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O01761 (UNC89_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Muscle M-line assembly protein unc-89
Alternative name(s):
Uncoordinated protein 89
Gene names
Name:unc-89
ORF Names:C09D1.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length8081 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Structural component of the muscle M-line. Myofilament lattice assembly begins with positional cues laid down in the basement membrane and muscle cell membrane. UNC-89 responds to these signals, localizes, and then participates in assembling an M-line. Ref.1 Ref.3

Tissue specificity

Localizes to the middle of A-bands. Expression is seen in body-wall, pharyngeal muscle and few muscle cells of the tail. Ref.1 Ref.3

Sequence similarities

Contains 1 DH (DBL-homology) domain.

Contains 2 fibronectin type-III domains.

Contains 50 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 PH domain.

Contains 2 protein kinase domains.

Contains 4 RCSD domains.

Contains 1 SH3 domain.

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform b (identifier: O01761-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform a (identifier: O01761-2)

The sequence of this isoform differs from the canonical sequence as follows:
     6633-8081: Missing.
Isoform c (identifier: O01761-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6688: Missing.
     6689-6696: LALVVFDN → MVRFTINC
Note: No experimental confirmation available.
Isoform d (identifier: O01761-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6685: Missing.
     6686-6696: DEKLALVVFDN → MFRLVEDCELC
Note: No experimental confirmation available.
Isoform e (identifier: O01761-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1880: Missing.
     6633-8081: Missing.
Note: No experimental confirmation available.
Isoform f (identifier: O01761-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1880: Missing.
Isoform g (identifier: O01761-7)

The sequence of this isoform differs from the canonical sequence as follows:
     6632-6695: Missing.
     7175-7186: DFQVEASEPSTP → VTEGDGCNMCGE
     7187-8081: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 80818081Muscle M-line assembly protein unc-89
PRO_0000072704

Regions

Domain63 – 12765SH3
Domain152 – 330179DH
Domain342 – 498157PH
Domain547 – 63387Ig-like C2-type 1
Domain648 – 73689Ig-like C2-type 2
Domain748 – 83891Ig-like C2-type 3
Domain946 – 103388Ig-like C2-type 4
Domain1044 – 113289Ig-like C2-type 5
Domain1140 – 122788Ig-like C2-type 6
Domain1375 – 1475101RCSD 1
Domain1479 – 1585107RCSD 2
Domain1597 – 169599RCSD 3
Domain1700 – 1799100RCSD 4
Domain1982 – 206786Ig-like C2-type 7
Domain2071 – 216393Ig-like C2-type 8
Domain2171 – 226191Ig-like C2-type 9
Domain2269 – 235991Ig-like C2-type 10
Domain2367 – 245589Ig-like C2-type 11
Domain2463 – 2564102Ig-like C2-type 12
Domain2563 – 265189Ig-like C2-type 13
Domain2657 – 274690Ig-like C2-type 14
Domain2754 – 2858105Ig-like C2-type 15
Domain2887 – 298094Ig-like C2-type 16
Domain2994 – 308188Ig-like C2-type 17
Domain3087 – 318397Ig-like C2-type 18
Domain3189 – 328092Ig-like C2-type 19
Domain3286 – 337691Ig-like C2-type 20
Domain3384 – 346986Ig-like C2-type 21
Domain3482 – 357291Ig-like C2-type 22
Domain3580 – 366788Ig-like C2-type 23
Domain3686 – 377792Ig-like C2-type 24
Domain3817 – 390892Ig-like C2-type 25
Domain3920 – 400990Ig-like C2-type 26
Domain4018 – 410689Ig-like C2-type 27
Domain4109 – 420193Ig-like C2-type 28
Domain4212 – 429786Ig-like C2-type 29
Domain4302 – 438786Ig-like C2-type 30
Domain4400 – 448586Ig-like C2-type 31
Domain4489 – 458092Ig-like C2-type 32
Domain4588 – 467891Ig-like C2-type 33
Domain4681 – 477191Ig-like C2-type 34
Domain4873 – 496189Ig-like C2-type 35
Domain4965 – 505793Ig-like C2-type 36
Domain5067 – 516094Ig-like C2-type 37
Domain5171 – 526090Ig-like C2-type 38
Domain5277 – 536690Ig-like C2-type 39
Domain5383 – 547290Ig-like C2-type 40
Domain5487 – 557892Ig-like C2-type 41
Domain5595 – 568591Ig-like C2-type 42
Domain5701 – 579090Ig-like C2-type 43
Domain5815 – 590490Ig-like C2-type 44
Domain5925 – 601490Ig-like C2-type 45
Domain6038 – 613093Ig-like C2-type 46
Domain6150 – 623990Ig-like C2-type 47
Domain6278 – 637497Fibronectin type-III 1
Domain6413 – 650290Ig-like C2-type 48
Domain6507 – 659690Ig-like C2-type 49
Domain6592 – 6878287Protein kinase 1
Domain7528 – 761790Ig-like C2-type 50
Domain7623 – 772199Fibronectin type-III 2
Domain7785 – 8035251Protein kinase 2
Compositional bias936 – 9416Poly-Glu
Compositional bias1272 – 131544Thr-rich
Compositional bias1372 – 1886515Lys-rich
Compositional bias7125 – 71284Poly-Gln

