAEAKPEMS GTLTAKAKNA 2250
    AGECETSAKV TVNGGNKKPE FVQAPQNHET TLEESVKFSA IVTGKPMPNV 2300
    TWYLNNKKLI QSEEVKVKYV HETGKTSIRI QKPLMEHNGT IRVEAENVSG 2350
    KVQATAQLKV DKKTEVPKFT TNMDDRQVKE GEDVKFTANV EGYPEPSVAW 2400
    TLNGEPVSKH PNITVTDKDG EHTIEISAVT PEQAGELSCE ATNPVGSKKR 2450
    DVQLAVKKVG DAPTFAKNLE DRLITEGELT LMDAKLNIVK PKPKITWLKD 2500
    GVEITSDGHY KIVEEEDGSL KLSILQTKLE DKGRITIKAE SEFGVAECSA 2550
    SLGVVKGRPM AKPAFQSDIA PINLTEGDTL ECKLLITGDP TPFVKWYIGT 2600
    QLVCATEDTE ISNANGVYTM KIHGVTADMT GKIKCVAYNK AGEVSTEGPL 2650
    KVVAPIPVEF ETSLCDATCR EGDTLKLRAV LLGEPEPVVS WYVNGKKLEE 2700
    SQNIKIHSEK GTYTVTIKDI TCDYSGQVVC EAINEYGKAT SEATLLVLPR 2750
    GEPPDFLEWL SNVRARTGTK VVHKVVFTGD PKPSLTWYIN NKEILNSDLY 2800
    TIVTDDKTST LTINSFNPDV HVGEIICKAE NDAGEVSCTA NMITYTSDMF 2850
    SESESEAQAE EFVGDDLTED ESLREEMHRT PTPVMAPKFI TKIKDTKAKK 2900
    GHSAVFECVV PDTKGVCCKW LKDGKEIELI ARIRVQTRTG PEGHITQELV 2950
    LDNVTPEDAG KYTCIVENTA GKDTCEATLT VIESLEKKSE KKAPEFIVAL 3000
    QDKTTKTSEK VVLECKVIGE PKPKVSWLHD NKTITQESIT VESVEGVERV 3050
    TITSSELSHQ GKYTCIAENT EGTSKTEAFL TVQGEAPVFT KELQNKELSI 3100
    GEKLVLSCSV KGSPQPHVDF YSFSETTKVE TKITSSSRIA IEHDQTNTHW 3150
    RMVISQITKE DIVSYKAIAT NSIGTATSTS KITTKVEAPV FEQGLKKTSV 3200
    KEKEEIKMEV KVGGSAPDVE WFKDDKPVSE DGNHEMKKNP ETGVFTLVVK 3250
    QAATTDAGKY TAKASNPAGT AESSAEAEVT QSLEKPTFVR ELVTTEVKIN 3300
    ETATLSVTVK GVPDPSVEWL KDGQPVQTDS SHVIAKVEGS GSYSITIKDA 3350
    RLEDSGKYAC RATNPAGEAK TEANFAVVKN LVPPEFVEKL SPLEVKEKES 3400
    TTLSVKVVGT PEPSVEWFKD DTPISIDNVH VIQKQTAVGS FSLTINDARQ 3450
    GDVGIYSCRA RNEAGEALTT ANFGIIRDSI PPEFTQKLRP LEVREQETLD 3500
    LKVTVIGTPV PNVEWFKDDK PINIDNSHIF AKDEGSGHHT LTIKQARGED 3550
    VGVYTCKATN EAGEAKTTAN MAVQEEIEAP LFVQGLKPYE VEQGKPAELV 3600
    VRVEGKPEPE VKWFKDGVPI AIDNQHVIEK KGENGSHTLV IKDTNNADFG 3650
    KYTCQATNKA GKDETVGELK IPKYSFEKQT AEEVKPLFIE PLKETFAVEG 3700
    DTVVLECKVN KESHPQIKFF KNDQPVEIGQ HMQLEVLEDG NIKLTIQNAK 3750
