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O01761

- UNC89_CAEEL

UniProt

O01761 - UNC89_CAEEL

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Protein

Muscle M-line assembly protein unc-89

Gene

unc-89

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Structural component of the muscle M-line. Myofilament lattice assembly begins with positional cues laid down in the basement membrane and muscle cell membrane. UNC-89 responds to these signals, localizes, and then participates in assembling an M-line.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei6749 – 67491Proton acceptorPROSITE-ProRule annotation
Active sitei7901 – 79011Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. phosphatase binding Source: WormBase
  3. protein kinase activity Source: InterPro
  4. Rho GTPase binding Source: WormBase
  5. Rho guanyl-nucleotide exchange factor activity Source: WormBase

GO - Biological processi

  1. myosin filament assembly Source: WormBase
  2. positive regulation of Rho GTPase activity Source: GOC
  3. skeletal muscle myosin thick filament assembly Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Muscle protein, Transferase

Enzyme and pathway databases

ReactomeiREACT_240521. DCC mediated attractive signaling.
REACT_246059. Rho GTPase cycle.
REACT_250475. G alpha (12/13) signalling events.
REACT_253015. NRAGE signals death through JNK.
REACT_257432. G alpha (q) signalling events.
SignaLinkiO01761.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Muscle M-line assembly protein unc-89
Alternative name(s):
Uncoordinated protein 89
Gene namesi
Name:unc-89
ORF Names:C09D1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiC09D1.1a; CE30426; WBGene00006820; unc-89.
C09D1.1b; CE34251; WBGene00006820; unc-89.
C09D1.1c; CE34252; WBGene00006820; unc-89.
C09D1.1d; CE37701; WBGene00006820; unc-89.
C09D1.1e; CE37702; WBGene00006820; unc-89.
C09D1.1f; CE37703; WBGene00006820; unc-89.
C09D1.1g; CE37704; WBGene00006820; unc-89.

Subcellular locationi

GO - Cellular componenti

  1. A band Source: WormBase
  2. M band Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 80818081Muscle M-line assembly protein unc-89PRO_0000072704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi568 ↔ 621CuratedPROSITE-ProRule annotation
Disulfide bondi2582 ↔ 2635PROSITE-ProRule annotation
Disulfide bondi2908 ↔ 2964PROSITE-ProRule annotation
Disulfide bondi3015 ↔ 3065CuratedPROSITE-ProRule annotation
Disulfide bondi3707 ↔ 3759CuratedPROSITE-ProRule annotation
Disulfide bondi3838 ↔ 3890PROSITE-ProRule annotation
Disulfide bondi5298 ↔ 5350CuratedPROSITE-ProRule annotation
Disulfide bondi5404 ↔ 5456PROSITE-ProRule annotation
Disulfide bondi5508 ↔ 5560CuratedPROSITE-ProRule annotation
Disulfide bondi5616 ↔ 5669CuratedPROSITE-ProRule annotation
Disulfide bondi5836 ↔ 5888PROSITE-ProRule annotation
Disulfide bondi5946 ↔ 5998CuratedPROSITE-ProRule annotation
Disulfide bondi7549 ↔ 7600PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO01761.
PRIDEiO01761.

Expressioni

Tissue specificityi

Localizes to the middle of A-bands. Expression is seen in body-wall, pharyngeal muscle and few muscle cells of the tail.2 Publications

Gene expression databases

ExpressionAtlasiO01761. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi37462. 2 interactions.
IntActiO01761. 11 interactions.
MINTiMINT-1090274.