Sites

Active site67491Proton acceptor By similarity
Active site79011Proton acceptor By similarity

Amino acid modifications

Disulfide bond568 ↔ 621 Potential
Disulfide bond2582 ↔ 2635 Potential
Disulfide bond2908 ↔ 2964 Potential
Disulfide bond3015 ↔ 3065 Potential
Disulfide bond3707 ↔ 3759 Potential
Disulfide bond3838 ↔ 3890 Potential
Disulfide bond5298 ↔ 5350 Potential
Disulfide bond5404 ↔ 5456 Potential
Disulfide bond5508 ↔ 5560 Potential
Disulfide bond5616 ↔ 5669 Potential
Disulfide bond5836 ↔ 5888 Potential
Disulfide bond5946 ↔ 5998 Potential
Disulfide bond7549 ↔ 7600 Potential

Natural variations

Alternative sequence1 – 66886688Missing in isoform c.
VSP_015541
Alternative sequence1 – 66856685Missing in isoform d.
VSP_015542
Alternative sequence1241 – 1880640Missing in isoform e and isoform f.
VSP_015543
Alternative sequence6632 – 669564Missing in isoform g.
VSP_015544
Alternative sequence6633 – 80811449Missing in isoform a and isoform e.
VSP_015545
Alternative sequence6686 – 669611DEKLALVVFDN → MFRLVEDCELC in isoform d.
VSP_015546
Alternative sequence6689 – 66968LALVVFDN → MVRFTINC in isoform c.
VSP_015547
Alternative sequence7175 – 718612DFQVE…EPSTP → VTEGDGCNMCGE in isoform g.
VSP_015548
Alternative sequence7187 – 8081895Missing in isoform g.
VSP_015549

Experimental info

Sequence conflict21371A → P in AAB00542. Ref.1
Sequence conflict2245 – 22473AKA → PKP in AAB00542. Ref.1
Sequence conflict22581A → P in AAB00542. Ref.1
Sequence conflict22841E → G in AAB00542. Ref.1
Sequence conflict22971M → I in AAB00542. Ref.1
Sequence conflict35311A → G in AAB00542. Ref.1
Sequence conflict3884 – 38885DAGEY → RRRRI in AAB00542. Ref.1
Sequence conflict39291A → V in AAB00542. Ref.1
Sequence conflict51341A → P in AAB00542. Ref.1
Sequence conflict51451T → S in AAB00542. Ref.1
Sequence conflict51851G → A in AAB00542. Ref.1
Sequence conflict51991K → N in AAB00542. Ref.1
Sequence conflict52021L → F in AAB00542. Ref.1
Sequence conflict52131F → L in AAB00542. Ref.1
Sequence conflict61781A → G in AAB00542. Ref.1
Sequence conflict62681K → E in AAB00542. Ref.1

Secondary structure

..................... 8081
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform b [UniParc].

Last modified September 13, 2005. Version 3.
Checksum: 67C804953CF62228

FASTA8,081894,252
        10         20         30         40         50         60 
MASRRQKQFD RKYSSYRKFT ATEDVNYSTH SSRSSYRSES LTSRTDGRGR STSSEIIAGS 

        70         80         90        100        110        120 
ESRSYPVYIA IQDYTPDKED VEAIPLEQGQ IVEVLDKKNS VRWLVRTKAR PPRSGWVPGS 

       130        140        150        160        170        180 
YFETPTEFYK QRRRTREIEN VSLSDEQAAL VKRDQVYHEL LRSEEEFVSS LRTCVDDYIK 

       190        200        210        220        230        240 
VLDDPEVPEA VKKNREELTL NIPELYNFHA NVMLKGLNYY SDDPGKVGQT FVRLEKDFES 

       250        260        270        280        290        300 
HVEFYKQYAD TLKLLEEPEI KRFFEGLSAK NDAGASSFVD HVKEIADRMV QYQNYFKEFV 

       310        320        330        340        350        360 
KYSARAHGSS KSIQKALELV TTIPQRVHDL EFTNNLKQHP GDTGKLGRII RHDAFQVWEG 

       370        380        390        400        410        420 
DEPPKLRYVF LFRNKIMFTE QDASTSPPSY THYSSIRLDK YNIRQHTTDE DTIVLQPQEP 

       430        440        450        460        470        480 
GLPSFRIKPK DFETSEYVRK AWLRDIAEEQ EKYAAERDAI SMTATSEMTA SSVDFDMNAS 

       490        500        510        520        530        540 
DQQSEFSEWS GSRKSSLFPG PEEGGPPRKK VKSPPVISPT GSSTSIYSGG SSSIDWTTTG 