    KEDVGAYRCE AVNVAGKANT NADLKIQFAA KVEEHVTDES GQLEEIGQFE 3800
    TVGDTASSKT DTGRGAPEFV ELLRSCTVTE KQQAILKCKV KGEPRPKIKW 3850
    TKEGKEVEMS ARVRAEHKDD GTLTLTFDNV TQADAGEYRC EAENEYGSAW 3900
    TEGPIIVTLE GAPKIDGEAP DFLQPVKPAV VTVGETAVLE GKISGKPKPS 3950
    VKWYKNGEEL KPSDRVKIEN LDDGTQRLTV TNAKLDDMDE YRCEASNEFG 4000
    DVWSDVTLTV KEPAQVAPGF FKELSAIQVK ETETAKFECK VSGTKPDVKW 4050
    FKDGTPLKED KRVHFESTDD GTQRLVIEDS KTDDQGNYRI EVSNDAGVAN 4100
    SKVPLTVVPS ETLKIKKGLT DVNVTQGTKI LLSVEVEGKP KTVKWYKGTE 4150
    TVTSSQTTKI VQVTESEYKL EIESAEMSDT GAYRVVLSTD SFSVESSATV 4200
    TVTKAAEKIS LPSFKKGLAD QSVPKGTPLV LEVEIEGKPK DVKWYKNGDE 4250
    IKDGKVEDLG NGKYRLTIPD FQEKDVGEYS VTAANEAGEI ESKAKVNVSA 4300
    KPEIVSGLVP TTVKQGETAT FNVKVKGPVK GVKWYKNGKE IPDAKTKDNG 4350
    DGSYSLEIPN AQVEDAADYK VVVSNDAGDA DSSAALTVKL ADDGKDKVKP 4400
    EIVSGLIPTT VKQGETATFN VKVKGPVKQV KWYKNGKEIP NAKAKDNGDG 4450
    SYSLEIPNAQ LDDTADYKVV VSNDAGDADS SAALTVKLPG IAIVKGLEDA 4500
    EVPKGKKAVL QVETNKKPKE IKWYKNGKEI TPSDKAQPGS DGDNKPQLVI 4550
    PDAGDDDAAE YKVVLTDEDG NTADSSCALT VKLPAKEPKI IKGLEDQVVS 4600
    IGSPIKLEIE TSGSPKTVKW YKNGKELPGA AAKTIKIQKI DDNKYVLEIP 4650
    SSVVEDTGDY KVEVANEAGS ANSSGKITVE PKITFLKPLK DQSITEGENA 4700
    EFSVETNTKP RIVKWYKNGQ EIKPNSRFII EQKTDTKYQL VIKNAVRDDA 4750
    DTYKIVLENT AGEAESSAQL TVKKAKAGLC KIVKGLEDQV VAKGAKMVFE 4800
    VKIQGEPEDV RWLRDANVIS AGANAIIEKI DDTTYRLIIP SADLKDAGEY 4850
    TVEVINESGK AKSDAKGEVD EKPEIVRGLE NIEIPEGDDD VFKVEVSAPV 4900
    RQVKWYKNDQ EIKPNSHLEA KKIGPKKYEL AINRAQLDDG ADYKVVLSNA 4950
    AGDCDSSAAL TVVKPNVLKI VDGLKDVDVE EPQPVELKVK VEGIPKVIKW 5000
    YKNGQELKPD ADGFKFEEKP ESGEFSLTIP SSKKSDGGAY RVVLGNDKGE 5050
    VYSGSVVHVK SAKSSEPTSG ANFLSPLKDT EVEEGDMLTL QCTIAGEPFP 5100
    EVIWEKDGVV LQKDDRITMR VALDGTATLR IRSAKKSDIG QYRVTAKNEA 5150
    GSATSDCKVT VTEQGEQPSK PKFVIPLKTG AALPGDKKEF NVKVRGLPKP 5200
    TLQWFLNGIP IKFDDRITLD DMADGNYCLT IRDVREEDFG TLKCIAKNEN 5250