Structurei

Secondary structure

1
8081
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi349 – 3579Combined sources
Beta strandi365 – 3728Combined sources
Beta strandi375 – 3817Combined sources
Beta strandi384 – 3874Combined sources
Beta strandi395 – 4006Combined sources
Beta strandi402 – 4065Combined sources
Beta strandi412 – 4165Combined sources
Beta strandi431 – 4344Combined sources
Helixi437 – 44711Combined sources
Helixi451 – 4544Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FHONMR-A341-458[»]
ProteinModelPortaliO01761.
SMRiO01761. Positions 341-458.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO01761.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 12765SH3CuratedPROSITE-ProRule annotationAdd
BLAST
Domaini152 – 330179DHCuratedPROSITE-ProRule annotationAdd
BLAST
Domaini342 – 498157PHCuratedPROSITE-ProRule annotationAdd
BLAST
Domaini547 – 63387Ig-like C2-type 1Add
BLAST
Domaini648 – 73689Ig-like C2-type 2Add
BLAST
Domaini748 – 83891Ig-like C2-type 3Add
BLAST
Domaini946 – 103388Ig-like C2-type 4Add
BLAST
Domaini1044 – 113289Ig-like C2-type 5Add
BLAST
Domaini1140 – 122788Ig-like C2-type 6Add
BLAST
Domaini1375 – 1475101RCSD 1CuratedAdd
BLAST
Domaini1479 – 1585107RCSD 2CuratedAdd
BLAST
Domaini1597 – 169599RCSD 3CuratedAdd
BLAST
Domaini1700 – 1799100RCSD 4CuratedAdd
BLAST
Domaini1982 – 206786Ig-like C2-type 7Add
BLAST
Domaini2071 – 216393Ig-like C2-type 8Add
BLAST
Domaini2171 – 226191Ig-like C2-type 9Add
BLAST
Domaini2269 – 235991Ig-like C2-type 10Add
BLAST
Domaini2367 – 245589Ig-like C2-type 11Add
BLAST
Domaini2463 – 2564102Ig-like C2-type 12Add
BLAST
Domaini2563 – 265189Ig-like C2-type 13Add
BLAST
Domaini2657 – 274690Ig-like C2-type 14Add
BLAST
Domaini2754 – 2858105Ig-like C2-type 15Add
BLAST
Domaini2887 – 298094Ig-like C2-type 16Add
BLAST
Domaini2994 – 308188Ig-like C2-type 17Add
BLAST
Domaini3087 – 318397Ig-like C2-type 18Add
BLAST
Domaini3189 – 328092Ig-like C2-type 19Add
BLAST
Domaini3286 – 337691Ig-like C2-type 20Add
BLAST
Domaini3384 – 346986Ig-like C2-type 21Add
BLAST
Domaini3482 – 357291Ig-like C2-type 22Add
BLAST
Domaini3580 – 366788Ig-like C2-type 23Add
BLAST
Domaini3686 – 377792Ig-like C2-type 24Add
BLAST
Domaini3817 – 390892Ig-like C2-type 25Add
BLAST
Domaini3920 – 400990Ig-like C2-type 26Add
BLAST
Domaini4018 – 410689Ig-like C2-type 27Add
BLAST
Domaini4109 – 420193Ig-like C2-type 28Add
BLAST
Domaini4212 – 429786Ig-like C2-type 29Add
BLAST
Domaini4302 – 438786Ig-like C2-type 30Add
BLAST
Domaini4400 – 448586Ig-like C2-type 31Add
BLAST
Domaini4489 – 458092Ig-like C2-type 32Add
BLAST
Domaini4588 – 467891Ig-like C2-type 33Add
BLAST
Domaini4681 – 477191Ig-like C2-type 34Add
BLAST
Domaini4873 – 496189Ig-like C2-type 35Add
BLAST
Domaini4965 – 505793Ig-like C2-type 36Add
BLAST
Domaini5067 – 516094Ig-like C2-type 37Add
BLAST
Domaini5171 – 526090Ig-like C2-type 38Add
BLAST
Domaini5277 – 536690Ig-like C2-type 39Add
BLAST
Domaini5383 – 547290Ig-like C2-type 40Add
BLAST
Domaini5487 – 557892Ig-like C2-type 41Add
BLAST
Domaini5595 – 568591Ig-like C2-type 42Add
BLAST
Domaini5701 – 579090Ig-like C2-type 43Add
BLAST
Domaini5815 – 590490Ig-like C2-type 44Add
BLAST
Domaini5925 – 601490Ig-like C2-type 45Add
BLAST
Domaini6038 – 613093Ig-like C2-type 46Add
BLAST
Domaini6150 – 623990Ig-like C2-type 47Add
BLAST
Domaini6278 – 637497Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini6413 – 650290Ig-like C2-type 48Add
BLAST
Domaini6507 – 659690Ig-like C2-type 49Add
BLAST
Domaini6592 – 6878287Protein kinase 1PROSITE-ProRule annotationAdd
BLAST
Domaini7528 – 761790Ig-like C2-type 50Add
BLAST
Domaini7623 – 772199Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini7785 – 8035251Protein kinase 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi936 – 9416Poly-Glu
Compositional biasi1272 – 131544Thr-richAdd
BLAST
Compositional biasi1372 – 1886515Lys-richAdd
BLAST
Compositional biasi7125 – 71284Poly-Gln