       550        560        570        580        590        600 
TTLEMQGTRV TRTQYGFRTL QESSAKMCLK VTGYPLPDIT WYKDDVQLHE DERHTFYSDE 

       610        620        630        640        650        660 
DGFFAMTIDP VQVTDTGRYT CMATNEYGQA STSAFFRVLK VEKEAAPPAF VTKLRDKECK 

       670        680        690        700        710        720 
EGDVIDFECE VEGWPEPELV WLVDDQPLRP SHDFRLQYDG QTAKLEIRDA QPDDTGVYTV 

       730        740        750        760        770        780 
KIQNEFGSIE SKAELFVQAD PDKNHVAPEF QATIEYVECD EGEEVRFKSV ITGDPNPEII 

       790        800        810        820        830        840 
WFINGKPLSE SEKVKFISED GICILTIKDV TRHFDGMVTC QGSNRLGSAS CDGRLKVRVP 

       850        860        870        880        890        900 
PAPPTFNKPL EDKTVQEKST VVFEVDVSGW PEPTLTFTLC GKELKNGEEG VEIVGHDGFY 

       910        920        930        940        950        960 
RISIPNTSMD KHDGEIVAKA QNEHGTAESR ARLTVEQEEE ESRSAPTFLK DIEDQTVKTG 

       970        980        990       1000       1010       1020 
EFAVFETTVR GNPNPEVTWF INGHKMDQGS PGVKIEAHNH DHKLTIDSAQ YAGTVLCRAE 

      1030       1040       1050       1060       1070       1080 
NAVGRFETKA RLVVLAPEKQ KKPPKFVEIL VDKTETVDNT VVFEVRVEGE PKPTVTWYLK 

      1090       1100       1110       1120       1130       1140 
GEELKQSDRV EIREFDGSIK ISIKNIKIED AGEIRAVATN SEGSDETKAK LTVQKKPFAP 

      1150       1160       1170       1180       1190       1200 
EFDLRPVSLT VEKGSEAVFS AHAFGIPLPT YEWSVNGRKV RDGQEGARVT RDESTVDGAS 

      1210       1220       1230       1240       1250       1260 
ILTIDTATYY SEVNHLTISV VAENTLGAEE TGAQLTIEPK KESVVVEKQD LSSSEVQKEI 

      1270       1280       1290       1300       1310       1320 
AQQVKEASPE ATTTITMETS LTSTKTTTMS TTEVTSTVGG VTVETKESES ESATTVIGGG 

      1330       1340       1350       1360       1370       1380 
SGGVTEGSIS VSKIEVVSKT DSQTDVREGT PKRRVSFAEE ELPKEVIDSD RKKKKSPSPD 

      1390       1400       1410       1420       1430       1440 
KKEKSPEKTE EKPASPTKKT GEEVKSPKEK SPASPTKKEK SPAAEEVKSP TKKEKSPSSP 

      1450       1460       1470       1480       1490       1500 
TKKEKSPSSP TKKTGDEVKE KSPPKSPTKK EKSPEKPEDV KSPVKKEKSP DATNIVEVSS 

      1510       1520       1530       1540       1550       1560 
ETTIEKTETT MTTEMTHESE ESRTSVKKEK TPEKVDEKPK SPTKKDKSPE KSITEEIKSP 

      1570       1580       1590       1600       1610       1620 
VKKEKSPEKV EEKPASPTKK EKSPEKPASP TKKSENEVKS PTKKEKSPEK SVVEELKSPK 

      1630       1640       1650       1660       1670       1680 
EKSPEKADDK PKSPTKKEKS PEKSATEDVK SPTKKEKSPE KVEEKPTSPT KKESSPTKKT 

      1690       1700       1710       1720       1730       1740 
DDEVKSPTKK EKSPQTVEEK PASPTKKEKS PEKSVVEEVK SPKEKSPEKA EEKPKSPTKK 

      1750       1760       1770       1780       1790       1800 
EKSPEKSAAE EVKSPTKKEK SPEKSAEEKP KSPTKKESSP VKMADDEVKS PTKKEKSPEK 

      1810       1820       1830       1840       1850       1860 
VEEKPASPTK KEKTPEKSAA EELKSPTKKE KSPSSPTKKT GDESKEKSPE KPEEKPKSPT 

      1870       1880       1890       1900       1910       1920 
PKKSPPGSPK KKKSKSPEAE KPPAPKLTRD LKLQTVNKTD LAHFEVVVEH ATECKWFLDG 

      1930       1940       1950       1960       1970       1980 
KEITTAQGVT VSKDDQFEFR CSIDTTMFGS GTVSVVASNA AGSVETKTEL KVLETPKETK 

      1990       2000       2010       2020       2030       2040 
KPEFTDKLRD MEVTKGDTVQ MDVIALHSPL YKWYQNGNLL EDGKNGVTIK NEENKSSLII 