    GTDETVCEFQ QGAGHDDGSR DDLRYPPRFN VPLWDRRIPV GDPMFIECHV 5300
    DANPTAEVEW FKDGKKIEHT AHTEIRNTVD GACRIKIIPF EESDIGVYMC 5350
    VAVNELGQAE TQATYQVEIL EHVEEEKRRE YAPKINPPLE DKTVNGGQPI 5400
    RLSCKVDAIP RASVVWYKDG LPLRADSRTS IQYEEDGTAT LAINDSTEED 5450
    IGAYRCVATN AHGTINTSCS VNVKVPKQEV KKEGEEPFFT KGLVDLWADR 5500
    GDSFTLKCAV TGDPFPEIKW YRNGQLLRNG PRTVIETSPD GSCSLTVNES 5550
    TMSDEGIYRC EAENAHGKAK TQATAHVQMA LGKTEKPKMD EGKPPKFILE 5600
    LSDMSVSLGN VIDLECKVTG LPNPSVKWSK DGGPLIEDSR FEWSNEASKG 5650
    VYQLRIKNAT VHDEGTYRCV ATNENGSATT KSFVRMDDGL GSGVVTASQP 5700
    PRFTLKMGDV RTTEGQPLKL ECKVDASPLP EMVWYKDGAI VTPSDRIQIS 5750
    LSPDGVATLL IPSCVYDDDG IYRVIATNPS GTAQDKGTAT VKKLPRDSGA 5800
    RRSADRDVFD ANKAPKLMEP LENIRIPEKQ SFRLRCKFSG DPKPTIKWFK 5850
    DGERVFPYGR LQLIESPDGV CELVVDSATR QDAGGYRCVA ENTYGSARTS 5900
    CDVNVIRGDR KPRDIDSSIR EGKAPGFTTP LTIRRAKPGD SVTFECLPFG 5950
    NPFPSIKWLK DGLELFSDEK IKMEAAADGT QRLILSDVTF LSEGYFRCVA 6000
    TNEHGTASTK AELVIEGDRT IGSRPLPEVN GEPEECKPRI RRGLYNMSIH 6050
    EGNVVEMIVC ATGIPTPTVK WYKDGQEIVG DGPDGKRVIF TDERGIHHLV 6100
    IVNASPDDEG EYSLEATNKL GSAKTEGSLN IIRPRHIADA DERGGMPFPP 6150
    GFVRQLKNKH VFNHMPTIFD CLVVGHPAPE VEWFHNGKKI VPGGRIKIQS 6200
    CGGGSHALII LDTTLEDAGE YVATAKNSHG SASSSAVLDV TVPFLDSIKF 6250
    NGEIDVTPYL TEEYGFKKLN TASLPTPPDR GPFIKEVTGH YLTLSWIPTK 6300
    RAPPRYPQVT YVIEIRELPE KQWSLLEYNI PEPVCKVRNL ELGKSYQFRV 6350
    RAENIYGISD PSPASPPSRL MAPPQPVFDR RTNKVIPLLD PYAEKALDMR 6400
    YSEQYACAPW FSPGVVEKRY CAENDTLTIV LNVSGFPDPD IKWKFRGWDI 6450
    DTSSPTSKCK VYTYGGSETT LAITGFSKEN VGQYQCFAKN DYGDAQQNIM 6500
    VDLATRPNFI QPLVNKTFSS AQPMRMDVRV DGEPFPELKW MKEWRPIVES 6550
    SRIKFVQDGP YLCSLIINDP MWRDSGIYSC VAVNDAGQAT TSCTVTVEAE 6600
    GDYNDVELPR RRVTIESRRV RELYEISEKD EKLAAEGAPF RVKEKATGRE 6650
    FLAQLRPIDD ALMRHVDIHN SLDHPGIVQM HRVLRDEKLA LVVFDNANST 6700
    IDGLSSLAHP GVEIAEPKGV NRETCVRVFV RQLLLALKHM HDLRIAHLDL 6750