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 PH domain.CuratedPROSITE-ProRule annotation
Contains 2 protein kinase domains.PROSITE-ProRule annotation
Contains 4 RCSD domains.Curated
Contains 1 SH3 domain.CuratedPROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120473.
InParanoidiO01761.
OMAiDQAEYKC.
OrthoDBiEOG74BJR3.
PhylomeDBiO01761.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.10. 55 hits.
InterProiIPR000219. DH-domain.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR007850. RCSD.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 51 hits.
PF00069. Pkinase. 2 hits.
PF05177. RCSD. 6 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 25 hits.
SM00408. IGc2. 24 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 50 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform b (identifier: O01761-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MASRRQKQFD RKYSSYRKFT ATEDVNYSTH SSRSSYRSES LTSRTDGRGR
60 70 80 90 100
STSSEIIAGS ESRSYPVYIA IQDYTPDKED VEAIPLEQGQ IVEVLDKKNS
110 120 130 140 150
VRWLVRTKAR PPRSGWVPGS YFETPTEFYK QRRRTREIEN VSLSDEQAAL
160 170 180 190 200
VKRDQVYHEL LRSEEEFVSS LRTCVDDYIK VLDDPEVPEA VKKNREELTL
210 220 230 240 250
NIPELYNFHA NVMLKGLNYY SDDPGKVGQT FVRLEKDFES HVEFYKQYAD
260 270 280 290 300
TLKLLEEPEI KRFFEGLSAK NDAGASSFVD HVKEIADRMV QYQNYFKEFV
310 320 330 340 350
KYSARAHGSS KSIQKALELV TTIPQRVHDL EFTNNLKQHP GDTGKLGRII
360 370 380 390 400
RHDAFQVWEG DEPPKLRYVF LFRNKIMFTE QDASTSPPSY THYSSIRLDK
410 420 430 440 450
YNIRQHTTDE DTIVLQPQEP GLPSFRIKPK DFETSEYVRK AWLRDIAEEQ
460 470 480 490 500
EKYAAERDAI SMTATSEMTA SSVDFDMNAS DQQSEFSEWS GSRKSSLFPG
510 520 530 540 550
PEEGGPPRKK VKSPPVISPT GSSTSIYSGG SSSIDWTTTG TTLEMQGTRV
560 570 580 590 600
TRTQYGFRTL QESSAKMCLK VTGYPLPDIT WYKDDVQLHE DERHTFYSDE
610 620 630 640 650
DGFFAMTIDP VQVTDTGRYT CMATNEYGQA STSAFFRVLK VEKEAAPPAF
660 670 680 690 700
VTKLRDKECK EGDVIDFECE VEGWPEPELV WLVDDQPLRP SHDFRLQYDG
710 720 730 740 750
QTAKLEIRDA QPDDTGVYTV KIQNEFGSIE SKAELFVQAD PDKNHVAPEF
760 770 780 790 800
QATIEYVECD EGEEVRFKSV ITGDPNPEII WFINGKPLSE SEKVKFISED
810 820 830 840 850
GICILTIKDV TRHFDGMVTC QGSNRLGSAS CDGRLKVRVP PAPPTFNKPL
860 870 880 890 900
EDKTVQEKST VVFEVDVSGW PEPTLTFTLC GKELKNGEEG VEIVGHDGFY
910 920 930 940 950
RISIPNTSMD KHDGEIVAKA QNEHGTAESR ARLTVEQEEE ESRSAPTFLK
960 970 980 990 1000
DIEDQTVKTG EFAVFETTVR GNPNPEVTWF INGHKMDQGS PGVKIEAHNH
1010 1020 1030 1040 1050
DHKLTIDSAQ YAGTVLCRAE NAVGRFETKA RLVVLAPEKQ KKPPKFVEIL
1060 1070 1080 1090 1100
VDKTETVDNT VVFEVRVEGE PKPTVTWYLK GEELKQSDRV EIREFDGSIK
1110 1120 1130 1140 1150
ISIKNIKIED AGEIRAVATN SEGSDETKAK LTVQKKPFAP EFDLRPVSLT
1160 1170 1180 1190 1200
VEKGSEAVFS AHAFGIPLPT YEWSVNGRKV RDGQEGARVT RDESTVDGAS
1210 1220 1230 1240 1250
ILTIDTATYY SEVNHLTISV VAENTLGAEE TGAQLTIEPK KESVVVEKQD
1260 1270 1280 1290 1300
LSSSEVQKEI AQQVKEASPE ATTTITMETS LTSTKTTTMS TTEVTSTVGG
1310 1320 1330 1340 1350
VTVETKESES ESATTVIGGG SGGVTEGSIS VSKIEVVSKT DSQTDVREGT
1360 1370 1380 1390 1400
PKRRVSFAEE ELPKEVIDSD RKKKKSPSPD KKEKSPEKTE EKPASPTKKT
1410 1420 1430 1440 1450
GEEVKSPKEK SPASPTKKEK SPAAEEVKSP TKKEKSPSSP TKKEKSPSSP
1460 1470 1480 1490 1500
TKKTGDEVKE KSPPKSPTKK EKSPEKPEDV KSPVKKEKSP DATNIVEVSS
1510 1520 1530 1540 1550
ETTIEKTETT MTTEMTHESE ESRTSVKKEK TPEKVDEKPK SPTKKDKSPE
1560 1570 1580 1590 1600
KSITEEIKSP VKKEKSPEKV EEKPASPTKK EKSPEKPASP TKKSENEVKS
1610 1620 1630 1640 1650
PTKKEKSPEK SVVEELKSPK EKSPEKADDK PKSPTKKEKS PEKSATEDVK
1660 1670 1680 1690 1700
SPTKKEKSPE KVEEKPTSPT KKESSPTKKT DDEVKSPTKK EKSPQTVEEK