      2050       2060       2070       2080       2090       2100 
PNAQDSGKIT VEASNEVGSS ESSAQLTVNP PSTTPIVVDG PKSVTIKETE TAEFKATISG 

      2110       2120       2130       2140       2150       2160 
FPAPTVKWTI NEKIVEESRT ITTIKTEDVY TLKISNAKIE QTGTVKVTAQ NSAGQDSKQA 

      2170       2180       2190       2200       2210       2220 
DLKVEPNVKA PKFKSQLTDK VADEGEPLRW NLELDGPSPG TEVSWLLNGQ PLTKSDTVQV 

      2230       2240       2250       2260       2270       2280 
VDHGDGTYHV TIAEAKPEMS GTLTAKAKNA AGECETSAKV TVNGGNKKPE FVQAPQNHET 

      2290       2300       2310       2320       2330       2340 
TLEESVKFSA IVTGKPMPNV TWYLNNKKLI QSEEVKVKYV HETGKTSIRI QKPLMEHNGT 

      2350       2360       2370       2380       2390       2400 
IRVEAENVSG KVQATAQLKV DKKTEVPKFT TNMDDRQVKE GEDVKFTANV EGYPEPSVAW 

      2410       2420       2430       2440       2450       2460 
TLNGEPVSKH PNITVTDKDG EHTIEISAVT PEQAGELSCE ATNPVGSKKR DVQLAVKKVG 

      2470       2480       2490       2500       2510       2520 
DAPTFAKNLE DRLITEGELT LMDAKLNIVK PKPKITWLKD GVEITSDGHY KIVEEEDGSL 

      2530       2540       2550       2560       2570       2580 
KLSILQTKLE DKGRITIKAE SEFGVAECSA SLGVVKGRPM AKPAFQSDIA PINLTEGDTL 

      2590       2600       2610       2620       2630       2640 
ECKLLITGDP TPFVKWYIGT QLVCATEDTE ISNANGVYTM KIHGVTADMT GKIKCVAYNK 

      2650       2660       2670       2680       2690       2700 
AGEVSTEGPL KVVAPIPVEF ETSLCDATCR EGDTLKLRAV LLGEPEPVVS WYVNGKKLEE 

      2710       2720       2730       2740       2750       2760 
SQNIKIHSEK GTYTVTIKDI TCDYSGQVVC EAINEYGKAT SEATLLVLPR GEPPDFLEWL 

      2770       2780       2790       2800       2810       2820 
SNVRARTGTK VVHKVVFTGD PKPSLTWYIN NKEILNSDLY TIVTDDKTST LTINSFNPDV 

      2830       2840       2850       2860       2870       2880 
HVGEIICKAE NDAGEVSCTA NMITYTSDMF SESESEAQAE EFVGDDLTED ESLREEMHRT 

      2890       2900       2910       2920       2930       2940 
PTPVMAPKFI TKIKDTKAKK GHSAVFECVV PDTKGVCCKW LKDGKEIELI ARIRVQTRTG 

      2950       2960       2970       2980       2990       3000 
PEGHITQELV LDNVTPEDAG KYTCIVENTA GKDTCEATLT VIESLEKKSE KKAPEFIVAL 

      3010       3020       3030       3040       3050       3060 
QDKTTKTSEK VVLECKVIGE PKPKVSWLHD NKTITQESIT VESVEGVERV TITSSELSHQ 

      3070       3080       3090       3100       3110       3120 
GKYTCIAENT EGTSKTEAFL TVQGEAPVFT KELQNKELSI GEKLVLSCSV KGSPQPHVDF 

      3130       3140       3150       3160       3170       3180 
YSFSETTKVE TKITSSSRIA IEHDQTNTHW RMVISQITKE DIVSYKAIAT NSIGTATSTS 

      3190       3200       3210       3220       3230       3240 
KITTKVEAPV FEQGLKKTSV KEKEEIKMEV KVGGSAPDVE WFKDDKPVSE DGNHEMKKNP 

      3250       3260       3270       3280       3290       3300 
ETGVFTLVVK QAATTDAGKY TAKASNPAGT AESSAEAEVT QSLEKPTFVR ELVTTEVKIN 

      3310       3320       3330       3340       3350       3360 
ETATLSVTVK GVPDPSVEWL KDGQPVQTDS SHVIAKVEGS GSYSITIKDA RLEDSGKYAC 

      3370       3380       3390       3400       3410       3420 
RATNPAGEAK TEANFAVVKN LVPPEFVEKL SPLEVKEKES TTLSVKVVGT PEPSVEWFKD 

      3430       3440       3450       3460       3470       3480 
DTPISIDNVH VIQKQTAVGS FSLTINDARQ GDVGIYSCRA RNEAGEALTT ANFGIIRDSI 

      3490       3500       3510       3520       3530       3540 
PPEFTQKLRP LEVREQETLD LKVTVIGTPV PNVEWFKDDK PINIDNSHIF AKDEGSGHHT 