    RPETILLQDD KLKLADFGQA RRLLRGLITG EIKGSPEFVS PEIVRSYPLT 6800
    LATDMWSTGV LTYVLLTGLS PFHGDNDNET LANVDSCQFD SSPLGNFSYD 6850
    AGDFVKKLLT EIPVSRLTVD EALDHPWIND EKLKTEPLSA DTLREFKYQH 6900
    KWLERRVFVQ QTPSEQILEA ILGPATAQAQ QNAPVAPEGR RPAEIYDYLR 6950
    IQPKKPPPTV EYVPQPRKEH PPFIDEFGQL IDGDAFDRPE GTGFEGPHRQ 7000
    PPQIPPQPQR PNQAAHDSRR HEQQPQHQGQ PQRIPVDQYG RPLVDPRYLN 7050
    DPSHRPSSLD DAPFYVDKYG NPVHFDKYGR PMAPQNLEKR KLIPQDKGET 7100
    PSHSKKEKTQ HPVATPILAS PGGDQQQQKI PMRMIRGERR EIEEEIANRI 7150
    LSDISEEGSI AGSLASLEDF EIPKDFQVEA SEPSTPTLTP EVTIRETIPK 7200
    PTPSPTSPQK SPVPQPQGLL IPAKVTYSDS ILAGLPAADK KVLEDAENDP 7250
    SIPVGAPLFL EGLHGSDLTI DTTSASGLIK VTSPAINLSP NPKSPRRSTP 7300
    GTKSPVVLSP RQEHSMEVLI ATKRGKPGFL PPGELAEDID DEDAFMDDRK 7350
    KQVKPKDHDG ENDFKDEKER LEKDKNRRTV NLDDLDKYRP SAFYKDDSDF 7400
    GHPGYDIDAT PWDSHYQIGP DTYLMAARGA AFNSRVRNYR EELFGMGAPT 7450
    VKQGFLGVRN RDITVRERRR YTDILRETTQ GLEPKSHEQS TALLQKAPSA 7500
    TAIERIKADI EKVTPCATKK NDDGTFAPIF TARLRDVYLR KNQPAIFECA 7550
    VSASPAPKVT WDFQGKILES NDRVTIEQDN NVARLILNHA APYDLGEYVC 7600
    TAINEYGTDK SSCRLISGET PSRPGRPEAE LSSDTEIFIQ WEAPEGPTYL 7650
    EGITYRLEYR VAGPNDHGDP WITVSEKIDD ESVIVKHLSP LGIYQFRVTA 7700
    QNGFGLGLPS LSSRIVQTHG KGAPKLQIDV LKSEIRLNVV SMPQKSTNQL 7750
    GGISEESEED SEARTANEDM KSNLQLQTDD PTGRFQIGGL KFKGRFSVIR 7800
    DAVDSTTEGH AHCAVKIRHP SSEAISEYES LRDGQHENVQ RLIAAFNNSN 7850
    FLYLLSERLY EDVFSRFVFN DYYTEEQVAL TMRQVTSALH FLHFKGIAHL 7900
    DVNPHNIMFQ SKRSWVVKLV DFGRAQKVSG AVKPVDFDTK WASPEFHIPE 7950
    TPVTVQSDMW GMGVVTFCLL AGFHPFTSEY DREEEIKENV INVKCDPNLI 8000
    PVNASQECLS FATWALKKSP VRRMRTDEAL SHKFLSSDPS MVRRRESIKY 8050
    SASRLRKLAA MIRQPTFSQP ISEELESKYG K 8081
    Length:8,081
    Mass (Da):894,252
    Last modified:September 13, 2005 - v3
    Checksum:i67C804953CF62228
    GO
    Isoform a (identifier: O01761-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         6633-8081: Missing.