1710 1720 1730 1740 1750
PASPTKKEKS PEKSVVEEVK SPKEKSPEKA EEKPKSPTKK EKSPEKSAAE
1760 1770 1780 1790 1800
EVKSPTKKEK SPEKSAEEKP KSPTKKESSP VKMADDEVKS PTKKEKSPEK
1810 1820 1830 1840 1850
VEEKPASPTK KEKTPEKSAA EELKSPTKKE KSPSSPTKKT GDESKEKSPE
1860 1870 1880 1890 1900
KPEEKPKSPT PKKSPPGSPK KKKSKSPEAE KPPAPKLTRD LKLQTVNKTD
1910 1920 1930 1940 1950
LAHFEVVVEH ATECKWFLDG KEITTAQGVT VSKDDQFEFR CSIDTTMFGS
1960 1970 1980 1990 2000
GTVSVVASNA AGSVETKTEL KVLETPKETK KPEFTDKLRD MEVTKGDTVQ
2010 2020 2030 2040 2050
MDVIALHSPL YKWYQNGNLL EDGKNGVTIK NEENKSSLII PNAQDSGKIT
2060 2070 2080 2090 2100
VEASNEVGSS ESSAQLTVNP PSTTPIVVDG PKSVTIKETE TAEFKATISG
2110 2120 2130 2140 2150
FPAPTVKWTI NEKIVEESRT ITTIKTEDVY TLKISNAKIE QTGTVKVTAQ
2160 2170 2180 2190 2200
NSAGQDSKQA DLKVEPNVKA PKFKSQLTDK VADEGEPLRW NLELDGPSPG
2210 2220 2230 2240 2250
TEVSWLLNGQ PLTKSDTVQV VDHGDGTYHV TIAEAKPEMS GTLTAKAKNA
2260 2270 2280 2290 2300
AGECETSAKV TVNGGNKKPE FVQAPQNHET TLEESVKFSA IVTGKPMPNV
2310 2320 2330 2340 2350
TWYLNNKKLI QSEEVKVKYV HETGKTSIRI QKPLMEHNGT IRVEAENVSG
2360 2370 2380 2390 2400
KVQATAQLKV DKKTEVPKFT TNMDDRQVKE GEDVKFTANV EGYPEPSVAW
2410 2420 2430 2440 2450
TLNGEPVSKH PNITVTDKDG EHTIEISAVT PEQAGELSCE ATNPVGSKKR
2460 2470 2480 2490 2500
DVQLAVKKVG DAPTFAKNLE DRLITEGELT LMDAKLNIVK PKPKITWLKD
2510 2520 2530 2540 2550
GVEITSDGHY KIVEEEDGSL KLSILQTKLE DKGRITIKAE SEFGVAECSA
2560 2570 2580 2590 2600
SLGVVKGRPM AKPAFQSDIA PINLTEGDTL ECKLLITGDP TPFVKWYIGT
2610 2620 2630 2640 2650
QLVCATEDTE ISNANGVYTM KIHGVTADMT GKIKCVAYNK AGEVSTEGPL
2660 2670 2680 2690 2700
KVVAPIPVEF ETSLCDATCR EGDTLKLRAV LLGEPEPVVS WYVNGKKLEE
2710 2720 2730 2740 2750
SQNIKIHSEK GTYTVTIKDI TCDYSGQVVC EAINEYGKAT SEATLLVLPR
2760 2770 2780 2790 2800
GEPPDFLEWL SNVRARTGTK VVHKVVFTGD PKPSLTWYIN NKEILNSDLY
2810 2820 2830 2840 2850
TIVTDDKTST LTINSFNPDV HVGEIICKAE NDAGEVSCTA NMITYTSDMF
2860 2870 2880 2890 2900
SESESEAQAE EFVGDDLTED ESLREEMHRT PTPVMAPKFI TKIKDTKAKK
2910 2920 2930 2940 2950
GHSAVFECVV PDTKGVCCKW LKDGKEIELI ARIRVQTRTG PEGHITQELV
2960 2970 2980 2990 3000
LDNVTPEDAG KYTCIVENTA GKDTCEATLT VIESLEKKSE KKAPEFIVAL
3010 3020 3030 3040 3050
QDKTTKTSEK VVLECKVIGE PKPKVSWLHD NKTITQESIT VESVEGVERV
3060 3070 3080 3090 3100
TITSSELSHQ GKYTCIAENT EGTSKTEAFL TVQGEAPVFT KELQNKELSI
3110 3120 3130 3140 3150
GEKLVLSCSV KGSPQPHVDF YSFSETTKVE TKITSSSRIA IEHDQTNTHW
3160 3170 3180 3190 3200
RMVISQITKE DIVSYKAIAT NSIGTATSTS KITTKVEAPV FEQGLKKTSV
3210 3220 3230 3240 3250
KEKEEIKMEV KVGGSAPDVE WFKDDKPVSE DGNHEMKKNP ETGVFTLVVK
3260 3270 3280 3290 3300
QAATTDAGKY TAKASNPAGT AESSAEAEVT QSLEKPTFVR ELVTTEVKIN
3310 3320 3330 3340 3350
ETATLSVTVK GVPDPSVEWL KDGQPVQTDS SHVIAKVEGS GSYSITIKDA
3360 3370 3380 3390 3400
RLEDSGKYAC RATNPAGEAK TEANFAVVKN LVPPEFVEKL SPLEVKEKES
3410 3420 3430 3440 3450
TTLSVKVVGT PEPSVEWFKD DTPISIDNVH VIQKQTAVGS FSLTINDARQ
3460 3470 3480 3490 3500
GDVGIYSCRA RNEAGEALTT ANFGIIRDSI PPEFTQKLRP LEVREQETLD
3510 3520 3530 3540 3550
LKVTVIGTPV PNVEWFKDDK PINIDNSHIF AKDEGSGHHT LTIKQARGED
3560 3570 3580 3590 3600
VGVYTCKATN EAGEAKTTAN MAVQEEIEAP LFVQGLKPYE VEQGKPAELV
3610 3620 3630 3640 3650
VRVEGKPEPE VKWFKDGVPI AIDNQHVIEK KGENGSHTLV IKDTNNADFG
3660 3670 3680 3690 3700
KYTCQATNKA GKDETVGELK IPKYSFEKQT AEEVKPLFIE PLKETFAVEG
3710 3720 3730 3740 3750
DTVVLECKVN KESHPQIKFF KNDQPVEIGQ HMQLEVLEDG NIKLTIQNAK
3760 3770 3780 3790 3800
KEDVGAYRCE AVNVAGKANT NADLKIQFAA KVEEHVTDES GQLEEIGQFE
3810 3820 3830 3840 3850
TVGDTASSKT DTGRGAPEFV ELLRSCTVTE KQQAILKCKV KGEPRPKIKW
3860 3870 3880 3890 3900