      3550       3560       3570       3580       3590       3600 
LTIKQARGED VGVYTCKATN EAGEAKTTAN MAVQEEIEAP LFVQGLKPYE VEQGKPAELV 

      3610       3620       3630       3640       3650       3660 
VRVEGKPEPE VKWFKDGVPI AIDNQHVIEK KGENGSHTLV IKDTNNADFG KYTCQATNKA 

      3670       3680       3690       3700       3710       3720 
GKDETVGELK IPKYSFEKQT AEEVKPLFIE PLKETFAVEG DTVVLECKVN KESHPQIKFF 

      3730       3740       3750       3760       3770       3780 
KNDQPVEIGQ HMQLEVLEDG NIKLTIQNAK KEDVGAYRCE AVNVAGKANT NADLKIQFAA 

      3790       3800       3810       3820       3830       3840 
KVEEHVTDES GQLEEIGQFE TVGDTASSKT DTGRGAPEFV ELLRSCTVTE KQQAILKCKV 

      3850       3860       3870       3880       3890       3900 
KGEPRPKIKW TKEGKEVEMS ARVRAEHKDD GTLTLTFDNV TQADAGEYRC EAENEYGSAW 

      3910       3920       3930       3940       3950       3960 
TEGPIIVTLE GAPKIDGEAP DFLQPVKPAV VTVGETAVLE GKISGKPKPS VKWYKNGEEL 

      3970       3980       3990       4000       4010       4020 
KPSDRVKIEN LDDGTQRLTV TNAKLDDMDE YRCEASNEFG DVWSDVTLTV KEPAQVAPGF 

      4030       4040       4050       4060       4070       4080 
FKELSAIQVK ETETAKFECK VSGTKPDVKW FKDGTPLKED KRVHFESTDD GTQRLVIEDS 

      4090       4100       4110       4120       4130       4140 
KTDDQGNYRI EVSNDAGVAN SKVPLTVVPS ETLKIKKGLT DVNVTQGTKI LLSVEVEGKP 

      4150       4160       4170       4180       4190       4200 
KTVKWYKGTE TVTSSQTTKI VQVTESEYKL EIESAEMSDT GAYRVVLSTD SFSVESSATV 

      4210       4220       4230       4240       4250       4260 
TVTKAAEKIS LPSFKKGLAD QSVPKGTPLV LEVEIEGKPK DVKWYKNGDE IKDGKVEDLG 

      4270       4280       4290       4300       4310       4320 
NGKYRLTIPD FQEKDVGEYS VTAANEAGEI ESKAKVNVSA KPEIVSGLVP TTVKQGETAT 

      4330       4340       4350       4360       4370       4380 
FNVKVKGPVK GVKWYKNGKE IPDAKTKDNG DGSYSLEIPN AQVEDAADYK VVVSNDAGDA 

      4390       4400       4410       4420       4430       4440 
DSSAALTVKL ADDGKDKVKP EIVSGLIPTT VKQGETATFN VKVKGPVKQV KWYKNGKEIP 

      4450       4460       4470       4480       4490       4500 
NAKAKDNGDG SYSLEIPNAQ LDDTADYKVV VSNDAGDADS SAALTVKLPG IAIVKGLEDA 

      4510       4520       4530       4540       4550       4560 
EVPKGKKAVL QVETNKKPKE IKWYKNGKEI TPSDKAQPGS DGDNKPQLVI PDAGDDDAAE 

      4570       4580       4590       4600       4610       4620 
YKVVLTDEDG NTADSSCALT VKLPAKEPKI IKGLEDQVVS IGSPIKLEIE TSGSPKTVKW 

      4630       4640       4650       4660       4670       4680 
YKNGKELPGA AAKTIKIQKI DDNKYVLEIP SSVVEDTGDY KVEVANEAGS ANSSGKITVE 

      4690       4700       4710       4720       4730       4740 
PKITFLKPLK DQSITEGENA EFSVETNTKP RIVKWYKNGQ EIKPNSRFII EQKTDTKYQL 

      4750       4760       4770       4780       4790       4800 
VIKNAVRDDA DTYKIVLENT AGEAESSAQL TVKKAKAGLC KIVKGLEDQV VAKGAKMVFE 

      4810       4820       4830       4840       4850       4860 
VKIQGEPEDV RWLRDANVIS AGANAIIEKI DDTTYRLIIP SADLKDAGEY TVEVINESGK 

      4870       4880       4890       4900       4910       4920 
AKSDAKGEVD EKPEIVRGLE NIEIPEGDDD VFKVEVSAPV RQVKWYKNDQ EIKPNSHLEA 

      4930       4940       4950       4960       4970       4980 
KKIGPKKYEL AINRAQLDDG ADYKVVLSNA AGDCDSSAAL TVVKPNVLKI VDGLKDVDVE 

