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Protein
Submitted name:

DeHydrogenases, Short chain

Gene

dhs-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-5365859. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
DeHydrogenases, Short chainImported
Gene namesi
Name:dhs-2Imported
ORF Names:CELE_F55A12.4Imported, F55A12.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF55A12.4a; CE26924; WBGene00000966; dhs-2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 5426HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiO01758.
PaxDbiO01758.
PRIDEiO01758.

Expressioni

Gene expression databases

BgeeiWBGene00000966.
ExpressionAtlasiO01758. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.F55A12.4a.

Structurei

3D structure databases

ProteinModelPortaliO01758.
SMRiO01758. Positions 70-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00840000129713.
InParanoidiO01758.
OMAiYGATYLD.
OrthoDBiEOG091G0LMI.
PhylomeDBiO01758.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O01758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVNISLSL ALNVTDKEPD FQSLEMLGIL YWILNLTVVE SVFYLVVAFL
60 70 80 90 100
LFLIGRHFIE KLQINNLSKR AVFITGCDSG FGRGLALKCL EQGMPVFAGC
110 120 130 140 150
LTEQGIESLS AEARKSIGNG RSLDAFLMDV TSDESVGEVA KRLEKKCEQY
160 170 180 190 200
GGLHAVVNNA GITGKHIADD FLDINEYLKV ANINLWGPIR TTMAVKKLLK
210 220 230 240 250
KARGRVVTVA SICARVGLPG LGPYSVSKYG VSAYCDVIRQ ELRPFGISVH
260 270 280 290 300
VLEPGFFNTP LINREKIDAE ILEAWKHAPN EVKQEYGEKF FNDARESTHL
310 320 330 340 350
FLNSVASSQI SLVVDAYFHA ITSKHPRSRY QIGWDSILLF IPFSYLPTGL
360
QDYIFAAAGL FLPKPACR
Length:368
Mass (Da):40,771
Last modified:October 1, 2001 - v2
Checksum:i1658F5B694A1968F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CCD65438.1.
RefSeqiNP_491575.1. NM_059174.6.
UniGeneiCel.18633.

Genome annotation databases

EnsemblMetazoaiF55A12.4a; F55A12.4a; WBGene00000966.
GeneIDi172183.
KEGGicel:CELE_F55A12.4.
UCSCiF55A12.4a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CCD65438.1.
RefSeqiNP_491575.1. NM_059174.6.
UniGeneiCel.18633.

3D structure databases

ProteinModelPortaliO01758.
SMRiO01758. Positions 70-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F55A12.4a.

Proteomic databases

EPDiO01758.
PaxDbiO01758.
PRIDEiO01758.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF55A12.4a; F55A12.4a; WBGene00000966.
GeneIDi172183.
KEGGicel:CELE_F55A12.4.
UCSCiF55A12.4a. c. elegans.

Organism-specific databases

CTDi172183.
WormBaseiF55A12.4a; CE26924; WBGene00000966; dhs-2.

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00840000129713.
InParanoidiO01758.
OMAiYGATYLD.
OrthoDBiEOG091G0LMI.
PhylomeDBiO01758.

Enzyme and pathway databases

ReactomeiR-CEL-5365859. RA biosynthesis pathway.

Gene expression databases

BgeeiWBGene00000966.
ExpressionAtlasiO01758. baseline.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO01758_CAEEL
AccessioniPrimary (citable) accession number: O01758
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: October 1, 2001
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.