TKEGKEVEMS ARVRAEHKDD GTLTLTFDNV TQADAGEYRC EAENEYGSAW
3910 3920 3930 3940 3950
TEGPIIVTLE GAPKIDGEAP DFLQPVKPAV VTVGETAVLE GKISGKPKPS
3960 3970 3980 3990 4000
VKWYKNGEEL KPSDRVKIEN LDDGTQRLTV TNAKLDDMDE YRCEASNEFG
4010 4020 4030 4040 4050
DVWSDVTLTV KEPAQVAPGF FKELSAIQVK ETETAKFECK VSGTKPDVKW
4060 4070 4080 4090 4100
FKDGTPLKED KRVHFESTDD GTQRLVIEDS KTDDQGNYRI EVSNDAGVAN
4110 4120 4130 4140 4150
SKVPLTVVPS ETLKIKKGLT DVNVTQGTKI LLSVEVEGKP KTVKWYKGTE
4160 4170 4180 4190 4200
TVTSSQTTKI VQVTESEYKL EIESAEMSDT GAYRVVLSTD SFSVESSATV
4210 4220 4230 4240 4250
TVTKAAEKIS LPSFKKGLAD QSVPKGTPLV LEVEIEGKPK DVKWYKNGDE
4260 4270 4280 4290 4300
IKDGKVEDLG NGKYRLTIPD FQEKDVGEYS VTAANEAGEI ESKAKVNVSA
4310 4320 4330 4340 4350
KPEIVSGLVP TTVKQGETAT FNVKVKGPVK GVKWYKNGKE IPDAKTKDNG
4360 4370 4380 4390 4400
DGSYSLEIPN AQVEDAADYK VVVSNDAGDA DSSAALTVKL ADDGKDKVKP
4410 4420 4430 4440 4450
EIVSGLIPTT VKQGETATFN VKVKGPVKQV KWYKNGKEIP NAKAKDNGDG
4460 4470 4480 4490 4500
SYSLEIPNAQ LDDTADYKVV VSNDAGDADS SAALTVKLPG IAIVKGLEDA
4510 4520 4530 4540 4550
EVPKGKKAVL QVETNKKPKE IKWYKNGKEI TPSDKAQPGS DGDNKPQLVI
4560 4570 4580 4590 4600
PDAGDDDAAE YKVVLTDEDG NTADSSCALT VKLPAKEPKI IKGLEDQVVS
4610 4620 4630 4640 4650
IGSPIKLEIE TSGSPKTVKW YKNGKELPGA AAKTIKIQKI DDNKYVLEIP
4660 4670 4680 4690 4700
SSVVEDTGDY KVEVANEAGS ANSSGKITVE PKITFLKPLK DQSITEGENA
4710 4720 4730 4740 4750
EFSVETNTKP RIVKWYKNGQ EIKPNSRFII EQKTDTKYQL VIKNAVRDDA
4760 4770 4780 4790 4800
DTYKIVLENT AGEAESSAQL TVKKAKAGLC KIVKGLEDQV VAKGAKMVFE
4810 4820 4830 4840 4850
VKIQGEPEDV RWLRDANVIS AGANAIIEKI DDTTYRLIIP SADLKDAGEY
4860 4870 4880 4890 4900
TVEVINESGK AKSDAKGEVD EKPEIVRGLE NIEIPEGDDD VFKVEVSAPV
4910 4920 4930 4940 4950
RQVKWYKNDQ EIKPNSHLEA KKIGPKKYEL AINRAQLDDG ADYKVVLSNA
4960 4970 4980 4990 5000
AGDCDSSAAL TVVKPNVLKI VDGLKDVDVE EPQPVELKVK VEGIPKVIKW
5010 5020 5030 5040 5050
YKNGQELKPD ADGFKFEEKP ESGEFSLTIP SSKKSDGGAY RVVLGNDKGE
5060 5070 5080 5090 5100
VYSGSVVHVK SAKSSEPTSG ANFLSPLKDT EVEEGDMLTL QCTIAGEPFP
5110 5120 5130 5140 5150
EVIWEKDGVV LQKDDRITMR VALDGTATLR IRSAKKSDIG QYRVTAKNEA
5160 5170 5180 5190 5200
GSATSDCKVT VTEQGEQPSK PKFVIPLKTG AALPGDKKEF NVKVRGLPKP
5210 5220 5230 5240 5250
TLQWFLNGIP IKFDDRITLD DMADGNYCLT IRDVREEDFG TLKCIAKNEN
5260 5270 5280 5290 5300
GTDETVCEFQ QGAGHDDGSR DDLRYPPRFN VPLWDRRIPV GDPMFIECHV
5310 5320 5330 5340 5350
DANPTAEVEW FKDGKKIEHT AHTEIRNTVD GACRIKIIPF EESDIGVYMC
5360 5370 5380 5390 5400
VAVNELGQAE TQATYQVEIL EHVEEEKRRE YAPKINPPLE DKTVNGGQPI
5410 5420 5430 5440 5450
RLSCKVDAIP RASVVWYKDG LPLRADSRTS IQYEEDGTAT LAINDSTEED
5460 5470 5480 5490 5500
IGAYRCVATN AHGTINTSCS VNVKVPKQEV KKEGEEPFFT KGLVDLWADR
5510 5520 5530 5540 5550
GDSFTLKCAV TGDPFPEIKW YRNGQLLRNG PRTVIETSPD GSCSLTVNES
5560 5570 5580 5590 5600
TMSDEGIYRC EAENAHGKAK TQATAHVQMA LGKTEKPKMD EGKPPKFILE
5610 5620 5630 5640 5650
LSDMSVSLGN VIDLECKVTG LPNPSVKWSK DGGPLIEDSR FEWSNEASKG
5660 5670 5680 5690 5700
VYQLRIKNAT VHDEGTYRCV ATNENGSATT KSFVRMDDGL GSGVVTASQP
5710 5720 5730 5740 5750
PRFTLKMGDV RTTEGQPLKL ECKVDASPLP EMVWYKDGAI VTPSDRIQIS
5760 5770 5780 5790 5800
LSPDGVATLL IPSCVYDDDG IYRVIATNPS GTAQDKGTAT VKKLPRDSGA
5810 5820 5830 5840 5850
RRSADRDVFD ANKAPKLMEP LENIRIPEKQ SFRLRCKFSG DPKPTIKWFK
5860 5870 5880 5890 5900
DGERVFPYGR LQLIESPDGV CELVVDSATR QDAGGYRCVA ENTYGSARTS
5910 5920 5930 5940 5950
CDVNVIRGDR KPRDIDSSIR EGKAPGFTTP LTIRRAKPGD SVTFECLPFG
5960 5970 5980 5990 6000
NPFPSIKWLK DGLELFSDEK IKMEAAADGT QRLILSDVTF LSEGYFRCVA
6010 6020 6030 6040 6050
TNEHGTASTK AELVIEGDRT IGSRPLPEVN GEPEECKPRI RRGLYNMSIH