      4990       5000       5010       5020       5030       5040 
EPQPVELKVK VEGIPKVIKW YKNGQELKPD ADGFKFEEKP ESGEFSLTIP SSKKSDGGAY 

      5050       5060       5070       5080       5090       5100 
RVVLGNDKGE VYSGSVVHVK SAKSSEPTSG ANFLSPLKDT EVEEGDMLTL QCTIAGEPFP 

      5110       5120       5130       5140       5150       5160 
EVIWEKDGVV LQKDDRITMR VALDGTATLR IRSAKKSDIG QYRVTAKNEA GSATSDCKVT 

      5170       5180       5190       5200       5210       5220 
VTEQGEQPSK PKFVIPLKTG AALPGDKKEF NVKVRGLPKP TLQWFLNGIP IKFDDRITLD 

      5230       5240       5250       5260       5270       5280 
DMADGNYCLT IRDVREEDFG TLKCIAKNEN GTDETVCEFQ QGAGHDDGSR DDLRYPPRFN 

      5290       5300       5310       5320       5330       5340 
VPLWDRRIPV GDPMFIECHV DANPTAEVEW FKDGKKIEHT AHTEIRNTVD GACRIKIIPF 

      5350       5360       5370       5380       5390       5400 
EESDIGVYMC VAVNELGQAE TQATYQVEIL EHVEEEKRRE YAPKINPPLE DKTVNGGQPI 

      5410       5420       5430       5440       5450       5460 
RLSCKVDAIP RASVVWYKDG LPLRADSRTS IQYEEDGTAT LAINDSTEED IGAYRCVATN 

      5470       5480       5490       5500       5510       5520 
AHGTINTSCS VNVKVPKQEV KKEGEEPFFT KGLVDLWADR GDSFTLKCAV TGDPFPEIKW 

      5530       5540       5550       5560       5570       5580 
YRNGQLLRNG PRTVIETSPD GSCSLTVNES TMSDEGIYRC EAENAHGKAK TQATAHVQMA 

      5590       5600       5610       5620       5630       5640 
LGKTEKPKMD EGKPPKFILE LSDMSVSLGN VIDLECKVTG LPNPSVKWSK DGGPLIEDSR 

      5650       5660       5670       5680       5690       5700 
FEWSNEASKG VYQLRIKNAT VHDEGTYRCV ATNENGSATT KSFVRMDDGL GSGVVTASQP 

      5710       5720       5730       5740       5750       5760 
PRFTLKMGDV RTTEGQPLKL ECKVDASPLP EMVWYKDGAI VTPSDRIQIS LSPDGVATLL 

      5770       5780       5790       5800       5810       5820 
IPSCVYDDDG IYRVIATNPS GTAQDKGTAT VKKLPRDSGA RRSADRDVFD ANKAPKLMEP 

      5830       5840       5850       5860       5870       5880 
LENIRIPEKQ SFRLRCKFSG DPKPTIKWFK DGERVFPYGR LQLIESPDGV CELVVDSATR 

      5890       5900       5910       5920       5930       5940 
QDAGGYRCVA ENTYGSARTS CDVNVIRGDR KPRDIDSSIR EGKAPGFTTP LTIRRAKPGD 

      5950       5960       5970       5980       5990       6000 
SVTFECLPFG NPFPSIKWLK DGLELFSDEK IKMEAAADGT QRLILSDVTF LSEGYFRCVA 

      6010       6020       6030       6040       6050       6060 
TNEHGTASTK AELVIEGDRT IGSRPLPEVN GEPEECKPRI RRGLYNMSIH EGNVVEMIVC 

      6070       6080       6090       6100       6110       6120 
ATGIPTPTVK WYKDGQEIVG DGPDGKRVIF TDERGIHHLV IVNASPDDEG EYSLEATNKL 

      6130       6140       6150       6160       6170       6180 
GSAKTEGSLN IIRPRHIADA DERGGMPFPP GFVRQLKNKH VFNHMPTIFD CLVVGHPAPE 

      6190       6200       6210       6220       6230       6240 
VEWFHNGKKI VPGGRIKIQS CGGGSHALII LDTTLEDAGE YVATAKNSHG SASSSAVLDV 

      6250       6260       6270       6280       6290       6300 
TVPFLDSIKF NGEIDVTPYL TEEYGFKKLN TASLPTPPDR GPFIKEVTGH YLTLSWIPTK 

      6310       6320       6330       6340       6350       6360 
RAPPRYPQVT YVIEIRELPE KQWSLLEYNI PEPVCKVRNL ELGKSYQFRV RAENIYGISD 

      6370       6380       6390       6400       6410       6420 
PSPASPPSRL MAPPQPVFDR RTNKVIPLLD PYAEKALDMR YSEQYACAPW FSPGVVEKRY 

      6430       6440       6450       6460       6470       6480 
CAENDTLTIV LNVSGFPDPD IKWKFRGWDI DTSSPTSKCK VYTYGGSETT LAITGFSKEN 