    Show »
    Length:6,632
    Mass (Da):731,685
    Checksum:i262D3EDD62960E89
    GO
    Isoform c (identifier: O01761-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6688: Missing.
         6689-6696: LALVVFDN → MVRFTINC

    Note: No experimental confirmation available.

    Show »
    Length:1,393
    Mass (Da):156,297
    Checksum:iF947C1BCE4EB9CE9
    GO
    Isoform d (identifier: O01761-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6685: Missing.
         6686-6696: DEKLALVVFDN → MFRLVEDCELC

    Note: No experimental confirmation available.

    Show »
    Length:1,396
    Mass (Da):156,671
    Checksum:iF42D06301E7185C2
    GO
    Isoform e (identifier: O01761-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1241-1880: Missing.
         6633-8081: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:5,992
    Mass (Da):661,677
    Checksum:i7E5F00BF18A251D4
    GO
    Isoform f (identifier: O01761-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1241-1880: Missing.

    Show »
    Length:7,441
    Mass (Da):824,244
    Checksum:i4B102760FC1131D7
    GO
    Isoform g (identifier: O01761-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         6632-6695: Missing.
         7175-7186: DFQVEASEPSTP → VTEGDGCNMCGE
         7187-8081: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:7,122
    Mass (Da):786,772
    Checksum:iE0AADE021082BD5B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2137 – 21371A → P in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti2245 – 22473AKA → PKP in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti2258 – 22581A → P in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti2284 – 22841E → G in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti2297 – 22971M → I in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti3531 – 35311A → G in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti3884 – 38885DAGEY → RRRRI in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti3929 – 39291A → V in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti5134 – 51341A → P in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti5145 – 51451T → S in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti5185 – 51851G → A in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti5199 – 51991K → N in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti5202 – 52021L → F in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti5213 – 52131F → L in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti6178 – 61781A → G in AAB00542. (PubMed:8603916)Curated
    Sequence conflicti6268 – 62681K → E in AAB00542. (PubMed:8603916)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 66886688Missing in isoform c. CuratedVSP_015541Add
    BLAST
    Alternative sequencei1 – 66856685Missing in isoform d. CuratedVSP_015542Add
    BLAST
    Alternative sequencei1241 – 1880640Missing in isoform e and isoform f. CuratedVSP_015543Add
    BLAST
    Alternative sequencei6632 – 669564Missing in isoform g. CuratedVSP_015544Add
    BLAST
    Alternative sequencei6633 – 80811449Missing in isoform a and isoform e. CuratedVSP_015545Add
    BLAST
    Alternative sequencei6686 – 669611DEKLALVVFDN → MFRLVEDCELC in isoform d. CuratedVSP_015546Add
    BLAST
    Alternative sequencei6689 – 66968LALVVFDN → MVRFTINC in isoform c. CuratedVSP_015547
    Alternative sequencei7175 – 718612DFQVE…EPSTP → VTEGDGCNMCGE in isoform g. CuratedVSP_015548Add
    BLAST
    Alternative sequencei7187 – 8081895Missing in isoform g. CuratedVSP_015549Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33058 Genomic DNA. Translation: AAB00542.1.
    FO080458 Genomic DNA. Translation: CCD63864.1.
    FO080458 Genomic DNA. Translation: CCD63865.1.
    FO080458 Genomic DNA. Translation: CCD63866.1.
    FO080458 Genomic DNA. Translation: CCD63867.1.
    FO080458 Genomic DNA. Translation: CCD63868.1.
    FO080458 Genomic DNA. Translation: CCD63869.1.
    FO080458 Genomic DNA. Translation: CCD63870.1.
    AY724774 mRNA. Translation: AAU21474.1.
    AY714779 mRNA. Translation: AAU14146.1.
    PIRiT29757.
    RefSeqiNP_001020984.1. NM_001025813.1. [O01761-2]
    NP_001020985.1. NM_001025814.2. [O01761-1]
    NP_001020988.1. NM_001025817.2. [O01761-5]
    NP_001020989.1. NM_001025818.1. [O01761-6]
    NP_001020990.1. NM_001025819.1. [O01761-7]
    UniGeneiCel.7125.