6060 6070 6080 6090 6100
EGNVVEMIVC ATGIPTPTVK WYKDGQEIVG DGPDGKRVIF TDERGIHHLV
6110 6120 6130 6140 6150
IVNASPDDEG EYSLEATNKL GSAKTEGSLN IIRPRHIADA DERGGMPFPP
6160 6170 6180 6190 6200
GFVRQLKNKH VFNHMPTIFD CLVVGHPAPE VEWFHNGKKI VPGGRIKIQS
6210 6220 6230 6240 6250
CGGGSHALII LDTTLEDAGE YVATAKNSHG SASSSAVLDV TVPFLDSIKF
6260 6270 6280 6290 6300
NGEIDVTPYL TEEYGFKKLN TASLPTPPDR GPFIKEVTGH YLTLSWIPTK
6310 6320 6330 6340 6350
RAPPRYPQVT YVIEIRELPE KQWSLLEYNI PEPVCKVRNL ELGKSYQFRV
6360 6370 6380 6390 6400
RAENIYGISD PSPASPPSRL MAPPQPVFDR RTNKVIPLLD PYAEKALDMR
6410 6420 6430 6440 6450
YSEQYACAPW FSPGVVEKRY CAENDTLTIV LNVSGFPDPD IKWKFRGWDI
6460 6470 6480 6490 6500
DTSSPTSKCK VYTYGGSETT LAITGFSKEN VGQYQCFAKN DYGDAQQNIM
6510 6520 6530 6540 6550
VDLATRPNFI QPLVNKTFSS AQPMRMDVRV DGEPFPELKW MKEWRPIVES
6560 6570 6580 6590 6600
SRIKFVQDGP YLCSLIINDP MWRDSGIYSC VAVNDAGQAT TSCTVTVEAE
6610 6620 6630 6640 6650
GDYNDVELPR RRVTIESRRV RELYEISEKD EKLAAEGAPF RVKEKATGRE
6660 6670 6680 6690 6700
FLAQLRPIDD ALMRHVDIHN SLDHPGIVQM HRVLRDEKLA LVVFDNANST
6710 6720 6730 6740 6750
IDGLSSLAHP GVEIAEPKGV NRETCVRVFV RQLLLALKHM HDLRIAHLDL
6760 6770 6780 6790 6800
RPETILLQDD KLKLADFGQA RRLLRGLITG EIKGSPEFVS PEIVRSYPLT
6810 6820 6830 6840 6850
LATDMWSTGV LTYVLLTGLS PFHGDNDNET LANVDSCQFD SSPLGNFSYD
6860 6870 6880 6890 6900
AGDFVKKLLT EIPVSRLTVD EALDHPWIND EKLKTEPLSA DTLREFKYQH
6910 6920 6930 6940 6950
KWLERRVFVQ QTPSEQILEA ILGPATAQAQ QNAPVAPEGR RPAEIYDYLR
6960 6970 6980 6990 7000
IQPKKPPPTV EYVPQPRKEH PPFIDEFGQL IDGDAFDRPE GTGFEGPHRQ
7010 7020 7030 7040 7050
PPQIPPQPQR PNQAAHDSRR HEQQPQHQGQ PQRIPVDQYG RPLVDPRYLN
7060 7070 7080 7090 7100
DPSHRPSSLD DAPFYVDKYG NPVHFDKYGR PMAPQNLEKR KLIPQDKGET
7110 7120 7130 7140 7150
PSHSKKEKTQ HPVATPILAS PGGDQQQQKI PMRMIRGERR EIEEEIANRI
7160 7170 7180 7190 7200
LSDISEEGSI AGSLASLEDF EIPKDFQVEA SEPSTPTLTP EVTIRETIPK
7210 7220 7230 7240 7250
PTPSPTSPQK SPVPQPQGLL IPAKVTYSDS ILAGLPAADK KVLEDAENDP
7260 7270 7280 7290 7300
SIPVGAPLFL EGLHGSDLTI DTTSASGLIK VTSPAINLSP NPKSPRRSTP
7310 7320 7330 7340 7350
GTKSPVVLSP RQEHSMEVLI ATKRGKPGFL PPGELAEDID DEDAFMDDRK
7360 7370 7380 7390 7400
KQVKPKDHDG ENDFKDEKER LEKDKNRRTV NLDDLDKYRP SAFYKDDSDF
7410 7420 7430 7440 7450
GHPGYDIDAT PWDSHYQIGP DTYLMAARGA AFNSRVRNYR EELFGMGAPT
7460 7470 7480 7490 7500
VKQGFLGVRN RDITVRERRR YTDILRETTQ GLEPKSHEQS TALLQKAPSA
7510 7520 7530 7540 7550
TAIERIKADI EKVTPCATKK NDDGTFAPIF TARLRDVYLR KNQPAIFECA
7560 7570 7580 7590 7600
VSASPAPKVT WDFQGKILES NDRVTIEQDN NVARLILNHA APYDLGEYVC
7610 7620 7630 7640 7650
TAINEYGTDK SSCRLISGET PSRPGRPEAE LSSDTEIFIQ WEAPEGPTYL
7660 7670 7680 7690 7700
EGITYRLEYR VAGPNDHGDP WITVSEKIDD ESVIVKHLSP LGIYQFRVTA
7710 7720 7730 7740 7750
QNGFGLGLPS LSSRIVQTHG KGAPKLQIDV LKSEIRLNVV SMPQKSTNQL
7760 7770 7780 7790 7800
GGISEESEED SEARTANEDM KSNLQLQTDD PTGRFQIGGL KFKGRFSVIR
7810 7820 7830 7840 7850
DAVDSTTEGH AHCAVKIRHP SSEAISEYES LRDGQHENVQ RLIAAFNNSN
7860 7870 7880 7890 7900
FLYLLSERLY EDVFSRFVFN DYYTEEQVAL TMRQVTSALH FLHFKGIAHL
7910 7920 7930 7940 7950
DVNPHNIMFQ SKRSWVVKLV DFGRAQKVSG AVKPVDFDTK WASPEFHIPE
7960 7970 7980 7990 8000
TPVTVQSDMW GMGVVTFCLL AGFHPFTSEY DREEEIKENV INVKCDPNLI
8010 8020 8030 8040 8050
PVNASQECLS FATWALKKSP VRRMRTDEAL SHKFLSSDPS MVRRRESIKY
8060 8070 8080
SASRLRKLAA MIRQPTFSQP ISEELESKYG K
Length:8,081
Mass (Da):894,252
Last modified:September 13, 2005 - v3
Checksum:i67C804953CF62228
GO
Isoform a (identifier: O01761-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     6633-8081: Missing.