      6490       6500       6510       6520       6530       6540 
VGQYQCFAKN DYGDAQQNIM VDLATRPNFI QPLVNKTFSS AQPMRMDVRV DGEPFPELKW 

      6550       6560       6570       6580       6590       6600 
MKEWRPIVES SRIKFVQDGP YLCSLIINDP MWRDSGIYSC VAVNDAGQAT TSCTVTVEAE 

      6610       6620       6630       6640       6650       6660 
GDYNDVELPR RRVTIESRRV RELYEISEKD EKLAAEGAPF RVKEKATGRE FLAQLRPIDD 

      6670       6680       6690       6700       6710       6720 
ALMRHVDIHN SLDHPGIVQM HRVLRDEKLA LVVFDNANST IDGLSSLAHP GVEIAEPKGV 

      6730       6740       6750       6760       6770       6780 
NRETCVRVFV RQLLLALKHM HDLRIAHLDL RPETILLQDD KLKLADFGQA RRLLRGLITG 

      6790       6800       6810       6820       6830       6840 
EIKGSPEFVS PEIVRSYPLT LATDMWSTGV LTYVLLTGLS PFHGDNDNET LANVDSCQFD 

      6850       6860       6870       6880       6890       6900 
SSPLGNFSYD AGDFVKKLLT EIPVSRLTVD EALDHPWIND EKLKTEPLSA DTLREFKYQH 

      6910       6920       6930       6940       6950       6960 
KWLERRVFVQ QTPSEQILEA ILGPATAQAQ QNAPVAPEGR RPAEIYDYLR IQPKKPPPTV 

      6970       6980       6990       7000       7010       7020 
EYVPQPRKEH PPFIDEFGQL IDGDAFDRPE GTGFEGPHRQ PPQIPPQPQR PNQAAHDSRR 

      7030       7040       7050       7060       7070       7080 
HEQQPQHQGQ PQRIPVDQYG RPLVDPRYLN DPSHRPSSLD DAPFYVDKYG NPVHFDKYGR 

      7090       7100       7110       7120       7130       7140 
PMAPQNLEKR KLIPQDKGET PSHSKKEKTQ HPVATPILAS PGGDQQQQKI PMRMIRGERR 

      7150       7160       7170       7180       7190       7200 
EIEEEIANRI LSDISEEGSI AGSLASLEDF EIPKDFQVEA SEPSTPTLTP EVTIRETIPK 

      7210       7220       7230       7240       7250       7260 
PTPSPTSPQK SPVPQPQGLL IPAKVTYSDS ILAGLPAADK KVLEDAENDP SIPVGAPLFL 

      7270       7280       7290       7300       7310       7320 
EGLHGSDLTI DTTSASGLIK VTSPAINLSP NPKSPRRSTP GTKSPVVLSP RQEHSMEVLI 

      7330       7340       7350       7360       7370       7380 
ATKRGKPGFL PPGELAEDID DEDAFMDDRK KQVKPKDHDG ENDFKDEKER LEKDKNRRTV 

      7390       7400       7410       7420       7430       7440 
NLDDLDKYRP SAFYKDDSDF GHPGYDIDAT PWDSHYQIGP DTYLMAARGA AFNSRVRNYR 

      7450       7460       7470       7480       7490       7500 
EELFGMGAPT VKQGFLGVRN RDITVRERRR YTDILRETTQ GLEPKSHEQS TALLQKAPSA 

      7510       7520       7530       7540       7550       7560 
TAIERIKADI EKVTPCATKK NDDGTFAPIF TARLRDVYLR KNQPAIFECA VSASPAPKVT 

      7570       7580       7590       7600       7610       7620 
WDFQGKILES NDRVTIEQDN NVARLILNHA APYDLGEYVC TAINEYGTDK SSCRLISGET 

      7630       7640       7650       7660       7670       7680 
PSRPGRPEAE LSSDTEIFIQ WEAPEGPTYL EGITYRLEYR VAGPNDHGDP WITVSEKIDD 

      7690       7700       7710       7720       7730       7740 
ESVIVKHLSP LGIYQFRVTA QNGFGLGLPS LSSRIVQTHG KGAPKLQIDV LKSEIRLNVV 

      7750       7760       7770       7780       7790       7800 
SMPQKSTNQL GGISEESEED SEARTANEDM KSNLQLQTDD PTGRFQIGGL KFKGRFSVIR 

      7810       7820       7830       7840       7850       7860 
DAVDSTTEGH AHCAVKIRHP SSEAISEYES LRDGQHENVQ RLIAAFNNSN FLYLLSERLY 

      7870       7880       7890       7900       7910       7920 
EDVFSRFVFN DYYTEEQVAL TMRQVTSALH FLHFKGIAHL DVNPHNIMFQ SKRSWVVKLV 

      7930       7940       7950       7960       7970       7980 
DFGRAQKVSG AVKPVDFDTK WASPEFHIPE TPVTVQSDMW GMGVVTFCLL AGFHPFTSEY 

      7990       8000       8010       8020       8030       8040 
DREEEIKENV INVKCDPNLI PVNASQECLS FATWALKKSP VRRMRTDEAL SHKFLSSDPS 

      8050       8060       8070       8080 
MVRRRESIKY SASRLRKLAA MIRQPTFSQP ISEELESKYG K 

« Hide

Isoform a [UniParc].