    Genome annotation databases

    EnsemblMetazoaiC09D1.1b; C09D1.1b; WBGene00006820. [O01761-1]
    GeneIDi171990.
    KEGGicel:CELE_C09D1.1.
    UCSCiC09D1.1g. c. elegans. [O01761-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33058 Genomic DNA. Translation: AAB00542.1 .
    FO080458 Genomic DNA. Translation: CCD63864.1 .
    FO080458 Genomic DNA. Translation: CCD63865.1 .
    FO080458 Genomic DNA. Translation: CCD63866.1 .
    FO080458 Genomic DNA. Translation: CCD63867.1 .
    FO080458 Genomic DNA. Translation: CCD63868.1 .
    FO080458 Genomic DNA. Translation: CCD63869.1 .
    FO080458 Genomic DNA. Translation: CCD63870.1 .
    AY724774 mRNA. Translation: AAU21474.1 .
    AY714779 mRNA. Translation: AAU14146.1 .
    PIRi T29757.
    RefSeqi NP_001020984.1. NM_001025813.1. [O01761-2 ]
    NP_001020985.1. NM_001025814.2. [O01761-1 ]
    NP_001020988.1. NM_001025817.2. [O01761-5 ]
    NP_001020989.1. NM_001025818.1. [O01761-6 ]
    NP_001020990.1. NM_001025819.1. [O01761-7 ]
    UniGenei Cel.7125.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FHO NMR - A 341-458 [» ]
    ProteinModelPortali O01761.
    SMRi O01761. Positions 341-458.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 37462. 2 interactions.
    IntActi O01761. 11 interactions.
    MINTi MINT-1090274.

    Protein family/group databases

    MEROPSi I43.001.

    Proteomic databases

    PaxDbi O01761.
    PRIDEi O01761.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C09D1.1b ; C09D1.1b ; WBGene00006820 . [O01761-1 ]
    GeneIDi 171990.
    KEGGi cel:CELE_C09D1.1.
    UCSCi C09D1.1g. c. elegans. [O01761-1 ]

    Organism-specific databases

    CTDi 3346201.
    WormBasei C09D1.1a ; CE30426 ; WBGene00006820 ; unc-89.
    C09D1.1b ; CE34251 ; WBGene00006820 ; unc-89.
    C09D1.1c ; CE34252 ; WBGene00006820 ; unc-89.
    C09D1.1d ; CE37701 ; WBGene00006820 ; unc-89.
    C09D1.1e ; CE37702 ; WBGene00006820 ; unc-89.
    C09D1.1f ; CE37703 ; WBGene00006820 ; unc-89.
    C09D1.1g ; CE37704 ; WBGene00006820 ; unc-89.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000118717.
    InParanoidi O01761.
    OMAi DQAEYKC.
    OrthoDBi EOG74BJR3.
    PhylomeDBi O01761.

    Enzyme and pathway databases

    SignaLinki O01761.

    Miscellaneous databases

    EvolutionaryTracei O01761.
    NextBioi 873555.
    PROi O01761.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.10. 55 hits.
    InterProi IPR000219. DH-domain.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR007850. RCSD.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF07679. I-set. 51 hits.
    PF00069. Pkinase. 2 hits.
    PF05177. RCSD. 6 hits.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 2 hits.
    SM00409. IG. 25 hits.
    SM00408. IGc2. 24 hits.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF49265. SSF49265. 2 hits.
    SSF50044. SSF50044. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS50010. DH_2. 1 hit.
    PS50853. FN3. 2 hits.
    PS50835. IG_LIKE. 50 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains."
      Benian G.M., Tinley T.L., Tang X., Borodovsky M.
      J. Cell Biol. 132:835-848(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A), FUNCTION, TISSUE SPECIFICITY.
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.
    3. "Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains."
      Small T.M., Gernert K.M., Flaherty D.B., Mercer K.B., Borodovsky M., Benian G.M.
      J. Mol. Biol. 342:91-108(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5922-7990 (ISOFORMS B/F), ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY.
      Strain: Bristol N2.
    4. "Functional diversity of PH domains: an exhaustive modelling study."
      Blomberg N., Nilges M.
      Fold. Des. 2:343-355(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 341-458.

    Entry informationi

    Entry nameiUNC89_CAEEL
    AccessioniPrimary (citable) accession number: O01761
    Secondary accession number(s): Q17362
    , Q5W614, Q5W615, Q5W616, Q5W617, Q646H5, Q64EQ8, Q7Z119, Q7Z120
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 132 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3