Show »
Length:6,632
Mass (Da):731,685
Checksum:i262D3EDD62960E89
GO
Isoform c (identifier: O01761-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6688: Missing.
     6689-6696: LALVVFDN → MVRFTINC

Note: No experimental confirmation available.

Show »
Length:1,393
Mass (Da):156,297
Checksum:iF947C1BCE4EB9CE9
GO
Isoform d (identifier: O01761-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6685: Missing.
     6686-6696: DEKLALVVFDN → MFRLVEDCELC

Note: No experimental confirmation available.

Show »
Length:1,396
Mass (Da):156,671
Checksum:iF42D06301E7185C2
GO
Isoform e (identifier: O01761-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1880: Missing.
     6633-8081: Missing.

Note: No experimental confirmation available.

Show »
Length:5,992
Mass (Da):661,677
Checksum:i7E5F00BF18A251D4
GO
Isoform f (identifier: O01761-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1880: Missing.

Show »
Length:7,441
Mass (Da):824,244
Checksum:i4B102760FC1131D7
GO
Isoform g (identifier: O01761-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     6632-6695: Missing.
     7175-7186: DFQVEASEPSTP → VTEGDGCNMCGE
     7187-8081: Missing.

Note: No experimental confirmation available.

Show »
Length:7,122
Mass (Da):786,772
Checksum:iE0AADE021082BD5B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2137 – 21371A → P in AAB00542. (PubMed:8603916)Curated
Sequence conflicti2245 – 22473AKA → PKP in AAB00542. (PubMed:8603916)Curated
Sequence conflicti2258 – 22581A → P in AAB00542. (PubMed:8603916)Curated
Sequence conflicti2284 – 22841E → G in AAB00542. (PubMed:8603916)Curated
Sequence conflicti2297 – 22971M → I in AAB00542. (PubMed:8603916)Curated
Sequence conflicti3531 – 35311A → G in AAB00542. (PubMed:8603916)Curated
Sequence conflicti3884 – 38885DAGEY → RRRRI in AAB00542. (PubMed:8603916)Curated
Sequence conflicti3929 – 39291A → V in AAB00542. (PubMed:8603916)Curated
Sequence conflicti5134 – 51341A → P in AAB00542. (PubMed:8603916)Curated
Sequence conflicti5145 – 51451T → S in AAB00542. (PubMed:8603916)Curated
Sequence conflicti5185 – 51851G → A in AAB00542. (PubMed:8603916)Curated
Sequence conflicti5199 – 51991K → N in AAB00542. (PubMed:8603916)Curated
Sequence conflicti5202 – 52021L → F in AAB00542. (PubMed:8603916)Curated
Sequence conflicti5213 – 52131F → L in AAB00542. (PubMed:8603916)Curated
Sequence conflicti6178 – 61781A → G in AAB00542. (PubMed:8603916)Curated
Sequence conflicti6268 – 62681K → E in AAB00542. (PubMed:8603916)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66886688Missing in isoform c. CuratedVSP_015541Add
BLAST
Alternative sequencei1 – 66856685Missing in isoform d. CuratedVSP_015542Add
BLAST
Alternative sequencei1241 – 1880640Missing in isoform e and isoform f. CuratedVSP_015543Add
BLAST
Alternative sequencei6632 – 669564Missing in isoform g. CuratedVSP_015544Add
BLAST
Alternative sequencei6633 – 80811449Missing in isoform a and isoform e. CuratedVSP_015545Add
BLAST
Alternative sequencei6686 – 669611DEKLALVVFDN → MFRLVEDCELC in isoform d. CuratedVSP_015546Add
BLAST
Alternative sequencei6689 – 66968LALVVFDN → MVRFTINC in isoform c. CuratedVSP_015547
Alternative sequencei7175 – 718612DFQVE…EPSTP → VTEGDGCNMCGE in isoform g. CuratedVSP_015548Add
BLAST
Alternative sequencei7187 – 8081895Missing in isoform g. CuratedVSP_015549Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33058 Genomic DNA. Translation: AAB00542.1.
FO080458 Genomic DNA. Translation: CCD63864.1.
FO080458 Genomic DNA. Translation: CCD63865.1.
FO080458 Genomic DNA. Translation: CCD63866.1.
FO080458 Genomic DNA. Translation: CCD63867.1.
FO080458 Genomic DNA. Translation: CCD63868.1.
FO080458 Genomic DNA. Translation: CCD63869.1.
FO080458 Genomic DNA. Translation: CCD63870.1.
AY724774 mRNA. Translation: AAU21474.1.
AY714779 mRNA. Translation: AAU14146.1.
PIRiT29757.
RefSeqiNP_001020984.1. NM_001025813.1. [O01761-2]
NP_001020985.1. NM_001025814.2. [O01761-1]
NP_001020988.1. NM_001025817.2. [O01761-5]
NP_001020989.1. NM_001025818.1. [O01761-6]
NP_001020990.1. NM_001025819.1. [O01761-7]
UniGeneiCel.7125.

Genome annotation databases

EnsemblMetazoaiC09D1.1b; C09D1.1b; WBGene00006820. [O01761-1]
GeneIDi171990.
KEGGicel:CELE_C09D1.1.
UCSCiC09D1.1g. c. elegans. [O01761-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33058 Genomic DNA. Translation: AAB00542.1 .
FO080458 Genomic DNA. Translation: CCD63864.1 .
FO080458 Genomic DNA. Translation: CCD63865.1 .
FO080458 Genomic DNA. Translation: CCD63866.1 .
FO080458 Genomic DNA. Translation: CCD63867.1 .
FO080458 Genomic DNA. Translation: CCD63868.1 .
FO080458 Genomic DNA. Translation: CCD63869.1 .
FO080458 Genomic DNA. Translation: CCD63870.1 .
AY724774 mRNA. Translation: AAU21474.1 .
AY714779 mRNA. Translation: AAU14146.1 .
PIRi T29757.
RefSeqi NP_001020984.1. NM_001025813.1. [O01761-2 ]
NP_001020985.1. NM_001025814.2. [O01761-1 ]
NP_001020988.1. NM_001025817.2. [O01761-5 ]
NP_001020989.1. NM_001025818.1. [O01761-6 ]
NP_001020990.1. NM_001025819.1. [O01761-7 ]
UniGenei Cel.7125.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FHO NMR - A 341-458 [» ]
ProteinModelPortali O01761.
SMRi O01761. Positions 341-458.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 37462. 2 interactions.
IntActi O01761. 11 interactions.
MINTi MINT-1090274.

Protein family/group databases

MEROPSi I43.001.

Proteomic databases

PaxDbi O01761.
PRIDEi O01761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C09D1.1b ; C09D1.1b ; WBGene00006820 . [O01761-1 ]
GeneIDi 171990.
KEGGi cel:CELE_C09D1.1.
UCSCi C09D1.1g. c. elegans. [O01761-1 ]

Organism-specific databases

CTDi 3346201.
WormBasei C09D1.1a ; CE30426 ; WBGene00006820 ; unc-89.
C09D1.1b ; CE34251 ; WBGene00006820 ; unc-89.
C09D1.1c ; CE34252 ; WBGene00006820 ; unc-89.
C09D1.1d ; CE37701 ; WBGene00006820 ; unc-89.
C09D1.1e ; CE37702 ; WBGene00006820 ; unc-89.
C09D1.1f ; CE37703 ; WBGene00006820 ; unc-89.
C09D1.1g ; CE37704 ; WBGene00006820 ; unc-89.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00770000120473.
InParanoidi O01761.
OMAi DQAEYKC.
OrthoDBi EOG74BJR3.
PhylomeDBi O01761.

Enzyme and pathway databases

Reactomei REACT_240521. DCC mediated attractive signaling.
REACT_246059. Rho GTPase cycle.
REACT_250475. G alpha (12/13) signalling events.
REACT_253015. NRAGE signals death through JNK.
REACT_257432. G alpha (q) signalling events.
SignaLinki O01761.

Miscellaneous databases

EvolutionaryTracei O01761.
NextBioi 873555.
PROi O01761.

Gene expression databases

ExpressionAtlasi O01761. baseline and differential.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.10. 55 hits.
InterProi IPR000219. DH-domain.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR007850. RCSD.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 51 hits.
PF00069. Pkinase. 2 hits.
PF05177. RCSD. 6 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 2 hits.
SM00409. IG. 25 hits.
SM00408. IGc2. 24 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEi PS50010. DH_2. 1 hit.
PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 50 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains."
    Benian G.M., Tinley T.L., Tang X., Borodovsky M.
    J. Cell Biol. 132:835-848(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A), FUNCTION, TISSUE SPECIFICITY.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  3. "Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains."
    Small T.M., Gernert K.M., Flaherty D.B., Mercer K.B., Borodovsky M., Benian G.M.
    J. Mol. Biol. 342:91-108(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5922-7990 (ISOFORMS B/F), ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY.
    Strain: Bristol N2.
  4. "Functional diversity of PH domains: an exhaustive modelling study."
    Blomberg N., Nilges M.
    Fold. Des. 2:343-355(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 341-458.

Entry informationi

Entry nameiUNC89_CAEEL
AccessioniPrimary (citable) accession number: O01761
Secondary accession number(s): Q17362
, Q5W614, Q5W615, Q5W616, Q5W617, Q646H5, Q64EQ8, Q7Z119, Q7Z120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3