Checksum: 262D3EDD62960E89
Show »

FASTA6,632731,685
Isoform c [UniParc].

Checksum: F947C1BCE4EB9CE9
Show »

FASTA1,393156,297
Isoform d [UniParc].

Checksum: F42D06301E7185C2
Show »

FASTA1,396156,671
Isoform e [UniParc].

Checksum: 7E5F00BF18A251D4
Show »

FASTA5,992661,677
Isoform f [UniParc].

Checksum: 4B102760FC1131D7
Show »

FASTA7,441824,244
Isoform g [UniParc].

Checksum: E0AADE021082BD5B
Show »

FASTA7,122786,772

References

« Hide 'large scale' references
[1]"The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains."
Benian G.M., Tinley T.L., Tang X., Borodovsky M.
J. Cell Biol. 132:835-848(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A), FUNCTION, TISSUE SPECIFICITY.
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
[3]"Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains."
Small T.M., Gernert K.M., Flaherty D.B., Mercer K.B., Borodovsky M., Benian G.M.
J. Mol. Biol. 342:91-108(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5922-7990 (ISOFORMS B/F), ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY.
Strain: Bristol N2.
[4]"Functional diversity of PH domains: an exhaustive modelling study."
Blomberg N., Nilges M.
Fold. Des. 2:343-355(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 341-458.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U33058 Genomic DNA. Translation: AAB00542.1.
FO080458 Genomic DNA. Translation: CCD63864.1.
FO080458 Genomic DNA. Translation: CCD63865.1.
FO080458 Genomic DNA. Translation: CCD63866.1.
FO080458 Genomic DNA. Translation: CCD63867.1.
FO080458 Genomic DNA. Translation: CCD63868.1.
FO080458 Genomic DNA. Translation: CCD63869.1.
FO080458 Genomic DNA. Translation: CCD63870.1.
AY724774 mRNA. Translation: AAU21474.1.
AY714779 mRNA. Translation: AAU14146.1.
PIRT29757.
RefSeqNP_001020984.1. NM_001025813.1. [O01761-2]
NP_001020985.1. NM_001025814.2. [O01761-1]
NP_001020988.1. NM_001025817.2. [O01761-5]
NP_001020989.1. NM_001025818.1. [O01761-6]
NP_001020990.1. NM_001025819.1. [O01761-7]
UniGeneCel.7125.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FHONMR-A341-458[»]
ProteinModelPortalO01761.
SMRO01761. Positions 341-458.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid37462. 2 interactions.
IntActO01761. 11 interactions.
MINTMINT-1090274.

Protein family/group databases

MEROPSI43.001.

Proteomic databases

PaxDbO01761.
PRIDEO01761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC09D1.1b; C09D1.1b; WBGene00006820. [O01761-1]
GeneID171990.
KEGGcel:CELE_C09D1.1.
UCSCC09D1.1g. c. elegans. [O01761-1]

Organism-specific databases

CTD3346201.
WormBaseC09D1.1a; CE30426; WBGene00006820; unc-89.
C09D1.1b; CE34251; WBGene00006820; unc-89.
C09D1.1c; CE34252; WBGene00006820; unc-89.
C09D1.1d; CE37701; WBGene00006820; unc-89.
C09D1.1e; CE37702; WBGene00006820; unc-89.
C09D1.1f; CE37703; WBGene00006820; unc-89.
C09D1.1g; CE37704; WBGene00006820; unc-89.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000118717.
InParanoidO01761.
OMADQAEYKC.
OrthoDBEOG74BJR3.
PhylomeDBO01761.

Enzyme and pathway databases

SignaLinkO01761.

Family and domain databases

Gene3D1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.10. 55 hits.
InterProIPR000219. DH-domain.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000719. Prot_kinase_dom.
IPR007850. RCSD.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00041. fn3. 2 hits.
PF07679. I-set. 51 hits.
PF00069. Pkinase. 2 hits.
PF05177. RCSD. 6 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
SM00409. IG. 25 hits.
SM00408. IGc2. 24 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48065. SSF48065. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEPS50010. DH_2. 1 hit.
PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 50 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO01761.
NextBio873555.
PROO01761.

Entry information

Entry nameUNC89_CAEEL
AccessionPrimary (citable) accession number: O01761
Secondary accession number(s): Q17362 expand/collapse secondary AC list , Q5W614, Q5W615, Q5W616, Q5W617, Q646H5, Q64EQ8, Q7Z119, Q7Z120
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: September 13, 2005
Last modified: July 9, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase